20-INORGANIC PHARMACEUTICAL CHEMISTRY

Aims of the course: Understanding by the students of inorganic drug, including

chemical properties and biological role as well as of elements (metals and metalloids)
involved in its structure and synthesis. Aims comprise knowledge and skill (capacity)
of synthesis, qualitative control, characterization, quantitative control of
pharmaceutical preparations which contain inorganic drugs, their mechanism of action
at the molecular level as well as their use and side effects.

Scills: Familiarity with basic knowledge: a) biological activity of metals-metalloids b)

biological activity of inorganic compounds of pharmaceutical interest, c) their
interaction
with
biological
targets
and
d)
their
characterization

qualitative/quantitative control.
Teaching methods:
Lectures and Laboratory work.
Contents of the course:
Inspection of elements in the groups of periodic table in respect with ChemistryPharmacological/Toxicological activity, biological activity of metals-metalloids,
inorganic compounds of pharmaceutical interest: synthesis/origin , quality/quantity
control, properties, uses, side effects and their chemical explanation.
Group
Lithium. Lithium carbonate. Natrium (sodium), natrium carbonicum
and bicarbonicum, natrium sulfuricum, natrium thiosulfatum, natrium
citricum,natrium tetraboracium, natrium fluoratum, natrium chloratum,
natrium phosphoricum bibasicum andbiphosphoricum.
Potassium. Kalium iodatum, kalium permanganicum,potassium
chloride.
Group
. Magnesium, magnesium oxydatum, magnesium
carbonicum leve, magnesium sulfuricum, magnesium steaticum and
trisylicicum, magnesium hydroxidatum , magma magnesiamagnesium
chloratum.
Calcium. Calcium phosphoricum dibasicum, calcium phosphate,calcium
chloride , calcium glyconicum, calcium sulfuricum, calcium
hydroxidatum, calcium hydroxidatum solution, CalcciumPharmacology.
Barium. Barium sulfuricum .
Group
Borium. Acidum boricum.
Aluminium. Aluminium hydroxidatum, colloidale, aluminium
hydroxidatum gelatum siccum, alumen.
Group V
Carboneum, carboneum activate.
Silicium. Bentonitum, Kaolinum leve- Bolus-alba laevigata, talcum
purificatum.
Pliumbum.
Group V
Nitrogenum. Oxydum nitrosum, ammonia concentrate,ammonium
hydricum solutum, ammonium carbonicum,ammonium chloratum.
Arsenicum.Acidum arsenicum. Toxicity of arsenicums compounds and
their antidotes.
Stibium, Stibio-kalium tartaricum.
Bismuthum.
Group V

Oxygenium. Aqua destilata.Hydrogenium peroxidatum.

Sulfur. Sulfur praecipitatum..
Group V
Halogens.Acidum hydrochloricum, cxalcaria chlorata (calcium
hypochlorosum.
Iodum. Tinctura iodi.
Magganium as trace element.
Sub-groip
Cuprum. Cuprum sulfuricum. Role of cuprum in organism. Cuprum
sulfuricum.
Argentum. Argentum nitricum.Argentum compounds .
Sub-group
Zincum.Zincum oxidatum. Zincum as trace element. Consequences of
its deficient in organism.. Interaction of zincum with vitamines..
Hydrargirum. Hydrargyrum oxidatum flavum.Hydrargyrum
bichloratum.. Hydrargirum cyanicum.
Group V
Ferrum. Ferrum as trace element. Ferrum glyconicum. Ferrum
sulfuricum.
Also:
Tungsten, Thallium, Cadmium, Cobalt, Selenium, Vanadium, Nickel,
Platinum and compounds in pharmaceutical use as drugs.
Proposed Literature:
1. Remingtons:Pharmaceutical Sciences 14 Ed.Mac.Publishing Co.,
Easton, 1970.
2. Rogers Inorganic Pharmaceutical Chemistry, 8th ed., by T.O.Soine
and C.O.Wilson, Lea and Felinger, Filadelfia, 1967.
3. Bio-inorganic Chemistry R.W.Hay, editor llis Horwood (in Greek
language by . - & . ). Editor Papazisis, 1992
4. Bioinorganic Chemistry: Inorganic Elements in the Chemistry and
Life. An Introduction and Guide. W. Kaim & B. Schwderski. Editor
Wiley, 1994
5. National Formulary, National Drug Organization 2007

