Professional Documents
Culture Documents
disease
By: Kate Biese, Kristin Kirkman, and Tien Vo
Background: defining the problem
Allergic disease: condition of unfavorable
immune system reaction to foreign substance
that induces high sensitivity
Allergie introduced by Clemens von
Pirquet
Discovered while treating patients who reacted
with new symptoms
50% children have allergies
Background Allergic Reaction
Allergen Y Y
Y
initial exposure to Histamines
Y
allergen released Y
B cell Y
Y
Release of IgE Y Y
Antibody
Y
subsequent
Mast cell w/ IgE
Y
exposure to allergen
Y
Y
Y Y Y
Y
Y
Y
Public health and clinical importance
Barker hypothesis
Lack of exposures during critical period leads inability
to develop antibodies for allergens
Hygiene hypothesis
Hyper-cleanliness leads to unprepared immune system
Thrifty phenotype
Increased maternal exposure to disease prepares fetus for
life outside
Public health and clinical importance
Rush Medical College study shows breastfeeding
reduces infant risk for GI & respiratory infection
Maternal exposure to infection increases immune production
of antibodies transported through breastfeeding
Fetal exposure in utero lowers need for costly
antibiotics, EpiPens, etc.
Decreasing allergic disease
Increase potential for healthy habits (ie. exercise, diet,
etc.)
Increase immunity for posterity
Risk Factors: Maternal Nutrition
Maternal food consumption during pregnancy and asthma, respiratory and atopic
symptoms in 5-year-old children, Willers et al. 2007
Regulatory T cells
increased
FOXP3 levels increased
Postnatal exposures:breastfeeding
Postnatal Exposure: Hygiene Theory
Food Allergy
Eczema
Asthma
Future research
Recommendations for future research:
Critical window
Sensitive window