Professional Documents
Culture Documents
EDUCATION:
Fellow of College of Pathologist Pakistan (2010)
FCPS (Chemical Pathology), College of Physician & Surgeons, Pakistan (1999)
MBBS, Dow Medical College, Karachi University, Karachi, (1989)
HSC, St Josephs College, Karachi, Pakistan (1981)
SSC, Farhana Girls School, Karachi, Pakistan (1979)
RESEARCH INTERESTS
My research focus from 2005 onwards is on bone and mineral disorders. I use my own
original approach to develop primary research questions and future direction for leading the
research. Currently, I am working with many intra and inter departmental multidisciplinary
collaborative teams within AKU. This research has built its authenticity both nationally and
internationally as is evidenced by the awards received. I am hopeful that this research will
bring a strong impact on health outcomes of bone and mineral disorders in Pakistan in time to
come.
Prior to this I have researched in area of inborn errors of metabolism. Currently as I link
service initiatives with research and development in the Section of Chemical Pathology, I
would maintain my initial commitment and hope to expand the horizon of research in this
important area of metabolic medicine.
TRAINING
Clinical attachment at Institute of Medical Research (IMR) for training on profiling of
aminoacids and organic acids, Kuala Lumpur, Malaysia from 2nd -12th September 2012
Clinical attachment at Kings College Hospital in Clinical Biochemistry, NHS Trust,
London from 12th June 18th July 2007
Specialist Registrar, Chemical Pathology Royal Free Hospital, London, UK (Sep04-Dec
04)
Clinical Attachment, Kings College Hospital, NHS Trust, London, UK (Oct 03 Sep04)
Resident, Clinical Chemistry/Chemical Pathology, Aga Khan University, Karachi (1995-
1999)
Resident Pediatrics, Aga Khan University, Karachi (1994-1995)
Medical Officer, Imam Zainul Abedin Hospital, Karachi (1990-1994)
Internship in Pediatrics, Civil Hospital, Karachi (1989-1990)
POSITIONS
Assistant Professor, Department of Pathology & Microbiology, AKU (July 05-To
date)
Assistant Professor, Department of Medicine, AKU (July 08-To date)
Senior Instructor, Department of Pathology & Microbiology, AKU (Jan03-June05)
Instructor, Department of Pathology & Microbiology, AKU (Jan00-Dec03)
TEACHING EXPERIENCE
UNDERGRADUATE TEACHING
Leadership positions:
Chair endocrine and reproduction module (2011 todate)
Chair Year-II, undergraduate curriculum (2007 August 2011)
Membership:
Member of the sub-committee on review of content of undergraduate curriculum for
year I & II (2011)
Member, curriculum committee at Aga KhanUniversity (2007 2011)
Mentor and advisor in the mentorship programof UGME (2000 to date)
Founding member of the group for teaching of communication skills in UGME at
AKU (2000 to date)
Member of GIT and nutrition module committee (2009 2011)
Member of the foundinggroup for teaching of clinical skills to the year I &II medical
student (2000 2003)
Member Year I committee (2005 2007)
Member of the endocrine and genitourinary module (2006 2009)
Member question review committee.Ideveloped/modified MCQs and SEQ questions
in different module committees in the initial phase, now in use for testing the integrated
concepts across YI & YII (2000 2003)
Module Coordination:
GIT and metabolism (2002)
Endocrine and genitourinary (2006)
Module Facilitation:
Introductory
Musculoskeletal
Endocrinology &metabolism
GIT and nutrition
Other Activities:
Attend annual retreats organized by DED
Conducted and attended retreat for review of undergraduate curriculum (2010)
Question review and question making for undergraduate students
Developed question bank for YII
Pathology teaching in musculoskeletal and endocrine &reproduction modules
Examiner/Assessor
Assessment of MCPS and FCPS paper II theory exam at CPSP
Paper setter for FCPS and MCPS examinations at CPSP (2010to date)
Developed questions based on data interpretation for CPSP question bank (2010to
date)
Examiner of practical examination for FCPS part II by CPSP (2010 to date)
Other Activities
Clinical research discussions (2007to date)
Case discussion and interactive lectures for residents of FCPS program (2005 to date)
Supervisor of 4 Chemical Pathology residents for FCPS II (2006 to date)
Revised curriculum for FCPS chemical pathology residency training program for AKU
post graduate residency program
Organized theory and practical mock exams for FCPS candidates of AKUH
Organized FCPS practical exam for CPSP examination at AKUH (as an exam center)
Nursing Students
Conducted lecture for M.Sc. N students at School of Nursing (2010)
INNOVATIONS IN EDUCATION
Undergraduate Teaching
Designing and development of question bank for Y-II
Implementation of table of specification for all examination for paper setting
Introduced the concept of disorder of sexual differentiation in endocrine and
reproduction module (2006)
Medical Technologist
Initiated and submitted the draft concept of developing curriculum for technologist
training program at Clinical Laboratory. The initial proposal is made as an assignment for
Advanced level course on curriculum development conducted by DED. The assignment
has been reviewed by DED. It is being submitted for departmental review.
