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The flow properties of powders and granules are of critical importance in the production of
pharmaceutical dosage forms.
It is recommended that pharmaceutical powders and granules be free flowing (i.e. of good,
rapid and regular flowability) for the following reasons:
1. Uniform feed from storage containers (as machine hoppers) into the tablet dies and
capsule dosators, allowing uniform particle filling that maintains weight uniformity.
2. Uneven Powder flow can result in excess entrapped air within powder which may cause
capping or lamination of tablets.
3. Uneven powder flow can result from the presence of excess fines that are suggested to
increase particle - die wall friction and increase dust contamination risks during powder
transfer and processing.
(texture).
4. Surface roughness
5.Particle density.
2. Flow Rate.
3. Angle of repose.
Wt. (g)
5
--------= ---------- g/cm3
Vol (cm3)
V0
3. Drop and tap the cylinder carefully onto a hard surface for 10 times from a height of 5
cm.
4. Record the volume (V10) of the powder and calculate 10 which is the loose bulk
density.
5. Continue dropping and tapping the cylinder until no further reduction in volume (Vf) is
noticed (usually 40 50 times) and calculate f which is the final bulk density.
1 1.11
Excellent
11 15
1.12 1.18
Good
16 25
1.19 1.34
Pass
26 31
1.35 1.45
Poor
> 32
> 1.46
Very poor
8. Repeat the experiment three times for each sample and record your results in the
following tables.
Sample 1:
Exp.
No.
1
2
3
V0
V10
Vf
10
Hausners Carrs
ratio
index
Mean
Sample 2:
Exp.
V0
V10
Vf
10
No.
Hausners Carrs
ratio
index
1
2
3
Mean
Comment:
Particle shape.
Particle density.
Presence of moisture.
Techniques of measurement.
* Relationship between angle of repose () & powder flowability
Angle of repose ()
Flow behaviour
< 25
Excellent
26 - 30
Good
31 - 40
Pass
41 - 45
Poor
> 46
Very poor
H (cm)
D (cm)
Tan
Angle of repose
()
N0.
1
2
3
Mean
Sample 2
Exp. N0.
H (cm)
D (cm)
Tan
Angle of
repose ()
1
2
3
Mean
connection to the
earth.
IV. Drying of powders and storage under low humidity to minimize moisture.
V. Alteration of process condition by:
1. Using of force feeders i.e. by fitting vibrating baffles at the base of the feeding hopper.
2. Using of mechanically vibrated hoppers.
VI. Addition of flow activators (glidants) e.g., talc, magnesium stearate or silicon dioxide.
The use of glidants to improve powder flowability:
Glidants may act through different mechanisms to improve powder flowability, including:
1. Making the surface of the particles more smooth.
2. Reducing electrostatic charge adhesion and cohesion.
3. Reducing the moisture adsorbed on the particle surface.
1. Determine the "Angle of Repose" for the provided sample powder, without the addition
of glidants, as mentioned previously.
2. Mix well the powder with the glidant (1 %, w/w) and re-measure the angle of repose.
3. Repeat the same experiment with the addition of (3 and 5%, w/w) of the glidant,
respectively.
4. Record your results in the following table:
Sample
Diameter Height
(cm)
no glidant
Mean
+ 1% glidant
Mean
+ 3% glidant
Mean
+ 5% glidant
Mean
Comment:
(cm)
Tan
Angle of repose
()