RESEARCH PROPOSAL

BUDI-LN KEMENRISTEKDIKTI
1. TITLE OF PROPOSAL : Study Developing Signal and Image Processing Methods of
Ultrasound, CT (Computed Tomography) and MRI (Magnetic
Resonance Imaging) in Three-Dimensional Imaging Diagnosis
and Flow Analysis of Cardiovascular Tissues.

2. ABSTRACT

: the purpose of study was to develop signal and image

processing method of ultrasound, CT (computed tomography)
and MRI (magnetic resonance imaging) in three-dimensional
imaging diagnosis and flow analysis of cardiovascular tissues
and develop of acoustic microscope for precise biomedical
imaging. The method measurement is a system simulation on
basis of concept of flow observer.

3. INTRODUCTION
a. Backgrounds
Cardiovascular disease (CVD) is caused by disorders of the heart and blood vessels
and includes coronary heart disease (heart attacks). According to the World Health
Organization (WHO), CVD is the number one cause of death globally and is the
projected to remain the leading cause of death.
Clinical diagnosis, treatment and follow-up of cardiovascular disease are greatly aided
by a number of imaging techniques which provide qualitative and quantitative
information about morphology and function.
Many researchers have reported that the development, progress, and rupture of
aneurysms are related to the hemodynamics, the exiting diagnosis of the aneurysms
mainly considers the anatomical abnormalities shown by X-ray CT, MRI, or
ultrasonography.
For diagnostic measurement, ultrasonography is the common methodology.
Ultrasound is known as safe and portable imaging modality in clinical settings. The
application of ultrasound microscope also covers field of orthopedic surgery.

EchoDynamography represents the flow dynamics in the heart chamber by application

of some laws on fluid dynamics on clinical color Doppler echocardiography.

b. Significance of the proposed project

The combination of technology with developed 3D ultrasound microscope and
applied it assessment of aging of human skin and 3D blood flow analysis in MRI
imaging. Then our goal is to understand the interaction between myocardial blood
flow and blood flow and use mobile imaging for social health care system and disaster
medicine.

c. Purposes
1. Three dimensional / automatic precise diagnosis of cardiovascular tissues
2. Blood flow analysis of cardiovascular system
3. Development of acoustic microscope for precise biomedical imaging

4. METHODS
In this section, Numerical experiment procedure is first explained, and the settings of
numerical experiment to investigate signal and image processing methods of ultrasound, CT
(computed tomography) and MRI (magnetic resonance imaging) in three-dimensional
imaging diagnosis and flow analysis of cardiovascular tissues is explained in detail.
Recently, three dimensional blood flow simulation with realistic blood vessel
geometry has become a powerful tool yielding details of the blood flow field owing to
substantial progress in computational techniques and computer power. Each existing method
of measurement and computation entail its own difficulties in providing complete
information on the blood flow. To solve this problem, we must develop a system simulation
on basis of concept of flow observer.
Reproduction
of Real Flow

Real Flow

Ultrasonic, CT,
and MRI
Measurement

Feedback Law

Numerical
Simulation

Figure 1. Schematic Diagram of Simulation

5. TIME SCHEDULE
Years 1

Years 2

Years 3

Form Dissertation

Dissertation

Requirements

Committee

Meetings

Research Core

Dissertation

Thesis

Curriculum

Proposal Exam

Dissertation

Program Requirements Begin Coursework

and Milestones

(written)
Research Skills

Thesis Defense

Course

(oral)

Responsible Conduct
of Research
Research
Fundamental Exam
Program Expectations

Annual Progress

Annual Progress

Annual Progress

Update (2x)

Update

Update

Funding

Journal

Journal

Publications

Publications

Awards

Awards

Awards

6. OUTCOMES
1.

Development of numerical experiment to accurate for precise biomedical imaging

2.

Journal publications Development of acoustic microscope for precise biomedical

imaging on Conf Proc IEEE Eng Med Biol and Ann Biomed Eng.

7. REFERENCES
3.

Hagiwara Y, Saijo Y, Ando A, Onoda Y, Suda H, Chimoto E, Hatori K, Itoi E.

Comparison of articular cartilage images assessed by high-frequency ultrasound
microscope and scanning acoustic microscope. Int Orthop. Vol. 6, No. 1, 185-90,
2012.

