Immune System

Anat12C

Figure 11. Hilum in relation to cortex, medulla, and capsule

(dartmouth.edu)
III. SPLEEN

Remember that in function, it is not a lymphoid organ in

the sense that its main function is with your blood
circulatory system (filter blood rather than lymph)
No cortex nor medulla

A. Germinal Center

located at the boundary of white pulp

WP
RP

Figure 13. C = capsule; T = trabeculae; R = red pulp; W =

white pulp (junqueiras)
C. White Pulp
What can be seen? (2018)

Always contain a Central artery

Periarterial Lymphoid Sheath (PALS): T cell area

forming a sheath around a central artery

Lymphoid follicle: formed by B cells; usually located at

the edge of PALS

Mantle Zone: narrow zone of small lymphocytes at the

periphery of lymphoid follicles

Marginal Zone: less densely packed medium-sized

lymphocytes supported by a reticulin fibers; between
white pulp and spleen;

Germinal Center: center of B cell proliferation

Figure 12. Germinal Center (Spleen). WP = White pulp; RP =

red pulp
B. Trabeculae

Emerges from dense CT of capsule

Partially subdivide the parenchyma/splenic pulp

Figure 14. White Pulp (web)

Page 4 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.

Immune System

Anat12C

Figure 17. Green = white pulp; yellow = PALS; blue = central

artery

Figure 15. White pulp (2018)

Figure 18. central artery

D. Red Pulp

everything outside white pulp

Marginal zone area separating white and red pulp

Figure 16. circle = white pulp; arrow = central artery

Figure 19. Spleen. Arrow = central artery.

Page 5 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.

Immune System

Anat12C

Cortex highly ceullar part; contains thymocytes

(immature and maturing T cells; will appear as dark
colored cells in the cortex)

Medulla lighter; less cellular part; contains Hassal

corpuscle

Interlobular septa radiate from the capsule; contains

blood vessels

Capsule loose collagenous

*thymus does not have hilum

Figure 22. Cortex and medulla (Ross)

Figure 20. Red pulp. S = sinuses; C = cords (diFiores)

*splenic cords = cords of Billroth

Figure 23. Blue = cortex; green = medulla; dashed layer =

capsule

Figure 21. Red pulp. CB = cords of billroth; green = sinus

IV. THYMUS
A. Cortex and Medulla

Page 6 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.

Immune System

Anat12C
Figure 26. Hassals corpuscle (web)

Figure 24. green = medulla; blue = hassals corpuscle; black =

cortex

Figure 27. Hassal corpuscle.

Figure 25. green = lobule; Black = interlobular septa with

adipose tissue
B. Hassals Corpuscle

Groups of keratinized epithelial cells

Large concentric layers of flattened type VI
epithelioreticular cells
Eosinophilic

Figure 28. Hassal corpuscle. Mas halata to hehe.

Page 7 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.

Immune System

Anat12C

Figure 31. Palatine Tonsils

Figure 29. Hassal corpuscle (2018)

V. Mucosa Associated Lymphoid Tissue (MALT)

Mucosa associated they dont form organs, they

form: accumulation of lymphoid tissue in other organs
(can be found beneath epithelial surfaces)
A. Tonsils
Figure 32. Palatine Tonsils

Figure 30. H&E Stain; Low Magnification (diFiores)

Finding tonsillar crypts will help you identify the slide
as a lymphatic tonsil! (recall that they have stratified
squamous epithelium and tonsillar crypts are just
invaginations of SSE)
Lymphatic nodules are many and often lie close to the
crypts (including germinal centers)
Lymphatic sinuses absent in l.tonsils

Figure 33. Pharyngeal tonsil (2016)

B. Peyers Patches

Seen as little bumps in the GI wall (ileum)

Found in mucosa layer and may extend into submucosa
Overlaid by few villi
Gut-associated lymphoid tissue (GALT)
Remember na large aggregates of lymph nodules ang
peyers patch

Page 8 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.

Immune System

Anat12C

Figure 34. Peyers Patch N = nodules; V = villi

Figure 36. Peyers patch

Figure 35. Peyers patch. Green

Figure 37. Peyers patch (2018)

Page 9 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.

Immune System

Anat12C

Figure 38. Peyers Patch (2018)

V. LYMPHATIC VASCULAR SYSTEM
A. Lymphatic Capillaries

Figure 40. Lymphatic Vessel (LV) and Venule (V).

(Junqueiras)

Figure 39. L = lymph; e = endothelial cells

B. Lymphatic Vessels

Figure 41. LV = lymphatic vessels (Junqueiras)

solid arrow shows the direction of the lymph flow

dotted arrows show how the valves prevent lymph

backflow

Page 10 of 10
UPCD Batch 2019: Ablan, V.E., Hugo, J.V.S., Ladera, F.M.T.