ANTIBIOTIC CHEAT SHEET

Antibiotic MOA
Inhibition of
cell wall synthesis

Inhibition of
nucleic acid synthesis
Inhibition of
protein synthesis

Cell wall

Disruption of cell
membrane function

Cell
membrane

DNA

Block pathways and

inhibit metabolism

Folic acid

Ribosome

How and Where Various Antibiotics Work

Gram Negative

Gram Positive
Outer membrane
Lipoproteins
Peptidoglycan
Periplasmic
space
Cutoplasmic
membrane

Lipopolysaccharides

Gram +

Porin

Protein

Gram + and -

Penicillins
(Amoxicillin)
Gram + (Strep, Syphillis)
Disrupts synth of peptidoglycan

Tetracyclines
(tetracycline, doxycycline)
Broad spectrum (Gram +/-, atypicals)
Inhibit protein synth

Sulfonamides
(TMP-SMZ)
UTIs
Inhibit DNA synth

Macrolides
(azythromycin, erythromycin)
Gram + (URIs, Strep, Staph)
Inhibits protein synth

Cephalosporins
Disrupts synth of peptidoglycan
1st gen: Gram + (Keex)
2nd gen: Gram - > Gram + (Cefzil)
3rd gen: Gram - > Gram + Pseudomonas (cefdinir)
4th gen: Pseudomonas (Cefepime)
5th gen: MRSA (Ceftobiprole)

Carbapenems
(meropenem)
Broad spectrum
Disrupts synth of peptidoglycan

Fluoroquinolones
(Ciprooxacin, Levooxacin)
Broad spectrum
Inhibit DNA synth

Metronidazole
(Flagyl)
Anaerobes, protozoa
Disrupts DNA

Lincosamides (clindamycin)
Step, Staph
Inhibit protein synth

Gram Aminoglycosides
(streptomycin, tobramycin, gentamicin)
Gram - Psuedomonas - TB
Inhibit protein synth

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