4.

Tanaka Y, Saijo Y, Fujihara Y, Yamaoka H, Nishizawa S, Nagata S, Ogasawara T,

Asawa Y, Takato T, Hoshi K. Evaluation of the implant type tissue-engineered
cartilage by scanning acoustic microscopy. J Biosci Bioeng. 2011 Dec 2. [Epub ahead
of print]

5.

Kumagai K, Koike H, Kudo Y, Nagaoka R, Kubo K, Kobayashi K, Saijo Y. Imaging

of sebaceous glands of human skin by three-dimensional ultrasound microscopy and
its relation to elasticity. Conf Proc 33rd IEEE Eng Med Biol Soc. 7199-7202, 2011.

6.

Tanoue H, Hagiwara Y, Kobayashi K, Saijo Y. Ultrasonic tissue characterization of

prostate biopsy tissues by ultrasound speed microscope. Conf Proc 33rd IEEE Eng
Med Biol Soc. 8499-8402, 2011.

7.

Funamoto K, Hayase T, Saijo Y, Yambe T. Numerical Experiment of Transient and

Steady Characteristics of Ultrasonic-Measurement-Integrated Simulation in ThreeDimensional Blood Flow Analysis. Ann Biomed Eng. Vol. 37, No. 1: 34-49, 2009.

8.

Hagiwara Y, Saijo Y, Ando A, Chimoto E, Suda H, Onoda Y, Itoi E. Ultrasonic

intensity microscopy for imaging of living cells. Ultrasonics Vol. 49, No. 3: 386?388,
2009.

9.

Saijo Y. Acoustic microscopy: latest developments and applications. Imaging in

Medicine, Vol. 1, No. 1, 47-63, 2009.

10. Santos Filho E, Saijo Y, Tanaka A, Yoshizawa M. Detection and quantification of

calcifications in intravascular ultrasound images by automatic thresholding.
Ultrasound Med Biol. Vol. 34, No. 1: 160-165, 2008.
11. Saijo Y, Kobayashi K, Okada N, Hozumi N, Hagiwara Y, Tanaka A, Iwamoto T.
High frequency ultrasound imaging of surface and subsurface structures of
fingerprints. Conf Proc IEEE Eng Med Biol Soc. 2008: 2173-2176, 2008.
12. Iwamoto T, Saijo Y, Hozumi N, Kobayashi K, Okada N, Tanaka A, Yoshizawa M.
High frequency ultrasound characterization of artificial skin. Conf Proc IEEE Eng
Med Biol Soc. 2008: 2185-2188, 2008.
13. Funamoto K, Hayase T, Saijo Y, Yambe T. Numerical experiment for ultrasonicmeasurement-integrated simulation of three-dimensional unsteady blood flow. Ann
Biomed Eng. Vol. 36, No. 8: 1383-97, 2008.
14. Saijo Y, Hozumi N, Kobayashi K, OkadaN, Santos Filho ED, Sasaki H, Yambe T,
Tanaka M. Ultrasonic tissue characterization of atherosclerosis by a speed-of-sound
microscanning system. IEEE Trans Ultrason Ferroelectr Freq Control. Vol. 54, No. 8:
1571-1577, 2007.
15. Saijo Y, Hozumi N, Kobayashi K, Okada N, Ishiguro T, Hagiwara Y, Dos Santos
Filho E, Yambe T. Ultrasound speed and impedance microscopy for in vivo imaging.
Conf Proc IEEE Eng Med Biol Soc. Vol. 1: 1350-3, 2007.

16. Saijo Y, Hozumi N, Lee C, Nagao M, Kobayashi K, Oakada N, Tanaka N, Santos

Filho ED, Sasaki H, Tanaka M, Yambe T. Ultrasonic speed microscopy for imaging
of coronary artery. Ultrasonics, Vol. 44; Suppl. 1: e51-55, 2006.
17. Funamoto K, Hayase T, Saijo Y, Yambe T. Detection and correction of aliasing in
ultrasonic measurement of blood flows with Ultrasonic-Measurement-Integrated
simulation. Technol Health Care. Vol 13, No.4: 331-44, 2005.