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A. Histamine
B. Bradykinin
C. Leukotrines
D. Nitric oxide
E. Neuropeptide substance
Q2. TNF and IL-1 induce endothelial expression of the following molecules?
A. E-Selectins
B. P-Selectins
C. ICAM -1
D. VCAM -1
E. Integrins
a. 1,2,3
b. 1,4,5
c. 2,4,5
d. 1,3,4
e. 2,3,4
A. β 1 integrins
B. β2 integrins
C. CD44
D. CD31
E. A and C
Q4. In leukocytes adhesion deficiency type 2 the leukocytes are unable to bind to?
A. ICAM-1
B. VCAM-1
C. E-selectin
D. P-selectin
E. Both C and D
Q5. The surface proteins that mediate homing of lymphocytes in lymph node and
peripheral site of inflammation are respectively?
1. Rolling
2. Activation
3. Tethering
4. Migration
5. Firm adhesion
A. 1,2,3,4,5
B. 2,3,1,5,4
C. 3,1,2,4,5
D. 2,1,3,4,5
E. 3,2,1,4,5
A. Pain
B. Heat
C. Swelling
D. Necrosis
E. Loss of function
Q8. The changes in vascular flow and caliber during acute inflammation occur in what
order?
1. Blood stasis
2. Vasodilation
3. Exudation of plasma proteins
4. Transient arteriolar vasoconstriction
5. Increased microvascular permeability
A. 1, 2, 3, 4, 5
B. 2, 1, 4, 5, 3
C. 2, 4, 5, 3, 1
D. 4, 2, 5, 3, 1
E. 4, 2, 1, 5, 3
Q9. The net accumulation of fluid (edema) in tissues due to inflammation is caused by
which of the following mechanisms?
1) Increased oncotic pressure gradient between the tissues and the plasma
2) Decreased oncotic pressure gradient between the tissues and the plasma
3) Increased leakage of plasma water due to increased vascular permeability
4) Increased hydrostatic pressure gradient between the vasculature and the tissues
General pathology 2008-2009
Compiled by Bhupinder Bawa
5) Decreased hydrostatic pressure gradient between the tissues and the vasculature
A. 1, 3, 5
B. 1, 4
C. 2, 3, 4
D. 2, 5
E. 2, 4
Q10. Active hyperemia occurs as a result of the action of all of the following chemical
mediators except:
A. Bradykinin
B. Nitric oxide
C. Prostaglandins
D. Leukotriene B4
E. A and D
A. C3a
B. C5a
C. Peptidoglycan
D. Leukotriene B4
E. Lipopolysaccharide
Q12. Increased blood flow to a tissue in inflammation is due to which of the following?
Q13. Which of the following substances acts on venules 20-60 um in diameter to produce
larger intercellular gaps?
A. Histamine
B. Bradykinin
C. Substance P
D. Leukotrienes
E. All of the above
Q14. Which of the following is found pre-made in granules in platelets and endothelial
cells?
A. P-selectin
General pathology 2008-2009
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B. E-selectin
C. L-selectin
D. D-selectin
E. all of the above
Q15. TNF and IL-1 can induce expression of ligands for integrins such as?
A. ICAM
B. VCAM
C. E-selectin
D. P-selectin
E. a and b
Q16. Which of the following is a cause of increased vascular permeability during acute
inflammation?
1. Rolling
2. Adhesion
3. Tethering
4. Diapedesis
5. Margination
A. 2,3,1,4,5
B. 3,5,1,2,4
C. 3,2,1,4,5
D. 5,1,3,2,4
E. 5,3,1,2,4
Q18. Which of the following does not play a role in leukocyte adhesion?
A. Selectins
B. Integrins
C. Endothelins
D. Immunoglobulins
E. Mucin-like glycoproteins
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1. Rubor (Redness)
2. Calor (Heat)
3. Odor (Smell)
4. Tumor (Swelling)
5. Dolor (Pain)
A. 1, 2, 3, 4
B. 1, 2, 4, 5
C. 1, 2, 3, 5
D. 2, 3, 4, 5
E. 1, 2, 3, 4, 5
A. arterioles
B. capillaries
C. venules
D. lymphatics
E. both c & d
Q21. In the leukocyte adhesion cascade, tethering and rolling of leukocytes is largely
mediated by:
A. L- and P-selectins
B. E-selectin and β2 integrins
C. β2 integrins and ICAM-1
D. E-selectin and ICAM-2
E. PECAM-1 and JAM
Q22. Cattle, dogs, and humans with leukocyte adhesion deficiency (LAD) type I lack
functional expression of:
A. E-selectin
B. β2 integrins
C. ICAM-1
D. P-adherin
E. sialyl-Lewis X
F. Fibronectin
G. Fibrinogen
General pathology 2008-2009
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H. Phospholipase C
I. C-reactive protein
J. Mannose binding protein
A. neutropenia
B. platelet abnormalities
C. delayed microbial killing
D. giant granules in leukocytes
E. defective neutrophil chemotaxis
Q26. All of the following are present in azurophil granules of neutrophils except?
A. Elastase
B. Defensins
C. Lysozyme
D. Lactoferrins
E. Myeloperoxidase
A. Vasodilation
B. Vasoconstriction
C. Bronchoconstriction
D. Increased vascular permability
E. Leukocyte activation and chemotaxis
A. Profilin
B. Filamin
C. Gelsolin
D. Parafilin
E. Calmodulin
General pathology 2008-2009
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Q29. All of the following takes part in the activation of leukocytes except?
A. Antigen-antibody complexes
B. Cytokines and chemokines
C. Products of necrotic cells
D. Apoptotic cells
E. Microbes
Q30. Majority of the microbial killing of bacteria by phagocytes takes place by?
A. Altering pH in a phagolysosome
B. Pore forming proteins
C. Enzymatic digestion
D. Oxidative burst
E. All the above
A. 1&2
B. 1&3
C. 1&5
D. 2&3
E. 2&5
Q33. Which of the following is NOT part of the reactive oxygen burst that occurs in
neutrophils?
A. NADPH oxidase
B. Myeloperoxidase
C. Superoxide anion
D. Hydrogen peroxide
E. Superoxide dismutase
General pathology 2008-2009
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A. Chemokines
B. Complement components
C. N-formyl-methionine terminal amino acid
D. A&B
E. All of the above
A. Cytokines
B. Nitric oxide
C. Leukotrienes
D. Prostaglandins
E. Platelet-activating factors
Q38. Which two receptors typically initiate phagocytosis of microbes and dead cells?
1. Toll-like receptors
2. Mannose receptors
3. Scavenger receptors
4. Opsonin receptors
5. Seven-transmembrane G-protein-coupled receptors
A. 1&2
B. 1&5
C. 2&3
D. 2&5
E. 3&4
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A. chemotaxis
B. activation
C. phagocytosis
D. a&b
E. a&c
1. Histamine
2. Prostaglandins
3. Leukotrienes
4. Serotonin
5. Lysosomal enzymes
A. 1, 2, 3
B. 1, 4, 5
C. 2, 3, 4
D. 2, 4, 5
E. 3, 4, 5
A. lysozyme
B. NADPH oxidase
C. major basic protein
D. H2O2-MPO-halide
E. bactericidal permeability increasing enzyme
A. C5a
B. GCRs
C. IL8
D. LTB4
E. a&c
Q43. Toll- like receptors (TLRs) play an essential role in cellular response to the
following components of bacterial cell EXCEPT
A. LPS
B. RNA
C. Endotoxin
D. Proteoglycans
E. Unmethylated CpG nucleotides
General pathology 2008-2009
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A. myosin filaments
B. actin filaments
C. independent process
D. both a and b
E. none of above
A. MPO
B. Catalase
C. Elastase
D. Lysozymes
E. Major basic protein
Q46. What is the common cell precursor for mast cell and basophils that originates and
differentiates in bone marrow?
