Professional Documents
Culture Documents
CONCEPTS IN THE
IMMUNE RESPONSE (I)
Do Dr Nevriye Gnll
Our bodies defenses are similar to a
military defense
The initial defence mechanisms are
barriers: skin
acid
bile
mucus
These barriers inactivate and prevent entry
of the foreign agents
If these barriers are compromised or the
agent gains entry in another way
Low-molecular-weight proteins
3 days
Monocytes blood
Are 10 to 18 m in diameter
Single-lobed
Kidney bean-shaped nucleus
3% to 8% of peripheral blood leukocytes
Monocytes
Long-lived cells
Phagocytic
Contain lysosomes and
Unlike neutrophiles, have mitochondria
Macrophages-Functions
Phagocytosis
Antigen presentation (AP) to T cells to initiate
specific immune responses
Secretion of cytokines to activate and
promote innate and immune responses
Macrophages-cell surface receptors (I)
CR3
Macrophages-cell surface receptors (II)
Memory cells
CD45RO
release cytokines
recognize and kill virally infected cells, foreign
tissue transplants (non-self-grafts), and
tumor cells as cytotoxic killer T cells
suppress immune response
T cells
Y-shaped molecules
Fab and Fc fragments
Heavy and light chains
Immunoglobulin types