You are on page 1of 96

COMPUTER & OUR

SOCIETY {MEDICINE}

CONTENTS
Chapter 1

Introduction

Chapter 2

Literature Review

Patient Monitoring

10

Remote patient monitoring

13

Maintaining patient history & other records

19

Electronic Health Record

23

Health Information Management

48

Home Health Care Software

52

Diagnosing and Surgery

54

Computer Aided Diagnosing

62

Computer Aided Surgery

69

Research

86

Chapter 3

Findings and Discussion

83

Chapter 4

Conclusion

88

REFERENCES

ABSTRACT

CHAPTER ONE

INTRODUCTION
The history of computerization in medicine started in 70s. At that time, the main
purpose of computerization was labor-saving for the process of insurance claim and the
scope was limited only within administrative section in medical institutions. The physician
order entry system (POES) appeared in 80s by a centralized system of a host computer
and based on the computerization of clinical laboratory and pharmacy.
The POES contributed reducing patient's waiting time in clinical institutions and
also making the process of Insurance claim efficient. The growth of networking, especially
the Internet in 90s enhanced cooperation among clinical professionals or clinical
institutions. Also, the electronic medical record (EMR) came into realistic and a hospital
in the west of Japan implemented EMR and got rid of paper first in 1999.
In 2001, Japanese government established e-Japan policy, and health care and social
welfare is one of the main target fields. Then, the ministry of health labor and welfare
(MHLW) published "IT ground design for healthcare system" in the end of 2001.
It focused on EMR and the national standard software for electronic prcH2ess of
insurance claim. It made target to implement by the end of 2006; over of institutions
which has more than 400 beds should install EMR and over of institutions should install
the national standard software for electronic process of insurance claim. According to the
survey by the MHLW in 2002, only 1.3% out of total 8,023 hospitals have EMR and 15.3%
have

the

POES.

It is also only 2.3% that the percentage of hospitals installed the national standard
software for electronic process of insurance claim. However, such numbers are
dramatically increasing recently.
As overall, computers are very popular among Japanese people and international
survey in 2003 showed that had laptop or desktop computers in 2002 and had a mobile
phone in 2003 in Japan. The corresponding numbers for the US were 66% and 54%. The
percentage of the Internet users were 45% for Japan and 55% for the US in 2002 (ITU
Telecommunication Indicators).
There has been a rapid expansion of computer use in medicine recently in the US
for a number of uses including medical education at all levels, point of service medical
information (especially diagnostic, treatment, and medications), medical research,
EMRs, electronic billing, electronic prescribing, and the collection of data to determine
quality of care and quality of medical education.
Some possible reasons why computers are increasingly used in US medical care are
availability of high speed connections, availability of personal digital assistants (PDAs),
availability of wireless connections, decreasing cost of hardware and software, public and
government demands for increased quality of care and documentation of that quality,
too much information to process without electronic help. Wireless LANs are much more
common today in hospitals than in doctors ' offices. Only about 8 percent of physician
practices have gone wireless. By comparison, 61 percent of integrated delivery networks
and 36 percent of stand-alone hospitals have some wireless capability in the US.
In terms of security, wireless network should be protected, at least, by a
combination of wireless-specific ways such as WPA/EAP according to IEEE802.1X with
4

IPSec/VPN technologies. In addition, a separation of traffic by creating VIANs, and


installation of a firewall between wired and wireless networks tightened the security of
the

MIPA/EAP-equipped

wireless

networks.

How can computers Improve quality of care and document that quality? They can
avoid illegible hand- writing, can be programmed to find errors in dosage, medication
name, medication interactions, and identifying allergic patients or the wrong patient,
computerized records can be backed up and are less likely to be lost or unavailable,
computerized records can more easily be transferred even over long distances, more
easily collect data such as mortality or number of patients seen or types of diagnosis seen.
How can computers improve medical education? They can decrease the amount of
class time where there is information transfer without interaction, Increase the amount
of class time available to answer questions and concentrate on confusing or difficult
topics, teach medical students and residents how to efficiently get the most accurate,
useful, and up to date information through computer programs. They can then use this
technique for the rest of their career. Computers can decrease the amount of information
needed to be memorized and reduce the chance of error due to faulty memory. Finally,
they can decrease the amount of time needed to read journals and books while still
maintain

high

quality

knowledge.

