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Laboratory of Toxic and Hazardous Waste Management, Department of Environmental Engineers, Technical University of Crete,
GR-73100 Polytechnioupolis, Chania, Crete, Greece
Abstract
Hospital waste management is an imperative environmental and public safety issue, due to the wastes infectious and hazardous
character. This paper examines the existing waste strategy of a typical hospital in Greece with a bed capacity of 400600. The seg-
regation, collection, packaging, storage, transportation and disposal of waste were monitored and the observed problematic areas
documented. The concentrations of BOD, COD and heavy metals were measured in the wastewater the hospital generated. The
wastewaters toxicity was also investigated. During the study, omissions and negligence were observed at every stage of the waste
management system, particularly with regard to the treatment of infectious waste. Inappropriate collection and transportation pro-
cedures for infectious waste, which jeopardized the safety of sta and patients, were recorded. However, inappropriate segregation
practices were the dominant problem, which led to increased quantities of generated infectious waste and hence higher costs for their
disposal. Infectious waste production was estimated using two dierent methods: one by weighing the incinerated waste
(880 kg day1) and the other by estimating the number of waste bags produced each day (650 kg day1). Furthermore, measurements
of the EC50 parameter in wastewater samples revealed an increased toxicity in all samples. In addition, hazardous organic compounds
were detected in wastewater samples using a gas chromatograph/mass spectrograph. Proposals recommending the application of a
comprehensive hospital waste management system are presented that will ensure that any potential risks hospital wastes pose to pub-
lic health and to the environment are minimized.
2006 Elsevier Ltd. All rights reserved.
0956-053X/$ - see front matter 2006 Elsevier Ltd. All rights reserved.
doi:10.1016/j.wasman.2006.04.019
M. Tsakona et al. / Waste Management 27 (2007) 912920 913
important parameters, samples from the hospitals sewage the hospitals capacity, the number of medical sta, and
were collected and examined. The results are documented, the applied practices. Therefore, an on-site evaluation of
together with recommendations for the implementation of the hospital waste generated is considered the most appro-
an eective waste management system. priate technique.
In our study, the quantity of infectious waste produced
2. Healthcare waste generation was determined by weighing the material before disposal
(see Table 1). The average amount of infectious waste
2.1. Categories of generated waste produced (880 kg day1 or 1.9 kg (day bed)1) seemed
excessive in comparison with similar studies (about
Circumstantial waste characterization is of no great 0.5 kg (day bed)1 (Skordilis and Padazopoulos, 1988).
importance, due to the waste streams heterogeneity. The This is due to the inappropriate segregation of the waste
focus of concern is on infectious wastes and on their proper at the source. Previous studies reported that the amount
treatment and disposal. Potential infectious wastes, toxic of hospital waste varies between 1.7 and 4 kg (day bed)1
wastes and potential toxic wastes are classied as wastes (Pruss et al., 1999).
that require special handling. Moreover, an attempt was made to estimate the amount
In an attempt to gain a general appreciation of the type of solid infectious and municipal waste using a dierent
of wastes generated in a hospital, the waste stream of a typ- approach. Matrons of each department were asked to
ical hospital was observed and the following categories of assess the number of red and black bags collected from
hospital wastes were recorded, in accordance with similar their department, which contained infectious and munici-
studies (OTA, 1990; US EPA, 1991; Pruss et al., 1999): pal type waste, respectively. This procedure led to the
results presented in Table 2.
