Professional Documents
Culture Documents
Maturitas
journal homepage: www.elsevier.com/locate/maturitas
Review
Serum albumin and health in older people: Review and meta analysis
Nutrition Service, Clinica Los Manzanos, Grupo Viamed, Calle Hermanos Maristas, 26140 Lardero, Spain
Servei dAssessorament Metodolgic i Estadstic a la RecercaUnitat de Recerca i Desenvolupament, Parc Sanitari Sant Joan de Du Fundaci Sant Joan de
Du, Dr. Antoni Pujades 42, 08830 Sant Boi de Llobregat (Barcelona), Spain
c
Geriatric Department, Residencia San Prudencia, Calle Francia 35, 01002 Vitoria-Gasteiz, Spain
d
Geriatric Department, Orue Centro Socio Sanitario, Grupo Igurco, B San Miguel Dudea s/n, 48340 Amorebieta, Spain
e
Geriatric Department, Clinica Los Manzanos, Grupo Viamed, Calle Hermanos Maristas, 26140 Lardero, Spain
b
a r t i c l e
i n f o
Article history:
Received 18 February 2015
Received in revised form 20 February 2015
Accepted 21 February 2015
Keywords:
Hypoalbuminemia
Undernutrition
Ageing
Protein energy malnutrition
Nutritional screening
Body composition
a b s t r a c t
Albumin is the most abundant plasmatic protein. It is only produced by the liver and the full extent of its
metabolic functions is not known in detail. One of the main roles assigned to albumin is as an indicator of
malnutrition. There are many factors, in addition to nutrition, that inuence levels of albumin in plasma.
The main aim of this review is to assess the clinical signicance of albumin in elderly people in the
community, in hospital and in care homes. Following the review, it can be stated that age is not a cause of
hypoalbuminemia. Albumin is a good marker of nutritional status in clinically stable people. Signicant
loss of muscle mass has been observed in elderly people with low albumin levels. Hypoalbuminemia
is a mortality prognostic factor in elderly people, whether they live in the community or they are in
hospital or institutionalized. Low levels of albumin are associated to worse recovery following acute
pathologies. Inammatory state and, particularly, high concentrations of IL-6 and TNF-alpha, are two of
the main inuencing factors of hypoalbuminemia. In elderly patients with a hip fracture, albumin levels
below 38 g/L are associated to a higher risk of post-surgery complications, especially infections. Further
research is needed on the impact of nutritional intervention upon albumin levels and on the outcomes
in elderly people in the community, in hospital and in care.
2015 Elsevier Ireland Ltd. All rights reserved.
Contents
1.
2.
3.
4.
5.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Search strategy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2.1.
Statistical methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Albumin as an index of nutritional status . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3.1.
In the community . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3.2.
In hospitalized elderly . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3.3.
Meta-analysis results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
The association of serum albumin with function and health status . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4.1.
In community dwelling and in nursing home . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4.2.
In hospitalized elderly . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4.3.
In hip fracture patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Albumin as predictor of mortality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.1.
In community-dwelling elderly and in nursing-home residents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5.2.
In hospitalized elderly . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Corresponding author at: Geriatric Department, Clinica los Manzanos, Calle Hermanos Maristas, 26140 Lardero (La Rioja), Spain. Tel.: +34 941 499 490;
fax: +34 941 499 491.
E-mail address: vmalafarina@gmail.com (V. Malafarina).
http://dx.doi.org/10.1016/j.maturitas.2015.02.009
0378-5122/ 2015 Elsevier Ireland Ltd. All rights reserved.
18
18
18
20
20
20
21
22
22
22
22
22
22
25
18
6.
7.
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Competing interests . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Provenance and peer review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1. Introduction
Ongoing population ageing will lead to a doubling of the number
of people over 65, in the coming ve decades. There is increasing
evidence that caloricproteic malnutrition is a widespread problem in this section of the population [1]. Nutritional assessment
and treatment of malnutrition are imperative in order to attempt
to minimize the risk of illness or complications associated to old
age. Elderly people living in the community present the lowest incidence of malnutrition, whereas institutionalized elderly people are
the most malnourished [2].
Malnutrition in the elderly can be multi-factorial, with negative
consequences on most organs and systems [3].