What are the disadvantages of computer use in medicine? They can be less useful
for those physicians who cannot type quickly, take extra time and effort to get used to,
create psychological discomfort with a new way of practicing medicine, be vulnerable to
viruses and technical problems that risk loss of data unless backed up, be vulnerable to
5

breaches of patient confidentiality, sometimes increase the amount of time needed to


get work done, create fear that computerized data can be used by the legal system against
doctors and hospitals, create the fear of making the interaction between the patient and
doctor seem less personal and have

CHAPTER TWO

LITERATURE REVIEW
The electronic devices supplied with processing units became an important
component of our everyday life. Computers, smartphones and other apparatuses that
give us mobile access to Internet are fundaments of modern business, education and
sometimes even relationships. Health care as a vital part of contemporary society model
is also affected by the same technical trends as the other branches of business. As
personal healthcare is among most important aspects of everyone life many efforts are
put into medical researches on new treatment techniques. Because of that, all computer
methods that have proven to have technical and scientific potential are quickly developed
and utilized in medicine.
Now it is impossible to mention all possible applications of computers in
contemporary medicine because nearly all aspects of applied informatics are used in
practical medical solutions. The motivation of this article is presenting subjective list of
up to date applications of computer methods in medicine that might be good introduction
to this subject. In our opinion the role of computer methods in medicine is changing as
quick as computer science itself and there is a need for this type of review. Moreover, we
will describe our contribution to the state of the art methodology by introducing some of
our projects and achievements in this subject.
Our work is mainly concentrated on two- three- and four dimensional image data:
image processing and recognition (classification tasks), semantic interpretation, as well
as visualization and user interfaces. The data we are dealing with are mainly medical
7

images acquired from patients with suspicious of early stages of brain stroke. The proper
diagnosis of medical data in first hours after appearing the stroke syndromes is crucial not
only for patience live but also for further convalescence.
Computer is playing very important role in medical fields. Nearly every area of the
medical field uses computers. They are helping the doctors to diagnose diseases and for
many other purposes.

The four main/major uses of computer in medical field are described below:

1- Patient Monitoring
Different electronic scanning devices (medical equipment) are used in hospitals. They
are connected with computers. These devices are used to monitor the patient
continuously. Thus computers are normally used in the following medical units of
hospitals for monitoring patients.
o ICU

(Intensive Care Unit)

o Operation
o Recovery
o Medical
o ECG

Theater

Room

Ward

(Electrocardiograph)

The medical equipment with sensors is attached to the patient. It detects changes in
heart rate, pulse rate, blood pressure, breathing and brain activity. If any unbalancing
situation occurs, computer activates the alarming device, which creates sound and
alerts the medical staff.
8

2- Maintaining Patient History & Other Records


The complete bio-data as well as medical history of a patient is recorded into the
computer. The medical history is delivered to the related doctor for the checkup of the
patient. In this way, much of the doctor's time is saved.

In addition to patient history, other information about doctors, medicines, and


medical equipment is also maintained through computers. This information can be
retrieved very easily and quickly.

3- Diagnosis & Surgery


Computer is also used in hospitals for diagnosing diseases. Different medical tests
depend upon the computerized devices such as laboratory test of blood. One common
use of computer in hospitals is to scan the body of patient. A special scanner is used for
this purpose. For example, the CAT (Computerized Axial Tomography) scanner passes
rays over the patient. It displays an image of bone and tissue structure of patient on a
computer screen. This image is printed on the printer. It is also store in computer for
later use.
4- Research.
We would look at them one by one.

