Biosntesis lisina

L-Aspartate
4-Phospho-L-aspartate

ATP:L-aspartate 4-phosphotransferase

L-Aspartate 4-semialdehyde

L-Homoserine

L-Homoserine:NAD+ oxidoreductase

L-Aspartate 4-semialdehyde
(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate

L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing;

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate-forming]

2,3,4,5-tetrahydrodipicolinate:NADP+ 4-oxidoreductase

2,3,4,5-Tetrahydrodipicolinate

L-2-Amino-6-oxoheptanedioate

2,3,4,5-Tetrahydrodipicolinate

N-Acetyl-L-2-amino-6-oxopimelate

Acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase

N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Acetyl-L2-amino-6-oxopimelate + L-Glutamate

N6-Acetyl-LL-2,6-diaminoheptanedioate

2,3,4,5-Tetrahydrodipicolinate

N-Succinyl-2-L-amino-6-oxoheptanedioate

Succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate Nsuccinyltransferase

n-Succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate amino-transferase

N-Succinyl-LL-2,6-diaminoheptanedioate

LL-2,6-Diaminoheptanedioate

meso-2,6-Diaminoheptanedioate

LL-2,6-Diaminoheptanedioate 2-epimerase

L-2-Amino-6-oxoheptanedioate

meso-2,6-Diaminoheptanedioate

meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6diaminoheptanedioate gamma-ligase (ADP-forming);

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6diaminoheptanedioate ligase (ADP-forming)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6diaminoheptanedioate:D-alanyl-D-alanine ligase(ADP-forming)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-Dalanine;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-Dalanyl-D-alanine;
UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-6-carboxy-L-lysyl-Dalanyl-D-alanine

2-Oxoglutarate
(R)-2-Hydroxybutane-1,2,4-tricarboxylate

acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing,

carboxymethyl forming)

(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase

(Z)-But-1-ene-1,2,4-tricarboxylate

Homoisocitrate

Homoisocitrate hydro-lyase

Homoisocitrate

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase
(decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)

2-Oxoadipate

L-2-Aminoadipate

L-2-aminoadipate:2-oxoglutarate aminotransferase

L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase;
ATP:L-2-aminoadipate 6-O-adenylyltransferase

L-2-Aminoadipate adenylate

alpha-Aminoadipoyl-S-acyl enzyme

L-2-Aminoadipate 6-semialdehyde

L-2-Aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase

N6-(L-1,3-Dicarboxypropyl)-L-lysine

N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysineforming)

L-Lysine

L-2-Aminoadipate

LysW-gamma-L-alpha-aminoadipate

LysW:L-2-aminoadipate ligase (ADP-forming);

[lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate:L-2aminoadipate ligase (ADP-forming)

ATP:LysW-gamma-L-alpha-aminoadipate 6-phosphotransferase

LysW-gamma-L-alpha-aminoadipate 6-semialdehyde:NADP+ 6-oxidoreductase

(phosphorylating)

LysW-gamma-L-lysine:2-oxoglutarate 6-aminotransferase

LysW-gamma-L-lysine

LysW-gamma-L-lysine carboxypeptidase

(2R,3R)-3-Methylornithine
(2R,3R)-3-Methylornithinyl-N6-lysine

L-Lysine + (2R,3R)-3-Methylornithine + ATP <=> (2R,3R)-3Methylornithinyl-N6-lysine + Products of ATP breakdown

(2R,3R)-3-Methylornithinyl-N6-lysine + NAD+ + H2O <=> (2R,3R)-3Methylglutamyl-5-semialdehyde-N6-lysine + Ammonia + NADH

L-Pyrrolysine