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surgery since its advent, especially since the addition of phacoemulsification by Dr Charles
Kelman.1 However, with the addition of this powerful
2015 BY
METHODS
This study was designed as an experimental laboratory investigation. No human or animal studies were
done as part of this investigation.
! DESIGN:
RIGHTS RESERVED.
179
! PREVIOUS WORK:
180
! PHACOEMULSIFICATION
All trials used phacoemulsification tips with a 30 degree bevel and 0.9 mm
(20 gauge) tip diameter. Transversal ultrasound trials
were done with a 30 degree bent (Kelman) tip, while
micropulsed trials used a straight tip. All tips were made
by MicroSurgical Technology (Redmond, Washington,
USA). A new tip was used at the beginning of each condition to control for the effect of repeated contact with the
capsule surrogate on tip sharpness.
! PHACOEMULSIFICATION TIPS:
In order to
distinguish possible differences in safety between peristaltic
and Venturi pump modes, 2 techniques for contacting the
capsule surrogate simulated different clinical situations.
The first technique consisted of tapping the edge of the
tip against the plastic wrap by approaching the membrane
with the needle bevel up at an angle approximately 30 degrees above parallel to the testing membrane, with no tip
occlusion, as indicated in the Figure, Left (tip contact). Ultrasound was engaged during the approach to the surrogate
capsule, needle contact, and retraction away from the
membrane.
The second technique involved tapping the needle
opening at an appropriate angle against the plastic wrap
to achieve tip occlusion. To achieve proper and even occlusion, the handle was held such that the bevel of the
needle was facing downward with the needle opening parallel to the capsule surrogate as indicated in the Figure,
JULY 2015
FIGURE. Two approaches were used to contact a surrogate of the human lens capsule with a phacoemulsification needle, in order to
assess the risk of capsule rupture using peristaltic and Venturi vacuum pumps with micropulsed and transversal ultrasound. The line
represents the capsule surrogate. (Left) Tip contact: The needle is held bevel up, at an angle approach approximately 30 degrees from
the capsule surrogate. (Right) Tip occlusion: The needle is held bevel down, with the needle bevel opening parallel to the capsule
surrogate.
! STATISTICAL ANALYSIS:
RESULTS
SEVEN COMPARISONS WERE PERFORMED ON THE DATA SET:
181
TABLE. Breaks in a Capsular Surrogate for the Human Lens for Peristaltic and Venturi Phacoemulsification Pumps, Using Micropulsed
and Transversal Ultrasound Modalities, and Tip Contact or Tip Occlusion Techniques, With Machine Set at 550 mm Hg, 50 cm Bottle
Height (Actual), and When in Peristaltic Mode a 40 mL/min Flow Rate (Machine Indicated)
Conditions
Ultrasound Modality
1
2
3
4
5
6
7
8
Peristaltic
Peristaltic
Peristaltic
Peristaltic
Venturi
Venturi
Venturi
Venturi
Micropulsed
Micropulsed
Transversal
Transversal
Micropulsed
Micropulsed
Transversal
Transversal
Contact
Occlusion
Contact
Occlusion
Contact
Occlusion
Contact
Occlusion
400
200
400
200
400
200
400
200
246 (61.5%)
0
284 (71%)
0
208 (52%)
0
274 (68.5%)
0
P < .0001 for all tip contact vs occlusion (rows 1, 3, 5, & 7 vs 2, 4, 6, & 8).
P .013 peristaltic vs Venturi for all comparisons with contact (rows 1 & 3 vs 5 & 7).
P < .0001 for all micropulsed vs transversal with contact (rows 1 & 5 vs 3 & 7).
P .0067 for micropulsed contact only peristaltic vs Venturi (row 1 vs 5).
P .44 for transversal contact only peristaltic vs Venturi (row 3 vs 7).
DISCUSSION
CAPSULE RUPTURE MOST COMMONLY OCCURS DURING THE
JULY 2015
183
the capsule by the sharp point of the tip and is not secondary to occlusion even with ultrasound on. Because of this
finding, we did not see a significant difference in capsular
contact risk between Venturi and peristaltic vacuum
even when we used very aggressive parameters. The use
of transversal ultrasound appears to increase capsular
rupture risk, and our previous work has shown that edge
sharpness of the tip is an additional risk factor. Other tip
motions need to be assessed in an equally rigorous fashion.
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST.
Mr Gilbert, Dr Zaugg, Dr Stagg, and Dr Olson do not have any proprietary or financial interest, or any other conflicts of interest, to report. This study was
supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York, USA, to the Department of Ophthalmology and
Visual Sciences, University of Utah, Salt Lake City, Utah, USA. Dr Stagg and Dr Zaugg are recipients of Achievement Rewards for College Scientists
Foundation, Inc (ARCS), Utah Chapter, Salt Lake City, Utah, USA, Scholar Awards. MicroSurgical Technology (Redmond, Washington, USA)
donated the tips that were used for the study. All authors attest that they meet the current ICMJE requirements to qualify as authors.
Susan Schulman, University of Utah School of Medicine, Salt Lake City, Utah, served as a consulting medical writer.
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JULY 2015
Biosketch
Michael Gilbert, MD, graduated from the Creighton University School of Medicine. He is currently an intern at the
University of Kansas Medical Center and will be continuing there as a resident in the Department of Ophthalmology in
2016.
184.e1
Reproduced with permission of the copyright owner. Further reproduction prohibited without
permission.