PATIENT MONITORING
In medicine, monitoring is the observation of a disease, condition or one or several
medical parameters over time. It can be performed by continuously measuring certain
parameters by using a medical monitor (for example, by continuously measuring vital
signs by a bedside monitor), and/or by repeatedly performing medical tests (such as blood
glucose monitoring with a glucose meter in people with diabetes mellitus). Transmitting
data from a monitor to a distant monitoring station is known as telemetry or
biotelemetry.
Classification by target parameter
Monitoring can be classified by the target of interest, including:

Cardiac monitoring, which generally refers to continuous electrocardiography


with assessment of the patients condition relative to their cardiac rhythm. A
small monitor worn by an ambulatory patient for this purpose is known as a
Holter monitor. Cardiac monitoring can also involve cardiac output monitoring via
an invasive Swan-Ganz catheter.

Hemodynamic monitoring, which monitors the blood pressure and blood flow
within the circulatory system. Blood pressure can be measured either invasively
through an inserted blood pressure transducer assembly, or noninvasively with an
inflatable blood pressure cuff.

Respiratory monitoring, such as:

10

Pulse oximetry which involves measurement of the saturated percentage of


oxygen in the blood, referred to as SpO2, and measured by an infrared
finger cuff

Capnography, which involves CO2 measurements, referred to as EtCO2 or


end-tidal carbon dioxide concentration. The respiratory rate monitored as
such is called AWRR or airway respiratory rate)

Respiratory rate monitoring through a thoracic transducer belt, an ECG


channel or via capnography

Neurological monitoring, such as of intracranial pressure. Also, there are special


patient monitors which incorporate the monitoring of brain waves
(electroencephalography), gas anesthetic concentrations, bispectral index (BIS),
etc. They are usually incorporated into anesthesia machines. In neurosurgery
intensive care units, brain EEG monitors have a larger multichannel capability and
can monitor other physiological events, as well.

Blood glucose monitoring

Childbirth monitoring

Body temperature monitoring through an adhesive pad containing a


thermoelectric transducer

Medical monitor
A medical monitor or physiological monitor is a medical device used for monitoring.
It can consist of one or more sensors, processing components, display devices (which are
sometimes in themselves called "monitors"), as well as communication links for displaying
or recording the results elsewhere through a monitoring network.

11

Examples and applications


The development cycle in medicine is extremely long, up to 20 years, because of
the need for U.S. Food and Drug Administration (FDA) approvals, therefore many of
monitoring medicine solutions are not available today in conventional medicine.
Blood glucose monitoring
In vivo blood glucose monitoring devices can transmit data to a computer that can
assist with daily life suggestions for lifestyle or nutrition and with the physician can make
suggestions for further study in people who are at risk and help prevent diabetes mellitus
type 2 .
Stress monitoring
Bio sensors may provide warnings when stress levels signs are rising before human
can notice it and provide alerts and suggestions.
Serotonin biosensor
Future serotonin biosensors may assist with mood disorders and depression.
Continuous blood test based nutrition
In the field of evidence-based nutrition, a lab-on-a-chip implant that can run 24/7
blood tests may provide a continuous results and a computer can provide nutrition
suggestions or alerts.

12

Psychiatrist-on-a-chip
In clinical brain sciences drug delivery and in vivo Bio-MEMS based biosensors may
assist with preventing and early treatment of mental disorders.
Epilepsy monitoring
In epilepsy, next generations of long-term video-EEG monitoring may predict
epileptic seizure and prevent them with changes of daily life activity like sleep, stress,
nutrition and mood management.
Toxicity monitoring
Smart biosensors may detect toxic materials such mercury and lead and provide
alerts.

REMOTE PATIENT MONITORING


Remote patient monitoring (RPM) is a technology to enable monitoring of patients
outside of conventional clinical settings (e.g. in the home), which may increase access to
care and decrease healthcare delivery costs.
Incorporating RPM in chronic disease management can significantly improve an
individuals quality of life. It allows patients to maintain independence, prevent
complications, and minimize personal costs. RPM facilitates these goals by delivering care
right to the home. In addition, patients and their family members feel comfort knowing
that they are being monitored and will be supported if a problem arises. This is particularly
important when patients are managing complex self-care processes such as home
13

hemodialysis. Key features of RPM, like remote monitoring and trend analysis of
physiological parameters, enable early detection of deterioration; thereby, reducing
number of emergency department visits, hospitalizations, and duration of hospital stays.
The need for wireless mobility in healthcare facilitates the adoption of RPM both in
community and institutional settings. The time saved as a result of RPM implementation
increases efficiency, and allows healthcare providers to allocate more time to remotely
educate and communicate with patients.
Technological components
The diverse applications of RPM lead to numerous variations of RPM technology
architecture. However, most RPM technologies follow a general architecture that consists
of four components.:

