Liverprime

Product Details
Brand NameLiverprime
FormatCapsule

What is the medicine used for?

To help maintain liver health
As an adjunct in the management of a variety of liver disorders, including:
o Acute and chronic hepatitis
o Liver cirrhosis
o Liver damage from toxins
o Alcohol-related liver disease
o Fatty liver [e.g., Nonalcoholic fatty liver disease (NAFLD) or Nonalcoholic
steatohepatitis (NASH)]
What is in the medicine?
Liverprime contains a silybin-phosphatidylcholine complex which helps protect the liver by
conserving glutathione in the cells (silybin) while helping in the repair and replacement of cell
membranes (phosphatidylcholine). Phosphatidylcholine improves the absorption of silybin.

The combination of silybin and phosphatidylcholine in Liverprime is three times better

absorbed than plain Silymarin. Phytosome technology improves the bioavailability of silybin as
it is complexed with phosphatidylcholine.

The product also contains vitamin E and zinc, antioxidant nutrients that help protect the liver
from damaging toxins and free radicals; and B-vitamins that assist the liver in the breakdown of
proteins, fats and carbohydrates into energy that the body can use.

Ingredients Amount per Capsule

Silybin-phosphatidylcholine (1:2 ratio) 120 mg

dL-Alpha-tocopheryl acetate (Vitamin E) 12 mg (12 IU)

Thiamine Mononitrate (Vitamin B1) 1.1 mg

Riboflavin (Vitamin B2) 1.1 mg

 Niacinamide 14 mg

Pyridoxine HCl (Vitamin B6) 1.3 mg

Cyanocobalamin (Vitamin B12) 2.4 mcg

Calcium Pantothenate 5.4 mg

Zinc (as Sulfate) 5 mg

How much and how often should you use this medicine?
Direction for Use in Adults:
Orally, 1 capsule one to three times a day.

Or, as directed by a doctor.

http://www.unilab.com.ph/products/liverprime/

Manufacturer

Mergers Drugfil

Distributor

Mergers Drugfil

Contents

Vitamin B complex, carnitine orotate, amino acids, adenine HCl.

Indications / Uses

Treatment of mitochondrial dysfunctions, acute and chronic viral hepatitis, fatty liver, drug-

induced liver injury, cirrhosis, alcoholic and general intoxication.

Dosage / Direction for Use

Godex: Adults: 2 capsules 3 times daily. Children: 1 capsule 3 times daily.

Godex DS: Adults: 1 capsule 3 times daily.

Contraindications

Godex DS: Hypersensitivity to any of the components of Godex DS. Severe renal dysfunction

(serum creatinine >3 mg/100 mL).

Warnings

Caution During Administration: Follow recommended dosage and administration method and

physician's instructions for administration.

Caution During and After Administration of Godex/Godex DS: If there is any specific symptom

following administration, discontinue usage and consult the physician.

Consult the physician if there is no improvement after 1 month of treatment.

Godex/Godex DS is hygroscopic, therefore be cautious on storing after opening the case.

Special Precautions

Administration of doses of cyanocobalamin >10 mcg daily may produce a hematological

response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis.

Godex DS: Long-term use of large doses of pyridoxine is associated with the development of

severe peripheral neuropathies.

Adverse Reactions

Godex DS: Gastrointestinal disturbances eg, nausea, vomiting, diarrhea and abdominal cramps

have been reported after the daily use of large doses of levo-carnitine. Body odor has also been

noticed in some patients, possibly due to the formation of the metabolite trimethylamine.

Click to View ADR Monitoring Form

Interactions
Godex DS: Pyridoxine reduces the effects of levodopa and activity of altretamine. It has also

been reported to decrease serum concentrations of phenobarbital and phenytoin. Absorption of

vitamin B12 from the gastrointestinal tract may reduced by neomycin, aminosalicylic acid,

histamine H2 -antagonist and colchicines.

Storage

Store at temperatures not exceeding 30C. Avoid exposure to sunlight. Keep cool and dry.

Description

Godex: Each capsule contains carnitine orotate 150 mg, 17 amino acids 12.5 mg, pyridoxine

HCl (vit B6) 25 mg, adenine HCl 2.5 mg, cyanocobalamin (vit B12) 125 mcg and riboflavin (vit B2)

500 mcg.

