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Drugs & Diseases > Radiology
Author: Timothy J Mosher, MD; Chief Editor: Felix S Chew, MD, MBA, MEd more...
Patient education
For patient information resources, see the Breaks, Fractures, and Dislocations Center, as well as Knee Injury and Magnetic Resonance Imaging (MRI).
The extensor mechanism of the knee begins above the hip with the origin of the rectus femoris muscle on the anterior inferior iliac spine. The remainder of the
quadriceps muscle group, vastus lateralis, vastus intermedius, and vastus medialis originate on the femoral shaft. The quadriceps tendon represents the
confluence of the 4 muscle tendon units and inserts on the superior pole of the patella. The quadriceps tendon has 3 laminae, including (1) the most superficial
lamina, which is formed by the rectus femoris; (2) the intermediate lamina, which is formed by the vastus lateralis and vastus medialis; and (3) the deep lamina,
which is formed by the vastus intermedius.
Laterally, the iliotibial band supports the extensor mechanism and is an important lateral stabilizer of the patellofemoral joint. It originates above the hip joint as
a wide fascial band, originating from the gluteal muscles, tensor fascia lata, and vastus lateralis. Distally, the iliotibial band consists of two tracts. The iliotibial
tract inserts on Gerdy tubercle of the lateral tibial plateau. Fibers connecting the iliotibial band to the patella are referred to as the iliopatellar band.
The patellar retinaculum is an important soft tissue stabilizer of the patellofemoral joint. It is composed of a medial and lateral component. The thicker lateral
retinaculum comprises a distinct, thick deep layer and a thin superficial layer. The deep layer is a confluence of several fibrous structures consisting of the
lateral patellofemoral ligament and iliopatellar band. Deep to the medial patellar retinaculum, there are 3 focal capsular thickenings. These occasionally are
referred to as the medial patellofemoral, patellomeniscal, and patellotibial ligaments.
The patella, the largest sesamoid bone in the body, possesses the thickest articular cartilage. The articular surface, which can have a variable contour, articulates
with the trochlear groove of the femur. Most patellae possess a median ridge that divides the proximal patella into a medial and lateral facet; the medial facet
usually is the smaller of the two.
The patellar tendon, occasionally termed the patellar ligament, originates at the inferior pole of the patella and inserts onto the tibial tuberosity. The patellar
tendon is invested in a paratenon of loose fibrillar tissue.
Additional soft tissue structures of the knee extensor compartment consist of the infrapatellar fat pad and pretibial and prepatellar bursae. Injuries to these
structures are associated with extensor mechanism injuries and can result in anterior knee compartment pain.
subluxation (lateral displacement of the patella from the trochlear groove) is associated with a flat articular surface of the patella and a shallow trochlear
groove.
Additional soft tissue structures provide both dynamic and static stabilization of the patellofemoral joint. The vastus medialis obliquus (VMO) is an important
dynamic medial stabilizer of the patellofemoral joint. The VMO originates in the adductor tubercle of the distal medial femur and inserts on the medial
retinaculum and superomedial patella. The iliotibial band provides dynamic lateral stabilization of the patella through the iliopatellar band. Additional dynamic
stabilization is provided by insertion of fibers from the vastus medialis and lateralis onto the patellar retinacula. Static stabilizers consist of the medial and
lateral retinaculum and the joint capsule.
Pathophysiology of injury
Most chronic degenerative injuries of the extensor mechanism are related to patellar malalignment. Abnormal tracking of the patella within the trochlear groove
can produce focal areas of increased stress on the patellofemoral joint. The shallow trochlear groove seen with trochlear dysplasia allows the patella to sublux
laterally with knee flexion. Abnormal lateral patellar tilt can be seen with a tight lateral retinaculum and is associated with excessive lateral pressure syndrome
(ELPS) and patellar tendon-lateral femoral condyle friction syndrome. Over time, the abnormal stresses applied to the patellofemoral joint can result in focal
cartilage degeneration, patellofemoral osteoarthritis, and damage to the soft tissue stabilizers of the patellofemoral joint.
Overuse injuries typically are seen in high performance athletes, most commonly in sports requiring long distance running or jumping. Cumulative microtrauma
produced by repetitive knee flexion and extension results in focal inflammation.