Sensors on a device that is enabled by wireless communications to measure


physiological parameters.

Local data storage at patients site that interfaces between sensors and other
centralized data repository and/or healthcare providers.

Centralized repository to store data sent from sensors, local data storage,
diagnostic applications, and/or healthcare providers.

Diagnostic application software that develops treatment recommendations and


intervention alerts based on the analysis of collected data.
Depending on the disease and the parameters that are monitored, different

combinations of sensors, storage, and applications may be deployed.

14

Applications
Physiological data such as blood pressure and subjective patient data are collected
by sensors on peripheral devices. Examples of peripheral devices are: blood pressure cuff,
pulse oximeter, and glucometer. The data are transmitted to healthcare providers or third
parties via wireless telecommunication devices. The data are evaluated for potential
problems by a healthcare professional or via a clinical decision support algorithm, and
patient, caregivers, and health providers are immediately alerted if a problem is detected.
As a result, timely intervention ensures positive patient outcomes. The newer
applications also provide education, test and medication reminder alerts, and a means of
communication between the patient and the provider. The following section illustrates
examples of RPM applications, but RPM is not limited to those disease states.
Dementia and falls
For patients with dementia that are at risk for falls, RPM technology promotes
safety and prevents harm through continuous surveillance. RPM sensors can be affixed to
the individual or their assistive mobility devices such as canes and walkers. The sensors
monitor an individuals location, gait, linear acceleration and angular velocity, and utilize
a mathematical algorithm to predict the likelihood for falls, detect movement changes,
and alert caregivers if the individual has fallen. Furthermore, tracking capabilities via WiFi, global positioning system (GPS) or radio frequency enables caregivers to locate
wandering elders.

15

Diabetes
Diabetes management requires control of multiple parameters: blood pressure,
weight, and blood glucose. The real-time delivery of blood glucose and blood pressure
readings enables immediate alerts for patient and healthcare providers to intervene
when needed. There is evidence to show that daily diabetes management involving RPM
is just as effective as usual clinic visit every 3 months.
Congestive heart failure
A systematic review of the literature on home monitoring for heart failure patients
indicates that RPM improves quality of life, improves patient-provider relationships,
shortens duration of stay in hospitals, decreases mortality rate, and reduces costs to the
healthcare system.
Infertility
A recent study of a remote patient monitoring solution for infertility demonstrated
that for appropriately screened patients who had been seeking In-Vitro Fertilization (IVF)
treatment, a six-month remote monitoring program had the same pregnancy rate as a
cycle of IVF. The remote patient monitoring product and service used had a cost-perpatient of $800, compared to the average cost of a cycle of IVF of $15,000, suggesting a
95% reduction in the cost of care for the same outcome.
Whole System Demonstrator Trial in UK
The UKs Department of Healths Whole System Demonstrator (WSD) launched in
May 2008. It is the largest randomized control trial of telehealth and telecare in the world,
16

involving 6191 patients and 238 GP practices across three sites, Newham, Kent and
Cornwall. The trials were evaluated by: City University London, University of Oxford,
University of Manchester, Nuffield Trust, Imperial College London and London School of
Economics.