Leading the group for sectional activities for College of American Pathologist
accreditation. Currently developing and reviewing all process/all procedures and policies
and all manuals in the Section for CAP accreditation (2012)
Developed a program for point of care testing (POCT) for implementation at the
institutional level (2012). Work is in process
Developed several screening panels for laboratory testing like bone health and
osteoporosis. These testing panels are now very popular and have significant contribution
in volume and revenue growth (2011)
Team member for Process Improvement in Section of Chemical Pathology by Total Lab
Automation
Developed Manual of provocative testing in Chemical Pathology
Developed a tool for methodology evaluation of two tests
Working in collaboration with Molecular Pathology for starting of new molecular tests
Initiating a clinical laboratory service for diaagnosis of inborn errors of metabolism (Nov.
2012)
Initiation of sub-specialty of metabolic bone and mineral diseases from Chemical
Pathology platform (2008)
Initiated new bone markers in section of chemical pathology like vitamin D, N
telopeptide of type I collagen, ionized calcium, tubular indices for phosphate
reabsorption. Currently working on other markers (2005-2008)
C) SERVICE ON COMMITTEES WITHIN AND EXTERNAL TO THE UNIVERSITY
A. University related:
Chair of Endocrine and reproduction module (2011 2012)
Member YII Committee (2011 to date)
Member sub-committee of YII for reviewing the content of PBL in YI & II (2011to date)
Member of curriculum committee (2007- 2011)
Chair of YII committee (2007 2011)
Member of YI committee (2005-2007)
Interview panel for admission of undergraduates (2010, 2012)
Member of search committee for Chair of Pathology & Microbiology (2009)
B. Department/Section related:
Acting section head in absence of section head
Member departmental committee on ethics (2012)
Member task force for CAP accreditation
Co chair question review committee ( 2012-to date)
Member departmental sub-committee on appraisal & promotion (2012- to date)
Member departmental sub-committee on education (2012-to date)
Member departmental sub-committee on research (2011-to date)
4. AH Khan*, A Khan, F Ghani, M Khurshid. Low lead exposure and blood lead levels in
children: A Cross-sectional survey. Archives of environmental health. Nov/Dec 2001 [Vol.
56 (No. 6), 501-505.
B. LETTERS TO EDITOR
1. AH Khan*. Trisomy 16, cause of first trimester abortion. J.P.M.A, Vol. 51, No. 10, Oct,
2001.378-379
INTERNATIONAL
1. Q Humayun, R Iqbal, I Azam, AR Siddiqui, AH Khan, N Ansari. Development and
validation of sunlight exposure measurement questionnaire (SEM-Q) for use in adult
population residing in Pakistan. BMC Public Health 2012, 12:421
13. A Jabbar, Farooqi A, AH Khan, N Islam, Haque, J Akhter. Clinical Characteristics and
outcome of Diabetic Ketoacidosis in Pakistani adults with Type 2 Diabetes Mellitus.
Diabetic Medicine; 21, 920-923, 2004
IN PRESS:
14. AH Khan, R Iqbal, G Naureen, F Nasir, F Dar. Prevalence of vitamin D deficiency and
its correlates: Results of a community based study conducted in Karachi, Pakistan.
