29/7/2016

Acetaminophenreducessocialpain:behavioralandneuralevidence.PubMedNCBI

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PsycholSci.2010Jul21(7):9317.doi:10.1177/0956797610374741.Epub2010Jun14.

Acetaminophenreducessocialpain:behavioralandneuralevidence.
DewallCN1,MacdonaldG,WebsterGD,MastenCL,BaumeisterRF,PowellC,CombsD,SchurtzDR,Stillman
TF,TiceDM,EisenbergerNI.

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Abstract
Pain,whethercausedbyphysicalinjuryorsocialrejection,isaninevitablepartoflife.Thesetwotypesof
painphysicalandsocialmayrelyonsomeofthesamebehavioralandneuralmechanismsthatregister
painrelatedaffect.Totheextentthatthesepainprocessesoverlap,acetaminophen,aphysicalpain
suppressantthatactsthroughcentral(ratherthanperipheral)neuralmechanisms,mayalsoreduce
behavioralandneuralresponsestosocialrejection.Intwoexperiments,participantstook
acetaminophenorplacebodailyfor3weeks.Dosesofacetaminophenreducedreportsofsocialpainon
adailybasis(Experiment1).Weusedfunctionalmagneticresonanceimagingtomeasureparticipants'
brainactivity(Experiment2),andfoundthatacetaminophenreducedneuralresponsestosocial
rejectioninbrainregionspreviouslyassociatedwithdistresscausedbysocialpainandtheaffective
componentofphysicalpain(dorsalanteriorcingulatecortex,anteriorinsula).Thus,acetaminophen
reducesbehavioralandneuralresponsesassociatedwiththepainofsocialrejection,demonstrating
substantialoverlapbetweensocialandphysicalpain.
PMID:20548058 DOI:10.1177/0956797610374741
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http://www.ncbi.nlm.nih.gov/pubmed/20548058

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