45% reduction in mortality rates

20% reduction in emergency admissions

15% reduction in A&E visits

14% reduction in elective admissions

14% reduction in bed days

8% reduction in tariff costs


In the UK, the Government's Care Services minister, Paul Burstow, has stated that

telehealth and telecare would be extended over the next five years (2012-2017) to reach
three million people.
Limitations
RPM is highly dependent on the individuals motivation to manage their health.
Without the patients willingness to be an active participant in their care, RPM
implementation will likely fail.
Cost is also a barrier to its widespread use. Devices and peripherals currently cost
thousands of dollars, and for RPM to take hold in health care, costs need to come down
to the $300 to $500 range.
There is a lack of reimbursement guidelines for RPM services, which may deter its
incorporation into clinical practice. The shift of accountability associated with RPM brings
17

up liability issues. There are no clear guidelines in respect to whether clinicians have to
intervene every time they receive an alert regardless of the urgency. The continuous flow
of patient data requires a dedicated team of health care providers to handle the
information, which may, in fact, increase the workload. Although technology is
introduced with the intent to increase efficiency, it can become a barrier to some
healthcare providers that are not technological.
There are common obstacles that health informatics technologies encounter that
applies to RPM. Depending on the comorbidities monitored, RPM involves a diverse
selection of devices in its implementation. Standardization is required for data exchange
and interoperability among multiple components. Furthermore, RPM deployment is
highly dependent on an extensive wireless telecommunications infrastructure, which may
not be available or feasible in rural areas. Since RPM involves transmission of sensitive
patient data across telecommunication networks, information security is a concern.

18

MAINTAINING PATIENT HISTORY & OTHER RECORDS


Before the introduction of computers all medical records were kept in a patient
folder with handwritten notes by the doctor, other staff. Patients and ID details were on
the outside typed or handwritten by staff, all family's records went into one folder.

Outpatients records were kept in a printed folder with date stamped sheets of
notes inside it. when a patient came up for an appointment, he/she got a ticket and when
he came in to see the doctor -the doctor had the folder selected from the records room
and

placed

in

advance

on

his

table.

Examination notes were handwritten/ prescription were written too and tokens or
prescription cards were given to the patient. the patient then walked over to the
dispensary/pharmacy and collected his meds. All under one roof! records were accurate.
records were kept in a locked room, arranged in filing cabinets or similar cabinets. Records
were rarely ever lost!
Problems accompanied with this method were;
1. Costs of manual medical records
There are several types of costs associated with manual patient records. One type,
duplication of the record, requires paper and copying supplies, as well as the staff to
create and distribute the copies. Staff hired to assemble, file, retrieve, or distribute the
hard copy chart is a costly expense. Storage of the paper record necessitates the use of

19

valuable space that could be better utilized. The records also need to be protected from
water, fire, or mishandling of the paper to preserve their physical integrity.
One of the most expensive disadvantages of the paper record is duplicate patient
testing required to replace lost or missing test results. Repeating procedures may
jeopardize the patients health, creating a potential opportunity for an adverse medical
event. Duplicate testing wastes scarce medical resources (time, staff, supplies, and
equipment) that could be used for other patients. It is a contributing source to the rising
costs of health care by generating additional charges to be billed to the patient, insurance
company, or other third- party payer.
A related issue pertains to ordering procedures or tests that are either unnecessary
or contraindicated. These types of decisions, when based on inadequate information or
delayed results, create a potentially harmful situation for the patient and a needless
expense for all concerned. Claims submitted for medical errors that could have been
prevented with accurate and accessible patient information are issues that are seen with
the use of a paper record.
2. Lost productivity from manual medical records
Lost productivity results from various inadequacies of the paper record. This affects
multiple departments in a healthcare facility. Searches for misfiled charts waste time.
Staff members time is required to deliver paper records to a specific location. If the paper
record is not readily available, clerical staff responsible for filing documentation may need
to make several attempts before the task is completed. Medical errors may be made if
the staff makes decisions on inadequate information.