Acute traumatic injuries occur secondary to direct blunt trauma or excessive tension applied to the extensor mechanism through quadriceps contraction. Patellar
fractures are the most common traumatic injury of the knee extensor mechanism.
Sagittal fast spin-echo (FSE) T2-weighted images with chemical shift fat suppression or short tau inversion recovery (STIR) images
On sagittal images, the field of view should extend from the musculotendinous junction of the rectus femoris to just below the tibial tuberosity. On axial
images, the direction of phase encoding should be left to right to prevent pulsation artifact from the popliteal artery.
Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobutrol [Gadovist], gadobenate dimeglumine [MultiHance], gadodiamide
[Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have been linked to the development of nephrogenic systemic fibrosis (NSF) or
nephrogenic fibrosing dermopathy (NFD). For more information, see the Medscape Reference topic Nephrogenic Systemic Fibrosis. The disease has occurred
in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans.
NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and
tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain deep in the
hip bones or ribs; and muscle weakness. For more information, see the FDA Public Health Advisory or Medscape.
Extensor mechanism injuries of the knee. An axial fast spin-echo proton density-weighted image with fat
suppression of a 50-year-old man demonstrates mild thinning of the patellar cartilage associated with foci of abnormal increased signal intensity within the
patellar cartilage, consistent with areas of cartilage degeneration in mild patellofemoral osteoarthritis (arrow). Beware of pulsation artifact from the popliteal
artery (simulating a central osteophyte) projecting off the posterior articular surface of the patella (arrowhead). Note the small joint effusion and increased
signal intensity posteriorly resulting from a Baker cyst.
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Whether isolated focal cartilage hyperintensity without associated surface irregularity represents preclinical cartilage damage not visualized on arthroscopy is
under debate. Advanced stages of cartilage damage are associated with partial- or full-thickness loss of cartilage, osteophyte formation, and increased T2weighted signal in the subchondral bone with or without subchondral cyst formation (see the image below).
Extensor mechanism injuries of the knee. Axial fast spin-echo proton density-weighted image with fat
suppression in a 39-year-old woman demonstrates irregularity, fissuring, and marked thinning of patellar cartilage associated with osteophyte formation.
Findings are consistent with advanced osteoarthritis of the patellofemoral joint. Note the abnormal flat contour of the patellar articular surface. Abnormal joint
biomechanics resulting from patellar dysplasia are associated with an increased incidence of patellofemoral osteoarthritis.
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A study by Zanetti and coworkers indicates this subchondral signal abnormality corresponds to degenerative edema, necrosis, and cyst formation in the
subchondral bone marrow. [18]
Patellar dislocation
Patellar dislocation is often associated with dysplasia of the patella and trochlear groove. Hypoplasia of the femoral sulcus and lateral femoral condyle result in
a shallow trochlear groove, which decreases stability of the patellofemoral joint. Similarly, findings of patellar dysplasia with a poorly formed median ridge and
medial facet also are associated with abnormal patellar tracking and lateral dislocation, as reported by Resnick. [19, 20, 21]
An actual dislocation of the patella is rarely observed with MRI, although unusual cases of chronic patellar dislocation are documented (see the image below).
Extensor mechanism injuries of the knee. An axial fast spin-echo proton density-weighted image
with fat suppression of a 30-year-old man demonstrates a chronic congenital patellar dislocation. The small dysplastic patella is dislocated laterally (arrow).
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However, the sequela of patellar dislocation results in pathognomonic MRI findings, which include sprain or tear of the medial retinaculum, contusions of the
anterior lateral femoral condyle and medial patellar facet, strain or tear of the VMO, and concomitant joint effusion (see the image below).
Extensor mechanism injuries of the knee. Axial fast spin-echo proton density-weighted image with
fat suppression in an 18-year-old man with prior knee trauma demonstrates many findings of previous patellar dislocation. A large joint effusion with focal
marrow edema in the medial patellar facet and lateral femoral condyle is present. Edema and thickening of the medial retinaculum are compatible with partial
tear.
