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INTRODUCTION
2.
3.
4-7
2.
3.
4.
5.
6.
Bi-layer execution
conversion kit.
with
optional
2.
3.
4.
5.
6.
7.
8.
single
layer
34
Int. J. Pharm. Sci. Rev. Res., 20(1), May Jun 2013; n 07, 34-39
9.
4, 8
2.
3.
4.
BILAYERED
TABLETS:
REQUIREMENTS15-17
QUALITY
AND
GMP
35
Int. J. Pharm. Sci. Rev. Res., 20(1), May Jun 2013; n 07, 34-39
4, 10, 18
36
Int. J. Pharm. Sci. Rev. Res., 20(1), May Jun 2013; n 07, 34-39
Advantages:
2.
27
Bulk Density
28
Compressibility Index
Angle of Repose
Hausners ratio 29
General Appearance 33
Thickness 33
Hardness
27-32
37
Int. J. Pharm. Sci. Rev. Res., 20(1), May Jun 2013; n 07, 34-39
4.
Friability
31,33
5.
10
7.5
6.
2.
3.
4.
5.
Kulakarni A, Bhatia M. Development and evaluation of bilayer floating tablets of atenolol and lovastatin for biphasic
release profile, Iran. J. Pharm. Res., 2009, 8, 15-25.
6.
7.
8.
9.
Dissolution Studies 29
CONCLUSION
% Deviation
80mg or less
250 mg or more
Stability studies
37,38
38
Int. J. Pharm. Sci. Rev. Res., 20(1), May Jun 2013; n 07, 34-39
15. Bourne DW. Pharmacokinetics. Banker G.S. and Rhodes.
th
Modern pharmaceutics, 4 ed., Marcel Dekkar, New
York;2002, 67-92.
16. Lachman, Liberman HA, Kanig JL. The theory and practice of
pharmacy, 3 rd edition, Varghese publishing House,
Bombay;1987, 430-453.
17. M.E. Aulton, Aulton's Pharmaceutics: The Design and
Manufacture of Medicines, 1974.
29. Atram SC, Udavant YK, Salunke RJ, Neb GB, Shahi SR,
Gulecha BS, Padalkar AN. Formulation and evaluation of
bilayer tablet containing Metoprolol succinate and
Amlodipine besylate as a model drug for anti hypertensive
therapy. J Pharm Res. Vol. 2(8), 2009, 1335-47.
20. Abshagen U, Spo rl- Radun S.first data on the effect and
pharmacokinetics of Isosorbide 5- mononitrate in normal
man, Eur. J. Clin. Pharmacol. 1981;19, 423-429.
39