A. CD4
B. CD34+
C. IL-5
D. IL-3
E. All of the above
Q47. What is the normal distribution of mast cells in the connective tissue?
Q48. What is the typical location of the mast cells in the mucous membrane?
A. Respiratory epithelium
B. Intestinal epithelium
C. Cutaneous epithelium
D. a and b
E. b and c
Q49. Which two proteolytic enzymes released by mast cells are responsible for the
remodeling of the extracellular matrix?
A. Tryptase
General pathology 2008-2009
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B. Chymase
C. Elastase
D. a and b
E. b and c
Q50. The eosinophilic granules of horse eosinophils are rich in which of the following
amino acid
A. Glycine
B. Alanine
C. Arginine
D. Tryptophan
E. Ornithine
Q51. All of the following can inhibit complement activation system EXCEPT?
1. Mobilization of P-selectin
2. Induction of cyclooxygenase
3. Production of prostaglandins
4. Production of PAF and NO
5. expression of endothelial adhesion molecules
A. 1,2,3
B. 1,3,5
C. 2,3,4,5
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D. 1,2,4,5
E. 1,2,3,4,5
Q54. Which of the following is the most essential link between coagulation system and
inflammation?
A. Factor I
B. Factor II
C. Factor XI
D. Factor XIa
E. Factor II
A. Is inactivated by plasmin
B. Initiates the clotting cascade
C. Converts prekallikrein to kallikrein
D. Can be produced by kallikrein by feedback
E. Cleaved from factor XII by collagen and basement membranes
A. 1 and 2
B. 2 and 3
C. 2 and 4
D. 3 and 4
E. 4 and 5
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Q59. Which of the following is NOT a function of C5a?
A. Causes vasodilation
B. Acts as an opsonin
C. Chemotactic for neutrophils
D. Causes increased vascular permeability
E. Activates the lipoxygenase pathway of arachidonic acid metabolism in
neutrophils and monocytes
Q60. Anaphylatoxins C5a and C3a affect vascular permeability by which of the
following mechanisms?
1. Activation of C3
2. Activation of C5
3. Dissolution of fibrin
4. Activation of Hageman Factor
5. formation of the membrane attack complex
A. 1,2,3,4,5
B. 1,2,3,4
C. 1,2,3
D. 2,3,4,5
E. 2,3,4
Q62. Activation of the intrinsic clotting pathway can lead to which of the following?
A. C2 & C3
B. C2 & C4
C. C3 & C4
D. C2 & C5
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E. C3 & C5
A. C3
B. C5
C. C3a
D. C5a
E. All
A. Thromboxane-prostaglandins
B. Prostaglandins-leukotrienes
C. Thromboxane-prostacyclin
D. Thromboxane-leukotrienes
E. Prostacyclin-leukotrienes
A. Vasoconstriction
B. Platelet aggregation
C. Inhibit neutrophils chemotaxis
D. Stimulate neutrophil chemotaxis
E. Increased vascular permeability
A. C
B. CC
C. CXC
D. CX3C
E. CX2C
A. It is a potent vasodilator
B. Has microbicidal properties
C. Inhibits mast cell induced inflammation
D. Reduced platelet aggregation and adhesion
E. Endogenous enhancer of inflammatory responses
A. 1,2,4,5
B. 1,3,5
C. 1,3,4,5
D. 2,4,5
E. 3,5
General pathology 2008-2009
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Q75. TNF and IL-1 do not have an effect on
A. Acute-phase proteins
B. Endothelial cells
C. Myeloblasts
D. Leukocytes
E. Fibroblasts
A. Chemotaxis
B. Vasoconstriction
C. Platelet aggregation
D. Bronchoconstriction
E. Increased vascular permeability
Q79. Which of the following mediators is a potent chemotactic agent for neutrophils?
A. PGF2α
B. Lipoxin A4
C. Leukotriene B4
D. Prostaglandin D2
E. Thromboxane A2
Q81. Which of the following is NOT a function of platelet activating factor (PAF)?
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A. Vasoconstriction
B. Platelet aggregation
C. Bronchoconstriction
D. Leukocyte chemotaxis
E. Inhibition of the neutrophil oxidative burst mechanism
Q82.Platelet lipoxins LXA4 and LXB4 are generated by the action of platelet 12-
lipoxygenase on…
A. Platelet derived LTA4
B. Platelet derived LTB4
C. Neutrophil derived LTA4
D. Neutrophil derived LTB4
E. Macrophage derived LTB4
Q84. The systemic acute phase responses associated with infection or injury are induced
by…
1. TNF
2. IL-1
3. IL-6
4. IL-8
5. IFN-α
A. 1,2,3
B. 1,3,5
C. 2,3,5
D. 2,4,5
E. 1,2,3,4
Q87. Acute phase proteins are released from liver in response to?
A. IL-6
B. IL-1
C. TNF
D. All of the above
E. B and C only
A. C5a
B. TNF
C. IL-1
D. IFN-γ
E. IL-12
Q89. Necrotic tissue can perpetuate inflammation by which of the following ways?
A. activation of bradykinin
B. activation of coagulation
C. activation of complement
D. liberation of uric acid from cells
E. all of the above
A. IL-2
B. TNF
C. IL-10
D. IL-12
E. IFN-γ
Q91. The functions of acute phase proteins include all of the following except?
A. act as opsonins
B. Fix complement
C. Aid in clearing of nuclear debris
General pathology 2008-2009
Compiled by Bhupinder Bawa
D. Redirect lipids to macrophages for energy
E. Cause the accelerated release of leukocytes from bone marrow
1) C5a
2) TGF-α
3) Fibronectin
4) Platelet-derived growth factor
5) Monocyte-chemoattractant protein 1 (MCP-1)
A. 1, 2
B. 1, 2, 5
C. 1, 2, 3, 4, 5
D. 2, 3, 5
E. 5
Q93. One of the major eosinophil secretory substances that is toxic to parasites is?
A. Lysozyme
B. Substance P
C. Acid hydrolase
D. Myeloperoxidase
E. Major basic protein
Q94. The increase in which of the following component of acute phase proteins forms the
basis for measuring the erythrocyte sedimentation rate to determine the severity of
inflammation
A. Fibrinogen
B. C-reactive proteins
C. Serum amyloid A protein
D. A&B
E. A&C
A. IL-1
B. IFN-γ
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C. Endotoxin
D. Fibronectin
E. Both a and d
Q97. Increased concentrations of acute phase proteins can lead to all except...
A. Fever
B. Amyloidosis
C. Increased opsonization
D. Decreased erythrocyte sedimentation rate
E. Both a and d
Q98. Increased levels of IL-1 and/or TNF during an inflammatory response can lead to...
A. DIC
B. Fever
C. Leukocytosis
D. Increase in some acute phase proteins
E. All of the above (and then some)
1. Pox virus
2. Lupus erythematosus
3. Mycoplasma infection
4. Staphlococcus infection
5. Prolonged exposure to silica particulates
A. 1,2,3
B. 1,2,3,4,5
C. 2,3,5
D. 2,3,4,5
E. 3,4,5
A. Recruitment of monocytes
B. Local proliferation of macrophages
C. Immobilization of macrophages at the site of inflammation
D. A&B
E. All of the above
Q101. A granuloma
A. 1
B. 1,2
C. 1,2,3
D. 1,2,3,4
E. 1,2,3,4,5
Q103. Which of the following molecules are not involved in the LPS activation of acute
inflammatory cytokines?