Archive of Osteoporosis
15. AH Khan, G Naureen, R Iqbal. High prevalence of obesity call for a priority action for
non-communicable disease crises in adult women: findings of a community based study
in Karachi, Pakistan. Submitted to Food & Nutrition Bulletin. August 2012
NATIONAL
16. AH Khan, L Jafri, MA Hussain, S Ishaq. Diagnostic utility of anti-citrullinated protein
antibody and its comparison with rheumatoid factor in rheumatoid arthiritis. JCPSP 2012,
Vol 22(11)
17. AH Khan*, D Rohra, S Saghir, S Udani, R Wood, A Jabbar. Response of a single mega
intramuscular dose of vitamin D on serum 25OHD and parathyroid hormone levels in
volunteers in Karachi, Pakistan. JCPSP 2012, Vol 22 (4):207-212
18. FJ Dar, AH Khan*, I Siddiqui, F Ghani. Pattern of drug of Abuse in chemical samples.
JCPSP 2010, Vol 20 (9): 608-611
20. AH Khan*, NU Haq, J Raza, A Jabbar, T Moatter. Classic virilizing congenital adrenal
hyperplasia presenting late: case series from Pakistan. JPMA: Vol. 59 No. 9, September
2009, 643-646.
21. L Jafri, R Iqbal, AH Khan*. Correlation study of vitamin D levels between reference
method (RIA) and the test method (chemiluminescence). JPMA, volume 60 No. 2
Supplement April, 2009 S-01 S-49.
22. L Zuberi, AH Khan, Abdul J. Vitamin D deficiency in ambulatory patients. JPMA: Vol
58 No.9: September 2008, 482 484.
25. AH Khan*, I Azam, I Siddiqui, N Kayani, M Khurshid. Work flow analysis: Audit of the
turnaround time in clinical chemistry in a tertiary care hospital. Pak Journal of Pathology
2008; 19(3): 89-92.
SUBMITTED:
26. I Saher, AH Khan*. Frequency and distribution of congenital adrenal hyperplasia among
different provinces of Pakistan. Submitted to JCPSP in March 2012
27. R Iqbal, H Ali, F Dar, M Bilgirami, G Bano, AH Khan. Validation of a food frequency
questionnaire (FFQ) for assessing macronutrient and calcium intake in adult, Pakistani
population. Submitted to JCPSP December 2011
28. R Iqbal, L Jafri, A Haroon, AH Khan*. Illuminating the dark side: Vitamin D status in ten
different localities of Karachi, Pakistan. Submitted to JCPSP September 2011
B. LETTERS TO EDITOR
1. AH Khan*, L Jafri. Ionized calcium cannot predict vitamin D deficiency. Ind J Clin
Biochem. (Oct-Dec 2011) 26(4): 428-429
2. AH Khan*. Treating vitamin D deficiency (VDD) can also play a role in fight against
chronic disease. JPMA Vol 60 No. 2, February 2010
3. AH Khan*, R Iqbal. Vitamin D deficiency in an ample sunlight country. JCPSP 2009,
Vol. 19 (5): 267-268 (editorial)
4. AH Khan*. Vitamin D deficiency: Are we still ignoring the evidence. JPMA: Vol 58
No.9: September 2008, 482 484 (letter).
C. BOOK CO-AUTHORED
Farhan Dar and Aysha Habib Khan. Assessment of bone turnover in adult females and
its association with vitamin D blood levels.LAP Lambert Academic Publishing
ISBN 978-3-8473-1686-2, paperback, 184 Pages
10. R Maher, L Jafri, AH Khan. A comparison of vitamin D status in critically ill patients
and apparently healthy individuals at the 35th Annual & 5th International Conference of
Pakistan Association of Pathologist (PAP) 2011, CPSP, Karachi
12. G Naureen, AH Khan, F Dar, R Iqbal. Determination of bone health status in community
dwelling female in Karachi, Pakistan at 35th annual and 5thinternational conference of
Pakistan Association of Pathologist meeting at CPSP, December 2011. Awarded best oral
presentation
14. L Jafri, K Waqar, S Hira, T Javed, AH Khan,I Siddiqui,F Ghani. Utility of B-type
natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in chronic kidney
disease: a head to head comparison of two heart failure markers. (Awarded Best Oral
Presentation for 2011) at the 35thannual & 5thinternational conference of Pakistan
Association of Pathologist (PAP) 2011, CPSP, Karachi
15. S Iqbal, AH Khan, F Ghani, I Siddiqui. Frequency and distribution of congenital adrenal
hyperplasia in different regions of Pakistan. at the 35thannual & 5thinternational
conference of Pakistan Association of Pathologist (PAP) 2011, CPSP, Karachi
20. AH Khan, D Rohra, S Saghir, S Udani, R Wood, A Jabbar. Response of a single mega
intramuscular dose of vitamin D on serum 25OHD and parathyroid hormone levels in