Despite increasing scientic evidence that hepatic protein levels depend on other factors in addition to intake, these proteins
continue being used to assess nutritional state and to diagnose malnutrition [4,5] (Fig. 1). The biological functions of albumin have not
been comprehensively dened, but its inverse relation to mortality,
to the development of complications and to mean length of stay in
hospital for acute patients, is clear [68]. Procedures for measuring
concentration of albumin in serum can be affected by the higher
volume of distribution observed in patients in an acute phase [9].
For all these reasons, the main aim of this review is to assess published articles on the subject of albumin in elderly people in order to
attempt to understand its relationship with age, its importance as a
nutritional index and as a prognostic factor in the various geriatric
clinical settings (the community, hospitals and care homes).
2. Search strategy
We searched PubMed for articles published until July 2014, in
English, Italian and Spanish. We completed our search by revising
25
25
25
25
26
26
26
Fig. 1. Graphic representation of physiopathology and mechanisms that determine hypoalbuminemia. The result is accumulative, so the more factors occur in the same
person the greater the impact is on the risk of developing hypoalbuminemia. The dashed line represents factors whose importance in determining hypoalbuminemia depends
on the presence of other cofactors. The dotted line represents factors that increase the prevalence of other associated factors.
Table 1
Albumin as a nutritional index in hospitalized elderly.
Author
Year
Origin
Aim
Design
Population characteristics
n (menwomen)
Age mean SD (y)
BMI mean SD (kg/m2 )
Exclusion
Albumin
Mean value (g/L)
Results
Tamas [42]
1991
Switzerland
552 (197335)
80.3 7.5
NA
NA
35 5.6
Lumbers [54]
2001
UK
Retrospective
Hospitalized:
197 cancer
335 other disorders
Cross sectional
Hospitalized (HF)
Day centres (DC)
75 (075)
80.5 8.2
24.1 4.7
36.5 4.7
42.5 3.3
38.3 3.7
311 (111200)
79.9 11.3
NA
ICU
LOS <3 days
NA
Retrospective
Hip fracture patients
214 (43171)
84 18.2
NA
NA
NA
- Albas malnutrition
marker
- ADL association with Alb
Cross sectional
Outpatient clinic, nursing
home, geriatric hospitals
262 (86176)
81.8 7.5
19.7 3.9
36 5.7
Retrospective
Hip fracture patients
Retrospective (1y)
Hip fracture patients
Osteoarthritis fracture,
Rehabilitation <7days, Acute
disabilities
Pathologic fractures and
non-ambulatory before
fracture
36 4
Cross-sectional
Acute geriatric ward
Retrospective (1y)
Hip fracture patients
449 (90359)
82.1 6.9
NA
74 (2252)
M 76.86 8.85
W 78.29 8.05
NA
104 (2381)
84 (7889)
23.1 (2027.3)
200 (39161)
81
NA
Alb as a measure of
nutritional status
Prospective
Ischaemic stroke patients
Covinsky [30]
2002
USA
Symeonidis
[57]
2006
UK
Kuzuya [31]
2007
Japan
Mizrahi [51]
2007
Israel
ztrk [53]
2009
Turkey
32.9(1743)
NA
Median (IQR)
31 (2833)
NA
NA
Malabsorption, gastrectomy,
hepatic and renal impairment,
heart failure, sepsis and
malignancy
Gariballa [27]
2001
UK
Drescher [29]
2010
Switzerland
ODaly
[56]
2010
Ireland
50 (050)
79.8 7.5
27.5 4.9
201 (81120)
77.9 9.1
NA
19
33.8 4.5
Osteoporotic fractures, vehicle
accidents
ADL = activities of daily living; Alb = albumin; ASMM = Appendicular skeletal muscle mass; BI = Barthel Index; BMI = body mass index; BCM = body cell mass; COPD = chronic obstructive pulmonary disease; CRP = C-reactive
protein; E = energy; EAR = estimated average requirement; EMS = Elderly Mobility Score; FIM = functional independence measurement; FS = functional status; GFR = glomerular ltration rate; HF = Hip fracture; ICU: Intensive care
unit; IQR = interquartile ranges; LOS = length of hospital stay; LM = lean mass; M = men; MMSE = mini-mental state examination; MNA = mini nutritional assessment; MUAC = mid-upper arm circumference; NA = not available;
NRS = nutritional risk screening; r = Spearmans rank correlation; TLC = total lymphocyte count; TST = triceps skinfold thickness; W = women; = correlation; = increase.