Godex preparation has been developed by a Spanish pharmaceutical company as ethical

therapeutics for mitochondrial dysfunctions.

Carnitine orotate represents functional histological restoration effect to injured hepatocytes and

also acts as lipotropic factor to fatty liver. It promotes -oxidation of normal free fatty acids and

metabolism in hepatocytic mitochondria.

Hepatic (liver) extract antitoxic fraction (purified detoxicable liver extract hydrolysate) represents

highly activated detoxification effect on intrinsic and extrinsic hepatotoxic substances. Based on

clinical studies, it has excellent therapeutic results with marked improvement on many kinds of

functional histological profiles [ie, serum glutamic oxaloacetic transaminase (SGOT), serum

glutamic pyruvic transaminase (SGPT), bilirubin, biopsy] and vital signs (ie, weight loss,

nausea).

Godex DS: Each capsule contains carnitine orotate 300 mg, 17 amino acid 25 mg, adenine

hydrochloride 5 mg, pyridoxine hydrochloride (vitamin B6) 50 mg, riboflavin (vitamin B2) 1 mg

and cyanocobalamin (vitamin B12) 250 mcg.

Pyrimidine nucleotide precursor, orotate, combined with pharmaceutically acceptable salts

cationic carnitine, carnitine HCl, 17 amino acids and more agents (adenosine, pyridoxine HCl,

cyanocobalamin) with protective or supportive activity relative to mitochondrial structure and

function.

Carnitine Orotate, the molecular formula is C7H16NO3C5H3N2O4:C12H19N3O7; the molecular weight

is 333.34 g/mol, which when administered in vivo has a synergistic effect. It increases solubility

and is more easily absorbed by the injured cells, rather than the administration of carnitine

individually.

Cyanocobalamin (vitamin B12) is 5,6-dimethyl-benzimidazolyl cyanocobamide; molecular

formula is C63H88 C0N14O14P. The cobalt content is 4.34%. The molecular weight is 1355.39.

Vitamin B12 is bound to intrinsic factor during transit through the stomach; separation occurs in

the terminal ileum in the presence of calcium and vitamin B12 enters the mucosal cell for

absorption. It is then transported by the transcobalamin binding proteins.

Mechanism of Action

Pharmacology: Godex: Carnitine orotate is a pharmacologically activated ionic complex salt

with carnitine and orotic acid. When administered to the body, it is more easily absorbed than

administration of carnitine and orotic acid individually. These 2 substances represent dramatic

synergistic effect when administered with a type of complex salt for increasing solubility and

biological absorption.

After absorption, the complex salt is divided into 2 separate components and represents

pharmacologic actions separately.

Orotic acid is the precursor of nucleic acid (DNA, RNA) biosynthetic process, which is a very

important physiological process that promotes protein synthesis for injured cell proliferation.

Orotic acid prohibits necrosis of injured cells by normalizing cell proliferation process, hepatic

enzymatic system and normal hepatic function. Carnitine is an indispensable biostimulant for

the metabolism of fat. It is the component that promotes -oxidation process of free-fatty acid in

hepatocytes.

Denaturized fatty liver is induced by internal factors (ie, diabetes, pregnancy, hyperthyroidism or

external factors (ie, oral contraceptives, alcohol, toxic chemical substance).

Hepatic extract antitoxic fraction is a purified detoxicable hepatic extract that represents a very
highly activated detoxification effect on many kinds of toxic substances.

Cyanocobalamin as vitamin B12 and adenine hydrochloride act in synergistic effect for the

treatment of hepatic diseases.

Godex DS: Carnitine orotate is nonhygroscopic (does not absorb/adsorb water from the

surrounding environment), less deliquescent (does not readily liquefy when exposed to air) and

is more soluble in water relative to the extremely hygroscopic L-carnitine. The ionic complex salt

has the property of supplying the body with orotic acid and carnitine.

In effect, in order to exert its anti-mitochondrial dysfunction properties facilitating the synthesis

of proteins, orotic acid has to be saltified with an organic cation eg, carnitine, for its total

solubilization and subsequent ease of absorption.

