MTP Kit (Medical Termination of Pregnancy Kit) is a combination of

two drugs used and applied to induce medication abortion. These drugs
are Misoprostol Pills and Mifepristone Pills. This is a set of two
medicines especially used for medical abortion/termination of
intrauterine pregnancy up to 63 days of fertilization.

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 Pregnancy is a highly sensitive issue. Parents have to be prepared for it in
many ways. Pregnancy and subsequent childbirth, raising a family demands
huge financial, physical, mental and psychological resources. The role of
woman is more critical here. She sacrifices almost everything to become a
mother. She sacrifices her job, career, and health, even herself for this reason.
So if for certain reasons the parents or the pregnant woman is not prepared
for childbirth, medical termination of pregnancy remains a scientific, medical
solution. There are many legal and medical reasons those may also require
termination of unwanted pregnancy. A forced rape resulting into a
undesirable pregnancy or any fatal untreatable genetic disease that may carry
to the fetus also demands a safe and secured medical termination of that
pregnancy.
Medical Termination of Pregnancy Kit is highly sensitive product and
must be used under extreme discretion, with legal permission and most
importantly, under the observation of a specialist doctor.
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 Each kit contains 5 tablets of-
1 Mifepristone tablet- 200 mg.
4 Misoprostol tablets- 200 mcg.

Mifepristone tablet in the MTP Kit is to be taken orally and Misoprostol

tablets are to be administered through vaginal route.

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 The dosage is Mifepristone 200 mg
orally followed 1 - 3 days later by
Misoprostol 800 mcg, 4 tablets of 200
mcg, vaginally. The Misoprostol may
be administered by a health care
provider or self-administered by the
woman.

For women at 49 - 63 days of gestation, if abortion has not occurred 4

hours after administration of Misoprostol, a second dose of Misoprostol
400 mcg ,2 tablets of 200 mcg may be administered vaginally or orally,
depending upon preference and amount of bleeding.

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 Mifepristone Pills:- Mifepristone is a synthetic steroid with an anti-
progestational action as a result of competition with progesterone at the
progesterone receptors. This results in termination of pregnancy. Mifepristone
antagonizes the endometrial and myometrial effects of progesterone.
During pregnancy, it sensitizes the myometrium to the contraction - inducing
action of prostaglandin. During the first trimester, pre-treatment with
Mifepristone allows the dilatation and opening of the cervix uteri.
Misoprostol Pills:- Misoprostol is a synthetic prostaglandin E1 which is a
potent inhibitor of gastric acid secretion in humans. It also causes the cervix to
soften and the uterus to contract.
Prostaglandin E1 causes myometrial contractions by interacting with specific
receptors on myometrial cells. This interaction results in a change in calcium
concentration, thereby initiating muscle contraction. By interacting with
prostaglandin receptors, Misoprostol causes the cervix to soften and the uterus
to contract, resulting in the expulsion of the uterine contents.

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 The patient should return for a follow-up visit approximately 14 days after
the administration of Mifepristone. This visit is very important to confirm
by clinical examination or ultrasonography scan that a complete
termination of pregnancy has occurred.
A follow-up visit must take place within a period of 14 - 21 days after
administration of Mifepristone to verify by the appropriate means,
clinical examination, ultrasound scan, and beta-HCG measurement that
expulsion has been completed and that vaginal bleeding has stopped.
In case of persistent bleeding, even light, beyond the control visit, its
disappearance should be checked within a few days. If an ongoing
pregnancy is suspected, a further ultrasound scan may be required to
evaluate its viability.

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 Any known allergy to any of the ingredients of MTP kit, any chance of
ectopic pregnancy, IUD still in place, chronic adrenal failure, uterine
bleeding disorders, woman on any anti-coagulant therapy, steroid
dependent females, suffering from uncontrolled or severe asthma are the
contraindications of MTP Kit.

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