38.5 5
Hypo or hypernatremia,
hepatic or renal insufciency
125 (3491)
83.8 7.7
23.2 4.7
583 (167416)
82.4 7.3
NA
Alb relationship with LM,
BCM, morbidity and
mortality
Association of alb and
in-hospital mortality and
complications
Bouillanne [28]
2011
France
Pimlott [47]
2011
Canada
Cross sectional
Geriatric rehabilitation
care unit
Prospective
Hip fracture patients
Retrospective
Acute geriatrics ward
Results
Exclusion
Design
Population characteristics
Aim
Author
Year
Origin
n (menwomen)
Age mean SD (y)
BMI mean SD (kg/m2 )
Albumin
Mean value (g/L)
Table 1 (Continued)
20
21
Fig. 2. Forest Plots for hospitalized and community-dwelling meta-analyses on albumin mean level, with a results summary on both Fixed and Random effects models.
Squares represent mean albumin level for each study, and the horizontal bars represent 95% CIs. Sizes of the squares is inversely proportional to the standard error of the
mean of the study. Diamond shapes represent the mean estimators for both xed and random effects models with their 95% CIs, with vertical lines helping to compare them
with the individual studies.
22
included due to its sample size exceeding all other studies combined). In the Hospitalized studies, the random effects model
estimation of the albumin mean value was 36.04 g/L, 95% CI (34.81
and 37.28 g/L). In the Community-Dwelling studies, the random
effects model estimation of the albumin mean value was 41.13 g/L,
95% CI (40.26 and 42.00 g/L). In both cases, the heterogeneity among
studies was very high (I2 > 99%) and the Q statistic was signicant
(p < 0.0001), therefore we can consider that there are differences
in the albumin mean values among them. The xed effects models provided similar results, but the random effects one provides a
more conservative estimate and therefore is preferred.
Fig. 2 shows a forest plot for each group of studies (Hospitalized
and Community-Dwelling), and the results of the meta-analysis for
both xed and random effects models with the weight of each study
on both models.
In the elderly living in the community there is a clear association between albumin levels and long-term mortality (between 3
and 12 years) [13,33,5861]. However, in the elderly living in care
homes albumin was associated to short-term mortality (1 year)
but not to long-term mortality [13]. Chronic inammatory state
is an independent prognostic factor for mortality in 4 years [61].
In the presence of low concentrations of IL-6, mortality in 4 years
increases from albumin levels lower than or equal to 44 g/dL.
If we add disability in the ADL to hypoalbuminemia and walking
anomalies the risk of mortality may be as high as 7.5 (men) and
Table 2
Albumin as a nutritional index and its correlation with outcomes in community-dwelling elderly people.
Aim
Design
Population
characteristics
n (Men-Women)
Age mean SD (years)
BMI mean SD (kg/m2 )
Exclusion
Results
Cooper [10]
1989
USA
Salive [12]
1992
USA
Cross-sectional
Community dwelling
Serious illness
35.742.8 (range of
the mean)
Cross sectional
250 NH
3865 HL
241 (NA)
55101 (range)
NA
4115 (14862629)
> 71
NA
NA
40.5 3.1
NH
40.7 HL
Baumgartner
[14]
1996
New Mexico
Cross-sectional
Community dwelling
275 (108167)
M = 76.0 5.4
25.6 3.4
W = 75.7 6.4
25.1 3.8
M = 41.3 2.9
W = 40.9 2.4
Schalk [32]
2005
Netherlands
NA
M 45.2 3.2
W 45.0 3.3
Schalk [40]
2005
Netherlands
Longitudinal (3y)
NA
NA
Sergi [18]
2006
Italy
Cross-Sectional
Outpatients
1320 (644676)
M 75.6 6.6
W 75.4 6.6
NA
588 (NA)
5585 (range)
26.727.8 (range of the
means)
113
BMI > 20 n = 69 (3336)
80.7 7.9 y
BMI < 20 n = 44 (1628)
79.3 7.8 y
39.5 5.5
33.2 5.9
42.5 2.5
Gom [11]
2007
Japan
Cross-sectional
Longitudinal (5y)
Okamura [33]
