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Arylaminoalcohols
4-aminoquinolones:
Chloroquine
Amodiaquine
Amopyraquine
Structurally Related Compounds
Pyronaridine
Piperaquine
Quinine
Quinidine
Mefloquine
Halofantrine
Lumefrantrine
(Benflumetol)
8-aminoquinolones
Primaquine
Tafenoquine (Etaquine)
Dihydrofolate reductase inhibitors
Pyrimethamine
Proguanil
Chlorproguanil
Pyrimethamine-
sulfadoxine
Chlorproguanil-dapsone
Artemisinin and deriatives
Artemisinin
Artemether
Artesunate
Artemotil
Dihydroartemisinin
Hydroxynaphthaquinones
Atovaquone
Atovaquone-proguanil
Antibiotics with antimalarial activity
Sulfonamides
Tetracyclines
Chloramphenicol
Fluoroquinolones (weak)
Rifamycins (weak)
Macrolides
Clindamycin
Lincomycin
Drugs in italics are either still investigational, or are not widely available
Table 2. Dosing Schedule for Artesunate plus Amodiaquine
Age
511 months 25 () 25 25 76 () 76 76
16 years 50 (1) 50 50 153 (1) 153 153
713 years 100 (2) 100 100 306 (2) 306 306
>13 years 200 (4) 200 200 612 (4) 612 612
Antimalarial treatment of severe malaria in travelers is the same as the general recommendation
(table 7)
Positive pressure ventilation should be started in case of respiratory distress and coma with
breathing
abnormalities
1
Halofantrine is not recommended as first-line treatment for uncomplicated malaria because of
cardiotoxicity.
2
Doxycycline should not be used in children under 8 years of age and in pregnancy.
Artesunate1 2.4 mg/kg i.v. or i.m. on admission, at 12, 24 hours, then daily.
Artesunic acid (60mg) is dissolved in 1ml of 5% sodium
bicarbonate and further diluted into 5ml with 5% dextrose or
normal saline for intravenous injection (given as a bolus over 2
min). 1 ampoule=60mg
Artemether 3.2 mg/kg i.m. on admission followed by 1.6 mg/kg daily. NOT
for i.v. administration. 1 ampoule = 80mg. Injections to the
anterior thigh.
Where ACT has been adopted as the first-line treatment for P. falciparum malaria, it may
also be used for P. vivax malaria in combination with primaquine for radical cure.
Artesunate plus sulfadoxine-pyrimethamine is the exception as it will not be effective
against P. vivax in many places.
or
1 oral Artesunate 1 Tablet contains 50mg, a suspension is made by dissolving 1 tablet in 5ml of
water, 1ml equals 10mg, using a syringe
2
Malarone (AQ/PG) - one tablet contains 250 mg Atovaquone and 100 mg Proguanil. Give
Atovaquone-Proguanil with food. If patient vomits within 30 minutes of taking a dose, then
repeat the whole dose. If vomiting occurs after 3060mins of taking a dose, repeat half the
dosage.
3
to prevent recrudesence follow-on treatment should be given, when the patient is able to take
oral medication. Follow-on treatment can be a full course of the ACT of choice in the region (see
text).
Chloroquine-
resistant or
unknown 1st Quinine sulphate: 10 mg salt / kg every 8h for 7
resistance days
P. ovale
P. malariae