The Physiologists who are we?

Prof. George Brooks Prof. Steve Lehman Prof. Daniela Kaufer Dr. Darcy Kato Ernst

Dr. Robin Ball

Neurobiology of plasticity

Moelcular Prof.
Neural circuit and Daniela Kaufer
network level plasticity
Physiology Pathology/injury
Behavior cognitive

Social/emotional
Kaufer lab
Collaborators
Inbal Ben-Amie Bartal
Christapher Morrissey UC Berkeley
Aaron Friedman Darlene Francis
George Bentley
Kim long
Lance Kriegsfeld
Vlad Senatorov
George Brooks
Shawn Shirazi Linda Wilbrecht
Lydia Wood
Alon Friedman, DAL
Andrea Nicholas Uwe Heinemann, Charite
Soo young Kim John Huguenard, Stanford
Oscar Vasquez Marion Buckwalter, Stanford
David Prince, Stanford
Alana Wong Francois Tronche, INSERM
Funding
Noopur Amin David Pleasure, UC Davis
Marvin Maze, UCSF
Anna Geraghty
Albert Becker, Bonn
David Covarrubias Tom Neylan, UCSF and SF VA
Luisa Cachueax Mike Rogawsky, UC Davis
Sundari Chetty
Elizabeth Kirby
Sandra Murrow
Kereshmeh Taravosh-Lahn
Dr. Darcy Kato Ernst
Dr. Robin Ball
 Prof. Daniela Kaufer
danielak@berkeley.edu Th 9:45-10:45 , first floor OH space, LKS

Dr. Darcy Kato Ernst

darcy.kato@gmail.com Tu 9:30-10:30, 4111b VLSB

Dr. Robin Ball

rwball@berkeley.edu

Email policy: Questions will be answered in class and during office hours and discussion sections. Email should be
reserved for emergency purposes.
 Milan Amin Lisa Treidel
I graduated Integrative Biology
and Public Health from UC
Berkeley in 2016. I have since
been studying the cross
section of technology and
patient care in a joint UC
Berkeley-UCSF Masters in
Translational Medicine program
before I continue on to medical
school in August of this year.
106,108, 109
I completed my Bachelor's in
Biology and Psychology in 2012 at
Bucknell University and a Masters
in Biology at Illinois State
University in 2015. Currently I am a
2nd year PhD. student in IB, where
I work in Dr. Caroline Williams Lab
to investigate the role of energetics
in life history evolution.
101, 102, 105
Ghazal Naseri GSIs
I have a bachelor's and master's
degree in Biomedical
Engineering. However, after
graduating from University of
British Columbia I decided to
change my path to optometry. I
am now a second year
optometry student here at UC
Berkeley.
103,104, 107
Text Book:

Human Physiology: An Integrated Approach

Dee Silverthon

7th Edition

Available in book store,

But also used and electronic version.
iClicker
Quiz & lecture participation

Register:
http://www1.iclicker.com/
Syllabus on bCourse
note a new version
was uploaded last
night
What is Physiology?
 Homeostasis
What is it?

Who? Or Where are the origins of the concept?

Homeostasis, Walter Cannon:

is the property of a system, either open or closed, that regulates its internal environment and tends
to maintain a stable, constant condition.
Dynamic constancy
CONTROL SYSTEMS:

1.feedback control

The control action is somehow dependent on the output.

Negative feedback control

Positive feedback control

2. Feed forward control

The control action is independent of output.

33
Negative Feedback control system

One in which the control action

decreases the effect of any disturbance

Advantages of negative feedback:

- Automatic compensation for disturbances

34
________________________

________________________

________________________

________________________

________________________

________________________

36
Body temp (cold shivering, hot sweating)

Blood pressure (vasoconstriction and vasodilation)

Blood glucose levels (insulin, glucagon)

Production of red blood cells (EPO)

ATP inhibits PFK

37
NEGATIVE FEEDBACK CONTROL OF [ATP] in the Glycolytic
Pathway

38
Positive feedback control system

One in which the control action INCREASES

the effect of any disturbance

Advantages of positive feedback:

-Drives system to extreme

- Rapid , automatic response

40
41
Positive feedback examples:

________________________

________________________

________________________

________________________

________________________

________________________

42
Positive feedback examples:

-Proliferation of cells in development

-Childbirth

-Sexual arousal

-Voltage dependent Na+ channels in an action potential

-Blood clotting

-Clinical example: epileptic seizures

43
Feedforward control system

One in which the control action is

independent of the output

44
Advantages of feed-forward control

Can minimize (even eliminate) effects of disturbance

Fast because it anticipates effects of disturbance

Costs of feed-forward control

Needs good prediction (smart controller)

Mistakes can be costly

45
46
Feed-forward examples:

-________________________

-________________________

-________________________

47
Feed-forward examples:

- Saliva and acid production when you see food

- preparation for fight or flight response

-Anticipatory postural adjustments

48