20

There is no ability to sort data fields in a paper record. Staff responsible for
reporting mandated data elements to the appropriate organizations must perform a
manual review. This is a very labor-intensive process, and inaccuracies can occur.
3. Accessibility of medical records
Of great concern is the lack of access to the record. Only one person at a time may
use the chart and the chart has to be in a single location. Staff needing access to the record
must wait until it is available for their use. This also contributes to the difficulty of
updating the paper record, especially for an active patients chart since that chart travels
with the patient to each location of care. Delivering documentation by hand to the
patients temporary location lends itself to the potential for losing or misplacing the
records. Delayed access to the chart negatively affects coding, billing, and reimbursement
processes.
4. Quality of manual medical records
The issue of quality encompasses the physical record, the documentation, and
patient care. There are limitations to the physical quality of the paper record. The paper
is fragile and does not last permanently. Normal use of the record may result in torn or
stained documents. Also, over the years, the ink used to complete documentation can
fade. Actual damage resulting from water or fire is another threat to the physical integrity
of the paper record.
The quality of the actual documentation varies based on the health care providers
documentation skills and knowledge level. While standardization of the data
documentation has improved over the years, not all providers use the same
21

abbreviations, terminology, format, or chart organization. This can result in incomplete


or inaccurate healthcare data collection. Handwritten information may be illegible,
creating the potential for errors in patient treatment or medication orders.
5. Fragmentation caused by manual medical records
Fragmentation of the patients record occurs as the result of multiple encounters
with different healthcare providers. Due to disparate patient documentation and billing
systems, there is often minimal or no exchange of information that contributes to
compiling a longitudinal medical history for the patient. Each provider or facility has a
limited portion of the patients overall health information. Some minor communication
may be provided between referring and consulting physicians, but only for a specific
encounter. The level of fragmentation varies based on several factors. These factors
include:
the patients ability to communicate pertinent health information to the provider;
the ability of the provider to collect information that is accessible to other providers;
the providers ability to directly elicit health information from the patient and any
written documentation to create an appropriate treatment plan; and
the limitations of the patient record system(s) that are being utilized to collect and
disseminate information.
A well planned and implemented electronic medical record system should address
and/or alleviate many of the general disadvantages of the paper record. This is an
immense undertaking that requires an in-depth review of current processes, a detailed
22

strategy for determining the organizations future needs and goals, an organizations
willingness and ability to make significant changes, and the financial investment to
achieve the desired results. It is also a very time-intensive project that demands the
utmost dedication and commitment by the entire health system. Patients, providers, and
other interested parties could all expect to derive benefits from a properly planned and
installed an automated system.

ELECTRONIC HEALTH RECORD


An electronic health record (EHR), or electronic medical record (EMR), refers to
the systematized collection of patient and population electronically-stored health
information in a digital format. These records can be shared across different health care
settings. Records are shared through network-connected, enterprise-wide information
systems or other information networks and exchanges. EHRs may include a range of data,
including demographics, medical history, medication and allergies, immunization status,
laboratory test results, radiology images, vital signs, personal statistics like age and
weight, and billing information.
EHS systems are designed to store data accurately and to capture the state of a
patient across time. It eliminates the need to track down a patient's previous paper
medical records and assists in ensuring data is accurate and legible. It can reduce risk of
data replication as there is only one modifiable file, which means the file is more likely up
to date, and decreases risk of lost paperwork. Due to the digital information being
searchable and in a single file, EMR's are more effective when extracting medical data for
the examination of possible trends and long term changes in a patient. Population-based

23

studies of medical records may also be facilitated by the widespread adoption of EHR's
and EMR's.

Terminology
The terms EHR, electronic patient record (EPR) and EMR have often been used
interchangeably, although differences between the models are now being defined. The
electronic health record (EHR) is an evolving concept defined as a more longitudinal
collection of the electronic health information of individual patients or populations.
The EMR is, in contrast, defined as the patient record created by providers for
specific encounters in hospitals and ambulatory environments, and which can serve as a
data source for an EHR. It is important to note that an "EHR" is generated and maintained
within an institution, such as a hospital, integrated delivery network, clinic, or physician
office, to give patients, physicians and other health care providers, employers, and payers
or insurers access to a patient's medical records across facilities. (Please note that the
term "EMR" would now be used for the preceding description, and that many EMR's now
use cloud software maintenance and data storage rather than local networks.)
In contrast, a personal health record (PHR) is an electronic application for recording
personal medical data that the individual patient controls and may make available to
health providers.

