PHARMACEUTICAL

CHEMISTRY - 34066

12 ECTS CREDITS
ARA group

Lecturer in charge: Prof. M. Teresa Varea

Oce number 4-46 (4th oor)

Course guide http://aulavirtual.uv.es

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

-SUMMARY
-PREVIOUS KNOWLEDGE
-COMPETENCES
-LEARNING OUTCOMES:
After completing the course both in theory and laboratory contents the student should be
able to:
- properly use basic scientific terminology related to the subject
- express understanding and knowledge of the facts, concepts, principles, and basic theories
related to the content of the course
- know how to apply this knowledge of understanding and solving problems to daily life
- properly expose scientific works
- integrate pharmaceutical chemistry knowledge with those obtained in other subjects
- develop laboratory processes
- apply laboratory techniques of organic synthesis to the preparation of drugs
- evaluate and interpret the mode of action, and synthesize drugs
- estimate the risks associated with the use of chemicals and laboratory processes
- recognize and apply the scientific method
- understand and interpret scientific papers related to the subject

PHARMACEUTICAL CHEMISTRY - ARA GROUP

DESCRIPTION OF CONTENTS :
1.- Introduction
2.- Drug targets
3.- Basic concepts in the drug action
4.- Drug metabolism
5.- Design and development of new drugs
6.- Quantitative structure-biological activity relationships (QSAR)
7.- Introduction to drug synthesis
8.- Enzyme inhibitors as antibacterial drugs
9.- Acetylcholine modulating drugs
10.- Norepinephrine modulating drug
11.- Drugs modulating other neurotransmitters in the CNS
12.- Drugs modulating enkephalins and opioid receptors
13.- Introduction to spectroscopic analysis
14.- Laboratory

2016-2017

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

ANNUAL: TWO TERMS

FIRST TERM:

TWO/THREE THEORY CLASSES / WEEK (28 HOURS)

ONE SEMINAR SESSION / WEEK (12 HOURS)
THREE TUTORIAL SESSIONS (3 HOURS, TWO GROUPS, U1-U2)
SIX LABORATORY SESSIONS (25 HOURS, TWO GROUPS, L1-L2)

SECOND TERM:

TOTAL= 68 HOURS

TWO/THREE THEORY CLASSES/WEEK (30 HOURS)

ONE SEMINAR SESSION/WEEK (13 HOURS)
THREE TUTORIAL SESSIONS (3 HOURS, TWO GROUPS, U1-U2)

TOTAL= 46 HOURS

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

THEORY AND PROBLEM SOLVING SESSIONS

THEORY CLASSES
LECTURER (Main actor): expose the contents
STUDENTS (not less important): acTve aVendance
ASKING AND ANSWERING
MATERIAL : aula virtual + REFERENCES

PROBLEM SOLVING SEMINARS

STUDENTS: present and explain the answers
Previous Personal Job (individual or teamwork)
Proposals: aula virtual + references

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

SEMINARS / SOLVING PROBLEM

FIRST TERM: 12 ONE-HOUR SESSIONS - UNIT 13
STRUCTURE DETERMINATION (SPECTROSCOPY)
REMEMBER SPECTROSCOPY FUNDAMENTALS!


34065-INSTRUMENTAL TECHNIQUES
SECOND TERM: 13 ONE-HOUR SESSIONS
QUESTIONS RELATED TO THE UNITS 7-12
DRUG SYNTHESIS
REMEMBER FUNCTIONAL GROUP REACTIVITY!
34062-ORGANIC CHEMISTRY

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

SIX TUTORIAL SESSIONS

from 13:00h to 14:00 h or from 9:00h to 10:00h

OCTOBER 2016: remembering organic reacGons

NOVEMBER 2016: solving dicult problems and quesGons
DECEMBER 2016: working about previous exams
FEBRUARY 2017: solving dicult problems and quesGons
APRIL 2017: solving dicult problems and quesGons
MAY 2017: working about previous exams
Content can be changed in order to improve the benets of this acGvity