A. NFκB
B. TLR4
C. CD14
D. MyD88
E. Peptidoglycan
A. α-Defensins
B. β-Defensins
C. Cathelicidins
D. Surfactants A and D
E. A and B
A. α-Defensins
B. β-Defensins
C. Cathelicidins
D. Surfactants A and D
E. a,b, and c
1. Secretion of TNF
2. Activation of Bradykinin
3. Induction of TLR4 pathway
General pathology 2008-2009
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4. Activation of Hageman factor
5. Activation of complement cascade
A. 1,3,4
B. 1,4,5
C. 2,3,4
D. 2,4,5
E. 3,4,5
A. LPS
B. TNF
C. IL-1
D. IL-6
E. CD14
1. Serous
2. Catarrhal
3. Fibrinous
4. Suppurative
A. 1,2
B. 2,3
C. 3,4
D. 2,3,4
E. 1,2,3,4
Q110. The predominant cell type presenting antigen to naïve CD4+ lymphocyte is?
A. Dendritic cells
B. B-lymphocyte
C. Macrophages
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D. Neutrophils
E. Mast cells
A. IL-10
B. IL-12
C. IL-9
D. IL-5
E. IL-4
Q112. All of the following can inhibit preTh/CD4+ cells from committing to Th1
pathway except?
A. IL-4
B. IL-5
C. IL-10
D. IL-13
E. IL-12
Q113. Johne’s disease in sheep can have which of the following type of inflammation?
A. Lepromatous granulomatous
B. Eosinophilic granulomatous
C. Tuberculoid granulomatous
D. A and C only
E. All of the above
Q114. The strength and balance of Th-1 and Th-2 response can be regulated by?
A. Macrophages
B. Plasma cells
C. B-lymphocytes
D. α/β T-lymphocytes
E. Regulatory T- lymphocytes
A. 2,1,4,3,5
B. 1,2,3,4,5
C. 2,1,3,4,5
D. 4,3,2,1,5
E. 4,2,3,1,5
A. TGF- β
B. IL-12
C. TNF
D. IL-2
E. IFN
A. IFN-γ , TNF-β
B. IL-4, IL-13
C. IL-12
D. A&C
E. All
A. May be mineralized
B. Formation of nodular granulomas
C. Often contains central area of necrosis
D. Organisms not commonly detected with acid-fast stain
E. Typically seen with Johne’s disease (M. avium-intracellulare)
Q121. Which type of lymphocyte has been shown to contribute to granuloma formation?
A. B lymphocytes
General pathology 2008-2009
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B. γ/δ lymphocytes
C. α/β lymphocytes
D. Natural killer cells
E. T-regulatory lymphocytes
A. Albumin
B. Fibrinogen
C. Haptoglobin
D. Serum Amyloid A
E. C-reactive protein
ANSWERS:
1) D (Robbins pp 50)
2) D (Robbins pp 54)
3) E (Robbins pp 56)
4) E (Robbins pp 55-56)
5) A (Robbins pp 55)
6) C (PBVD pp 110-111)
7) D (Robbins pp 49) heat, swelling, pain, loss of function, redness are hallmarks of
acute inflammation
8) D (Robbins pp 50)
9) E (Robbins pp 50) Capillaries and venules are permeable to water in the resting
state. Fluid accumulation occurs due to increased hydrostatic pressure combined with
leakage of plasma proteins into tissues (increased vascular permeability) which
General pathology 2008-2009
Compiled by Bhupinder Bawa
lowers the oncotic pressure gradient that normally favors fluid movement back into
the venules.
10) E (PBVD p. 103) Bradykinin is involved in increasing vascular permeability and
causing pain. It does not cause vasodilation
11) A (PBVD p. 105)
12) E (Robbins pp50) In acute inflammation vasodilation is the result of arteriolar
dilation, opening of new capillary beds from the action of histamine and NO on
smooth muscle cells.
13) E (Robbins pp50) Binding of histamine and others substances to endothelial cells
of venules activates intracellular signaling pathways that result in the phosphorylation
and contraction of cytoskeletal proteins such as myosin which separates intercellular
junctions. This is short lived (15-30 minutes) and occurs rapidly. Cytokines such as
IL-1, TNF and IFN-γ produces a similar response but is delayed (4-6 hours after) and
long lived (last 24 hours).
14) A (Robbins pp54) P selectin was identified first in the secretory granules of
platelets, and then wsa found in secretory granules of endothelial cells called Weibel-
palade bodies.
15) E (Robbins pp54). VCAM is the ligand for the VLA-4 (β1) integrin and ICAM in
the ligand for LFA-1, and MAC (β2 integrins).
16) E (Robbins 51-52)
17) E (PBVD 110-112)
18) C (Robbins 54)
19) B (Robbins p. 49)
20) C (Robbins p. 50)
21) A (PBVD p.111)
22) B (PBVD p.114)
23) C (Robbins pp 50) except phosopholipase C the rest are plasma proteins which can coat
microbes and are recognized by phagocytes
24) B ( Robbins pp 61-62) H2O2-MPO-Halide is the most potent bactericidal and kills
bacteria by halogenation
25) E (Robbins pp 61-62) The gene associated with this syndrome encodes a large cytosolic
protein involoved in vesicular trafficing
26) D (PBVD pp 120) azurophils are primary granules and lactoferrin is present in specific or
secondary granules. Lactoferrin inhibits the growth of phagocytosed bacteria by
sequestering free iron.
27) C (PBVD pp 124)
28) D (Robbins P-57)
29) D (Robbins P-57)
30) D (Robbins P-59)
31) A (Robbins P-61)
32) B (Robbins p. 68)
33) E (Robbins p. 60)
34) D (Robbins 56)
35) D (Robbins 63)
36) C (PBVD 120)
37) E (Robbins 57-58)
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38) C (Robbins p. 59)
39) E (Robbins p. 57 and 59)
40) B (Robbins p. 63)
41) D (Robbins p. 61)
42) B (Robbins pg 56)
43) B (Robbins pBg 58)
44) B (Robbins pg 59)
45) A (Robbins pg 61)
46) B (PBVD pg 117)
47) E (PBVD pg 117)
48) D (PBVD pg 117)
49) D (PBVD pg 117)
50) C (PBVD pg 121)
51) D (Robbins pp 66) Plasmin activates complement activation system
52) E (Robbins pp 65-68) all these helps in activation of Hagemen factor
53) E (Robbins pp 67-68)All these can induce acute inflammation by activation of PAR-1
54) E (Robbins pp 65) Thrombin is the main link between coagulation system and
inflammation by binding to receptors called as protease activated receptors
expressed on platelets, endothelial cells and smooth muscle cells.
55) C (Robbins 65) kininase inactivates bradykinin
56) A (Robbins p 68) plasmin is capable of activating factor XIIa from XII
57) E (Robbins pp 66) C5 is part of the late complement activation
58) C (Robbins pp 66)
59) B (Robbins pp 64) C3b acts as opsonin
60) E. ( p64-66 Robbins) Both C5a and C3a cause the release of histamine from mast
cells, and C5a activates the lipoxygenase pathway (forming leukotirenes C,D,E) that
increase vascular permeability.
61) B (p 64-65 Robbins) several proteolytic enzymes in inflammatory exudate can
activate C5 and C3, including plasmin and lysosomal enzymes.
62) E (p68 Robbins) Activation of Hageman factor initiates the intrinsic clotting
cascade as well as activating the kinin cascade resulting in formation of Kallikrein
(activation of C5) Bradykinin (vascular permeability and vasodilation) and plasmin
(fibrinolysis and activation of C3 and C5). The clotting cascade results in the
formation of thrombin which in addition to activating fibrinogen also affects
endothelial cells and leukocytes.
