MCQ Series Practice Test

Basic Sciences

Author Email: sidharta123@yahoo.com

Total Marks: 25 | Pass Mark: 15

PHARMACOLOGY
Read the instructions at the begining carefully. Subjects inlude Pharmacology &
Clinical Pharmacology. Answer sheets are provided separately.
Please Note: There is a Negative Marking of (-1) for each incorrect response. There
may be more than one correct answer(s).
Multiple Choice Questions (MCQ)
Total time for test = 30 minutes
QUESTION 1. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding theophylline toxicity, spot the correct statements:
A) has a broad therapeutic index
B) theophylline toxicity may decrease heart rate
C) causes 'dose dumping' so should not be taken with fatty meals
D) theophylline toxicity can cause severe constipation
E) beta-blockers can accentuate theophylline toxicity
QUESTION 2. Choose the SINGLE MOST CORRECT option (A-E) listed below.
All of the following are first generation tricyclic antidepressants (TCAs) except:
A) imipramine
B) amoxapine
C) amitriptyline
D) citalopram
E) doxepin
QUESTION 3. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Factors that affect bone turn over by decreasing resorption:
1. Androgens
2. Growth hormone
3. Thiazide diuretics
4. Interleukin 1& 2
QUESTION 4. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct

Regarding induction of hepatic isoenzymes P450 CYP

1. phenytoin induce CYP3A
2. rifampin induces CYP2B1
3. rifampin induces CYP2D6
4. chronic alcohol consumption induces CYP2B1
QUESTION 5. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Regarding metabolism of theophylline, which of the following statements is/are correct?
A) theophylline is metabolized by enzyme CYP1C19
B) theophylline is metabolized by saturation kinetics
C) amoxicillin does not inhibit theophylline metabolism
D) erythromycin inhibits hepatic oxidation of theophylline
E) plasma concentration of theophylline is increased by ciprofloxacin
QUESTION 6. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Mechanism of action of omeprazole:
A) competitive inhibitor of Na+ K+ ATPase
B) non-competitive activator of H+ K+ ATPase
C) non-competitive inhibitor of H+ K+ ATPase
D) non-competitive inhibitor of Na+ K+ ATPase
E) competitive inhibitor of H+ K+ ATPase
QUESTION 7. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding sulfadiazine, correct is:
1. rapidly absorbed orally and rapidly excreted in urine
2. is not acetylated so crystalluria does not occur
3. attains similar concentration in CSF as in plasma
4. plasma protein binding is 90%
QUESTION 8. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following statements is correct about drugs precipitating pathologic conditions?
1. ramipril precipitates renal failure in patients with bilateral renal artery stenosis
2. naloxone precipitates withdrawal in pentazocine dependent subjects
3. Calcium synergises with digitalis and precipitates toxicity
4. aspirin precipitates urticaria

QUESTION 9. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the followingTricyclic antidepressants (TCAs) have seizure precipitating potential?
1. clomipramine
2. mianserin
3. doxepin
4. bupropion
QUESTION 10. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding H+ K+ ATPase, and the action of omeprazole on H+ K+ ATPase in the gastric parietal
cell membrane, true is
A) activation of H+K+ ATPase proton pump is responsible for gastric acid suppression
B) Omeprazole is rapidly metabolized in the lever by CYP2C9
C) ACh inhibit the proton pump H+ K+ ATPase
D) H+K+ATPase enzyme contains SH groups
E) Omeprazole is rapidly metabolized in the lever by CYP4A11
QUESTION 11. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Which of the following statements regarding theophylline is correct?
A) have no effect on histamine release
B) adenosine receptor antagonist
C) stimulates phosphodiesterases
D) adenosine receptor agonist
E) causes decreased cAMP
QUESTION 12. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the statements 'True' or 'False' related to adverse effects of these drugs:
A) first dose hypotension is more likely with enalapril
B) persistant dry cough is caused with captopril
C) Valproate can rarely cause fulminant hepatitis
D) hypokalemia is the most important adverse effect of amiloride
E) excess tachycardia is associated with Ivabradine
QUESTION 13. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding the pharmacology of Sulfonamides correct is:
1. Sulfonamides crosses placenta
2. Sulfamethopyrazine used in combination with pyrimethamine in the treatment of chloroquine
resistant malignant malaria
3. Sulfadoxine is an ultra-long acting compound with slow renal excretion

