All past paper of pharma BY DR SAJJAD YOUSUF ZARDARI

1. Which one combination

is correct: a. Thiopental

reduces heart rate

B. Profofol increases cerebral
blood flow
C Morphine reduces apnoeic
threshold d. Ketamine causes
bronchodilation

ANS:C

2.Most suitable NSAID

during Lactation: A.
Ibuprofen B. Peroxicam C.

Naproxen

ANS:A

3.Local Anesthetic having

Intirnsic sympathomimetc
activity: A. Xylocain B.

Tetracaine C. Procaine D.
Cocaine

ANS:D

4.Nitrous
oxide produces: A. Good analgesia
B. good muscle relaxation C.

cardiac depression

ANS:A

5.T/t of chloroquine resistant malaria:

a.mefloquine
b.pyrmethamine

ANS:A

6.Antibiotic for pseudomonas:

a.cipro
b.ceftriaxone

c.doxicycline

ANS:A

7.Doesnt act via receptors

a.naloxone
b.aluminuim hydroxide

ANS:B

8.Steroids drug action on cells:

A. Act on Genes
B. Adenyl cyclase
C. CGmp
D. Ip3

ANS:A

9. Which of the following increases lower eosophageal tone n speeds up gastric

emptying
time:

A. Aluminium hydrooxide
B. Metoclopramide

ANS:B

10.Patient presented in
emergency ,deeply
comatosed,not responding

to nalaxone: A. Heroin B.
Morphine C. Methadon
D. Phenobarbital E. Pethidine

ANS:D

11.Highest bioavailability of anti emetics:

A. Metacloprmide
B. Qdansetron

ANS:A

12.Patient aged 65 years, is diagnosed to have severe aplastic anemia. HLA

compatible
sibling is available. The best option of treatment is:

a) Anti thymocyte globulin followed by cyclosporine

b) A conventional bone marrow transplantation from the HLA identical sibling
c) A non-myeloablative bone marrow transplantation from the HLA identical sibling
d) Cyclosporine

ANS:A

13.Most common S/E of use

of histamine 1 blocker: A.
Blurred vision B. Blindness C.

Sedation

ANS:C

14.Wich Antiemetic has high bioavailability:

A. Metoclopramide
B. Prochlorthiazide

C. Ordansetron
D. Droperidol

ANS:A

15.Drug causing peripheral neuro and pancreatits:

A. Ziduvudine
B. Interfron
C. Diadenosine

ANS:C

16.Pregnant women 1st trimester develops Atrial fibrillation what would u give:
A. IV Heparin
B. IV Heparin Oral Aspirin

C. Aspirin
D. Anticoagulant

ANS:A

17.A pregnant full term patient came into the ER with pre-eclampsia. Her Blood
pressure was
190/110. She was admitted for emergency ceserean section. What is the best

medicine to
bring down the blood pressure:
A. Hydralazine
B. Sodium Nitroprusside
C. Verapamil
D. Propranolol

ANS:A

18.Patient was admitted in the ICU. HE had a central venous catheter for 10 days.
HE started
having fevers. Blood cultures were sent. It came back positive for Gram positive

cocci in
clusters. What medication will you start?
A. Amoxicillin
B. Imipenim
C. Ampicillin-Getamycin
D.Piperacillin-Gentamycin
E. Vancomycin

ANS:E

19.about Lignocaine what is true:

A. Blocks generation of impulses from free nerve endings
B. Prevents influx of Na ions across membrane

ANS:B

20. INR is for:

A. Heparin
B. Oral anticoagulation therapy

ANS:B

21.Analgesic causing tachycardia in therapeutic dose:

A. Pethidine
B. Morphine

C. Fentanyl

ANS:A
22.Following is a good analgesic but weak anaesthetic:
A. NO
B. Isoflurane

C. Sevoflurane

ANS:A

23.Effect of drug on a body:

A. Pharmakokinetics
B. Pharmodynamics

ANS:B

24.Patient was brought to the ER unconscious. The doctor gave Naloxone but it
was not
working. What is the likely cause of toxicity?

