DNAreplicationinthenucleus.1.

notebook

February01,2017
HowdoesDNAreplicateitself?

Wearelearning:
Enzymes

Receptorproteins

Breakingdownalcohol,digestion,producingflowercolors

Smelling,Tasting

Alcoholdehydrogenase,amylase

Receptorsonsensorycells

AnucleotideisthesingleunitofDNA(Sugar+Phosphate+Base)
DNAismadeoflotsofnucleotidesjoinedtogether.
Thereare4bases.A,T,C,G

Defenseproteins

Structuralproteins

Detectpathogens

Hair,nails,cocoons,ligaments

Antibodies

TodescribethefunctionofHelicase,primase,DNAPolymeraseandDNA
ligaseinDNAreplication.

Collagen,keratin,silks

TodescribeDNAreplicationassemiconservative.

Transportproteins

Motorproteins

Oxygentransportinblood,transportacross
membranes

Enablemusclecontractionandflagellamovement

Hemoglobin,canalproteins

Actin,myosin

Jan713:51

Jan1510:42

DNAisseparatedbyanenzymecalledDNAHelicase
Makenotesonyourpaperaswegothrough.Don'tworry,itwillallbecomeclear!

TheweakHydrogenbonds
areseparated(unzipped)by
theenzymeHelicase

Theexposednucleotidesarenolongerbasepairs

Jan2217:50

Theexposedbasesarenolongerinbasepairs.TheyhavebeenseparatedbyDNA
helicase.
NucleotidesfreefloatinginthenucleusaredrawntotheexposedareasoftheDNA
strandandfollowingthebasepairrules,Hbondtotheircomplimentarybasepair.

Jan2216:24

DNApolymeraseaddsDNAbasesfollowingthebasepairrulestocreatea
strandofDNAwhichconsistsofanold'templatestrand'andanewlyformed
strand.

TheEnzymeDNAPolymerasebondsthesugarphosphatebackbonetocreatea
strong'rail'

Jan2216:34

Jan2217:22

DNAreplicationinthenucleus.1.notebook

February01,2017

DNAligaseactslikeglueandbondsallofthefragmentstogethermaking2strong
doublestrandedpolymerswhichthenrecoiltomakeadoublestrandedhelix.

Jan2216:47

Jan2217:28

https://www.youtube.com/watch?v=TNKWgcFPHqw

Onyourdiagram,drawtheenzymeswiththeirfunctionstoshowsemi
conservativereplication.

Watchthisthroughtwiceandthenfilloutthetable.

EXTwhatdoesthetermsemiconservativereplicationmean?

Enzyme
Function
name
....
....
....
....
PutthenamesoftheenzymesintheorderatwhichtheyfunctioninDNA
replicationanddescribetheirfunction.

Jan2217:31

Jan1510:42

Jan1510:43