4. Sulfonamides do not crosses placenta freely

QUESTION 14. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Agranulocytosis as a side effect is associated by
A) rifampicin
B) tolcapone
C) clozapine
D) propinphenazone
E) olanzepine
QUESTION 15. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Which of the following statements are True or False regarding gout?
A) Colchicine is the fastest acting drug to control acute attack of gout
B) Probenecid is a first line drug in chronic gout
C) gout is due to undersecretion and overproduction of uric acid
D) Allopurinol is a first line drug in chronic gout
E) Allopurinol is the fastest acting drug to control acute attack of gout
QUESTION 16. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Drug that reduces the protein-binding of imipramine:
A) reboxetine
B) phenylbutazone
C) clonidine
D) phenobarbitone
E) carbamazepine
QUESTION 17. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following questions about theophylline is correct?
1. theophylline is metabolized by enzyme CYP1A 1/2
2. erythromycin inhibits hepatic oxidation of theophylline
3. amoxicillin does not inhibit theophylline metabolism
4. plasma concentration of theophylline is increased by ciprofloxacin
QUESTION 18. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Factors that affect bone turn over by increasing resorption:
1. Hypervitaminosis D
2. corticosteroids
3. Prostaglandin E2

4. Thiazide diuretics
QUESTION 19. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
MarkTrue or False regarding the following statements about methylxanthines:
A) have positive chronotropic action on heart
B) causes cerebral vasconstriction
C) methylxanthines causes diuresis
D) have negative inotropic action on heart
E) do not cross the placenta
QUESTION 20. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding the adverse effects of aminophylline, correct is:
A) causes nephropathy
B) causes alopecia
C) bone marrow toxicity
D) induce nausea and vomiting
E) causes excess bradycardia
QUESTION 21. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the following statements true or false:
A) Tetracycline reduces stool volume to half in cholera
B) Adverse effect of ondansetron includes diarrhea and tachycardia
C) Drug of choice for pseudomembranous enterocolitis is erythromycin
D) Yersinia enterocolitica is common in the tropics
E) Cisapride predisposes to Torsades de pointes
QUESTION 22. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Dose-dependent hepatotoxicity is associated with all of the following drugs except:
A) salicylates
B) vancomycin
C) tetracycline
D) azathioprine
E) methotrexate
QUESTION 23. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following TCAs causes marked hypotension and cardiac arrhythmias?
1. imipramine
2. trimipramine
3. doxepin
4. dosulpin

QUESTION 24. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding medications of gout, true is:
1. Probenecid inhibit renal tubular secretion of penicillin
2. Colchicine is suitable for acute gout
3. Ibuprofen is not suitable for acute gout
4. Probenecid is an uric acid synthesis inhibitor
QUESTION 25. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following statements is/are true regarding adverse side effects of these drugs?
1. vestibular ototoxicity is associated with gentamicin
2. leucopenia is associated with phenindione
3. bone marrow toxicity is associated with azathioprine
4. kanamycin is associated with hepatotoxicity

ANSWERS
QUESTION 1. Correct answer = C
QUESTION 2. Correct answer = D
QUESTION 3. Correct answer = A
QUESTION 4. Correct answer = B
QUESTION 5. Correct answers: A= F, B = T, C = T, D = T, E = T.
Essentials of Medical Pharmacology, Tripathy, KD
QUESTION 6. Correct answer = C
QUESTION 7. Correct answer = B
Plasma protein binding is 50%
20-40% is acetylated so crystalluria occurs
QUESTION 8. Correct answer = E
QUESTION 9. Correct answer = E
QUESTION 10. Correct answer = D
QUESTION 11. Correct answer = B
BRS Pharmacology
QUESTION 12. Correct answers: A= F, B = T, C = T, D = F, E = F.
QUESTION 13. Correct answer = A
QUESTION 14. Correct answer = C
QUESTION 15. Correct answers: A= T, B = F, C = T, D = T, E = F.
QUESTION 16. Correct answer = B
QUESTION 17. Correct answer = E
Essentials of Medical Pharmacology, Tripathy, KD
QUESTION 18. Correct answer = A
QUESTION 19. Correct answers: A= T, B = T, C = T, D = F, E = F.
QUESTION 20. Correct answer = D
QUESTION 21. Correct answers: A= T, B = F, C = F, D = F, E = T.
QUESTION 22. Correct answer = B
QUESTION 23. Correct answer = E
QUESTION 24. Correct answer = A
KD Tripathy Essentail of Medical Pharmacology
QUESTION 25. Correct answer = A