A. Methadone
B. Phenobarbital
C. Morphine

ANS:B

25.All anti psychotics are alike in:

A)anti emetic effect
B)anti pyschtic

C)potency in mili grams

ANS:A

26.Which of the following drugs is contraindicated in a patient with raised

intracranial
pressure:

a) Thiopentone
b) Propofol
c) Midazolarn
d) Ketamine

ANS:D

27. Fio2 max dose which does not cause fetolental adrenoplasia:
A. 0.5
B. 1

C. 2.5
D. 0.6

ANS:D

28.the blood level of wc of the following drugs is monitored usually after administration??
A. Cloxacillin
B. Penicillin

C. Vancomycin
D. CiprofloxAcin

ANS:C
29.Doc for Neisseria Meningitidis ?
A. Penicillin G B. Cloxacillin C.
Ampicillin

ANS:A

30.Anticoagulantion e heparin is C/I

in patients e? A. Hypertension
B. Thrombocytopenia

ANS:B

31.Which on has highest

bioavailibilty ?? A. Ondansetron B. Metoclopramide

ANS:B

32.In a pt of asthma and IHD, which

drug should b used to control bp
during an operation? A. Iv NGN

B. IV SODIUM
NITROPROSIDE C. Iv
HYDRALAZINE

ANS:B

33.side effect of cemitidine

A.inhibition of p45o
B.Agranulocytosis

C.Anti estrogen

ANS:A

34.Which of the folowing prolong use of drug will cause persistent inc in gastrin secretion
:a.antacids
b.antichollenergic

c.b blockers
d.H 2 antagonist
e.PPI

ANS:E

35.Which of the following increases lower eosophageal tone n speeds up gastric emptying time:A. Aluminium
hydroxide
B. Metoclopramide

ANS:B

36.55yr old Pt allergic to penicilin..prev h/o rhematoid heart disease..get dental treatment..
Prophylaxis
A.Vanco plus genta

B.Vanco
C.Clindamycin
D.Ampicilin
E.Amoxil

ANS:A
37.feature share by diazepam and chlropromazin:
A. Blurred vision
B. extra pyramidal effect

C. Sedation

ANS:C

38.overdose of antidepressant
cause
A high blood pressur

B urination c. tonic clonic seizures

ANS:C

39.aspirin toxicity cause

A coma
B alkalosis

C acidosis

ANS:B

40.anticoagulant are
cantaindicated
A anemia

B thrombocytopenia

ANS:B

41.cimitidin cause
A hepatic enzyme inducer
B heapatic enzyme inhibitor

ANS:B

42.in stomach H/K pump is inhibited by

A ranitidine
B omeprazol

ANS:B

44.patient has multiple

sclerosis develop urinary
incontinence which drug
should be given A beclofen
B methacholine c.oxybutynin

ANS:C

45.Drug which stable plaque in

Acute Coronary Syndrome? A.
Atorvastatin
B. Diuretecs C. Morphine

ANS:A

46.Adenosine
A. Half life 30 seconds
B. Transient Tachycardia C. action with thephylline D. Inhibit SA and
AV node

ANS:D

48.Drug for MRSA?

A. Co-trimaxazole
B. Co-

Amoxiclav

ANS:A

49.Succinylcholine toxicity in individuals having deficiency of

A.Acetyl cholinesterase
B.pseudocholinesteae

C.MAO

ANS:B

50.Dobutamine action
A. On alpha and beta
B. alpha, beta and dopamine

C. on only beta

ANS:A

51. Dm 2 + elderly
A.Metformin B.tolbutamode
C.glibenclamide

ANS:A

52.Most
effective Dvt prophylaxis
A.Warfarin ? B.heparin C.

low molecular wt heparin

ANS:C

53.Which drug can not cross BBB?