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Osteochondral injury
Acute or chronic osteochondral injuries subsequent to trauma frequently are the causes of anterior knee pain, as reported by Obedian. [22] The imaging
appearance and surgical management of these lesions has recently been reviewed by Gallo and Mosher. [23]
MRI FSE T2-weighted images with fat suppression or STIR images are sensitive to marrow edema and hemorrhage associated with radiographically occult
bone marrow contusions (see the first image below) or nondisplaced patellar fractures. If patellar contusion is suspected, scrutinize the overlying patellar
cartilage for focal cartilage tear or defects (see the second image below). [24]
Extensor mechanism injuries of the knee. Axial fast spin-echo proton density-weighted image with fat
suppression in an 18-year-old man following a fall on the knee. Diffuse hyperintensity of patellar marrow signal is compatible with acute bone marrow
contusion. This abnormal signal corresponds to hemorrhage and edema with areas of fractured trabecula. Marrow contusion of the medial femoral condyle and
moderate-sized joint effusion are seen.
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Extensor mechanism injuries of the knee. Axial fast spin-echo proton density-weighted image with fat
suppression in a 28-year-old man following a fall resulting in blunt anterior knee trauma demonstrates fissuring of the medial patellar cartilage with underlying
subchondral marrow edema. Abnormal fluid signal intensity extends in a linear fashion from the articular surface to involve the deep cartilage layer.
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Extensor mechanism injuries of the knee. This 42-year-old woman was referred for evaluation of
chronic anterior knee pain for 2 years following a motor vehicle accident. Sagittal T1-weighted image demonstrates areas of focal decreased signal involving
the posterior aspect of the patella and the medial femoral condyle, consistent with areas of chronic osteochondral injury (osteochondritis dissecans). With the
knee flexed, these areas are aligned (kissing contusions). This pattern is consistent with focal areas of traumatic osteochondral injury from impaction during the
motor vehicle accident.
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Unlike the dorsal defect of the patella, which, based on data reported by Safran, [27] typically is located in the superolateral patella, osteochondritis dissecans of
the patella occurs most frequently in the distal half of the medial facet, as reported by Schwarz. [28] Typically, the subchondral fragment remains in situ.
cells are identified in tendons of patients with chronic patellar tendinopathy, the term patellar tendonitis should be reserved for acute tendinopathy. [30] Patellar
tendonosis frequently is seen in participants in sports associated with jumping and is associated with malalignment syndromes, as described by Allen and
coworkers. [31]
MRI findings consist of focal thickening of the proximal patellar tendon, with increased signal on T1-weighted and T2-weighted images (see the image below).
Extensor mechanism injuries of the knee. Sagittal T1-weighted images in a 29-year-old man with
chronic infrapatellar knee pain demonstrate a focal area of abnormal increased signal intensity in the proximal portion of the patellar tendon at the bone-tendon
insertion. This involves the posterior portion of the tendon more extensively and is associated with focal enlargement of the tendon. Sparing of the anterior
component of the tendon is typical of chronic patellar tendonitis (jumper's knee) and helps distinguish this condition from an acute process. Note the lack of
subcutaneous edema in this patient.
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It is important to recognize that intermediate signal on T1-weighted images is observed in the posterior margin of the proximal patellar tendon and near the
tibial tuberosity in normal tendons, as described by Yu. [32] Edema in the paratenon, infrapatellar fat pad, and subcutaneous adipose tissue is associated with
acute patellar tendonitis, which is defined as symptoms of less than 2-week duration and patellar tendon tears. Acute patellar tendonitis is associated with
increased intrasubstance signal on T1-weighted and T2-weighted images without tendon thickening.
Extensor mechanism injuries of the knee. Patellar avulsion fracture resulting from acute trauma as a
result of a football injury. Sagittal FSE T2-weighted image with fat suppression demonstrates an avulsion fracture from the lower pole of the patella (arrow) and
associated tear of the patellar tendon (arrow) (Image courtesy of Gary Gold, Stanford University).
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Generally, discontinuity of the tendon is demonstrated on fluid-sensitive sagittal T2-weighted and STIR images. MRI findings in partial patellar tendon tears
can resemble acute patellar tendonitis. Correlation with a history of acute trauma is useful for specific diagnosis.
Quadriceps tendinopathy
Quadriceps tendinopathy occurs with much less frequency than patellar tendinopathy but demonstrates similar imaging findings. The distal tendon, at the
insertion in the patella, is the most common site of involvement.
