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Achalasia
Achalasia is an uncommon condition that affects the muscles of your gullet (oesophagus). It usually
causes difficulty in swallowing both food and fluids. There are different treatments available which
can improve symptoms.
What is achalasia?
In the gullet (oesophagus) there are both muscles and nerves. Achalasia affects both the muscles and the nerves
of the oesophagus, especially initially the nerves that cause the sphincter between the oesophagus and stomach
to relax. The muscles do not contract properly so the rhythmic contraction of muscles, which allows your food to
pass down your oesophagus (peristalsis), does not occur correctly. In addition, the sphincter does not relax
properly so food cannot pass through into your stomach easily. This makes it difficult for you to swallow food
properly.
The main part of your oesophagus then becomes enlarged and widened (dilated) with time.
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How common is achalasia and who is affected by it?
Achalasia is a very uncommon condition. Less than 1 in 100,000 people in the UK are diagnosed with it each
year. It mainly affects adults aged between 20-40 years. In most cases, no underlying cause can be found and
the reason why the nerves and muscles in the gullet (oesophagus) do not work so well is not clear. It is more
common in people with Chagas' disease (an infectious disease more common in South America), Parkinson's
disease and stomach cancer. However, the majority of people with these conditions do not have achalasia.
As your gullet (oesophagus) dilates, you may find that some of your food is brought back up (regurgitated). If this
happens during the night you may experience some choking or coughing.
Barium swallow
This is a specialised X-ray test. In this test, X-rays of your gullet (oesophagus) are taken after you swallow a liquid
called barium, which shows up as white on the X-ray. This test will show if your oesophagus has widened
(dilated). It will also show if the barium stays in your oesophagus for longer than normal. See separate leaflet
called Barium Swallow/Meal/Follow Through for more details.
Manometry
In this test, the pressure that is generated within your oesophagus when you swallow is monitored. During this
test, a thin tube is placed through your nose, down the back of your throat and into your oesophagus. This test
can often detect earlier changes than a barium swallow can.
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Gastroscopy - sometimes called endoscopy
A gastroscope (endoscope) is a thin, flexible telescope. It is passed through the mouth, into the oesophagus and
down towards the stomach and the first section of the intestine (the duodenum). The endoscope contains fibre-
optic channels which allow light to shine down so the doctor or nurse can see inside your oesophagus, stomach
and duodenum. See separate leaflet called Gastroscopy (Endoscopy) for more details.
Medication
Various medicines can help to relax the sphincter at the lower end of the gullet (oesophagus). Examples include
calcium-channel blockers (such as nifedipine) and nitrates (such as isosorbide dinitrate). These work best when
achalasia is first diagnosed. However, they usually only work in the short term and are most often prescribed for
people who cannot have other forms of treatment.
Dilatation
This is a procedure in which the sphincter is made wider (dilated). This is done by using a balloon which is
inflated to stretch the sphincter. This is done with the use of a gastroscope, to ensure the balloon is in the correct
position.
Surgery
In some cases, the muscle fibres in the sphincter are divided (cut) during an operation. This is often done by
keyhole surgery. This is usually very successful at easing the symptom of difficulty swallowing. However, it may
cause complications such as gastro-oesophageal reflux disease. This is a condition where the acid from your
stomach comes up into your oesophagus. This can cause heartburn.
Botulinum toxin
This is another method of treating achalasia. Botulinum toxin acts as a muscle relaxant and is injected into the
sphincter to weaken the muscle. This is usually a safe treatment. However, it only works for a few months, so
further injections are often necessary. It may be more suitable for people who are unable to have surgery.
There are also possible complications of some of the treatments. For example, widening (dilatation) of the
sphincter can sometimes lead to a puncture (perforation) of the oesophagus. If this occurs, it will need an
emergency operation to repair it.
There is a slightly increased risk of developing cancer of the oesophagus if it contains a large amount of food
which does not pass into the stomach in the normal way. Your doctor will be able to discuss this with you in more
detail.