A. Phenobarbitone
B. Diazepam

C. Dopamine
D. Levodopa
E. Phenytoin

ANS:C

55. MAO Inhibitor and

hypertensive crises A. Coffee B.
Chocolate

ANS:A

56.Which of following drug cause hyperuricemia

A. INH
B. Rifampin
C. Pyrazinamide

ANS:C

57.Uterine Atony occurs after delivery drug of choice

A. Oxytocin
B. Ergometrine

ANS:B

58.histamine release a. fentanyl b. morphine

ANS:B

59.Dilation of coronary vessels is caused by:

A. NO
B. adenosine

ANS:A

60.Which of the following drugs would you prescribe in a patient with cardiogenic shock:
A. epinephrine
B. acetylcholine

C. dopamine

ANS:C

61.Drug of choice for gas gangrene:

A. penicillin
B. clindamycin

ANS:A

62.Tachycarida is adverse affect of

A. Verapamil
B. Isosorbide

C. Propanaplol

ANS:B

63.DOC for Tourette Syndrome

A. Haloperidol
B. Carbamazepine

ANS:A

64.Centrally acting antiemetics

A. Metochlopromide
B. Butyrophenones

ANS:A

65.Which of the
following is a antifungal
A. Rifampine B. Cimetidine

C. Erythromycin D. Ketoconazole

ANS:D
66.A 60 years old patient
having hypertension, diabetes
with hyperthyroidism, which

drug will be safe for him?

A.Ca blockers B.ACE
C.B.Blockers

ANS:B

67.How much time digoxin required to

reach at stable level?
A.2 minutes

B.9 minutes

ANS:B

68.Acetozomalamide(diamox)
MOA? A. H+ absorption, Na K
exceretion B. Acts on Thick

ascending loop
C. Acts on DCT
D. Osmotic diuretic E. Causes
alkalosis A

ANS:A

69.A pregnant lady during 5th month

of Gestation is case of thyrotoxicosis,
most appropriate drug for treatment A. Methamazol

B. Propylthiouracil C. Thyroxine D.
Propranolol E. Labetalol

ANS:B

70.maximum effect produced by a drug is measure of its:

A)Potency
B)Efficacy

C)Efficiency

ANS:B

71.Before giving GA to a patient halothane is combined with

A)Thiopentone
B)Nitrous Oxide

C)oxygen

ANS:B

72.which drug has more effect on coxII than cox I ?

a.aspirin
B.celexocib

c. nalproxane
d.ketorolac

ANS:B
73.Which drug has more effect on coxII than cox I ,,
a.aspirin
B.celexocib

c. nalproxane
d.ketorolac

ANS:B

74.regarding tramadol true is,

a.kappa nd meu
b.strong kappa

c.weak kappa
d.strong meu
E.weak meu agonist

ANS:E

75.ketorolac analgesia most

preferable,,
a.Thoractosy patient with ozzing

blood from woundb. hernoraphy

wid patient of peptic ulcer
C.Non diabetic cholecyctectomy
D.Asthmatic patient having
inguinal hernia repair

ANS:C

76.n a 12 years old male, having

myoclonic seizures, what will you
advice A. Carbamazepine

B. Phenytoin
C. Ethosuximide
D. Phenobarbitone

ANS:A

77.Seizures, 3 spikes per second , management

A. Ethosuximide
B. Phenytoin

C. Carbamazepine
D. Phenobarbitone

ANS:A

78.Epinephrine is contraindicated for treatment of postural hypotension if patient is already taking which of
the following drug
A. Imipramine

B. Amitryptaline
C. Dopamine
D. Atropine

ANS:B

79.Which drug if given IV in clinical dose will cause increase heart rate and pupillary dilation
A. Epinephrine
B. Atropine

C. Dopamine
D. Acetylcholine

ANS:B

80.Patient with family history of IHD and Breast Cancer want prophylaxis to prevent Osteoporosis, you
will advice
A. Calcium n Vit D

B. Bisphosphonates
C. Combined Hormonal Replacement Therapy
D. Raloxifene

ANS:D

81.To facilitate action of atropine, TCA block which of the following receptor
A. Alpha
B. Beta 1