vitamin D deficient volunteers in Karachi, Pakistan. IOF Regionals 1st Middle East &
Africa Osteoporosis Meeting in Dubai (October 19-22, 2011)
21. AH Khan, F Dar, R Iqbal, F Ghani, I Siddiqui. Assessing bone health in adult
premenopausal females in KarachiA preliminary report from Pakistan. 4thnational
conference of Pakistan Society of Chemical Pathologist (PSCP), Lahore, February 2011
25. N Sherazi, AH Khan,I Siddiqui, F Ghani. Fibroblast growth factor 23 (FGF-23) levels in
healthy volunteers and its relationship with serum phosphate and tubular maximum for
phosphate reabsorption (TmP/GFR). 4thnational conference of Pakistan Society of
Chemical Pathologist (PSCP), Lahore, February 2011
26. R Iqbal, G Bano, M Bilgirami, F Dar, AH Khan*. Development and validation of a food
frequency questionnaire for assessing macronutrient and calcium in women residing in
Karachi. Poster presented at the ASBMR 2010 Annual meeting 15-19, at Metro
Convention Center, Toronto, Ontario, Canada
27. AH Khan, F Dar, R Iqbal, I Siddiqui, F Ghani. Assessing bone health in adult
premenopausal females in Karachi-A preliminary report from Pakistan. Poster presented
at the ASBMR 2010 annual meeting 15-19, at Metro Convention Center, Toronto,
Ontario, Canada
28. F Dar, AH Khan, R Iqbal, I Siddiqui, F Ghani. Assessment of bone turnover and its
association with vitamin D blood levels in adult female residing in Karachi.
1) Accepted for poster presentation in Focus 2009. The Association of Clinical
Biochemistry annual national meeting at Liverpool
2) Oral presentation at PAP Meeting at Abbottabad, 2008
29. L Jafri, AH Khan, R Iqbal, I Siddiqui, F Ghani. Correlation study of Vitamin D levels
between reference method (RIA) and test method (Chemiluminescence)
1) Oral presentation at PGME conference 2009, at AKU
2) Oral presentation at PAP meeting at Abbottabad, 2008.
30. R Iqbal, M Bilgirami, AH Khan, S Urooj, A Jabbar and D Rohra. Developing a food
frequency questionnaire for assessing dietary calcium intake in an adult population,
presented at Research Assembly 2008 at The Aga Khan University, Karachi, Pakistan.
34. S Kanwal, F Ghani,AH Khan, I Siddiqui. Chemical composition of renal stone and its
relationship with age, sex and weight of the renal stones evaluated from 1999 to 2006 at
referral laboratory. Abstract presented at the 31stnational conference of Pakistan
Association of Pathologist (PAP) 2007, Peshawar
37. AH Khan, M Aban, R UL Hassan N UL Haq, J Raza, A Jabbar, T Moatter. Mixed array
of mutations identified in 21 hydroxylase gene of patients with congenital adrenal
hyperplasia.
1) Association of Clinical Pathologist national scientific meeting 14 th -15th June 2007,
Church House, Westminster
2) Oral Presentation in 2ndbiennial conference of Pakistan Society of Chemical
Pathologist, AKU Karachi (Awarded Azhar gold medal for best paper
presentation)
3) Symposium of Baqai Medical College held at Baqai University, Karachi
4) Poster presentation in Pakistan Association of Pathologists meeting at Lahore 2006
5) 1stmultidisciplinary conference on human resource capacity building, East Africa, 4 th
-6th Sept
39. J Jabbar, I Siddiqui, F Ghani, F Riaz, AH Khan. Insulin tolerance test: cost
benefitsanalysis. Abstract presented at the 30 thnational conference of Pakistan Association
of Pathologist (PAP), Lahore, November 2006
41. LM Zuberi, AH Khan, S Arshad, M Islam and A Jabbar. Vitamin D deficiency in medical
clinic patients. Poster presentation in AKU research assembly on March 7- 8, 2006
F. OTHERS
2. Farhan J Dar, Aysha Habib Khan. Assessment of bone turnover in healthy adult females
and its association with vitamin D blood levels(2010)
3. Noreen Shirazi, Aysha Habib Khan. Fibroblast growth factor 23 levels in healthy
volunteers and correlation with serum phosphate and tubular maximum for phosphate
reabsorption (2012)
NEWSPAPER/NEWSLETTER ARTICLES
1. Report on 4th biennial course in Chemical Pathology for newsletter of International
Federation of Clinical Biochemistry (IFCC), 2012
2. Prevalence and causes of vitamin D deficiency in south Asian population residing in
different geographical areas. Dr Aysha Habib Khan, Ghazala Naureen, Dr. Romaina Iqbal.