MRI findings consist of fusiform tendon thickening with loss of the normal lamellated architecture and indistinctness of the intervening fatty tissue planes (see
the image below). Focal signal changes are observed less frequently than with patellar tendonitis.
Extensor mechanism injuries of the knee. Sagittal fast spin-echo proton density-weighted images with fat
suppression images in a 40-year-old man with anterior knee pain following trauma demonstrates diffuse thickening of the infrapatellar tendon as well as linear
areas of abnormal intermediate signal intensity within the substance of the tendon. Findings are consistent with an acute partial tear of the patellar tendon.
Chronic patellar tendonitis complicated by chronic tears associated with inflammation and necrosis can appear similar on MRI; however, in this patient,
subcutaneous edema anterior to the tendon also is seen, suggesting a relatively acute injury.
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MRI is useful in differentiating complete from partial quadriceps tendon tears. With complete tears, discontinuity of the tendon with associated retraction of the
proximal remnant usually is visualized best using T2-weighted images (see the image below).
Extensor mechanism injuries of the knee. FSE T2-weighted image demonstrating complete tear of the
quadriceps tendon in 67-year-old man. Retraction of the quadriceps tendon consistent with complete tear is observed (arrow) with mild undulating contour of
the patellar tendon. (Image courtesy of Douglas Goodwin, Dartmouth-Hitchcock Medical Center).
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Often, an associated hematoma is seen with heterogeneous signal intensity on T1-weighted images. Although an undulating contour of the patellar tendon can
be seen with complete quadriceps tendon tears, it also can result from hyperextension of the knee and is not a specific indirect sign. Partial tears most
commonly involve the anterior rectus femoris tendon fibers at the patellar insertion. Discontinuity of any of the quadriceps lamina is consistent with a partial
tear.
Myotendinous strain
Myotendinous strain is a common injury in athletes. The most commonly injured muscles are fusiform muscles that cross 2 joints. In these muscles, high tensile
stress develops when the muscle is forced to lengthen during active contraction, a process termed eccentric contraction. Because the rectus femoris muscle is
the only component of the quadriceps muscle group that crosses 2 joints, it is the most common site for myotendinous strain injuries in the knee extensor
mechanism.
MRI findings of strain injuries consist of focal edema centered on the central tendon of the rectus femoris. The presence of a focal hematoma is indicative of a
partial myotendinous tear (see the first image below). Complete myotendinous tears often are recognized clinically, and these patients less frequently undergo
MRI. Other abnormalities of the regional muscles, such as traumatic muscle tears (see the second image below), myositis, and infarction, can produce regional
knee pain.
Extensor mechanism injuries of the knee. Sagittal T1-weighted image in a 68-year-old man demonstrates abnormal
thickening of the quadriceps tendon associated with areas of linear abnormal increased signal intensity within the substance of the tendon (arrow). This is
consistent with a partial tear of the quadriceps tendon in this patient with acute injury. The normal tendon typically has a laminated appearance. Fusiform
thickening and loss of normal sharp margins of the quadriceps laminae are common manifestations of injury.
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Extensor mechanism injuries of the knee. FSE T2-weighted image demonstrating complete tear of the
quadriceps tendon in 67-year-old man. Retraction of the quadriceps tendon consistent with complete tear is observed (arrow) with mild undulating contour of
the patellar tendon. (Image courtesy of Douglas Goodwin, Dartmouth-Hitchcock Medical Center).
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Extensor mechanism injuries of the knee. Axial fast spin-echo T2-weighted image with fat
suppression in a 21-year-old soccer player demonstrates focal abnormal high signal intensity centered on the tendon of the rectus femoris, at the
musculotendinous junction. The location and appearance is indicative of a partial tear of the musculotendinous junction. These tears usually are seen in young
athletes and are associated with either forced muscle contraction or direct injury.
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The iliotibial band originates as a wide fascial band in the upper lateral pelvis and thigh and inserts on Gerdy tubercle of the lateral tibial plateau. Iliotibial band
friction syndrome (see the image below) results in pain in the lateral side of the knee during activity and, most frequently, is seen in long distance runners,
cyclists, or others performing tasks resulting in repetitive knee flexion. Symptoms arise from excessive friction between the iliotibial band and the lateral
femoral condyle.