63) B (Robbins P.64)
64) E (Robbins-P.65)
65) D (Robbins-P.65)
66) D (Robbins p.64)mannose-binding-lectin is involved with the lectin pathway to
directly activate C1
67) A (Robbins p.66) b (classical pathway C5 convertase), c (alternative pathway C3
convertase), d (alternative pathway C5 convertase), e (membrane attack complex)
68) E (Robbins p.68) all systems are initiated by factory XIIa
General pathology 2008-2009
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69) A (Robbins pp 70) activated neutrophils generates LTB4 from AA by the action
of 5-lipoxygenase. LTB4 translocates to platelets which has 12-lipoxygenase to
convert LTB4 to Lipoxins
70) C (Robbins pp 68)
71) B. (Robbins pp 69) vasoconstriction and increased vascular permeability (LTC-
E4) stimulate neutrophil chemotaxis (LTB4), Inhibit neutrophils chemotaxis
(Lipoxins)
72) C (Robbins pp 71-72) C attracts lymphocytes, CC attracts monocytes, basophils,
eosinophils and lymphocytes but not neutrophils, CX3C attracts T-cell and
monocytes
73) E (Robbins pp 72-73) Nitric oxide reduces inflammatory responses
74) E(Robbins 69)
75) C (Robbins 71)
76) E (PBVD 129) (low levels of PAF cause vasodilation and increased permeability)
77) E
78) A (Robbins p. 69) – prostacyclin is produced by vascular endothelium and causes
vasodilation
79) C (Robbins p. 69)
80) A (PBVD p. 128) Lipoxin A4 causes vasodilation and dampens leukotriene-
induced vasoconstriction
81) E (PBVD p. 128) PAF enhances the neutrophil oxidative burst mechanism
82) C (Robbins p.69)
83) D (Robbins p. 69) Vasoconstrictors= TXA2, LTC4, LTD4, LTE4, and PAF
Vasodilators= PGI2, PGE1, PGE2 PGD2, LXA4, LXB4
Robbins chapter 2
BGC
A. 1,2,3,4,5
B. 1.2.3.4
C. 1,2,3
D. 2,4,5
E. 3,4,5
Answer: B p49
1. necrosis
2. Tissue fibrosis
3. Blood vessels proliferation
4. The presence of lymphocytes, macrophages and neutrophils
A. 1.2,3,4
B. 1,2,3
C. 2,3,4
D. 2,3
E. 2
Answer: E pp50-51
4. Delayed prolonged leakage of venules and capillaries can be caused by which of the
following?
1. Mechanical trauma
2. Bacterial toxins
3. Thermal injury
4. UV radiation
5. X-ray
.
General pathology 2008-2009
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A. 1,2,3,4,5
B. 2,3,4,5
C. 3,4,5
D. 4,5
E. 5
Answer: B p52
5. Which of the following growth factors and cytokines causes increased transcytosis
through vesicular vacuolar organelles in vascular endothelium?
A. FGF
B. IL-1
C. VEGF
D. TNF-alpha
E. IFN-gamma
Answer: C p52
1. P-selectin
2. E-selectin
3. CD62E
4. ELAM-1
5. CD62P
A. 1,2
B. 1,2,3,4,5
C. 3,4,5
D. 3,4
E. 4,5
Answer: B p55. CD62E is E selectin, Cd62P is P selectin, and ELAM 1 is one of them
also- they are all synonyms
A. 1,2,3,4,5
B. 1,2,3
C. 2,3,4,5
D. 2,3
E. 3,4,5
Answer: B p54
1. chemotaxis
2. opsonization
3. lysis of microbes
4. activation of leukocytes
5. increased vascular permeability
A. 1,2,3
B. 1,2,3,5
C. 1,2,3,4,5
D. 2,3,5
E. 3,4,5
Answer: C p64
Answer: C p67
11. The clotting system intersects with the inflammatory cascade in all of the following
ways except:
General pathology 2008-2009
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A. Thrombin causes mobilization of P-selectin and production of chemokines
B. It causes induction of COX-2 and production of prostoglandins
C. Activated Hageman factor initiates the kinin system
D. Thrombin binds to protease-activated receptors
E. Thrombin converts C3 to C3a
Answer: E pp66-68
12. Arachidonic acid metabololites responsible for vasoconstriction include all of the
following except?
A. Thromboxane A2
B. LTC4
C. LTD4
D. LTB4
E. None of the above
Answer: D p69
13. Eicosnaoids that cause increased vascular permeanility include all of the following
except:
A. LTB4
B. LTC4
C. LTD4
D. LTE4
E. None of the above
14. All of the following statements about Lipoxins are true EXCEPT:
A. Lipoxins are generated by platelets from Leukotrienes
B. Contact between neutrophils and platelets are involved
C. 12-lipoxygenase converts LTA4 to lipoxin
D. Lipoxins inhibit leukocyte recruitment
E. None of the above
Answer: E p70
Answer: C p70
General pathology 2008-2009
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16. Which of the following are not functions of PAF?
A. Vasoconstriction
B. Bronchoconstriction
C. Increased venular permeability
D. Vasodilation
E. None of the above
Answer: E. p70 At very low concentrations it causes vasodilation and increased venular
permeability
Answer: E p70
18. Endothelial activation by TNF and IL-1 cause which of the following effects?
A. induce endothelial adhesion molecules
B. Increasing the surface thrombogenicity of endothelium
C. Production of enzymes associated with remodeling
D. Induction of NO and eicosanoids
E. All of the above
Answer: E. p71
19. The acute phase response produced by IL-1, TNF and IL-6 include which of the
following:
A. Fever
B. Loss of eappetite
C. Release of neutrophils
D. Corticotropin and Corticosteroid release
E. All of the above
Answer: B Il-8 is secreted by activated macrophages and endothelial cells and causes
activation and chemotaxis of neutrophils with limited activity on monocytes and
eosinophils
General pathology 2008-2009
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23. All of the following are true about the functions of NO except?
Answer: B. p73
24. Neutrophils contain both specific granules and azurophil granules. Which of them is
potentially more destructive if released extacellularly?
Answer: Azurophil granules p73. S[ecific granules are secreted extracellularly more
readily and by lower concentrations of agonists
25. Which of the following are serum antiproteases that limit neutrophil destructivity?
1. alpha-2 macroglobulin
2. alpha-1 antielastase
3. alpha-1 antitrypsin
4. Myeloperoxidase
General pathology 2008-2009
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A. 1,2
B. 1,3
C. 2,3
D. 2,4
E. None of the above
Answer: B p73
A. 1,2,3,4,5
B. 1,2,3,4
C. 2,3,4,5
D. 2,3,4
E. 3,4
Answer: B 73-74
A. 1,2,3,4,5
B. 1,2,3,5
C. 1,3,5
D. 2,3,5
E. 3,4,5
Answer: B p79
Answer: B p80
29. In severe bacterial sepsis, the combination of which two substances cause DIC by
inducing tissue factor?
A. LPS and IL-1
B. LPS and TNF
C. LPS and C3b
D. TNF and IL-1
E. None of the above
Answer B p85
30. . In severe bacterial sepsis, the combination of which two substances cause DIC by
inhibitng Tissue factor pathway inhibitor and endothelial cell thrombomodulin?
A. LPS and IL-1
B. LPS and TNF
C. LPS and C3b
D. TNF and IL-1
E. None of the above
Answer B p85
A. 1,2,3,4,5
B. 1,2,3,4
C. 1,3,4
D. 1,2,4,5
E. 2,3,4
Answer: B p85
Robbins Ch 2
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137) Which of the following are preformed chemical mediators of inflammation?
