Professional Documents
Culture Documents
ORAL ANTIDIABETICS. If patients with type 2 diabetes have not achieved suitable
control after about 3 months of dietary modification and increased physical
activity, then oral antidiabetics (oral hypoglycaemics) may be tried. The two
major classes are the sulfonylureas and the biguanides. Sulfonylureas act mainly
by increasing endogenous insulin secretion, while biguanides act chiefly by
decreasing hepatic gluconeogenesis and increasing peripheral utilisation of
glucose. Both types function only in the presence of some endogenous insulin
production. More recently developed classes of oral antidiabetics include the
alpha-glucosidase inhibitors, the meglitinides, and the thiazolidinediones. Alpha-
glucosidase inhibitors act by delaying the absorption of glucose from the
gastrointestinal tract; meglitinides increase endogenous insulin secretion; and
thiazolidinediones appear to increase insulin sensitivity.