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

LABORATORY PRACTICES

ONE-HOUR SEMINAR + SIX FOUR-HOUR SESSIONS

LABORATORY N 20 FIRST FLOOR

IT IS MANDATORY TO ATTEND THE INTRODUCTORY SEMINAR :
ON TUESDAY 4th OCTOBER at 13:00 CLASSROOM AF-14B

ALTERNATIVE DATES FOR THE SEMINAR:
B GROUP: 27th September at 12:00 classroom AF-17
C GROUP: 20th September at 16:00 classroom AF-17
D GROUP: 1st October at 16:00 classroom AF-3

LABORATORY SESSIONS:
L1: from 10th October to 18th (Pablo Barrio) FROM 15:00 TO 19:00
L2: from 19th October to 26th (Teresa Varea) FROM 15:00 TO 19:00

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

Evalua]on (more details in the course guide)

15% of the mark (1,5 points out of 10) corresponds to con]nuous
assessment:
ACTIVE ATTENDANCE TO tutorials: up to 0,4 points
ACTIVE ATTENDANCE TO theory classes and seminar sessions: up to 0,5 points
teamwork with oral presenta]on: up to 0,6 points

15% of the mark (1,5 points out of 10) comes from the laboratory
prac]ce mark (it is mandatory to pass this part in order to pass the
subject aVendance to all the lab sessions and to the introductory
seminar is required)

70% of the mark (7,0 points out of 10) derives from the results
obtained in the wrieen exams corresponding to the contents
included in lectures and problem seminars

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

REFERENCES (more details in the course guide)

- A. Delgado, E. Minguillon, J. Joglar. Introduccin a la Qumica Teraputica.
Daz de Santos, 2 Ed. 2.004.
- G. L. Patrick. An Introduction to Medicinal Chemistry. Oxford University
Press, 5th Ed. 2013 (There is a new edition but I havent it yet)
- C. Avendao. Introduccin a la Qumica Farmacutica. Ed. Interamericana McGraw-Hill, 2 edicin 2001
- G. L. Patrick. An Introduction to the Drug Synthesis. Oxford Universtity
Press, 2014.
- ChemBioOffice Ultra, PerkinElmer (CambridgeSoft). Wide selection of
applications and functionality that allows to study, draw, formulate, model and
edit chemical and biological molecular structures.)

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

REFERENCES
(more details in the course guide)

ADDITIONAL:

- A. Delgado, E. Minguillon, J. Joglar. Introduccin a la sntesis de frmacos.

Ed. Sntesis 2.002.
- Enrique Ravia. Medicamentos. Un viaje a lo largo de la evolucin
histrica del descubrimiento de frmacos. Editorial: Universidad de de
SanTago de Compostela, 2008.
- C. Avendao. Ejercicios de Qumica FarmacuGca. Ed. Interamericana.
Mc. Graw-Hill, 1.997.
- G. Thomas. Medicinal Chemistry. An introducGon. John Wiley and Sons,
Ltd. 2 edicin, 2007.
- J. A. Galbis, Panorama actual de la Q. FarmacuGca. Universidad de
Sevilla. 2.000.
- R. J. Anderson, D. J. Bendell, P. W. Groundwater, Organic Spectroscopic
Analysis, Tutorial Chemistry Texts, Royal Society of Chemistry, 2004.
- C. G. Wermuth and col. (eds) The PracAce of Medicinal Chemistry, 4th
ed., Elsevier, 2015.

PHARMACEUTICAL CHEMISTRY - ARA GROUP

2016-2017

InteresTng online material

Oxford University Press ORC (Online Resource Centre)
http://global.oup.com/uk/orc/chemistry/patrick5e/
http://global.oup.com/uk/orc/chemistry/patrick_synth/
http://global.oup.com/uk/orc/pharmacy/ifp_chemistry/01student

MORE LINKS WILL BE INCLUDED IN THE FILES THAT WILL BE

UPLOADED RELATIVE TO THE DIFFERENT UNITS