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Methylcobalamin 1500 mcg, Alpha Lipoic acid 200 mg, Pyridoxine HCl 3
extremely small amount of this vitamin has a marked effect on the growth of
yeast and certain bacteria. It forms part of several enzyme systems. Biotin is
freely soluble in hot water, but sparingly in cold water. It is insoluble in fat
solvents and sparingly soluble in alcohol. Water, sulpha drugs, oestrogen, food
bacteria, yeasts, molds, algae, and some plant species .Biotin is a B vitamin
amino acids. Although it is vitally necessary to the body, only exceedingly small
state can be produced artificially by including large quantities of raw egg white
in the diet; the whites contain avidin, a biotin antagonist. Especially good
sources of this widely distributed vitamin include egg yolk, kidney, liver,
Biotin is necessary for cell growth, the production of fatty acids, and the
metabolism of fats and amino acids. It plays a role in the citric acid cycle,
respiration. Biotin not only assists in various metabolic reactions, but also
blood sugar level. Biotin is often recommended for strengthening hair and
nails. Consequently, it is found in many cosmetics and health products for the
and health of the hair. It prevents premature greying of the hair as well as hair
loss. This vitamin helps to maintain the skin and the nervous system in a
DEFICIENCY SYMPTOMS
muscular weakness, pains, pins and needles (pricking of the skin), lassitude,
and lack of appetite. It may cause eczema, dandruff, hair loss and seborrhoea.
Other common problems which may occur are skin disorders, heart
abnormalities, lung infections, anaemia, extreme fatigue, confusion, mental
depression, and drowsiness. The fleshy part of the tongue may waste away.
Certain rare inborn diseases can leave people with depletion of biotin due to
biotin deficiency can develop, because a protein in the raw egg white inhibits
the absorption of biotin. Cooked eggs do not present this problem. Long-term
antibiotic use can interfere with biotin production in the intestine and increase
anemia, and nausea. Long-term use of anti-seizure medications may also lead
to biotin deficiency.3 Alcoholics and people with diseases of the stomach have
been reported to show evidence of poor biotin status. However, the usefulness
1991;10:296302.
5. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp
6. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal
RECOMMENDED DOSE
The amount of biotin found in most diets, combined with intestinal production,
estimated that 30 mcg per day appears to be an adequate intake for adults. 7
mcg per day. Larger amounts of biotin (816 mg per day) may be supportive for
diabetic neuropathy. 8,9Biotin in the amount of 2.5 mg per day strengthened the
clinical trial. 10
8. Coggeshall JC, Heggers JP, Robson MC, Baker H. Biotin status and plasma
10. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily
Intakes between 0.010 and 0.20 mg/day are both safe and adequate (COMA,
1991).
Anecdotal reports suggest that typical daily doses of 10 mg are without adverse
effects and toxicity has not been reported in individuals receiving as much as
200 mg per day. Clinical data are limited but studies have reported no biotin-
years, 10 mg/day for 15 days, 4 mg/day for 3 weeks or 2.5 mg/day for 6-15
months.
administered daily, by the oral route (in three divided doses), for up to 4 years,
diabetes. The number of patients followed up after 24, 30, 36 and 48 months
was 15, 15, 10 and 5, respectively. There was no control group included in the
study. Fasting blood glucose levels decreased to normal within 2 months and
were not significantly changed. The authors reported that there were no
used for risk assessment because of the unusual design and the small number
of subjects.
authors reported no adverse effects. This study cannot be used to define the
The numerous clinical case reports in the literature describe the outcome of
oral biotin administration to patients (infants, juveniles and adults) with biotin-
suspected, biotin has been administered prenatally, via the mother. Typically,
doses of 10 mg/day (250 x the average intake of the adult male in the UK) have
been studied for therapeutic effects, without reported adverse side effects.
have not been associated with adverse effects. The study is limited in that it
was performed in diabetics, there was no control group and only a few
individuals remained in the study after 4 years. The authors concluded that
there were no adverse effects related to the biotin treatment, although they
reported a tendency for the treatment to lower blood sugar. Due to the low
applied in this case to allow for inter-individual variation. Thus, for guidance
adverse effects, although this value may not be applicable to all life stages.
intake (from all sources) of 0.97 mg/day biotin (equivalent to 0.016 mg/kg
Several studies have reported different doses of Biotin {Intakes between 0.010
and 0.20 mg/day are both safe and adequate (COMA, 1991), Anecdotal reports
suggest that typical daily doses of 10 mg are without adverse effects and
toxicity has not been reported in individuals receiving as much as 200 mg per
al., 1995)}.
have not been associated with adverse effects. Thus, a supplemental daily
would not be expected to produce adverse effects, although this value may not
from food, an estimated total intake (from all sources) of 0.97 mg/day biotin
Based upon the different scientific literature & data it is concluded that the
Lipoic acid 200 mg, Pyridoxine HCl 3 mg, Folic acid 1.5 mg and Biotin
200 mcg do not have any side or adverse effect on human subjects. So the
Methylcobalamin 1500 mcg, Alpha Lipoic acid 200 mg, Pyridoxine HCl 3
REFERENCES
COMA (1991). Dietary Reference Values for Food Energy and Nutrients for the
Maebashi, M., Makino, Y., Furukawa, Y., Ohinata, K., Kimura, S., Sato, T.
Velazquez, A., Teran, M., Baez, A., Gutierriez, J., Rodriguez, R. (1995). Biotin