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    Quick drug table for depression

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    Quick drug table for depression

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    Download as DOCX, PDF, TXT or read online from Scribd
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    10 views1 page

    Depression

    Uploaded by

    Jayden
    Quick drug table for depression

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    SSRI: Selective Serotonin Reuptake Inhibitor

    NOTEs CONTRAINDICATIONS
    SSRI Class Side effect: BBW: suicidal ideation in age < 24 with
    MAOI > SSRI: 14d or 2 weeks Sexual SE (Best: Wellbutrin) MDD and other psychiatric disorder.
    (Fluoxetine: 5 weeks from; 7d to) Somnolence, insomnia, nausea, dry Consider risk prior to prescribing.
    mouth, weakness, tremor, dizziness CI: MOAI, linezolid, IV methylene blue or
    HA (benefit migraine long-term) pimozide
    Diaphoresis: dose-related
    SIADH, hyponatremia (elder) DDI: bleeding w. anticoagulant
    Fluoxetine (Prozac) Activation: take dose AM; PM if sedating BBW: pregnancy
    (+) OLANZapine (Symbryax) Symbryax: 6/25mg Qhs resistance
    FDA-W: DRESS reactions
    O: Sarafem, Prozac Weekly Switch to 90mg/weekly, 7 days from last CI: Thioridazine
    Paroxetine (Paxil) Both: 2D6 inhibitor
    (Brisdelle) 7.5mg: menopausal vasomotor
    Sertraline (Zoloft) PMDD; Best for cardiac dx CI: disulfiram (Antabuse, alcoholism)
    Citalopram (Celexa) Max: 40mg/day FDA-W: QTc prolongation
    Avoid: cardiac risk Risk: elderly (>60), liver dx, 2C19
    Escitalopram (Lexapro) Max: 20mg; elderly, 10mg poor metabolizer or inhibitor
    Sertraline is best in cardiac patient
    Fluvoxamine (Luvox) No solution; Only OCD; a lot DDI CI: alosetron, ramelteon, tizanidine

    SNRI: Serotonin and Norepinephrine Reuptake Inhibitor (5HT, NorE)

    NOTEs CONTRAINDICATIONS
    SNRI Class SE: SSRI (+) pulse, dilate pupil, dry C: Obstructive urinary disorder
    MAOI > SNRI: 14 days mouth, xs sweating, constipation W: BP (V > 150mg)
    SNRI > MAOI: 5-14d (D); 7d (V, D, L) Renal impair: dose-reduced
    Venlafaxine (Effexor / XR) Max: 375mg (IR); 225 (ER) Dulo: CrCl < 30 (avoid)
    Preferred: tamoxifen x hot flash Levo: CrCl < 15 (avoid)
    Duloxetine (Cymbalta) Dose > 60mg: ineffective
    Ideal: Pain + Depression
    Desvenlafaxine (Pristiq, Khedezla)
    Levomilnacipran (Fetzima)

    TRICYCLIC: 5HT, NorE Reuptake (+) block Acetylcholine (Ach) and Histamine (H1)

    NOTEs CONTRAINDICATIONS
    Tricyclic Antidepressant QTc (overdose; suicidal agents) All: Myocardial infarction
    ECG baseline: risks, > 50yrs Doxe: Glaucoma, urinary retention
    MAOI: 14d washout Orthostasis
    SE: 3* (A, D) > 2* (N) Overdose/toxicity
    Anticholinergic (req taper, rebound) QTc prolongation
    Dry mouth, blurred vision, urinary Myoclonus (muscle twitching)
    retention, constipation
    Amitriptyline (Elavil) Neuropathy/migraine ppl: 10-50mg Fall risk: Elder (sedation, ortho)

    Doxepin Zonalon, Prudoxin: pruritus Cr


    Silenor: 3.6mg insomnia
    Nortriptyline (Pamelor) Less anti-C, weight +, sedation

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