1. serotonin
2. histamine
3. leukotrienes
4. prostaglandins
5. lysosomal enzymes
A. 1,2,3
B. 1,2,4
C. 1,2,5
D. 1,2,3,4
E. 1,2,3,4,5
A. 1,2,3
B. 1,2,5
C. 1,2,3,4
D. 1,2,3,5
E. 1,2,3,4,5
A) CD11a/CD18
B) CD11b/CD18
C) CD11c/CD18
D) A and B
E) All
144) The following are the ligands for the G-protein coupled receptors
A) 1, 2, 3, 4, 5
B) 1, 2, 4, 5
C) 2, 4, 5
D) 1, 2, 4
E) 5
1) Fucose
2) Mannose
3) Sialic acid
4) N-acetyl-galactosamine
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A) 1, 2, 3, 4
B) 1, 2, 3
C) 1, 2
D) 2, 3
E) 2
1) C3b
2) C5a
3) IgG
4) IgA
5) Mannose binding lectin
A) 1, 2, 3, 4, 5
B) 1, 2, 3, 4
C) 1, 2, 3
D) 1, 3, 5
E) 2, 3, 5
A) NADPH oxidase
B) Fucosyl transferase
C) MPO-H2O2 system
D) Decreased oxidative burst
E) Defective protein involved in organelle membrane docking and fusion
1) Histamine
2) Seratonin
3) Prostaglandins
4) Platelet activating factor
A) 1, 2, 3, 4
B) 1, 2, 3
C) 1, 2, 4
D) 1, 2
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E) 1
1) Histamine
2) RANTES
3) Eotaxin
4) C5a
5) IL5
A) 1, 2, 3, 4, 5
B) 1, 2, 3, 5
C) 3, 5
D) 3
E) 5
A. 1,2,3,4,5
B. 1,3,4
C. 1,2,3
D. 2,3
E. 4,5
158) Which of the following statements is true regarding basophils and mast cells?
1. Fibroblasts and endothelial cells produce a glycoprotein that induces
CD34+ cells to mature.
2. Basophils and mast cells are derived form different stem cell lines
3. They arise from a common CD34+ progenitor in bone marrow
4. Basophils later differentiate into tissue mast cells
5. Differentiation is dependent on stem cell factor
A. 1,3,5
B. 1,3,4
C. 2,3,4
D. 3,4,5
E. 4,5
159) Mast cell degranulation releases which of the following substances in rodents?
A. TNF-alpha
B. Proteases
C. Serotonin
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D. tryptase
E. All of the above
A. 1,2,3,4,5
B. 1.2.3.4
C. 1,2,3
D. 2,4,5
E. 3,4,5
A. 1.2,3,4
B. 1,2,3
C. 2,3,4
D. 2,3
E. 2
163) Delayed prolonged leakage of venules and capillaries can be caused by which of the
following?
1. Mechanical trauma
2. Bacterial toxins
3. Thermal injury
4. UV radiation
5. X-ray
.
A. 1,2,3,4,5
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B. 2,3,4,5
C. 3,4,5
D. 4,5
E. 5
164) 5. Which of the following growth factors and cytokines causes increased
transcytosis through vesicular vacuolar organelles in vascular endothelium?
A. FGF
B. IL-1
C. VEGF
D. TNF-alpha
E. IFN-gamma
1. P-selectin
2. E-selectin
3. CD62E
4. ELAM-1
5. CD62P
A. 1,2
B. 1,2,3,4,5
C. 3,4,5
D. 3,4
E. 4,5
167) Firm adhesion of leukocytes to endothelium are the result of which of the
following?
1. TNF and IL-1 induced expression of integrins VCAM-1 and ICAM-1 on endothelial
cells
2. Chemokine induced expression of high affinity integrins in leukocytes
3. Chemokine induced expression of VLA-4 and LFA-1 in leukocytes
4. Chemokine induced expression of CD26L in lymphocytes
5. Chemokine induced expression of P-selectins
A. 1,2,3,4,5
General pathology 2008-2009
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B. 1,2,3
C. 2,3,4,5
D. 2,3
E. 3,4,5
168) Which of the following cells are sources of histamine? (p. 63)
1) platelets
2) basophils
3) mast cells
4) eosinophils
5) endothelial cells
A) 1, 2, 3
B) 1, 3, 5
C) 2, 3, 4
D) 2, 3, 5
E) 3, 4, 5
170) Which one of the following is not able to initiate the alternative pathway of the
complement cascade? (PBVD p. 124)
A) plasmin
B) antibody
C) kallikrein
D) lipopolysaccharide
E) activated factor XII
171) Which one of the following components of the complement cascade acts as an
opsonin? (PBVD p. 124)
A) C3a
B) C3b
C) C5a
D) C5b
E) C4
A) CD59
B) CD49
C) CD39
D) CD51
E) CD61
175) Which of the following are the major effects of leukotrienes? (PBVD p. 128)
1) vasodilation
2) vasoconstriction
3) leukocyte chemotaxis
4) complement activation
5) increased vascular permeability
A) 1, 2, 3
B) 1, 3, 4
C) 1, 4, 5
D) 2, 3, 4
E) 2, 3, 5
176) Which one of the following eicosanoids causes vasoconstriction and increased
vascular permeability? (p. 69)
A) lipoxin A4
B) prostacyclin
C) leukotriene C4
D) thromboxane A2
E) prostaglandin E2
177) Which of the following statements about prostacyclin (PGI2) is incorrect? (p 68)
A) it is a vasodilator
B) it acts as chemotaxin
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C) it is formed in vascular endothelium
D) it is a potent inhibitor of platelet aggregation
E) it potentiates the permeability-increasing and chemotactic effects of other mediators
178) Il-1 and TNF can mediate which of the following effects? (p 71)
1) Fever
2) Reduced appetite
3) Collagen synthesis
4) Increased procoagulant activity
5) Increased leukocyte adherence to endothelium
A) 1, 2, 3
B) 1, 2, 4
C) 1, 2, 4, 5
D) 1, 2, 5
E) 1, 2, 3, 4, 5
179) C-X-C chemokines are primarily chemoattractants for which leukocyte? (p 71)
A) Monocytes
B) Eosinophils
C) Neutrophils
D) Mast cells
E) Lymphocytes
A) Leukotrien C4
B) Leukotrien D4
C) Leukotrien E4
D) Prostaglandin E2
E) Thromboxane A2
A) PGI2
B) PGE1
C) PGE2
D) PGD2
E) LTB4
A) LTB4
B) LTC4
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C) LTD4
D) LTE4
E) PGD2
A) LTA4
B) LTB4
C) LTC4
D) TNF
E) Platelet activating factor
184) The following are true regarding primary granules of neutrophils except,
A) Contain defensins
B) Contain lysozymes
C) Are peroxidase-negative
D) Contain bactericidal permeability increasing protein
E) Requires high levels of agonists for their extracellular release
A) PGD2
B) PGE2
C) PGI2
D) PGF2
E) TXA2
1) Thromboxane A2
2) Thromboxane A3
3) Leukotriene B4
4) Leukotriene B5
A) 1, 2, 3, 4
B) 1, 2
C) 3, 4
D) 1, 3
E) 2, 4
187) The following enzymes are involved in synthesis of platelet activating factor from
lipid membranes
A) PAF-synthesizing phosphocholinetransferase
B) LysoPAF acetyltransferase
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C) PAF acetylhydrolase
D) A, B & C
E) A & B
188) Important products of the cycloxygenase pathway include which of the following?