2008
Japan
Cohort Prospective
(12.4y)
1844 (7971047)
NA
NA
CHD or Stroke
M 42.3 2.6
W 42.9 2.3
Onem [35]
2010
Turkey
Cross sectional
NH
180 (68112)
71.5 5.1
21.7 7.4
40.1 4.4
Snyder [41]
2012
USA
Kitamura [34]
2012
Japan
41.7 3.1
Cohort (2y)
Frail elderly
1267 (12670)
72.8 5.4
27.4 4.0
116 (3482)
83 8.3
20.6 (3.8)
Acute illness
Baseline
40 3
2y
39 4
Cross-sectional:
alb with age
incidence of alb < 35 g/L with age
Longitudinal:
alb 2% with age
Risk of mortality for 1 g/L alb:
(M) HR = 0.93 (0.880.97)
(W) HR = 0.92 (0.870.97)
OR of ADL:
(M) 0.93(0.811.06)
(W) 0.86 (0.770.96)
For Alb 40 g/L:
OR of ADL or mortality:
(W) 3.06 (1.894.95)
if added CH < 200 OR = 4.50 (2.259.02)
ADL MMSE: r = 0.66
ADL alb: r = 0.33
ADL BMI: r = 0.36
No signicant correlation of alb with MMSE and age
Baseline Alb baseline grip strength and leg power
Baseline and Alb inconsistent correlation with loss of ASMM,
HS, and LP
Alb and BI: r = 0.29
Alb and HS: r = 0.40
alb and BI: r = 0.23
HS and HS: r = 0.55
23
ADL = activities of daily living; Alb = albumin; ASMM = appendicular skeletal muscle mass; BI = Barthel index; BMI = body mass index; CH = cholesterol; CHD = coronary heart disease; CRP = C-reactive protein; = difference from the
two time points; ERT = oestrogen replacement therapy; FFM = free fatty mass; FS = functional status; HL = home Living; HR = hazard ratio; HS = handgrip strength; LP = leg power; M = men; MMSE = mini mental state examination;
NH = nursing home; OR = odds ratio; r = Spearmans rank correlation; y = years; W = women; = correlation; = increase; = decrease; = marked decrease.
Author
Year
Origin
24
Table 3
Association between albumin and mortality.
Aim
Design
Population characteristics
n (MW)
Age mean SD (years)
BMI mean SD (kg/m2 )
Exclusion
Albumin
mean value (g/L)
Results
Klonoff-Cohen
[60]
1992
USA
Corti [59]
1994
USA
Prospective (3y)
Community-dwelling
2342 (10451297)
NA
NA
NA
M 43.1 2.7
W 42.8 2.8
NA
M 40.6 3.1
W 40.5 3.1
Sahyoun [13]
1996
USA
Cohort (912y)
Non institutionalized
4116 (14862630)
M 78.1 5.5
W 79.1 5.7
M 25.9 4.1
W 25.3 5
287 (101186)
74.6
NA
176 (64112)
80.7
NA
Terminal, wasting
diseases and severe
metabolic disorder
M 41.8 2.4
W 41.3 2.4
Institutionalized
M 37.8 3
W 37 3.7
Reuben [61]
2000
USA
Longitudinal (4y)
Community-dwelling
632 (262370)
77.5 4.9
27.6 4.5
Disability in ADL
NA
Sullivan [65]
2005
USA
Prospective (5y)
Geriatric rehabilitation unit
Hospitalized
282 (2802)
75.4 8.6
23.9 4.3
Cancer and
terminal conditions
At discharge:
36.4 4.6.
At 3-month:
36.7 4.9
Iwata [63]
2006
Japan
Kitamura [58]
2010
Japan
Retrospective
Hospitalized
1638 (870768)
77.5 7.7
NA
38 6
Cohort (2y)
Community-dwelling
205 (63142)
83.6 8
19.7 3.8
Acute illness
NA
Tal [64]
2011
Israel
Predictors of
in-hospital mortality
Prospective
Hospitalized
1509 (573936)
81.5 7.1
NA
36 5
Hannan [62]
2012
USA
In-hospital mortality
with alb < 20 g/L
Retrospective
Hospitalized
543 (290253)
75.4
NA
B12 supplement,
liver, small bowel,
gastric and colon
disorders,
malignancy
Age <60y, Alb
>20 g/L, Admission
<24 h.
NA
ADL = activities of daily living; Alb = albumin; ASMM = appendicular skeletal muscle mass; BI = Barthel index; BMI = body mass index; CCI = Charlson co-morbidity index; CH = cholesterol; CHD = coronary heart disease; CRP = Creactive protein; = difference from the two time points; FFM = free fatty mass; FS = functional status; HL = home living; HR = hazard ratio; HS = handgrip strength; LOS = length of hospital stay; LP = leg power; M = men; MMSE = mini
mental state examination; NH = nursing home; OR = odds ratio; r = Spearmans rank correlation; RR = relative risk; W = women; = correlation; = increase; = decrease; = marked decrease.
