Professional Documents
Culture Documents
doi:10.1093/eurheartj/sup001
Beta-blockers substantially improve survival in chronic heart failure and after myocardial infarction. However, concern about side-effects may
deter clinicians from prescribing these life-saving drugs. In reality, absolute contraindications are rare. Only 35% of patients are intolerant
because of hypotension or bradycardia. Data from randomized controlled trials and retrospective studies show that most patients eligible to
* Corresponding author. Tel: 49 221 478 32511, Fax: 49 221 478 32512, Email: erland.erdmann@uni-koeln.de
Published on behalf of the European Society of Cardiology. All rights reserved. & The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.
A22 E. Erdmann
The option to administer beta-blockers to patients with COPD is Beta-blockers and the central
important, because COPD and CHF or CAD often coexist. More-
over, cardiovascular mortality among COPD patients is high. nervous system
About 37% of patients with COPD die from cardiovascular Rarely, unpleasant dreams, hallucinations, insomnia, and depression
events,7,8 compared with the 34% who die from COPD itself.8 can occur during beta-blocker therapy.17 Some researchers believe
Intriguingly, there is evidence that impaired lung function is an inde- that highly lipid-soluble drugs, such as propranolol may penetrate
pendent and powerful predictor of cardiac mortality.9 Thus, many the central nervous system more than the others. Although head-
patients with COPD and concomitant CAD or CHF stand to ache and depression are listed as possible side-effects of beta-
benefit greatly from beta-blockers.10 Despite this, physicians are blockers, in some patients beta-blockers have beneficial effects in
often reluctant to prescribe beta-blockers in COPD.11 For reducing anxiety, migraine, and depression.
example, the EuroHeart Failure Survey found that the presence
of COPD in patients with CHF decreased the likelihood of receiv-
ing a beta-blocker.2 Beta-blockers and diabetes
Set against this reluctance, there is evidence that beta-blockers
save lives in patients with coexistent COPD and CAD, with a mor- Increased insulin resistance and a higher incidence of new-onset
tality reduction of 15 43% in randomized controlled trials.10 In an diabetes mellitus were reported in early trials with beta-blockers.
analysis of data from more than 200 000 patients in the Coopera- However, more modern agents such as bisoprolol and carvedilol
Figure 1 A meta-analysis by Haas et al. showed that compared Figure 2 Pathophysiology of erectile dysfunction (ED). Note
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