Extensor mechanism injuries of the knee. Axial fast spin-echo T2-weighted image with fat
suppression in this 38-year-old woman presenting after direct trauma to the knee demonstrates abnormal increased signal intensity in the vastus medialis
oblique muscle consistent with myositis and edema from a partial tear. The vastus medialis oblique muscle provides dynamic medial force on the patella and is
an important stabilizer for patellar tracking.
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Imaging findings in this entity are abnormal increased signal on T2-weighted images centered between the iliotibial band and lateral femoral condyle.
Extensor mechanism injuries of the knee. Sagittal fast spin-echo T2-weighted image with fat
suppression in a 58-year-old woman demonstrates a complex fluid collection anterior to the knee in the region of the prepatellar bursa. The wall of the
prepatellar bursa is thickened and irregular in appearance, consistent with chronic prepatellar bursitis. Note the underlying degenerative changes of the knee
joint associated with osteophytic spurring. Irregularity of the Hoffa fat pad and a complex Baker cyst consistent with synovitis are seen. Synovial inflammatory
processes can predispose patients to prepatellar bursitis.
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Imaging findings in this entity include thickening and irregularity of the plicae.
Fibrosis
Patellofemoral maltracking can compress the superior lateral region of the infrapatellar fat pad between the patellar tendon and the lateral femoral condyle,
leading to focal inflammation. [34] Chronic impingement on the infrapatellar (Hoffa) fat pad may result in irritation and inflammation, culminating in fibrosis,
which is termed Hoffa disease, as described by Jacobson (see the image below). [35]
Extensor mechanism injuries of the knee. In this 27-year-old female marathon runner with anterolateral pain
superior to the joint line, coronal fast spin-echo T2-weighted image with fat suppression demonstrates edema between the iliotibial band and lateral femoral
condyle (arrow). The location of edema is consistent with the clinical diagnosis of iliotibial band friction syndrome.
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Typical MRI features consist of irregularity and heterogeneous edema within the fat pad identified as high signal on STIR or T2-weighted images with or
without fat suppression. Areas of fibrosis are identified by low signal intensity of the infrapatellar fat pad on T1-weighted and T2-weighted images. On rare
occasions, calcification can be seen, which should be differentiated from superficial irregularity of the superior surface of the infrapatellar fat pad (a nonspecific
sign of synovitis).
Extensor mechanism injuries of the knee. Sagittal gadolinium-enhanced T1-weighted image with fat
suppression in a 32-year-old man demonstrates thickened, irregular, abnormally enhancing synovium and a thick enhancing suprapatellar plica (arrow). A large
joint effusion is present as well, which aids in evaluating the abnormal appearing synovium and plica by distending the joint space.
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Extensor mechanism injuries of the knee. Osteochondrosis of the tibial tuberosity: A sagittal T1-weighted
image demonstrates bony fragmentation and irregularity of the tibial tuberosity. These findings are compatible with chronic Osgood-Schlatter condition in the
appropriate clinical setting.
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Sinding-Larsen-Johansson syndrome is osteochondrosis involving the distal patellar pole. [36]
Bipartite patella is a rare cause of anterior knee pain, as described by Iossifidis (see the first image below). [38] In symptomatic bipartite patellae, the pain may
result from chronic stress injury, a mechanism similar to that in the above two conditions (see the second image below).
Extensor mechanism injuries of the knee. Painful bipartite patella. This 33-year-old man has a 2-year
history of pain over the superolateral aspect of the patella. Axial fast spin-echo proton density-weighted image with fat suppression demonstrates a large amount
of edema in the synchondrosis, superolateral fragment, and adjacent soft tissues. Painful bipartite patella is a rare condition believed to be related to chronic
stress fracture and fibrous nonunion.
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Extensor mechanism injuries of the knee. A 19-year-old female runner with a long-standing history of
anterior knee pain. Sagittal T2-weighted gradient-echo image demonstrates an irregular area of abnormal signal intensity in the Hoffa fat pad, which represents
focal scarring and fibrosis. This is consistent with Hoffa disease, which is believed to result from repetitive impingement of the infrapatellar fat pad. Short term,
increased signal intensity in the fat pad is seen on T2-weighted images. Long term, as in this patient, the subsequent fibrosis results in decreased signal
intensity. Focal hypointensity on gradient-echo image is indicative of prior hemorrhage with hemosiderin deposits in the area of fibrosis.
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