C. Beta 2
D. Dopaminergic
E. Cholinergic

ANS:E

82.Lady having tremors, problem in writing, family history of similar complain, what u will advice
A. Amitryptiline
B. Ropirinole

C. Dopamine
D. Propranol

ANS:D

83.Patient presented with complain of tremors, no liver disease, no kayser Fleischer ring, normal thyroid
profile, no neck swelling, no palpitation, treatment
A. Pencillamine

B. Ceruloplasmin
C. Propranolol
D. Benztropine

ANS:C

84.Cause of Priapism
A. Trazodone
B. Atropine

ANS:A

85.Drug act on Neuromuscular Junction

A. Cocaine
B. Dopamine

C. Tubocurarine

ANS:C

86.20 years old, command hallucinations, apathy, drug advice

A. Olanzapine
B. Chlorperazine

C. Lithium

ANS:A

87.Patient, 40 yrs old brought by his father, complaining son has episodes of rage and mania, followed
by crying and asking for forgiveness, what you will prescribe to stabilize mood
A. Lithium

B. Carbamazepine

ANS:A

88.25 yrs old mother, delivered mentally challenged baby, most likely due to use of which of the following
A. Alcohol
B. Anticonvulsants

C. Antidepressants
D. Barbiturates

ANS:A

89. drugs inducing Rapid Eye Movement sleep

A. Benzodiazepines
B. Barbiturates

C. Hypnotics
D. No drug can do it

ANS:D

90.. Barbiturates
A. Hepatic enzyme inducer
B. Increase REM

ANS:A

91.phase 1 drug reaction

A. Oxidation b.Acetylation
C.Methylation

D.Glucuronidation

ANS:A

92.Which drug has more effect on coxII than cox I ,,

a.aspirin
B.celexocib

c. nalproxane
d.ketorolac

ANS:B

93.Gemifibrozil mechanism of action A.

Oxidation of lipids
B. Vldl hydrolysis or lipolysis C hdl
hydrolysis or lipolysis
d.It causes lipid hydrolysis by lip
protien lipase
ANS:D

