October 2017

Stacey E. Alexeeff
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Office Address
Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

Email Stacey.Alexeeff@kp.org

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Education
2013 Ph.D. Biostatistics, Harvard University, Cambridge, MA

2009 M.Sc. Statistics, Carnegie Mellon University, Pittsburgh, PA

2006 B.Sc. Applied Mathematics - Biology, Brown University, Providence, RI

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Appointments
2015 present Research Scientist I Biostatistician
Kaiser Permanente Division of Research, Oakland, CA

2013 2015 NSF Mathematical Sciences Postdoctoral Research Fellow

National Center for Atmospheric Research, Boulder, CO

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Professional Activities
2014 Chair for Speed Session Poster Presentations: Topics in Epidemiology and Survey Research
Methods, Part 2. American Statistical Association, Joint Statistical Meetings, Boston, MA.
2012 Organizer for Topic-Contributed Session: Statistical Challenges of Spatial Multi-Pollutant
Data in Environ-mental Epidemiology. International Biometric Society ENAR Conference,
Washington, DC.
2012 present Refereed for journals:
Biometrics; Environmental Health Perspectives; Epidemiology; Circulation: Cardiovascular
Genetics; Indoor Air; PLOS ONE

Memberships
2012 present American Statistical Association (ASA)
2010 present International Biometric Society (IBS)
2014 present International Society of Environmental Epidemiology (ISEE)

Grant Review Activities

2016 present Ad hoc Reviewer for Agency for Healthcare Research and Quality (AHRQ) Health Care
Effectiveness and Outcomes Research (HEOR) Study Section

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Funding
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Current:
04/08/2016
Environmental Defense Fund Grant
03/31/2018
(PI: Van Den Eeden)
Novel Air Pollution Mapping and Health Disparities in Oakland, CA
The Environmental Defense Fund is collecting air pollution data for high resolution air quality
mapping. The target study region will include areas of East, West and downtown Oakland, as
defined by the boundaries of the data collected by the Environmental Defense Fund. Air
pollution data will be linked to geocoded addresses and electronic medical records in the
Kaiser Permanente Northern California database. We will estimate the relationship between
differences in traffic-related air pollution levels and health disparities across multiple disease
areas.
Role: Co-Investigator
09/25/2013
U01 CA183081-03
08/31/2018
(PI: Mandelblatt, Lieu, Ramsey)
Optimizing Personalized Care Using Economic Studies of Genomic Testing
This project will identify ways of enhancing personalized health care by evaluating the impact
of physician, patient, and healthcare system factors using a genomic test for breast cancer
prognosis as the exemplar and applying an innovative multi- criteria decision analysis
approach that incorporates physician and patient preferences for important psychological and
qualitative factors, as well as health outcomes and costs. Our work will develop a
generalizable framework and tools useful for other emerging technologies and for other
chronic diseases.
Role: Biostatistician

09/30/2012
U54 NS081760-04
08/31/2017
(PI: Sidney, Bibbins-Domingo)
The Discovering Healthcare Innovations to Address Disparities in Stroke (DIADS)
DIADS is collaboration between Kaiser Permanente Northern California (KPNC) and the
University of California, San Francisco (UCSF). DIADS seeks to design, implement, and
evaluate a clinically-delivered hypertension control intervention that consists of both a clinical
algorithm for rapid and effective blood pressure control, as well as a culturally-tailored dietary
intervention aimed at more effective sustained blood pressure control.
Role: Biostatistician
09/19/2013
R01 DK099108-03
07/31/2018
(PI: Grant)
Pre-Visit Prioritization for Complex Primary Care Patients with Diabetes
We propose to implement and evaluate a novel, patient-centered intervention designed to
facilitate communication between patients and their primary care providers with the goal of
enabling more effective primary care for complex patients with poorly controlled diabetes.
Role: Biostatistician

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06/01/2013
R01 CA175011-03
05/31/2018
(PI: Caan)
Body Composition, Weight, and Colon Cancer Survival
This study will examine the extent of excess body fat and muscle loss among persons
diagnosed with colorectal cancer in order to see if levels of body fat or muscle mass are
related to survival. Study findings could provide important insight into the role of energy
balance and body composition in cancer survival and may lead to more tailored treatment
strategies.
Role: Biostatistician

08/01/2012
R01 CA166827
05/31/2017
(PI: Sieh, Habel)
Genome-Wide Association Study of Mammographic Density
Mammographic density (MD) is one of the strongest known risk factors for breast cancer. Our
primary goal is to identify novel genes for MD by conducting a GWAS in 30,000 Caucasian
women participating in KPNCs Research Program on Genes, Environment and Health
(RPGEH). We will obtain routine screening mammograms and assess breast density.
RPGEH and KPNC databases will provide genome-wide marker data for over 650K SNPs as
well as extensive epidemiologic and medical data, including BMI, lifestyle and reproductive
factors, and use of prescription medications.
Role: Co-Investigator

Past:
2013 2015 NSF MSPRF 1304321
Statistical Methodology for Modeling Big Data to Quantify the Effect of Climate Change on Air
Pollution and Human Health, with a Focus on Model Uncertainty
Host institution: National Center for Atmospheric Research
Role: Principal Investigator