Municipal wastes (paper, cardboard, food wastes, etc.). The results gave an average of 55 large-sized red bags
For the purpose of the current study this type of waste (120 L) and 240 large-sized black bags collected daily from
refers to waste with the same characteristics as munici- all of the hospitals departments. The calculation of waste
pal waste. mass was based on a related reference, which identied a
Human blood and blood products (including plasma, bulk density of 100 kg m3 for infectious waste and
blood cotton batting, etc.). 180 kg m3 for municipal waste (Seramidou et al.,
Microbiological wastes (laboratory cultures and stocks 1992). Following the procedure described in the previous
suspected to contain pathogens). paragraph, the authors took into account the fact that
Pathological wastes (human tissues, uids, organs and applied practices of waste collection included the removal
body parts). of each bag after being lled up to about three-fourths of
Isolated wastes (wastes from patients carrying highly its volume. Taking into consideration the inappropriate
contagious diseases). segregation practices used at the hospital, for the purposes
Contaminated/uncontaminated sharps (needles, hypo- of this study, the bulk density of infectious waste was
dermic needles, scalpels, etc.). increased to 130 kg m3 and the bulk density of municipal
Pharmaceutical wastes (pharmaceutical products that waste decreased to 150 kg m3 for a closer approximation
have expired or are no longer required). to actual values.
Chemical wastes (laboratory solvents and pigments, Finally, it was determined that 650 kg of infectious
photographic xing and developing solutions, etc.). waste and 3250 kg of municipal waste were being produced
Genotoxic wastes (wastes of cytotoxic chemicals and each day. For an average bed-capacity of 450 beds, the
cytostatic drugs). above quantities corresponded to 1.4 kg of infectious waste
Low-level radioactive wastes the hospital selected for (day bed)1 and 7 kg of municipal waste (day bed)1. The
this study was not producing any radioactive waste at latter did appear to be considerably high when compared
the time its wastes were being analyzed. to a related reference (4.5 kg (day bed)1) (Seramidou
Wastes including high concentrations of heavy metals et al., 1992).
(mercury wastes, batteries, etc.).
Wastewater (from laboratories and units where patients
with contagious diseases are treated).
Table 1
Daily disposed mass of infectious waste
2.2. Quantities of generated waste
Days Infectious waste (kg day1)
It is important to know the quantity of waste generated 1st 993
(by type) in order to examine the various treatment 2nd 1014
3rd 978
options. However, estimating the quantity of the produced
4th 789
waste stream often is a dicult task since, in practice, rel- 5th 615
ative mathematical equations have produced dierent
Mean average 880
results for each hospital. Waste production depends on
914 M. Tsakona et al. / Waste Management 27 (2007) 912920
Table 2
Daily collection of waste bags per hospital department
Department Number of red bags Number of black bags Number of the
collection frequency
Pathological Unit
A 0 Pathology Department 23 10 23
B 0 Pathology Department 1 20 23
Midwifery Department 12 25 12
Nephrology Department 1 67 23
Pediatrics Department 2 6 23
Pulmonary Department 2 20 23
Cardiology Department 12 67 23
Oncology Department 1 30 34
Hematology Department
Neurology Department
Surgical Unit
A 0 Surgery Department 3 25 3
B 0 Surgery Department 1 1 1
Neurosurgery Department 4 30 1
General Surgery Department 10 10 *
Anaesthesiology Department
Orthopaedics Department 1 10 3
Urology Department 1 25 3
Special Units
Articial Kidney Unit (Not recorded) (Not recorded) 23
Mediterranean Anemia Care Unit 1 4 2
Intensive Care Unit 67 1012 3
Coronary Care Unit 2 4 2
Laboratory Units
X-Ray Department 1/2 (Not recorded) (Not recorded)
Tomography Department 2 5 2
Hematology Department 2 34 2
Microbiology Department
Biochemistry Department 34 34 12
Anatomic Pathology Department 1/2 1/2 1
Cytology Department 1 1 1
Mean average 55 240
At the hospital where the research was conducted, the The collection stage includes the process of packaging
following segregation practices were applied: and labeling. At the hospital under observation, the col-
lection of infectious waste (red bags) was limited to the
Infectious waste was collected in red bags. stas work place and in the rooms of patients with
Municipal waste was collected in black bags. highly infectious diseases, in order to minimize the num-
Sharps were collected in yellow plastic containers. ber of persons being exposed to infectious waste. On the
Cytotoxic/cytostatic drugs were collected in their other hand, black bags were placed in patients rooms,
original packaging. oces, bathrooms and rest areas. Each bag was collected
only after it was lled up to three-fourths of its volume
The following practices were identied as problematic: so as to avoid overloading, which could lead to direct
exposure for the waste handler or to puncture of the col-
Insucient segregation of infectious waste from munici- lected bag.
