ENGLISH V TASK REPAIR

Journal Severity of periodontal disease in adult patients with diabetes

mellitus in relation to the type of diabetes and Mepolizumab Treatment in
Patients with Severe Eosinophilic Asthma

By

SIREGAR YOGA PRATAMA (10214028)

STUDY PROGRAM S1 NURSING

THE FACULTY OF HEALTH SCIENCES
INSTITUT ILMU KESEHATAN BHAKTI WIYATA
KEDIRI
2017
N Journal title Researcher Publication Research methods
o. name Year
1. Severity of Alma 2014 Study participants were 179
periodontal disease in Pranckevicienea, randomly selected 18-62-year-aged
adult patients with Jolanta Siudikienea, patients with type 1 diabetes
diabetes mellitus Rytas Ostrauskasb, mellitus and 87 randomly selected
in relation to the type Vita Machiulskienea 32-70-year-aged patients with type
of diabetes 2 diabetes. Metabolic control of
diabetes was determined by the
values of glycosylated haemoglobin
(HbA1c). The periodontal status of
all patients was evaluated by
simplifying oral debris index (DI-
S), probing pocket depth (PPD),
gingival recession (GR), clinical
attachment level (CAL), and
bleeding on probing (BOP). Data
analysis was performed with
respect to patients age, diabetes
duration, metabolic control level,
and diabetes type. Binary
regression was used to test
relationship of various parameters
with CAL.
Method. Randomized Controlled
Trial (RCT) is a method commonly
known in Hygiene. This method is
a comparative experimental study
Result
Severity of periodontal disease
associated with diabetes,
become more pronounced in
patients with type 2 diabetes
patients than in patients with
type 1 diabetes dental plaque
appears to be a major factor for
all patients with progressive
periodontitis.
for type 2 DM patients, the risk
of having severe periodontitis is
two times higher than type 1
DM. long duration of diabetes
had nearly double the risk,
while the parameters of
periodontal DI-S> 1 and broad
BOP (> 50%) had twice the risk
for developing severe
periodontal disease. However,
HbA1c increased by over 7%
did not appear to influence the
course of periodontitis.
 in controlled,
in which researchers give two or
more interventions to patients using
for the study sample.
2. Mepolizumab Hector G. Ortega, 2014 In this randomized, double-blind, Mepolizumab administered
Treatment in Patients M.D., Sc.D., double-dummy study, we assigned either intravenously or
with Severe Mark C. Liu, M.D., 576 patients with recurrent asthma subcutaneously significantly
Eosinophilic Asthma Ian D. Pavord, D.M., exacerbations and evidence of reducing asthma exacerbations
Guy G. Brusselle, eosinophilic inflammation despite and associated with improved
M.D., high doses of inhaled markers of asthma control.
J. Mark FitzGerald, glucocorticoids to one of three Level of exacerbations was
M.D., study groups. Patients were reduced by 47% (95%
Alfredo Chetta, assigned to receive mepolizumab, a confidence interval [CI], 28 to
M.D., humanized monoclonal antibody 60) among patients who
Marc Humbert, M.D., against interleukin-5, which was received intravenous
Ph.D., administered as either a 75-mg mepolizumab and 53% (95%
Lynn E. Katz, intravenous dose or a 100-mg CI, 36 to 65) among those who
Pharm.D., subcutaneous dose, or placebo received mepolizumab
Oliver N. Keene, every 4 weeks for 32 weeks. The subcutaneous, compared with
M.Sc., primary outcome was the rate of those who received placebo (P
Steven W. Yancey, exacerbations. Other outcomes <0.001 for both comparisons).
M.Sc., and Pascal included the forced expiratory
Chanez M.D., Ph.D., volume in 1 second (FEV1) and
scores on the St. Georges
Respiratory Questionnaire (SGRQ)
and the 5-item Asthma Control
Questionnaire (ACQ-5). Safety was
also assessed
Method. Placebo-controlled study
is to examine the ways in which
medical therapy, in addition to a
group of subjects who received the
treatment to be evaluated, a
separate control group received a
sham "placebo" treatments that are
specifically designed to have a
noticeable effect. Placebos are most
often used in a blind test, in which
subjects do not know whether they
received the real treatment or the
placebo. Often, there are also
"natural history" advanced group
that received no treatment at all.