On the other hand, carnitine not only prevents and checks the tendency of orotic acid to the fatty

deposit in the liver, but also facilitates the degradation and elimination of the existing fatty

deposits.

The orotic component is the base substance of pyrimidine nucleotides, which in turn change into

nucleotides and these into uridine triphosphate (UTP), adenosine triphosphate (ATP), up to the

final synthesis of proteins.

The carnitine component intervenes in the transport oxidation of fatty acids, acting as a

lipotropic and an antilipemic factor in the body.

Adenine is main component of ATP, which activates methionine, a necessary condition for the

later to give the methylic groups used in the reactions of transmethylation.

Pyridoxine acts in the process of decarboxylation of serine, changing it into ethanolamine in the

process of synthesis of choline.

Cyanocobalamin, intervenes in the reduction of a format in the methyl group, that changes UTP

into TTP, it also activates the enzymes intervening in the oxidation of choline into betaine.

Hepatic extract antitoxic fraction is specifically hydrolyzed 17 amino acid complex, which is

prepared by enzymatic hydrolysis from the bovine liver in order to ensure bioefficiency of its

detoxifying effects.
Pharmacokinetics: General: Godex DS peak plasma concentrations are observed about 30

min after dosing.

Adenosine IV is rapidly cleared from the circulation via cellular uptake, primarily by erythrocytes

and vascular endothelial cells. The process involves a specific transmembrane nucleoside

carrier system that is reversible, nonconcentrative and bidirectionally symmetrical. Intracellular

adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by

adenosine kinase or via deamination to inosine by adenosine deaminase in the cytosol.

Pyridoxine HCl (vitamin B6) is readily absorbed from the gastrointestinal tract, mainly in the

jejunum and is converted to pyridoxal phosphate which is totally bound to plasma proteins.

Hepatic extract antitoxic fraction is a specifically hydrolyzed 17 amino acid complex, which is

prepared by enzymatic hydrolysis from the liver and readily absorbed from the gastrointestinal

tract.

Metabolism and Elimination: Godex DS is predominantly metabolized in the liver.

Carnitine orotate is metabolized in the liver which when metabolized leaves free its carnitine

content. A different behavior was observed in the elimination of exogenous carnitine via urine. In

animal experiment, the elimination of carnitine was rapid and proportional to the dose of

carnitine orotate. While in man, the moderate ingestion of carnitine orotate does not produce an

increase carnitine elimination in the urine, the retention of carnitine in the body tissues means a

better utilization of the substance in the body.

Adenosine has a very short t. In human blood, its t is <10 sec. There are 2 important

metabolic fates for adenosine. Most importantly, adenosine is rapidly transported into red blood

cells (and other cell types) where it is rapidly deaminated by adenosine deaminase to inosine,

which is further broken down to hypoxanthine, xanthine and uric acid, which is excreted by the

kidneys.

Adenosine can be acted on by adenosine kinase and rephosphorylated to adenosine

monophosphate (AMP). The salvage pathway helps maintain the adenine nucleotide pool in

cells.
Pyridoxine is stored mainly in the liver with lesser amounts stored in muscle and brain.

Biotransformation is hepatic and almost entirely as metabolites excreted in the urine. Excess

beyond daily needs is excreted, largely unchanged in urine. In dialysis, removed by

hemodialysis.

Cyanocobalamin is transported via specific B12 binding proteins, transcobalamin I and II to the

various tissues. The liver is the main organ for vitamin B12 storage, excreted in the bile,

undergoes extensive enterohepatic recycling, and part of a dose is excreted in the urine. Body

retention is 55% of cyanocobalamin.

Hepatic extract antitoxic fraction, a purified exogenous 17 amino acids are metabolized in the

liver and eliminated in the kidney via urine.

Elimination: Godex DS is excreted in the urine.

MIMS Class

Cardiac Drugs / Cholagogues, Cholelitholytics & Hepatic Protectors

ATC Classification

A05BA - Liver therapy ; Used in liver therapy.

Regulatory Classification

Rx

Presentation / Packing

Godex: Cap (yellowish-brown, granulized powder in hard gelatin cap with dark chocolate cap

and pale chocolate-colored body) 100's.

Godex DS: Cap (chocolate colored) 100's.

http://www.mims.com/philippines/drug/info/godex-godex%20ds?type=full