pal waste. Several situations were observed during which The following problematic areas were observed at the
municipal waste was placed with infectious waste in the collection stage:
same red bags. Such a practice increases the amount of
infectious waste and the cost of their disposal. The use of inappropriate means of collection. Red bags
The lack of segregation between ammable materials, were characterized by thinness and low resistance to
toxic substances and other materials that require special tears, which enabled the stagnation of liquids on the
handling. oor and the creation of a focus of infection.
M. Tsakona et al. / Waste Management 27 (2007) 912920 915
The absence of appropriate labeling. The name of the Storage of wastes for many hours at times for more
wastes generator was marked on a few red bags only than 24 h.
on rare occasions a fact that hindered the identica- Storage of municipal waste in contact with infectious
tion of the generator and the type of waste. waste.
Failure to clean the storerooms after every transporta-
tion cycle. The stagnation of liquids on oors was
5. Transport observed in some cases it remained for more than 24 h.
Failure to clean the refrigerator. The stagnation of liq-
Medical wastes are transported through pre-established uids from infectious waste was observed on the oor
routes, which include specic corridors and elevators on and walls.
each oor and are strictly used to transport wastes from
the intermediate storerooms to the nal storerooms in the 7. Recycling reuse
basement of the hospital.
The problematic areas at this stage were: The most common practice to minimize the volume and
mass of wastes is through recycling and reuse. At the hos-
The transfer of infectious waste with improper means of pital evaluated, reusable materials such as medical tools
transport. The trolleys used for transportation did not and equipment made from metallic or plastic components
provide protection against leakage. In many cases, med- were being sterilized at the hospitals Sterilization Depart-
ical waste was transported by hand and made contact ment. At the X-Ray Department the generated residue is
with the oor, thereby increasing the danger of the waste collected and recycled by a public company. Paper is also
handler being injected or cut by contaminated sharps recycled in cooperation with the local authorities.
(such as needles or glass). Furthermore, on many
occasions municipal waste was transported by the same 8. Treatment disposal
vehicle that had been previously used to transport
infectious waste, thereby increasing the possibility of 8.1. Infectious waste
contaminating the municipal waste with pathogenic
microorganisms. The main purpose of treating infectious waste is to
Inappropriate cleaning of the trailers, which contributes destroy any infectious agent so that it does not pose a haz-
to creating a focus of infection. ard for anyone exposed to it. The technique used to treat
Overloading of trailers. infectious waste at the hospital is through pyrolitic com-
Unsuitable protective clothing. The wearing of thin bustion. The healthcare facility operates a two-chamber
gloves and fabric aprons were the only protective mea- pyrolitic combustor, with a capacity of 180 kg h1, during
sures taken during the collection and transportation of 18 h per day (6 h combustion and 12 h cooling). The rst
medical waste. Waste handlers were at risk of contract- chamber is operated at between 650 and 900 C and the
ing diseases such as hepatitis B and tetanus by possible second at 850 C. Proper operation of the combustion
injection from infectious needles. ensures 90% (v/v) and 70% (w/w) reduction of the com-
Elevators used for waste were often used by the medical busted waste.
sta, which contributed to the transfer of infectious The main problems arising from the process were:
agents to dierent hospital departments.
