Created by Bennett Waxse, UTSW

Updated 5/26/2016
For corrections, comment or contact me
More med school reference docs here
b-lactam
penicillin G/V
anti-staph pen
oxacillin, nafcillin
ampicillin, amoxicillin
amino-penicllin
amp-sulb, amox/clav
ticarcillin/clavulanate,
anti-pseudo pen
piperacillin/tazobactam
meropenam
imipenem
carbapenam
ertapenam
1st-gen ceph
cefazolin, cephalexin
2nd-gen ceph
cefoxitin, cefuroxime
cefotaxime
ceftazidime
3rd-gen ceph
ceftriaxone
adv-gen ceph
ceftaroline
4th-gen ceph
cefepime
vancomycin
lincopeptide
daptomycin
linezolid
clindamycin
TMP-SMX
erythromycin
macrolide
azithromycin clarithromycin
doxycycline
tetracycline
minocycline
ciprofloxacin
fluroquinolone
moxifloxacin, levo
monobactam
aztreonam
amikacin
aminoglycoside
gentamicin
rifampin
nitrofurantoin
metronidazole

Gram Positive
MSSA MRSA S. epi GABS GBBS S. pneu E. faec L. mono P. aerug
GPC GPC GPC GPC GPC GPC
GPC
GPR
GNR
fac
fac
fac
fac
fac
fac
aerotol
fac
fac
+*
+
+*
+
+
+*
+
+
+
+
+
+
+
+*
+*
+
+
+
+
+*
+*
+
+
+
+
+
+
+*
tic, pip
+
+
+
+
+

+
+*
+
+
+
+
+
+
+
+*
+
+
+
+
+

+*
+
+
+
+
+
+
+
+
+
+
+

+
+
+*
+
+*
+
+
+

+*
+*
+
+
+
+
+

+
+
+
+
+*
+^
+*
+*
+
+
+*
+
+
+
+*
+
+
+
+
VRE

+
+*
+
+
+
+*
VRE
+
+ (CA)
+
+
+
+
+*

+
+*
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+*
+*
+*
+*
+

+*
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-

Gram Negative
Anaerobes
Serr. Citrob. Enterob. P. mira E. coli Kleb. H. influ M. catar Neiss. B. frag Prevo. C. diff Peptos. Actino.
GNR GNR
GNR
GNR GNR GNR GNCB GNDC GNDC GNR GNR GPR
GPC
GPR
ob
ob
ob
ob
fac
fac
fac
fac
fac
fac
fac
aer
fac
fac
+
+
+
+
+
+

+
+*
+*
+
+
+
+
+
+
+
+
+
+
+
+*
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+*
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+*
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+*
+*
+*
+*
+*
+*
+*
+*
+*
+
+*
+
+*
+
+
+
+
+*
+
+
+
+
+
+
+
+
+
+
+
-

Other
Syphilis

Empiric Therapy

MSSA bacteremia/endocarditis,
OM, CNS
Syphilis,
Necrotizing faciitis (S. pyogenes)
ifns
ENT favorite
Meningitis, sepsis,ENT
brain
abscess,
favorite

Nocardia PNA alternative

Borrelia
Resistance-prone (SPAICE)
Resistance-prone (SPAICE)
Resistance-prone (SPAICE)
BMT patients (febrile
neutropenia -

VP shunt,
HCAP
(w/ levaquin),
aspiration
ab
ifn, HCAP
(prevent resistance,
CAP,unknown
sepsis
anaerobes)
Lower URI, UTI, ab
ifn, sepsis, endocarditis, VP
shunt, HCAP (prevent resistance,
Pelvic ifns, CAP,
ab ifn, complicated UTI
anaerobes)
SSTI, perioperatively
URI, OM, GU
Sepsis, meningitis, ab ifn, UTI, CAP
Sepsis, meningitis, ab ifn, UTI, CAP

