BIOC 454 - NUCLEIC ACIDS (CRN 816)

TIMETABLE
Fall 2015
Lecturers:
J. Dostie (Coordinator), Room 815A, McIntyre Medical Building, Tel: 398-4975, josee.dostie@mcgill.ca
I. Gallouzi, Room 915B, McIntyre Medical Building, Tel: 398-4537, imed.gallouzi@mcgill.ca
S. Huang, Room 800C, McIntyre Medical Building, Tel: 398-4447, sidong.huang@mcgill.ca
T. Duchaine, Room 707B, McIntyre Medical Building, Tel: 398-8649, thomas.duchaine@mcgill.ca
N. Sonenberg, Room 615, Life Sciences Cancer Pavillion, Tel: 398-7274, nahum.sonenberg@mcgill.ca
J. Teodoro, Room 616, Life Sciences Cancer Pavillion, Tel: 398-3273, jose.teodoro@mcgill.ca
J. Pelletier, Room 810B, McIntyre Medical Building, Tel: 398-2323, jerry.pelletier@mcgill.ca
M. Tremblay, Room 617, Life Sciences Cancer Pavillion, Tel: 398-7290, michel.tremblay@mcgill.ca
M. Bouchard, Room 415, Life Sciences Cancer Pavillion, Tel: 398-3532 maxime.bouchard@mcgill.ca
G. Shore Room 915D, McIntyre Medical Building, tel: 398-7282, gordon.shore@mcgill.ca
A. Nepveu, Room 414, Life Sciences Cancer Pavillion, Tel: 398-5839, alain.nepveu@mcgill.ca
M. Park, Room 514, Life Sciences Cancer Pavillion, Tel: 398-5749, morag.park@mcgill.ca

Location and Time: McIntyre Medical Sciences Building, Room 521 from 9:35AM-10:25AM
Prerequisites: BIOC 311 and BIOC 312
DATE DAY LECTURE TITLE LECTURE LECTURER
Sept. 04 F Introduction: Topics in Nucleic Acids 1 JD
07 M LABOUR DAY NO CLASSES
09 W Genome structure and function: lecture 1 2 JD
11 F Genome structure and function: lecture 2 3 JD
14 M Genome structure and function: lecture 3 4 JD
16 W Genome structure and function: lecture 4 5 JD
18 F Genome structure and function: lecture 5 6 JD
21 M Genome structure and function: lecture 6 7 JD
23 W Genome structure and function: lecture 7 8 JD
25 F Cellular movement of RNAs 9 IG
28 M mRNA stability 10 IG
30 W mRNA decay 11 IG
Oct. 02 F High-throughput screening with sh/si and chemical libraries 12 SH
05 M High-throughput screening with sh/si and chemical libraries 13 SH
07 W High-throughput screening with sh/si and chemical libraries 14 SH
09 F Genome structure and function: lecture 8 15 JD
12 M THANKSGIVING NO CLASSES
14 W Genome structure and function: lecture 9 16 JD
16 F Genome structure and function: lecture 10 17 JD
19 M MicroRNA-mediated gene regulation 18 TD
21 W RNAi and chromatin 19 TD
23 F The PIWI proteins in stem cell biology 20 TD
26 M NO LECTURE
26 M MIDTERM EXAM (Evening: 19:00 21:00 MCMED, Room 504)
28 W Telomeres 21 JT
30 F Telomeres and Cancer 22 JT
Nov. 02 M CRISPR/Cas9 Technology 23 JP
04 W Genomic alterations in the mouse 24 MB
06 F Genomic alterations in the mouse 25 MB
09 M Stem cells 26 MT
11 W Overview of Gene Regulation and Apoptosis 27 GS
13 F Mechanisms of Gene Regulation and Apoptosis 28 MB
16 M RNA Splicing 29 NS
18 W RNA Splicing 30 NS
20 F DNA Damage Responses: DNA Repair Mechanisms 31 AN
23 M DNA Damage Responses: Checkpoint Control 32 AN
25 W Genomic Instability, Point Mutations and Cancer 33 AN
27 F Genomic Instability, Point Mutations and Cancer 34 AN
30 M Model Systems for the Study of Aging 35 AN
Dec. 02 W Oncogenes and Tumor Suppressors in Cancer 36 MP
04 F Oncogenes and Tumor Suppressors in Cancer 37 MP
07 M Oncogenes and Tumor Suppressors in Cancer 38 MP
MARKING SYSTEM:
Midterm Examination (40%): lectures 1 to 17 incl.; Final Examination (55%): lectures 18 to 38 incl. Class participation (5%).
IMPORTANT NOTE: Midterm and final exams are in the same format and consist of short written answers and multiple-choice
questions. Students unable to attend midterm or final exam for medical reasons ABSOLUTELY MUST provide a medical note
WITHIN 2 weeks of scheduled midterm and final exams. If legitimate doctors notes are not provided, you will receive a zero on the
midterm and your grade will be based on the final exam (55%) and class participation (5%). Students who have failed the class will
be allowed to take a supplemental examination (worth 100% of final grade and based on lectures 1 to 38 incl.). Supplemental
examinations will be given in the same format as scheduled midterm and final exams, and will include short written answers and
multiple-choice questions.
McGill University values academic integrity. Therefore, all students must understand the meaning and consequences of cheating, plagiarism and oth er
academic offences under the Code of Student Conduct and Disciplinary Procedures (see www.mcgill.ca/students/srr/honest/ for more information).

In accord with McGill Universitys Charter of Students Rights, students have the right to submit in English or in French any written work that is to be graded
(except in courses where knowledge of a language is one of the objectives of the course).
In the event of extraordinary circumstances beyond the Universitys control, the content and/or evaluation scheme in this course is subject to change.
Instructor generated course materials (e.g., handouts, notes, summaries, exam questions, etc.) are protected by law and may not be copied or distributed in
any form or in any medium without explicit permission of the instructor. Note that infringements of copyright can be subject to follow up by the University
under the Code of Student Conduct and Disciplinary Procedures.