Changes made in the new MSPN table as compared to the Kim et al 2013 paper

Reactions

kf
(nM
s)
1

Old
kcat
kb
(s
(s)
)

New
Kd or
Km
(nM)

kf (nM
s)

kb (s)

kcat
(s)

Kd or
Km
(nM)

GsGTP GsGDP
Ca + pmca pmcaCa pmca
+ CaOut
Ca + ncx ncxCa ncx +
CaOut
CaOut + Leak CaOutLeak
Ca + Leak
Ca + Calbindin CalbindinCa

0.125

0.05

3.5

210

0.05

240.00

0.0168

11.2

5.6

1000

0.011

11.2

5.6

1527.27

0.0015

1.1

1.1

1466.66

0.002

1.1

1.1

1100.00

0.028

19.6

700

0.028

19.6

700

Glu GluOut

0.00002

0.0

Glu + MgluR GluMgluR

GluMgluR GluMgluRdesens
Gqabg + GluMglu
GqabgGluMglu GqaGTP +
GluMglu

0.0001
0.25

0.000
02
10
0.001

100000

0.002
0.0625

1
0.001

500

0.015

7.2

513.33

0.0015

0.68

Plc + Ca PlcCa
PlcCa + GqaGTP PlcCaGqaGTP PlcCa+GaqGDP
Plc + GqaGTP PlcGqaGTP
PLC+GaqGDP
PlcGqaGTP+Ca
PlcCaGqaGTP

0.02

120

6000

0.0005

0.1

10

100

0.0035

0.7

12

200

0.01

12

1200

0.0007

0.7

12

1000

0.08

40

500

0.0025

0.5

30

0.5

453.33
2000

400

PlcCaGqaGTP + PIP2
PlcCaGqaGTPPIP2
PlcCaGqaGTPDag + Ip3
PlcCaGqaGTP + PIP2
PlcCaGqaGTPPIP2
PlcCaGqaGTP+Dag + Ip3

0.015

250

21666.6
6
0.00166
5

PlcCa + PIP2 PlcCaPIP2

PlcCa+Dag + Ip3

0.006

PlcCaDag PlcCa + Dag

200

Ip3 Ipdeg
PIkinase+IP3deg IP3degPIK
PIkinase+PIP2
Ca + Dgl CaDgl
Dag + CaDgl DagCaDgl
CaDgl + 2ag
2ag 2agdeg
Pkc + Ca PkcCa

10

PkcCa + Dag Pkct

75

5.00E005
Persuma
bly 10
0.1

60

30

54054.0
5

1.8

0.45

45000.0
0

0.1

1000

10

25

5833.33

0.002

1000

0.0005

0.4

0.125

50

400

0.125

50

0.0025

1.5

1400

0.0005

2500.00
10000.0
0

0.25
0.02
0.00001
5

5
0.02
0.00001
5

50
0.15

50
0.15

400.00
0.25

2500
2500.00
10000.0
0