The composition of the combusted waste did not fulll
6. Storage the requirements. A large amount of municipal waste
and liquids (chemical, cytostatic/cytotoxic drugs) were
Intermediate storage takes place on every oor in spe- combusted along with infectious waste a practice that
cially designed storage areas that fulll all of the require- limited the eciency of the combustion process (Lee and
ments needed to store medical waste for up to 12 h Human, 1996). The problem mainly derives from the
(ventilation, re protection, cleaning facilities, etc.). Stor- inappropriate segregation of the waste at the source.
age before disposal takes place in the basement where The combustor operates at low temperatures, at which
infectious wastes are kept in a refrigerator at a temperature pollutants produced from materials such as plastics
of 34 C so as to avoid biodegradation, odors and the and cytotoxic/cytostatic drugs are dicult to destroy.
attraction of insects and rodents. Municipal wastes are According to the Greek Joint Ministerial Decision
stored in a dierent room at the same level, which also ful- 37591/2031/03, materials that consist of more than 1%
lls the conditions of acceptable storage. of halogen organic compounds (expressed in terms of
Problems were observed in the following areas: the concentration of chlorine) become inactivated at
temperatures above 1100 C. In addition, most cyto-
The inability to ensure that access to the storerooms is toxic/cytostatic drugs require temperatures above
restricted to those people involved in the handling of 1000 C, with some requiring more than 1200 C (Pruss
medical waste. et al., 1999).
916 M. Tsakona et al. / Waste Management 27 (2007) 912920
Emissions from the incinerator did not undergo any fur- rium phosphoreum microorganisms. The bacteria were
ther treatment before being released into the exposed to the solutions for 5 and 15 min. The extent of
atmosphere. absorption of the incident ray was measured by the Micro-
The resulting ash was not adequately treated. After tox equipment. EC50, which refers to the eective concen-
cooling down the combustor, the ash was collected in tration of a substance (wastewater) that produces a toxic
bags or cardboard boxes, and disposed in landlls. Tak- eect (death) in 50% of the test organisms in a given pop-
ing into account the composition of the combusted ulation under a dened set of conditions, is determined by
waste, heavy metals are likely to exist in signicant con- using mathematical equations that relate absorption to tox-
centrations in the resulting ash, which requires special icity (Gidarakos, 2003). Lower and upper bounds for EC50
handling a fact conrmed by earlier studies (US were calculated at the 95% level of signicance and the
EPA, 1991). results are presented in Table 3.
The operator of the combustion unit did not have even a The toxicity of the wastewater produced at the laborato-
basic knowledge of the process of pyrolitic combustion ries was high at the exit of the chemical neutralization unit,
or of the hazard to which he was exposed. Therefore, which presumably was due to the fact that only the pH was
the protective measures being taken were unsatisfactory being controlled. However, at the entrance of the municipal
(thin disposable gloves, disposable apron and face mask sewerage system, toxicity was found lower than in samples
no leg protectors or protective shoes). taken from the exit of the chemical neutralization unit.
This suggests that the toxicity of the hospitals sewage
8.2. Municipal waste derives mainly from laboratories. In addition, it is interest-
ing to note that the toxicity of the wastewater owing into
Local authorities are responsible for the treatment of the the municipal wastewater treatment plant is approximately
municipal waste. The hospitals administration is responsi- the same as that of samples taken at the exit of the hospi-
ble only for the proper transfer of the waste from the store- tals sewerage system.
rooms to a specially designed area outside the hospitals
yard. The waste is nally transported to a local sanitary 10. BOD/COD
landll for disposal.
The wastewaters biological oxygen demand (BOD) and
8.3. Wastewater from laboratories chemical oxygen demand (COD) were determined at spe-
cic locations of the hospitals sewerage system to ascertain
Many hospitals in Greece do not have a separate sewer- their organic load and biodegradation ability.
age system. However, at the hospital where the study was The results, presented in Table 4, show that the COD
conducted, wastewater from laboratories is drained away exceeds the permitted limits for sewage to be safely
in a separate sewerage system where it undergoes chemical discharged into the municipal sewerage system. The same
neutralization. A solution of H2SO4 at 98% concentration conclusions were drawn for the BOD of some samples,
and another solution of NaOH at 98.4% concentration
are used to neutralize the alkalinity and the acidity,
respectively.