a. Thromboxane
b. Prostacyclin
c. Leukotrienes
d. Lipoxin
e. Prostaglandins
a. A, B, C
b. A, B , D
c. A, B, E
d. A and B only
e. C and D only
1. vasodilation
2. vasoconstriction
3. bronchoconstriction
4. increased chemotaxis
5. increased leukocyte adhesion
General pathology 2008-2009
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A. 1,2,3
B. 2,3,4
C. 2,3,5
D. 1,3,4,5
E. 1,2,3,4,5
1) Tissue destruction
2) Formation of edema
3) Infiltration with mononuclear cells
4) Infiltration with predominantly neutrophils
5) Attempts at healing by connective tissue replacement of damaged tissue
A) 1, 2, 3
B) 1, 2, 3, 4, 5
C) 1, 2, 3, 5
D) 1, 3, 5
E) 3, 5
A. Rhodococcus equi
B. Hairy vetch toxicosis
C. Porcine circovirus type 2
D. Malignant catarrhal fever (ovine herpesvirus 2)
E. Mycobacterium avium-intracellulare paratuberculosis
196) Which of the following products produced by activated macrophages can contribute
to the development of fibrosis? (p. 80)
1) IFN-γ
2) fibronectin
3) fibroblast growth factor
4) transforming growth factor β
5) platelet-derived growth factor
A) 1, 2, 3
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B) 1, 3, 5
C) 2, 3, 4
D) 2, 4, 5
E) 3, 4, 5
197) Which one of the following is NOT a positive acute phase protein? (p. 84, FVCP p.
260-261)
A) transferrin
B) fibrinogen
C) haptoglobin
D) serum amyloid A
E) C-reactive protein
A) 1, 2, 3
B) 1, 2, 4
C) 1, 3, 4
D) 1, 2, 3, 4
199) TH1 immunologic responses often occur in response to? (PBVD p157)
1) Asthma
2) Foreign bodies
3) Mycobacterium spp
4) Histoplasma capsulatum
5) Endogenous antigens such as myelin basic protein
A) 1, 2, 3
B) 1, 3, 4, 5
C) 2, 3, 4
D) 2, 3, 4, 5
E) 1, 2, 3, 4, 5
A) Allergen
B) Foreign bodies
C) Myelin basic protein
General pathology 2008-2009
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D) Mycobacterium bovis
E) Listeria monocytogenes
201) The following cytokines are associated with TH2 type immunologic response
except,
A) IL 4
B) IL 5
C) IL 10
D) IL 12
E) IL 13
1) Polyamines
2) Citrulline
3) Proline
4) TGF-β
5) IL-13
A) 1, 2, 3, 4, 5
B) 1, 3, 4, 5
C) 2, 3, 4, 5
D) 3, 4, 5
E) 3, 4
a. 1.002
b. 1.008
c. 1.012
d. 1.016
e. 1.020
a. 1.002
b. 1.008
c. 1.012
General pathology 2008-2009
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d. 1.016
e. 1.020
a. 12 mm Hg
b. 20 mm Hg
c. 25 mm Hg
d. 32 mm Hg
e. 50 mm Hg
a. Sunburn
b. Histamine
c. Bradykinin
d. Leukotrienes
e. Neuropeptide substance P
Which of the following endothelial molecule binds with the leukocyte receptor
CD11/CD18?
a. ICAM-1
b. PECAM
c. VCAM-1
d. P-selectin
e. E-selectin
a. CD31
b. ICAM-1
c. VCAM-1
d. P-selectin
e. GlyCam-1
General pathology 2008-2009
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a. ICAM-1
b. VCAM-1
c. P-selectin
d. E-selectin
e. GlyCam-1
(KK) Memo:
• CD11b CD18 (Mac-1) mediate leukocyte attachment to endothelium and
subsequent extravasation and also functions as a fibrinogen receptor and as a
complement receptor on phagocytic cells
• CD11a CD18 (LFA-1, leukocyte function-associated antigen-1) plays an
important role in the adhesion of lymphocytes and other leukocytes with other
cells
• CD11c CD18 (CR4) mediate leukocyte attachment to endothelium and
subsequent extravasation
(Answer 1, 3, 4 ref. page 55, Box 2-1. CD31: ligand for CD31, homophilic
adhesion molecules. VCAM-1 (vascular cell adhesion molecule): ligand for VLA-4
(α4β1) integrin.
a. Zinc dependent
b. Sodium dependent
c. Calcium dependent
d. Potassium dependent
Which of the following mediator increases extravasation through increasing the number
of vesiculovacuolar organelles?
a. IGF-1
b. VEGF
c. Bradykinin
d. Leukotrienes
e. Neuropeptide substance P
Answer: E pg 50-52
1. ICAM-1
2. PECAM
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3. VCAM-1
4. P-selectin
5. E-selectin
A. 1,2,3
B. 1,3,5
C. 2,3,4
D. 2,3,5
E. 3,4,5
1. C3a
2. IL-8
3. heat
4. substance P
5. histamine-releasing proteins
A. 1,2,3
B. 2,3,4
C. 3,4,5
D. 1,3,4,5
E. 1,2,3,4,5
(KK) All of the followings are actin-regulating proteins interact with actin in the
filopodium, EXCEPT:
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a. Profilin
b. Filamin
c. Gelsolin
d. Lipophilin
e. Calmodulin
a. Integrin
b. Toll-like receptor
c. Mannose receptor
d. Scavenger receptor
e. Seven α-helical transmembrane receptor
(KK) Which of the following are receptors on macrophages to bind microbe for
phagocytosis?
1. Mac-1
2. Toll-like receptor
General pathology 2008-2009
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3. Mannose receptor
4. Scavenger receptor
5. Seven α-helical transmembrane receptor
a. 1, 2, 3
b. 1, 3, 4
c. 1, 4, 5
d. 2, 3, 4
e. 3, 4, 5
(KK) Which of the following is the most efficient bactericidal system in neutrophils?
a. Defensins
b. Lysozyme
c. Lactoferrin
d. Halogenation
e. Permeability increasing protein
1. C3a
2. C3b
3. C4a
4. C5a
5. C5b
a. 1, 2, 3
b. 1, 3, 4
c. 1, 4, 5
d. 2, 3, 5
e. 3, 4, 5
Which of the following act as an opsonin when fixed to the bacterial cell wall?
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a. C3a
b. C3b
c. C4a
d. C5a
e. C5b
a. Lung
b. Liver
c. Heart
d. Spleen
e. Kidney
1. C1
2. C2
3. C3
4. C4
5. C5
a. 1, 3
b. 1, 4
c. 2, 4
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d. 2, 5
e. 3, 5
October 4, 2005
Robbins Chap 2 page 68-75
Kei K.