Meningitis, ab ifn, UTI, CAP, gonorrhea,

pyelo,
AOM
CAP, SSTI
Sepsis, HCAP,
lower
RTI,
ab ifn, CAP, SSTI,skin,
pyelo bone,C. diff
Pseudomonas)
(PO, if Flagyl-unresponsive)
SSTI, R-sided endocarditis (aureus),VRE,
PNA (surfactant
inactivation)
MDR TB, Nocardia
Resistance
(MRSA PNA,
VRE, HAP, CAP)
CA-MRSA,
cellulitis,
MRSAnecrotizing
SSTI, PCP, faciitis,
UTI, Nocardia,
Anaerobes above diaphragm
Strep/Staph,
Legionella,
TSS,
dental
ifn
Chlamydia,
Gonorrhea,
PCP, Nocardia, Toxo
Toxo,Listeria meningitis (pen allergy)
Chlamydia,
Gonorrhea,
M. pneumoniae,
MAC,
Colorectal decontamination
M.
pneumoniae,
Meningitis,
Q fever,
Bartonella
AOM, atypical PNA, PID, GU ifns, MAC
Rickettsia,
Chlamydia,
Bartonella
Rickettsia,
Chlamydia,
Lyme disease, Malaria PPx (clq resistance), acne
Lyme,
non-TB
myco, Q
RMSF,
Syphilis
Penicillin back-up, Malaria PPx (clq resistance), acne
fever,
2
Syphilis
Legionella,
GU, prostatitis,
Legionella, M.
M.
HCAPHCAP,
(w/ Zosyn),
GU, prostatitis,
pneumoniae
pyelo,
osteo
(Hgb
SS)SS)
pneumoniae
pyelo
(moxi),
osteo
(Hgb
Mycobacteria, MDR TB, Upper and lower RTI, sepsis, SSTI, gyn,GN w/ pen
Nocardia
MDR, 2 agent forallergy
G- bacilli and some G+
Mycobacteria, MDR TB,
Bone ifns, RTI, SSTI, abdominal ifns, UTIs, endocarditis
Nocardia
Biofilms
Active TB, never use alone
Increasedbelow
activitydiaphragm
in urine
Anaerobes
(+ CNS), protozoa

UTIs ( ESRD)
BV, trich, PID, Giardia, C. diff

(severe)

Adverse Effects (precautions)

Rash, seizure threshold

AIN (urine eosinophils)

Urticarial, mobiliform rash, angioedema, StevensUrticarial, mobiliform rash, angioedema, StevensJohnson

Johnson
N, D, C
N, D
seizure threshold
D
Rash (<10% cross-reactive), cytopenias (CBC),
Rash
(<10% cross-reactive),
mild cholestasis
(alk phos) cytopenias (CBC),
mild cholestasis (alk phos)
Rash (<10% cross-reactive), cytopenias (CBC),
Rashcholestasis
(<10% cross-reactive),
mild
(alk phos) cytopenias (CBC),
mild cholestasis (alk phos)
Rash (<10% cross-reactive), cytopenias (CBC),
mild cholestasis (alk phos)
Positive Coombs (without hemolysis)
Anaphylaxis,
red(without
man syndrome
Positive Coombs
hemolysis) (IgE),
HA, D, N, optic
n.Bullous
damage,Dematosis
peripheral
AKI,Linear
IgA

neuropathy,
serotonin
syndrome,
BM
HTN,
edema, Rhabdo
(check
CK, CI: statins)
Hyperkalemia,
Stevens-Johnson,
suppression (2+
weeks)
pancytopenia, crystaluria,
AKI, taste
G6PD
Pseudomembranous
colitis, metallic
hemolysis, pancreatitis
QTc
QTc prolongation,
prolongation, heartburn/GI
heartburn/GI upset/D
upset/D
(prokinetic)
(prokinetic)
Photosensitivity,
Photosensitivity, pill
pill esophagitis,
esophagitis, grey
grey teeth,
teeth,
no
urine
penetration
blue discoloration
Tendonitis/rupture,
(less),
Tendonitis/rupture, QTc
QTc prolongation
prolongation,
neuropathy, G6PD
G6PD hemolysis
hemolysis
neuropathy,
Rash, TEN, N, V, D, neutropenia, transaminitis,
little
cross-reactivity
Nephrotoxicity,
ototoxicitywith pens
Nephrotoxicity, ototoxicity
Disulfiram-like
taste,
Orange urine, OCPsrxn,
don't metallic
work
neuropathy,
N, V, pulmonary fibrosis, hepatitis, G6PD hemolysis

N, V, QTc prolongation