Author
Year
Origin
12.5 (women) times higher than in the elderly with albumin values
higher than 43 g/L and without disability [59].
5.2. In hospitalized elderly
Low levels of albumin are associated to higher mortality during
hospital stay [6264] (Table 3).
Sullivan et al. studied the change in albumin levels 3 months
after discharge from hospital and observed these levels were more
closely associated to long-term mortality than albumin levels at the
time of discharge [65].
6. Discussion
From our literature review, we can conclude that there is agreement that the healthy elderly have normal albumin values, which
indicates that age in itself is not a physiopathological mechanism
of hypoalbuminemia.
Albumin values are a sensitive index for nutritional screening
that indicates the need for a more complete and detailed nutritional assessment. In the elderly, whether in the community, or
in care or hospital, hypoalbuminemia is a prognostic indicator for
complications, for the onset of disability and for mortality. Despite
hypoalbuminemia often also depending on non-nutritional factors,
serum concentration of albumin is strongly correlated to the Mini
Nutritional Assessment both in hospitalized elderly people and
those in nursing homes [29,66].
Intake reduction is one of the main causes of chronic malnutrition in the elderly [8,67]. Among the most important causes of
what is known as geriatric anorexia (a para-physiologic process
associated to age) are alterations in taste and smell, changes in the
hormones that regulate gastric and intestinal motility, and mood
alterations (depression, loneliness and dementia, among others)
[68].
Proteins are the macronutrients most lacking in elderly peoples diets, with intake well below recommended quantities for this
population group [69,70].
The lack of a universally accepted denition of malnutrition in
elderly people is one of the causes of it being under diagnosed
and hinders a standardized ltering process and, therefore, a correct intervention and nutritional follow-up [71]. Various methods
for nutritional assessment based on the combination of several
parameters have been developed and then validated in elderly
populations [72,73].
Despite the higher or lower sensitivity of the various ltering
and diagnostic tests for malnutrition, weight is the fundamental
basis of nutritional assessment, which should not be missing in
any complete geriatric assessment. Anthropometric indices (BMI,
skin folds, muscular diameters, etc.), despite their important limitations as indirect markers of body composition in the elderly,
enhance nutritional assessment and aid in diagnosing malnutrition.
Elderly patients with a hip fracture are of special interest in geriatrics, due to their having undergone an acute episode, which often
unmasks a slowly evolving chronic process and which in many
cases triggers serious complications and disability. The prevalence
of malnutrition in these patients varies widely among the papers
reviewed, reaching 50% in several of them [26,54,74,75]. Two of
the long term consequences of an insufcient calorie and protein
intake are loss of strength and osteoporosis, which leads to fractures due to increase in falls and a reduction of bone resistance to
impact [74].
Hip fracture patients are often malnourished to start with. These
patients suffer a hypercatabolic state secondary to two factors. One
is inammation, which increases muscle loss and the second factor
25
26
Funding
None.
Provenance and peer review
Not commissioned; externally peer reviewed.
References
[1] Agarwal E, Miller M, Yaxley A, Isenring E. Malnutrition in the elderly: a narrative
review. Maturitas 2013;76(4):296302.
[2] Kergoat MJ, Leclerc BS, PetitClerc C, Imbach A. Discriminant biochemical markers for evaluating the nutritional status of elderly patients in long-term care.
Am J Clin Nutr 1987;46(5):84961.
[3] Ballmer PE. Causes and mechanisms of hypoalbuminaemia. Clin Nutr (Edinburgh, Scotland) 2001;20(3):2713.
[4] Fuhrman MP, Charney P, Mueller CM. Hepatic proteins and nutrition assessment. J Am Diet Assoc 2004;104(8):125864.
[5] Moshage HJ, Janssen JA, Franssen JH, Hafkenscheid JC, Yap SH. Study of the
molecular mechanism of decreased liver synthesis of albumin in inammation.
J Clin Invest 1987;79(6):163541.
[6] Vincent JL, Dubois MJ, Navickis RJ, Wilkes MM. Hypoalbuminemia in acute illness: Is there a rationale for intervention? A meta-analysis of cohort studies
and controlled trials. Ann Surg 2003;237(3):31934.