Educational activities:
Lectures and laboratory work.
Evaluation process and methods: Advance written exams (A), exams in the end of
semester (B).
Examination is based on some questions which should be answered according to the
obtained knowledge during semester as well as to the ability to combine knowledge
with information and the critical thought of the students.
Exams in the end of semester take place on date and hours as well as in auditoriums
announced by the Department.
Duration of exams is 3 h.
Marks are rotatable.
) Advance examination
The right to participate in this examination is given to students of the 3d semester
who have attended the lectures (3 among 6 lectures).
There are two examinations, one in the middle of the course and another to the end.
Only students who have succeeded (mark 5 or higher) in the first examination can

participate in the second. Students succeeded in this examination are relieved from
the examination in the end of semester and the total mark is an average of two
examinations.
During laboratory practice students present the composition of their results. At the
end of laboratory practice students have a written examination. Success in laboratory
practice (average of notebook and test should be 5 at least) is obliged for the
participation in exams in the end of semester. The laboratory practice mark
represents the 20% of the final mark.
Use of IC / Electronic distribution of the lectures:
Tutors:
1) A. Geronikaki
Lectures are presented as Powerpoint.
2) Dimitra Hadjipavlou-Litina, professor
Lectures, notes, statements etc are presented in the corresponding place of the
website of the School of Pharmacy.
Teaching:
) Lectures. The lectures take place 1 hour twice per week uditorium D12, in the
building of the School of Natural Sciences.

Lecture
1
2-4
5
6
7
8
9

10
11
12
13
14

15
16
17
18
19
20-21

Title
Quality and quantity control
Group .Introduction. Lithium, lithium
carbonicum. Natrium and its compounds
Compounds of sodium and potassium
Group .Introduction. Magnesium and
its compounds
Magnesium and its compounds. Calcium
Compounds of calcium
Compounds of calcium,its
pharmacology. Barium. Barium
sulfuricum.
Group . Borium and its compounds
Group . Aluminum and its compounds
Aluminum and its compounds
Group IV.Carboneum.Carboneum
activate. Silicium
Group IV.Bentonite, Kaolin and talcum.
Pliumbum, its absorption, toxicity and
therapy.
Group V.Nutrogenum and its
compounds
Bismuthium. Group V. xygenium
Aqua destilata, hydrogenium
peroxidatum
Sulfur. Group V. Halogens, fluoride as
trace element , hydrochloric acid, ,
calcaria chlorata
odine . Manganium
Arsenic-Antinonium

Tutor
A. Geronikaki
A. Geronikaki
A. Geronikaki
A. Geronikaki
A. Geronikaki
A. Geronikaki
A. Geronikaki

A.
A.
A.
A.

Geronikaki
Geronikaki
Geronikaki
Geronikaki

A. Geronikaki

A. Geronikaki
A. Geronikaki
A. Geronikaki
A. Geronikaki
A. Geronikaki
D.Hadjipavlou-

22

Tungsten, Thallium, Cadmium, Cobalt

23-24

Selenium,Vanadium,Nickel,Platinum

25-26

Copper, Mercury, Zinc

Laboratory
1-3

Title
Preparation of boric acid and calcium
phosphoricum bibasicum.
Praparation of original solutions

4-5

Quantitative determination of borax

and boric acid

6-8

Quantitative determination of tincture

iodine (I2 + KI)

Quantitative determination of ferrum

sulfuricum and potassium
permanganicum
Quantitative determination of cuprum
sulfuricum

10

11

Quantitative determination of
magnesium sulfuricum

12

Quantitative determination of KMnO4

by chromatometric method

13

Quantitative determination of sodium

sulfuricum

Litina
D.HadjipavlouLitina
D.HadjipavlouLitina
D.HadjipavlouLitina
Tutor
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas
Geronikaki,
HadjipavlouLitina, Gavalas

)
Laborator
y