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Teaching Experience

Teaching Assistant, Harvard School of Public Health, Biostatistics Department

2012 BIO-211: Regression and Analysis of Variance
Graduate level course for PhD, MPH and Biostatistics masters students
2012 BIO-226: Applied Longitudinal Analysis
Graduate level course for PhD, MPH and Biostatistics masters students
Topics: covariance pattern models, random effects and growth curve models, generalized
estimating equations (GEE) and generalized linear mixed effects models (GLMMs)

Teaching Assistant, Carnegie Mellon University, Statistics Department

2009 36-626: Probability and Mathematical Statistics II
2008 36-201: Statistical Reasoning and Practice
2008 36-220: Engineering Statistics and Quality Control
2007 36-309: Experimental Design for Behavioral and Social Sciences
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Invited Presentations

1. Kaiser Permanente, Division of Research, May 2015.

2. Indo U.S. Workshop on Environmental Statistics. Kolkata, India, March 2015.
3. Johns Hopkins University, Department of Biostatistics, Jan 2015.
4. University of Colorado Denver, Department of Mathematics and Statistics, Jan 2015.
5. University of Michigan, Department of Biostatistics, Nov 2014.
6. Colorado State University, Department of Statistics, Nov 2014.
7. University of Nevada Reno, Department of Mathematics and Statistics, Oct 2014.
8. California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, Sept 2014.
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Conference Presentations

1. International Society for Environmental Epidemiology Annual Conference, Sydney, Australia, Sept 2017.
2. International Biometric Society ENAR Conference, Austin, TX, March 2016.
3. American Statistical Association, Joint Statistical Meetings, Seattle, WA, Aug 2015.
4. International Biometric Society ENAR Conference, Miami, FL, March 2015.
5. International Society for Environmental Epidemiology Annual Conference, Seattle, WA, Aug 2014.
6. American Statistical Association, Joint Statistical Meetings, Boston, MA, Aug 2014.
7. SIAM Conference on Uncertainty Quantification, Savannah, GA, March 2014.
8. International Biometric Society ENAR Conference, Baltimore, MD, March 2014.
9. American Statistical Association, Joint Statistical Meeting, Montreal, Quebec, Canada, Aug 2013.
10. International Biometric Society ENAR Conference, Orlando, FL, March 2013.
11. American Statistical Association, Joint Statistical Meetings, San Diego, CA, Aug 2012.
12. International Biometric Society ENAR Conference, Washington, DC, April 2012.
13. International Biometric Society ENAR Conference, Miami, FL, March 2011.
14. American Statistical Association, Joint Statistical Meetings, Vancouver, British Columbia, Canada, Aug 2010.
15. American Thoracic Society Intl Conference, New Orleans, LA, May 2010.
16. American Thoracic Society Intl Conference, San Francisco, CA, May 2007.

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Peer Reviewed Publications

1. Cespedes Feliciano E, Kroenke CH, Meyerhardt JA, Prado CM, Bradshaw PT, Kwan ML, Xiao J, Alexeeff S,
Corley D, Weltzien E, Castillo AL, Caan BJ. 2017. Muscle mass at the time of diagnosis of nonmetastatic colon
cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: The C-
SCANS study. Cancer. doi: 10.1002/cncr.30950. PMID: 28881381.
2. Cespedes Feliciano EM, Kroenke CH, Meyerhardt JA, Prado CM, Bradshaw PT, Kwan ML, Xiao J, Alexeeff S,
Corley D, Weltzien E, Castillo AL, Caan BJ. 2017. Association of Systemic Inflammation and Sarcopenia with
Survival in Nonmetastatic Colorectal Cancer: Results from the C SCANS Study. JAMA Oncology. doi:
10.1001/jamaoncol.2017.2319. PMID: 28796857.
3. Alexeeff SE, Odo N, Lipson JA, Achacoso N, Rothstein JH, Yaffe MJ, Liang RY, Acton L, McGuire V, Whitmore
AS, Rubin DL, Sieh W*, Habel LA*. 2017. Age at menarche and late adolescent adiposity associated with
mammographic density on processed digital mammograms in 24,840 women. Cancer Epidemiology, Biomarkers
& Prevention. doi: 10.1158/1055-9965.EPI-17-0264. PMID:28698185. *co-last authors