[7] Sullivan DH, Sun S, Walls RC. Protein-energy undernutrition among elderly
hospitalized patients: a prospective study. JAMA 1999;281(21):20139.
[8] Seiler WO. Clinical pictures of malnutrition in ill elderly subjects. Nutrition
(Burbank, Los Angeles County, Calif) 2001;17(6):4968.
[9] Franch-Arcas G. The meaning of hypoalbuminaemia in clinical practice. Clin
Nutr (Edinburgh, Scotland) 2001;20(3):2659.
[10] Cooper JK, Gardner C. Effect of aging on serum albumin. J Am Geriatr Soc
1989;37(11):103942.
[11] Gom I, Fukushima H, Shiraki M, et al. Relationship between serum albumin level
and aging in community-dwelling self-supported elderly population. J Nutr Sci
Vitaminol 2007;53(1):3742.
[12] Salive ME, Cornoni-Huntley J, Phillips CL, et al. Serum albumin in older persons:
relationship with age and health status. J Clin Epidemiol 1992;45(3):21321.
[13] Sahyoun NR, Jacques PF, Dallal G, Russell RM. Use of albumin as a predictor of
mortality in community dwelling and institutionalized elderly populations. J
Clin Epidemiol 1996;49(9):9818.
[14] Baumgartner RN, Koehler KM, Romero L, Garry PJ. Serum albumin is associated with skeletal muscle in elderly men and women. Am J Clin Nutr
1996;64(4):5528.
[15] Campion EW, deLabry LO, Glynn RJ. The effect of age on serum albumin in healthy males: report from the normative aging study. J Gerontol
1988;43(1):M1820.
[16] Flood A, Chung A, Parker H, Kearns V, OSullivan TA. The use of hand grip
strength as a predictor of nutrition status in hospital patients. Clin Nutr (Edinburgh, Scotland) 2014;33(1):10614.
[17] Miller MD, Thomas JM, Cameron ID, et al. BMI: A simple, rapid and clinically meaningful index of under-nutrition in the oldest old? Br J Nutr
2009;101(9):13005.
[18] Sergi G, Coin A, Enzi G, et al. Role of visceral proteins in detecting malnutrition
in the elderly. Eur J Clin Nutr 2006;60(2):2039.
[19] Visser M, Kritchevsky SB, Newman AB, et al. Lower serum albumin concentration and change in muscle mass: the health, aging and body composition study.
Am J Clin Nutr 2005;82(3):5317.
[20] Clark BC, Manini TM. Functional consequences of sarcopenia and dynapenia in
the elderly. Curr Opin Clin Nutr Metab Care 2010;13(3):2716.
[21] Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Sarcopenia in the elderly:
diagnosis, physiopathology and treatment. Maturitas 2012;71(2):10914.
[22] Keller HH. Use of serum albumin for diagnosing nutritional status in the
elderlyis it worth it? Clin Biochem 1993;26(6):4357.
[23] Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical
relevance. Am J Clin Nutr 2006;83(4):73543.
[24] Neumann SA, Miller MD, Daniels L, Crotty M. Nutritional status and clinical outcomes of older patients in rehabilitation. J Hum Nutr Diet 2005;18(2):
12936.
[25] Kyle UG, Genton L, Pichard C. Hospital length of stay and nutritional status. Curr
Opin Clin Nutr Metab Care 2005;8(4):397402.
[26] Hedstrom M, Ljungqvist O, Cederholm T. Metabolism and catabolism in hip
fracture patients: Nutritional and anabolic interventiona review. Acta Orthop
2006;77(5):7417.
[27] Gariballa SE. Malnutrition in hospitalized elderly patients: when does it matter? Clin Nutr (Edinburgh, Scotland) 2001;20(6):48791.
[28] Bouillanne O, Hay P, Liabaud B, Duche C, Cynober L, Aussel C. Evidence
that albumin is not a suitable marker of body composition-related nutritional status in elderly patients. Nutrition (Burbank, Los Angeles County, Calif)
2011;27(2):1659.
[29] Drescher T, Singler K, Ulrich A, et al. Comparison of two malnutrition risk
screening methods (MNA and NRS 2002) and their association with markers
[30]
[31]
[32]
[33]
[34]
[35]
[36]
[37]
[38]
[39]
[40]
[41]
[42]
[43]
[44]
[45]
[46]
[47]
[48]
[49]
[50]
[51]
[52]
[53]
[54]
[55]
27