a. Platelets
b. Neutrophils
c. Macrophages
d. Lymphocytes
e. Vascular endothelium
a. PGI2
b. TxA2
c. PGE2
d. PGD2
e. PGF2α
a. PGI2
b. TxA2
c. PGE2
d. LTC4
f. Lipoxin
a. IL-18
b. MCP-1 (monocytes chemoattractant protein)
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c. Eotaxin
d. MIP-1α (macrophage inflammatory protein-1α)
e. RANTES (regulated and normal T cell expressed and secreted)
a. Basophiles
b. Monocytes
c. Eosinophils
d. Neutrophils
e. Lymphocytes
a. Glycine
b. Cysteine
c. Arginine
d. Glutamic acid
e. Asparatic acid
a. Catalase
b. Transferring
c. Ceruloplasmin
d. Superoxide dismutase
e. Glutathione peroxidase
a. C3a
b. C5a
c. PAF
d. LTB4
e. Substance P
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(Answer d ref. page 74, Table 2-5, 2-6)
a. C3a
b. C5a
c. PAF
d. LTB4
e. Nitric oxide
a. 1 day
b. 3 days
c. 1 week
d. 3 weeks
e. 1 month
a. C3a
b. C5a
c. PDFG
d. TFG-α
e. MCP-1
a. C chemokine
b. C-C chemokine
c. CX2C chemokine
d. CX3C chemokine
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e. C-X-C chemokine
Answer: A page 54
A) 1,2
B) 1,4
C) 2,3
D) 2,4
E) 4,5
Answer: D page 64
Answer: E page 65
Answer: B page 63
Answer: D page 58
11-30-04
1) Bradykinin is degraded by
a) Kallikrein
b) Plasmin
General pathology 2008-2009
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c) C3 convertase
d) Kininase
e) Thrombin
a) C1
b) C3a
c) C5a
d) C3b
e) C9
Answer- d, Ref:- 64
Q. Which of the following factor usually increases vascular permeability in all levels of
microcirculation?
f. Histamine
g. Bradykinin
h. Leukotriene C4D4E4
i. Lytic bacterial infections
j. Neuropeptide substance P
1) Margination
2) Rolling
3) Pavementing
4) Emigration
5) Chemotaxis
6) Phagositosis
a) 1, 2, 3, 4, 5, 6
b) 1, 3, 2, 4, 5, 6
c) 1, 2, 3, 5, 4 ,6
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d) 2, 1, 3, 5, 4, 6
e) 2, 3, 1, 5, 4, 6
A) Laminin
B) Fibrinogen
C) IgG antibodies
D) Mannose-binding lectin
E) Complement protein C3
A) CD31
General pathology 2008-2009
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B) ICAM-1
C) GlyCam-1
D) E-Selectin
E) P-Selectin
Which of the following adhesion molecules is specific for lymphocyte homing to high
endothelial venules in lymph nodes?
A) CD31
B) ICAM-1
C) GlyCam-1
D) E-Selectin
E) P-Selectin
Please place the following processes involved in the inflammatory process in the correct
order?
A) 1, 4, 3, 5, 2
B) 1, 5, 3, 2, 4
C) 4, 1, 5, 3, 2
D) 4, 3, 5, 1, 2
E) 5, 1, 2, 4, 3
Which of the following is the correct order of the vascular events of inflammation?
1) Vasodilation
2) Neovascularization
3) Transient vasoconstriction
4) Increased vascular permeability
A) 1, 2, 3, 4
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B) 1, 3, 4, 2
C) 3, 2, 1, 4,
D) 3, 1, 4, 2
E) 4, 1, 2, 3
All of the following can lead to increased vascular permeability in the inflammatory
process EXCEPT?
A) Angiogenesis
B) Vasodilation
C) Histamine release
D) Apoptosis of endothelial cells
E) Leukocyte-dependent injury of endothelial cells
1. Nitric oxide
2. Prostaglandin E2
3. Thromboxane A2
4. Platelet-activating factor
5. Prostaglandin I2 (prostacyclin)
a. 1 and 2
b. 2 and 3
c. 3 and 4
d. 4 and 5
e. 1 and 5
a. C3a
b. C5a
c. IL-1
d. 5-HETE
e. Platelet-activating factor
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A. a. ref. page 69, 74 (Table 2-5), 75 (Table 2-6)
a. C5a
b. TGF-β
c. MCP-1
d. Fibronectin
e. Platelet-derived growth factor
A. b ref. page 80
Answer: C page 55
Answer: B page58-59
The following are directly involved in the alternative pathway of complement activation:
1) C4b2b
2) Factor B
3) Properdin
4) Bacterial LPS
5) Antigen-antibody complex
A) 1,2,3,
B) 1,3,4
C) 2,3,4
D) 2,4,5
D) 3,4,5
Answer: C page 66
The following are true regarding the acute phase response except:
A) Increased plasma concentration of fibrin
B) Fever is produced in response to pyrogens
C) Increased plasma concentration of C-reactive protein
D) Accelerated release of leukocytes from bone marrow
E) Increased plasma concentration of serum amyloid A (SAA) protein
A) TGF-β
B) FGF
C) IgG
D) TNF
E) NO
Answer: C Page #: 80
A) IFN-γ
B) PDGF
C) FGF
D) TGF
E) NO
A) COX
B) IL-1
C) PGE2
D) SAA
E) TNF
Answer: D Page #: 84
A) Bradykinin
B) Leukotriene C4, D4, E4
C) Platelet activating factor
D) Tumor necrosis factor (TNF)
E) Complement components C3a and C5a
Answer: D Page #: 74
A) C5a
B) IL-8
C) LTB4
D) LXB4
E) 5-HETE
A) C5a
B) IL-8
C) LTB4
D) LXB4
E) 5-HETE
The sequence of events for extravasation of leukocytes to the interstitium occurs in the
following order:
A) Migration, margination, rolling, pavementing and transmigration
B) Pavementing, rolling, margination, transmigration and migration
C) Margination, pavementing, rolling, transmigration and migration
D) Margination, rolling, pavementing, transmigration and migration
E) Migration, transmigration, margination, rolling and pavementing
Answer: D
THF and IL-1 induce endothelial expression of the following ligand for the LFA-1 and
Mac-1 integrins:
A) ELAM-1
General pathology 2008-2009
Compiled by Bhupinder Bawa
B) VCAM-1
C) ICAM-1
D) P-selectin
E) GlyCam-1
All of the following are actin regulating proteins that are important for leukocyte
chemotaxis except:
A) Filamin
B) Prolifin
C) Gelsolin
D) Porphyrin
E) Calmodulin
Answer: D page 57
Which of the following receptors is a macrophage lectin that binds terminal mannose and
fucose residues of glycoproteins and glycolipids:
A) FCγ receptors
B) Mannose receptors
C) Scavenger receptors
D) CR1-Type 1 complement receptors
E) Seven transmembrane G-proetin-coupled receptors
A. 1, 2, 3
B. 1, 2, 4
C. 1, 4, 5
D. 2, 3, 4
E. 3, 4, 5
General pathology 2008-2009
Compiled by Bhupinder Bawa
A. P-selectin
B. E-selectin
C. VCAM-1
D. PCAM-1
E. ICAM-1
A. CD31
B. L-selectin
C. α4β1 integrin
D. Sialyl-Lewis X
E. CD11/CD18 integrin
Weibel-Palade bodies (normal organells in the endothelium, the main constituent is von
Willebrand factor) redistribution of P-selectin by histamine, thrombin and PAF (page
56, fig 2-7)
A. Phosphorous-dependent
B. Magnesium-dependent
C. Calcium-dependent
D. Copper-dependent
E. Zinc-dependent
A. It is reversible.
B. It is short-lived (15-30 minutes).
C. Capillaries and arterioles are not affected.
D. It is due to direct damage to the endothelium.
E. It occurs rapidly after exposure to the mediator.
Answer: D
A. Sialyl-Lewis X
B. GlyCAM-1
C. PSGL-1
D. ESL-1
E. CD34
Answer: A
A. Mac-1
B. PECAM
C. P-selectin
D. L-selectin
E. E-selectin
Answer: E
Which of the following statements regarding ICAM-1 and VCAM-1 is/are correct? (p 54-
55)
A. 1, 2
B. 1, 2, 3, 4
C. 1, 2. 5
D. 1, 3, 5
General pathology 2008-2009
Compiled by Bhupinder Bawa
E. 5
Answer: A
Which of the following endothelial molecules are responsible for leukocyte rolling?