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4. Alexeeff SE, Yau V, Qian Y, Davignon M, Lynch F, Crawford P, Davis R, Croen LA. 2017. Medical conditions in
the first years of life associated with future diagnosis of ASD in children. Journal of Autism and Developmental
Disorders, 47(7):2067-2079. doi: 10.1007/s10803-017-3130-4.
5. Herrinton LJ, Liu L, Alexeeff S, Carolan J, Shorstein NH. 2017. Immediate Sequential vs. Delayed Sequential
Bilateral Cataract Surgery: Retrospective Comparison of Postoperative Visual Outcomes. Ophthalmology, S0161-
6420(17)30282-8. doi: 10.1016/j.ophtha.2017.03.034.
6. Caan BJ, Meyerhardt JA, Kroenke CH, Alexeeff S, Xiao J, Weltzien E, Cespedes E, Castillo AL, Quesenberry C,
Kwan ML, Prado CM. 2017. Explaining the obesity paradox: The association between body composition and
colorectal cancer survival. Cancer Epidemiology, Biomarkers & Prevention, 26(7):1008-1015. doi:
10.1158/1055-9965.EPI-17-0200.
7. Lieu TA, Ray GT, Prausnitz SR, Habel LA, Alexeeff S, Li Y, Ramsey SD, Phelps CE, Chawla N, ONeill S,
Mandelblatt JS. 2017. Oncologist and organizational factors associated with variation in breast cancer multigene
testing. Breast Cancer Res Treat. doi: 10.1007/s10549-017-4158-z.
8. Alexeeff SE, Nychka D, Sain SR, Tebaldi C. 2016. Emulating mean patterns and variability of temperature
across and within scenarios in anthropogenic climate experiments. Climatic Change, 1-15. doi: 10.1007/s10584-
016-1809-8.
9. Alexeeff SE, Carroll RJ, Coull B. 2016. Spatial measurement error and correction by spatial SIMEX in linear
regression models when using predicted air pollution exposures. Biostatistics. 17(2):377-389. doi:
10.1093/biostatistics/kxv048.
10. Alexeeff SE, Pfister GG, Nychka D. 2016. A Bayesian model for quantifying the change in mortality associated
with future ozone exposures under climate change. Biometrics. 72(1):281-288. doi: 10.1111/biom.12383.
11. Alexeeff SE, Schwartz J, Kloog I, Chudnovsky A, Koutrakis P, Coull BA. 2014. Consequences of kriging and
land use regression for PM2.5 predictions in epidemiologic analyses: insights into spatial variability using high-
resolution satellite data. J Expo Sci Environ Epidemiol. doi: 10.1038/jes.2014.40.
12. Colicino E, Power MC, Cox DG, Weisskopf MG, Hou L, Alexeeff SE, Sanchez-Guerra M, Vokonas P, Spiro A
3rd, Schwartz J, Baccarelli AA. 2014. Mitochondrial haplogroups modify the effect of black carbon on age-related
cognitive impairment. Environ Health. 13(1):42.
13. Alexeeff SE, Baccarelli A, Halonen J, Coull BA, Wright RO, Tarantini L, Bollati V, Sparrow D, Vokonas PS,
Schwartz J. 2013. Association between Blood Pressure and DNA Methylation of Retrotransposons and pro-
inflammatory genes. Int J Epidem. 42(1):270-80.
14. Power MC, Weisskopf MG, Alexeeff SE, Wright RO, Coull BA, Spiro A 3rd, Schwartz J. 2013. Modification by
hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in
older men: a cohort study. Environ Health. 12:16.
15. Schwartz J, Alexeeff SE, Mordukhovich I, Gryparis A, Vokonas PS, Suh H, Coull BA. 2012. Association between
long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging
Study. Occup Environ Med. 69(6):422-427.
16. Fang SC, Mehta AJ, Alexeeff SE, Gryparis A, Coull B, Vokonas P, Christiani DC, Schwartz J. 2012. Residential
black carbon exposure and circulating markers of systemic inflammation in elderly males: the normative aging
study. Environ Health Perspect. 120(5):674-80.
17. Alexeeff SE, Coull BA, Gryparis A, Suh H, Sparrow D, Vokonas PS, Schwartz J. 2011. Medium-term exposure
to traffic-related air pollution and markers of inflammation and endothelial function. Environ Health Perspect.
119(4):481-486.
18. Wilker EH, Alexeeff SE, Suh H, Vokonas PS, Baccarelli A, Schwartz J. 2011. Ambient pollutants,
polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study.
Environ Health. 10:45.
19. Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro A 3rd, Schwartz J. 2011. Traffic-related air
pollution and cognitive function in a cohort of elderly men. Environ Health Perspect. 119(5):682-877.

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20. Wilker EH, Alexeeff SE, Poon A, Litonjua AA, Sparrow D, Vokonas PS, Mittleman MA, Schwartz J. 2009.
Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction
in elderly men. Atherosclerosis. 206(2):480-485.
21. Alexeeff SE, Litonjua AA, Wright RO, Baccarelli A, Suh H, Sparrow D, Vokonas PS, Schwartz J. 2008. Ozone
exposure, antioxidant genes, and lung function in an elderly cohort. Occup Environ Med. 65(11):736-742.
22. Alexeeff SE, Litonjua AA, Suh H, Sparrow D, Vokonas PS, Schwartz J. 2007. Ozone exposure and lung
function: effect modified by obesity and airways hyperresponsiveness. Chest. 132(6):1890-1897.
23. Alexeeff SE, Litonjua AA, Sparrow D, Vokonas PS, Schwartz J. 2007. Statin use reduces decline in lung
function: VA Normative Aging Study. Am J Respir Crit Care Med. 176(8):742-747.

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