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154]
Review Article
A B S T R A C T
This manuscript reviews and describe the burden of cervical cancer in world and India, epidemiology of HPV infection, screening
methods, prevention, control strategy, types of HPV vaccines, schedule, age of administration, dose, route, anatomical site of human
papillomavirus vaccination, cold chain, vaccine coverage and roll out plan in Delhi, India.
Keywords: Adolescent, cervical cancer, epidemiology, immunization, malignancy, prevention, program, women
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2016 CHRISMED Journal of Health and Research | Published by Wolters Kluwer -Medknow
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Figure1: World map showing the incidence of cervical cancer, 2012(agestandardized rate per 100,000 women)
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Conventional cytology
VIA
Sensitivity(%)
Specificity (%)
Number of visits required
for screening and treatment
Comments
47-62
60-95
2 or more
66-100
62-96
2 or more
67-79
49-86
1 or 2
Table2: Prevention and control of cervical cancer over the life course
Primary prevention
Secondary prevention
Tertiary prevention
Figure2: World map showing countries with human papillomavirus vaccine introduced in the National Health Program
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Age of
administration
Gardasil
Girls and women:
(quadrivalent 9 through 26years;
vaccine)
males: 9 through
26years
Cervarix
Girls and women:
(bivalent
9 through 26years
vaccine)
Gardasil 9
(9vHPV)
Dose
Schedule* Route
0.5 ml
0, 2 and
of liquid
6 months
suspension
0.5 ml
0, 1 and
of liquid
6 months
suspension
Site
Cold chain
Availability
2-8C(shelf
Single dose vial (0.5 ml)
life: 36 months) in a package of 1, 10
and 100 vials
2-8C(shelf
life: 36 and
48 months)
*Girls <15years(9-13years) require two doses at least 6 months apart but within 12-15 months of first dose; girls >15years or immunecompromised(e.g., HIV) women
require three doses for full protection. HPV: Human papillomavirus
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