APFCB newsletter (2012)
3. Report on Pakistan Society of Chemical Pathologist APFCB newsletter 2011
4. Bone health for life. Womens Own, April 2011
5. Growing interest in assessing vitamin D status and issues of vitamin D testing:
Experience from Pakistan. Newsletter of Asian Pacific Federation of Clinical Chemistry.
2010
6. Assessment of osteoporosis risk by NTx A biochemical marker. LABRAD, January
2010
7. N-telopeptide of type I collagen: A biochemical tool for assessing bone turnover.
LABRAD, January 2009
8. Vitamin D deficiency: Are we still ignoring the evidence. LABRAD, September 2008
9. Vitamin D measurement. LABRAD, September 2007.
10. Lab diagnosis of metabolic bone diseases. LABRAD, May 2007
11. Overseas development award. ACP National Scientific Meeting 14th -15th June 2007,
Church House, Westminster and attachment at Kings College Hospital, London 12 th June
-18th July, Aysha Habib Khan. Association of Clinical Pathologist newsletter, UK
September issue 2007
12. What causes Vitamin D deficiency? Physician Newsletter, AKUH
13. Vitamin D deficiency. Gulf Today, December 2006
14. The battle to conquer osteomalacia. DAWN, Health Page, 11th Dec 2002
15. CAH: defeating myths and dogmas. DAWN, Health Page, 10th July 2002
GRANTS
URC:
1. Evaluation of bone health in Pakistani children with beta thalassemia major. Co-PI, URC
2012.Rs 17,00,000 only
2. Efficacy of 25 (OH) vitamin D supplementation and physical activity in improving
musculoskeletal health in individuals with chronic kidney disease (CKD). Investigator,
URC 2012 $22857 only. Work in progress
3. Determination of effective vitamin D replacement and monitoring strategies in vitamin D
deficient state (EVIREST). Co-PI, Seed Grant from URC 2011. PKR 9,23,863,Work in
progress
GRANTS CLOSED & PUBLICATIONS ACHIEVED
1. To assess the effect of dietary calcium intake and vitamin D status on bone turnover
markers in Pakistani adult females. PI, Awarded from Pakistan Science Foundation in
May 2010 December 2011, Rs 19, 844, 16 only
1. Hafsa Majid; 2010 todate (Primary Supervisor); Polymorphism of CaSR gene and its
association in subjects with vitamin D deficiency. US $ 1000. 2011 resident seed grant
from Department of Pathology & Microbiology. Ongoing
2. Talha Naeem; 2009 todate (primary Supervisor); To determine the validity of bone
turnover markers in patients with osteoporosis and osteopenia presenting at a metabolic
bone clinic. US $ 1000. 2010 resident seed grant from Department of Pathology &
Microbiology. Ongoing
3. Noreen Shirazi; 2008-2012 (primary supervisor);. Fibroblast growth factor 23 levels in
healthy volunteers and correlation with serum phosphate and tubular maximum for
phosphate reabsorption. US $ 1050. 2009 resident seed grant from Department of
Pathology & Microbiology. Ongoing. Completed
4. Farhan Dar; 2007 2010 (primary Supervisor); Assessment of bone turnover and its
association with vitamin D blood levels in adult females.US$ 1000 from resident seed
grant, 2007 from Department of Pathology & Microbiology,US$ 3000 from URC of Aga
Khan University. Completed
Anna Zulfiqar (E11002); 2010 todate; (Committee member) Association of dental caries with
passive smoking in 3-11 years old children of Karachi, Pakistan. Ongoing