Table 3
Common problems are: Hospitals wastewater toxicity (EC50) and pH from dierent sampling
points
Only the pH is controlled. Parameters such as toxicity
Sampling point Samples EC50 EC50 pH
are not evaluated. Measurements carried out at the (5 min)a (%) (15 min)b (%)
authors laboratory showed that treated laboratory
Chemical 1 1.406 2.036 6.57
wastewater had an increased toxicity capable of causing neutralization-exit
dysfunction to the municipal wastewater treatment 2 1.303 0.7612 6.57
plant. 3 0.6322 0.3959 6.57
Hospitals 1 15.66 6.777 77.5
9. Measurements sewerage-exit
2 5.083 2.390 77.5
9.1. Toxicity 3 4.996 1.683 77.5
Primary treatment 1 7.634 4.163 7-7.5
One of the purposes of the current study was to evaluate tank Entrancec
a
the toxicity of wastewater produced at a healthcare facility EC50 (5 min): the eective concentration of wastewater which produces
at the exit of the tank where chemical neutralization is a toxic eect (death) in 50% of test organisms in a given population under
5 min of exposure.
applied, and at the exit of the hospitals general sewerage b
EC50 (15 min): the eective concentration of wastewater which pro-
system before the sewage enters the municipal sewerage duces a toxic eect (death) in 50% of test organisms in a given population
system. The toxicity was measured using the 81.9% Basic under 15 min of exposure.
c
test, Microtox equipment and Vibrio scheriPhotobacte- It refers to the local wastewater treatment plant.
M. Tsakona et al. / Waste Management 27 (2007) 912920 917
Table 7 Transport
Proposed characteristics for storage bags Purchase of good quality carts that would provide
Height length Thickness Material impermeability, be resistant to perforation, and also
(cm cm) (mm) be easy to handle and clean. The carts must be
Black bags labeled with the name of the department in which
Large size 110 80 0.05 Polyethylene (virgin) they are used.
Medium size 80 60 0.05 Polyethylene (virgin)
Small size 60 55 0.03 Polyethylene (virgin)
Storage
Red bags
Strict entrance prohibition into waste storerooms.
Large size 110 80 0.1 Polyethylene (virgin)
Medium size 80 60 0.1 Polyethylene (virgin) Only waste handlers should be allowed to enter these
areas.
Green bags
Adjusting the frequency of waste collection according
Large size 110 80 0.05 Polyethylene (virgin)
Medium size 80 60 0.05 Polyethylene (virgin) to the facilitys waste production. Wastes should not
remain in any storeroom for more than 24 h, with the
exception of infectious waste that can remain in store-
Apart from the black and red bags used for the collec- rooms at a temperature below 34 C for up to 5 days
tion of municipal and infectious waste, respectively, (US EPA, 1991).
the purchase of green bags is necessary. Materials that
consist of more than 1% of halogen organic com- Recycling
pounds (expressed in terms of chlorine concentration) Applying a complete recycling and reuse program.
must be collected in dierent color bags (green) and Plastic, glass, metals, batteries and plaster can be
combusted at temperatures above 1100 C (Joint recycled. However, a cost analysis would be required
Ministerial Decision 37591/2031, 2003). before further action could be taken.
Fig. 1. Schematic representation of the waste categories and the proposed treatment and disposal methods at the hospital where research was conducted
(Tsakona et al., 2005).
M. Tsakona et al. / Waste Management 27 (2007) 912920 919
US Environmental Protection Agency (US EPA), Oce of Solid Wastes Xia, H., Xianghua, W., Hangjun, D., Ruopeng, L., Yi, O., 2001. Hospital
et al., 1991. Medical Waste Management and Disposal, Pollution wastewater treatment using a membrane bioreactor. In: China/Italy
Technology Review No. 200, Noyes Data Corp., Park Ridge, NJ, Workshop Membrane Process for Clean Production and for Sustain-
USA. able Industrial Growth, Beijing, China, pp. 188191.