94.Patient developed uti. and now we

see that there is pseduomonas
auregonisa and treatment or antibiotic

to be given A. Co trimazole B.
Ciprofloaxcin C. Gentamycin D.
Ceftriaxone

ANS:B

95.Drug after giving orally absorbed by aquious diffusion

a. benzo
b. pheno

c. ethanol
d. ephidrine
e. chlorpromazine

ANS:C

96.Resistent to chloroquine what to give

a. mefloquine
b. primaquine

ANS:A

97. benzo..pheno and other antiepileptics act by

a. GABA
b. glutamate

c. Ach

ANS:A

98. grade 4 hepatoencephlopathy caused by

a. paracetamole
B. amphetamine

ANS:A

99. CCB,
given in HOCM a. verapamil b. diltiazm
c. nefedipine d nimodipine e.

amlodipine

ANS:A

100.. selective action of

a timolol acts on B1 b. butaxalol on B1
c. Levobunolol on B1 d. Levobunolol

on B2 e. butaxolol on B2

ANS:B

101.After oral antiguagulant which

factor inhibited first a. factor 7 b.
factor 11 c. factor 12 d. factor 5
ANS:A

102.LMWH and Heparin has in

common a. same action on factor 10 b.
same action on prothrombin c. same

action on factor 5

ANS:A

103.Which drug cause tachycardia in therapeutic

doses:
a.morphine
b.Fentanyl
C.pethidine

ANS:B

104.Drug which is strong analgesic but not a good

anesthetic
a.desflurane

b.isofurane
c.nitrous oxide

ANS:C

105.lidocaine mechanism of action

a.blocks na channels
b.block k channels

ANS:A

106.. pre-eclamptic pt,high bp,medicine given before anesthesia

a. nitroprusside
b. hydralazine

ANS:B

107.which antiemetic is preffered in pts of chemotherapy

a. odansterone
b. metochlopramide

ANS:A

109.drug interaction
a. pharmacokinetic only
b. pharmacodynamic only

c. both pharmacokinetic and pharmacodynamic

ANS:C

110.. ranitidine is different from cemitidine as

a. it has less CNS toxicity
b. less potent

ANS:A

111.dicumarol side effect

a. platelets aggregation
b. inc clotting
c. dec clotting
d. inc bleeding time

ANS:C

112.dexamethasone as compare to hydrocortisone

a. immunosuppression
b. hyperglycemia

ANS:B

113.vol of distribution is not affected by a. age ,b. gender

ANS:B

114.histamine
releasing opioid a. morphine
b. tramdol

ANS:A

115.morphine is used in -a. biliary

colic -b. terminal cancer pain

ANS:B

116.antihypertensive acting
directly on SA node a.
verapamil b. nifidipine

ANS:A

117.mode of action of
cephalosporin a. dec
peptidoglycan synthesis b.

inhibit transpeptidase

ANS:B

118.What is used for traveller's diarrhea ?

A. metochlopramide
b. Diphenoxylate

ANS:B

119. lithium is a toxic antipsychotic. when should it be stopped ? ( dont remember the exact
statement )
a. when levels more than 1.2mmol

B. coarse tremrs
C. nausea and vomiting
D. hypothyroidism

ANS:B

120. Pt on ATT , cant differentiate btw red and green . which drug is responsible ?
A. ethambutol
B. INH

ANS:A
121.Heparin primarily works through :
A. anti thrombin 3
B. factor X

ANS:A

122.Pt with bee sting.after 4 hours , he has periorbital edema , Hypotension bp 100 by 6o.
Pulse 110(delayed anaphylactic reaction ban rha tha ) what to give ?
A. IM adreanline

B. Hydrocortisone

ANS:A

123. What is the mediator of allergy ?

A. 5 hydroxy tryptamine
B. Bradykinin

C. Adrenaline

ANS:A

124..4 yrs child with meningitis plus rash ( meningococcal meningitis ka scenario ban rha
tha ) treatment
A. 3rd generation cephalosporines

B. 2nd generation cephalosprns.

C. Benzylpenicillin
D. Eryhtromycin
E. 1st generation cephalosporins

ANS:A

125.Alpha-2-agonist used in ICU for sedation

a. Clonidine
b. Phentolamine

c. Phenoxybenzamine
d. Prazosin
e. Dexmedetomidine

ANS:E

126.Clavulinic
Acid is use with Penicilline to a.
Decrease penicilline Resistance

b. It inhibit beta lactamase

ANS:B

127.Ondasentron M/A was asked a.

Block dopaminergic in
ChemoTriger Zone b. 5-HT3

antagonist

ANS:B

128.-Edrophonium most common adverse effect

a. Diaphoresis
b. Dry mouth

c. Nausea
d. Euphorea
e. Sweating

ANS:C

129.A man with Bp of 200/100mmHg and glucose level of 200mg/dl, which drug you will
give
a. Linisopril
b. Furosamide
c. Amlodipine
d. Propanolol

ANS:A

130.Which drug cause Hypoglycemia most rapidly

a. NPH
b. Glibenclamide

c. Metformin
d. Insulin lente

ANS:B

131.Systemic fungal infection .drug given.

A. Amphotericin
b. B.ketoconazole

ANS:A

132. Insulin is inhibited by.

A. B.blockers
B. Secretin

C. Glucagon
D.b.agonists

ANS:A

134.A female delivered a baby and she was started on warfarin as she developed dvt.The
next day she has a purplish patch on
Her right thight what can be the cause
A lupus anticoagulant
b.warfarin overdose
c.proteinc def
d.proteins def

ANS:C

135.Bupivacain first sign of over doze

a.arrythmias
b-ringingine ars
c.hypotention
d.death
e.decco

ANS:B

136.Antibiotic should b given

A 6 hrx before surgery
B 12 hrx before srgery

C on operating table
D after the surgery
E on first dressing

ANS:C

137.Acute beta 2 blockage causes?a)hypoglycemia b)lipolysis )vasocons in muscles

ANS:A

138.Warfarin overdose causes brain haemorrhage immediately give?a)vit k + ffp b) ffp