1. ICAM-1
2. PECAM
3. VCAM-1
4. P-selectin
5. E-selectin
A. 1,2
B. 1,3
C. 2,3
D. 3,4
E. 4,5
Answer: D pg 54-55
A. Lipopolysaccharide
B. Double-stranded RNA
C. Bacterial proteoglycan
D. N-formylmethionyl residues
E. Unmethylated CpG nucleotides
Exchange of GTP for GDP on which of the following receptors activates numerous
cellular enzymes?
A. Toll-like receptors
General pathology 2008-2009
Compiled by Bhupinder Bawa
B. Opsonin receptors
C. Cytokine receptors
D. Mannose receptors
E. Seven-transmembrane G-protein-coupled receptors
Answer: E pg 58-59
Answer: C
A. Toll-like receptors
B. Mannose receptors
C. Scavenger receptors
D. Receptors of cytokines
E. Receptors for opsonins
Answer: C
A. Defensins
B. Lysozyme
C. Lactoferrin
D. Major basic protein
E. Bactericidal permeability increasing protein
Answer: D
Which of the following is the most efficient bactericidal system in neutrophils? (p 61)
A. Defensins
B. Lysozyme
C. NADPH oxidase
D. Major basic protein
E. H2O2-MPO-Halide system
General pathology 2008-2009
Compiled by Bhupinder Bawa
Answer: E
A. C3b
B. C5b
C. C7
D. C8
E. C9
A. C5-C9 complex
B. C4b2b complex
C. C3bBb complex
D. C4b2b3b complex
E. C3bBb3b complex
A. C3a
B. C3b
C. C4a
D. C5a
E. C5b
Answer: D
A. Kallikrein
B. C3bBb3b
C. C4b2b3b
D. Plasmin
E. C4b2b
Answer: E
Answer: B
A. HMWK
B. Kininase
C. Thrombin
D. Kallikrein
E. Prekallikrein
Answer: D
A. Mobilization of P-selectin
B. Production of chemokines
C. Production of prostaglandin
D. Production of PAF and nitric oxide
E. Suppression of endothelial adhesion molecules for integrins
Answer: E
Which of the following is directly responsible for forming C5convertase which in turn
results in the formation of the membrane attack complex?
A. C1a
B. C1b
C. C3a
D. C3b
E. C5a
Answer: D pg 64
Which of the complement factors also acts as an opsonin when fixed to bacterial cell
walls?
F. C1b
G. C3a
General pathology 2008-2009
Compiled by Bhupinder Bawa
H. C3b
I. C4a
J. C4b
Answer: C pg 64
Deficiencies in which of the complement proteins are associated with systemic lupus
erythermatosus?
1. C1
2. C2
3. C3
4. C4
5. C5
K. 1,2
L. 1,3
M. 2,3
N. 2,4
O. 4,5
A. Lipoxin
B. Prostacyclin
C. Prostaglandin E2
D. Prostaglandin D2
E. Thromboxane A2
A. C3a
B. C5a
C. Nitric oxide
D. Leukotriene B4
E. Platelet activating factor
Which of the following inflammatory mediator does not increase vascular permeability?
A. C3a
B. C5a
C. Nitric oxide
D. Leukotriene B4
E. Platelet activating factor
Answer: D page 64
A) 1
B) 1,3
C) 1,4
D) 2,3
E) 3, 5
Answer: C page 65
Factor 12 fragment converts prekallikrein to Kallikrein that cleave high molecular weight
kininogen to bradykinin
Answer: A D=monocytes and T lymphocytes; all other WBC for other choices
Which of the following mediators directly causes both vascular leakage and chemotaxis?
1) C5a
2) Histamine
3) Bradykinin
4) Nitric oxide
5) Leukotriene B4
A) 1,2
B) 1,4
C) 1,2,3,4
D) 2,3,4
E) 3,4,5
Answer: B page 74
Histamine, bradykinin= vascular leakage LTB4=chemotaxis and activation and
adhesion
A. PGE1
B. Lipoxin A4
C. Leukotriene B4
D. Leukotriene C4
E. Thromboxane A2
Answer: D
Which of the following is false regarding nitric oxide (NO) roles in inflammation? (pp
72-73)
A. It is a vasoconstrictor.
B. It reduces platelet adhesion.
C. It reduces platelet aggregation.
D. It inhibits mast cell-induced inflammation.
E. Endogenously it regulates leukocyte recruitment.
Answer: A
Which of the followings are the main cytokines released from activated macrophages
during chronic inflammation that promote leukocyte recruitment? (p 81)
F. IFN-γ
G. IL-12
H. TNF
I. IL-6
J. IL-1
A. 1, 2, 3
B. 2, 4
C. 3, 4, 5
D. 3, 4
E. 3, 5
Answer: D
All of the following statements regarding serum amyloid A (SAA) are correct EXCEPT:
(p 84)
F. It binds to chromatin.
G. It binds to microbial cell wall.
H. It acts as opsonins and fixes complement.
I. Its synthesis by liver is upregulated by IL-6.
J. It may cause secondary amyloidosis in chronic inflammation.
Answer: D
General pathology 2008-2009
Compiled by Bhupinder Bawa
Which of the following products of activated macrophages does not cause tissue injury
during a chronic inflammation? (p 80)
Answer: E
6. IL-1
7. IL-4
8. IL-6
9. IFNγ
10. TGFα
Answer: C
A. vasodilation
B. degranulation
C. bronchodilation
D. vasoconstriction
E. increased vascular permeability
Answer: C pg 70
Which of the following mediators induces increased vascular permeability and leukocyte
adhesion?
F. C5a
G. IL-1
H. TNF
I. Leukotriene B4
J. Oxygen metabolites
A. IgA
B. IgD
General pathology 2008-2009
Compiled by Bhupinder Bawa
C. IgE
D. IgG
E. IgM
Answer: C pg 82
Which of the following are endogenous pyrogens:
1) C3a
2) TNF
3) IL-1
4) IL-12
5) IFN-γ
A) 1,2
B) 2,3
C) 2, 5
D) 3,5
E) 4,5
All of the following are functions of platelet derived growth factor (PDGF) except:
A) Stimulates angiogenesis
B) Stimulates wound contraction
C) Promotes platelet aggregation
D) Chemotactic for PMN’s and macrophages
E) Causes migration and proliferation of fibroblasts
Which of the following growth factors blocks the cell cycle by increasing expression of
Cip/Kip and INK4/ARF families?
A) HGF
B) EGF
C) VEGF
D) TGF-α
E) TGF-β
Answer: E page 96
Which of the following is an adaptor protein of the MAP kinase pathway that binds with
SOS?
A) IP3
B) GRB-2
C) ERK (MK)
General pathology 2008-2009
Compiled by Bhupinder Bawa
D) MEK (MKKK)
E) RAF (MKKK)
Answer: B page 99
Answer: C
F) 1, 2, 3
G) 1, 3, 5
H) 2, 3, 4
I) 2, 3, 5
J) 3, 4, 5
Answer: A
All of the following are characteristics of Chediak-Higashi syndrome except: (p. 61-62)
F) neutropenia
G) defective chemotaxis
H) abnormal melanocytes
I) delayed microbial killing
J) giant granules in leukocytes
Answer: B
F) 1, 2, 3
G) 1, 3, 5
H) 2, 3, 4
I) 2, 4, 5
J) 3, 4, 5
Answer: E
Which one of the following is NOT a positive acute phase protein? (p. 84, FVCP p. 260-
261)
F) transferrin
G) fibrinogen
H) haptoglobin
I) serum amyloid A
J) C-reactive protein