ANS:B

139.increased bioavailibility
A.metoclopramide
B.Cyclizine

C.Dapsone

ANS:A

140..Aspirin and other NSAIDS work by acting on

A)Lipoxygenase
B)Cyclo-oxygenase

C)HMG Co A reuctase inhibitor

ANS:B

141.Drug used to treat Endometriosis

A)Danazole
B)Flutamide

C)Tamoxifen
D)Ketoconazole

ANS:A

142.Phospholipase most likely to be inhibited by

A. Steroids
B. Aspirin

C. Streptokinase

ANS:A

143.Patient on antituberculous drugs, presents with pin and needle sensations , what
drug should be
stopped

a. Isonazide
b. Pyrazinamide
c. ethambutol

ANS:A
144.Drug of choice in actinobacter bouneii
a. Imipenem
b. Tetracycline

ANS:A

145.Benzodiazepines causes
a. Dependence
b. tolerance

ANS:A

146.Angina worsen by which drug

a. Theophylline
b. Salbutamol

c. Vasopressin
d. Verapamil
e. metoprolol

ANS:A

147.Rivastigmine
a) acetylcholine estrase inhibitor
b) mao inhibiter

c) comt inhibitor

ANS:A

148.Drug which when given increase effect of antiseizure drugs

a. valproate
b. phenobarbitol

c. carbamezapine
d. phenytoin

ANS:A

149.Patient was given thiopentone he developed severe pain what should be the management :
a.Naloxone
a.Lignocaine

c.Epinephrine

ANS:B

150.atient underwent limb surgery now complain of moderate pain on 3rd post op day what
should be given
a.Paracetamol

b.Ketorolac

ANS:B

151.Chlorthalidone causes :
a.Hypercalcemia
b.Hyperuricemia

ANS:B
152.Which agent releases maximum histamine
a.Tubocurarine,b.Atracurium

ANS:B

153.Patient underwent liver transplant which of the drug you will prescribe which is nephrotoxic
and doesnt causes bone marrow depression
a.Cyclophosphamide

b.Cyclosporine
c.Prednisolone

ANS:B

154.Hyperthyroid lady with ventricular tachycardia heart rate of 180 pulse irregulary regular
treatment of choice :
a.Propanolol

b.Amiodarone
c.Verapami

ANS:A

155.digoxin toxicity is increased by :

a.Increase potassium
a.Increase intracellular calcium

ANS:B

156.More local anesthetic concentration in the blood by :

a.Epidural block
b.Caudal block

c.Spinal block
d.Brachial plexus block

ANS:C

157.Young girl with severe ronchi breathlessness PEFR less than 50 % of predicted
management :
a.Bronchodilators

b.Inhaled steroids
c.Ipratropium
d.Iv steroids plus bronchodilators

ANS:D

159.Patient solving airthematic problem EEG wave present :

a.Alpha
b.Beta

ANS:B

161.Aspirin MOA
A...inhibit prostaglandin production
B..inhibit phosphoralase

ANS:A
162.neurolepticmalignantsyndromecausedbydrug
A.Haloperidol
B.reserpine

ANS:A

163..thrombocytopeniacaused by
A.quinine
B.chloramphenicol

ANS:B

164.half life depends on

A.drug clearance
B.drug distribution

ANS:A

165.A person developed urine infection.Urine culture plate yielded a greenish growth having
fruity smell.This organism was oxidase positive and non lactose fermenting. The most
appropriate drug in this case would be

A. Ampilcilin
B. Ceftazidime
C .Ceftriaxone
D. Ciprofloxacine
E. Gentamycin

ANS:D

166. Inhalational agent which increases cerebral blood flow

A. Halothane
B, Isoflurane

D.sevoflurane

ANS:A

167.Rheumatic fever and infective endocarditis treatment to prevent disease is

A. pencillin G
B. Vancomycin

ANS:A

168.most common cause of increase BT is

A. von villibrand disease
B.haemophillia

C. aspirin toxicity

ANS:C