24

Comparison with paper-based records


Federal and state governments, insurance companies and other large medical
institutions are heavily promoting the adoption of electronic medical records. The US
Congress included a formula of both incentives (up to $44,000 per physician under
Medicare, or up to $65,000 over six years under Medicaid) and penalties (i.e. decreased
Medicare and Medicaid reimbursements to doctors who fail to use EMRs by 2015, for
covered patients) for EMR/EHR adoption versus continued use of paper records as part
of the Health Information Technology for Economic and Clinical Health (HITECH) Act,
enacted as part of the American Recovery and Reinvestment Act of 2009.
One VA study estimates its electronic medical record system may improve overall
efficiency by 6% per year, and the monthly cost of an EMR may (depending on the cost of
the EMR) be offset by the cost of only a few "unnecessary" tests or admissions.
Jerome Groopman disputed these results, publicly asking "how such dramatic
claims of cost-saving and quality improvement could be true". A 2014 survey of the
American College of Physicians member sample, however, found that family practice
physicians spent 48 minutes more per day when using EMRs. 90% reported that at least
1 data management function was slower after EMRs were adopted, and 64% reported
that note writing took longer. A third (34%) reported that it took longer to find and review
medical record data, and 32% reported that it was slower to read other clinicians' notes.
The increased portability and accessibility of electronic medical records may also
increase the ease with which they can be accessed and stolen by unauthorized persons
or unscrupulous users versus paper medical records, as acknowledged by the increased
security requirements for electronic medical records included in the Health Information
25

and Accessibility Act and by large-scale breaches in confidential records reported by EMR
users. Concerns about security contribute to the resistance shown to their widespread
adoption.
Handwritten paper medical records may be poorly legible, which can contribute to
medical errors. Pre-printed forms, standardization of abbreviations and standards for
penmanship were encouraged to improve reliability of paper medical records. Electronic
records may help with the standardization of forms, terminology and data input.
Digitization of forms facilitates the collection of data for epidemiology and clinical studies.
EMRs can be continuously updated (within certain legal limitations see below). If
the

ability

to

exchange

records

between

different

EMR

systems

were

perfected("interoperability") would facilitate the co-ordination of health care delivery in


non-affiliated health care facilities. In addition, data from an electronic system can be
used anonymously for statistical reporting in matters such as quality improvement,
resource management and public health communicable disease surveillance.
Implementation, end user and patient considerations
Quality
Several studies call into question whether EHRs improve the quality of care.
However, a recent multi-provider study in diabetes care, published in the New England
Journal of Medicine, found evidence that practices with EHR provided better quality care.
EMR's may eventually help improve care coordination. An article in a trade journal
suggests that since anyone using an EMR can view the patient's full chart, that it cuts
down on guessing histories, seeing multiple specialists, smooths transitions between care
26

settings, and may allow better care in emergency situations. EHRs may also improve
prevention by providing doctors and patients better access to test results, identifying
missing patient information, and offering evidence-based recommendations for
preventive services.
Costs
The steep price of EHR and provider uncertainty regarding the value they will derive
from adoption in the form of return on investment has a significant influence on EHR
adoption. In a project initiated by the Office of the National Coordinator for Health
Information (ONC), surveyors found that hospital administrators and physicians who had
adopted EHR noted that any gains in efficiency were offset by reduced productivity as the
technology was implemented, as well as the need to increase information technology
staff to maintain the system.
The U.S. Congressional Budget Office concluded that the cost savings may occur
only in large integrated institutions like Kaiser Permanente, and not in small physician
offices. They challenged the Rand Corporation's estimates of savings. "Office-based
physicians in particular may see no benefit if they purchase such a productand may
even suffer financial harm. Even though the use of health IT could generate cost savings
for the health system at large that might offset the EHR's cost, many physicians might not
be able to reduce their office expenses or increase their revenue sufficiently to pay for it.
For example, the use of health IT could reduce the number of duplicated diagnostic tests.
However, that improvement in efficiency would be unlikely to increase the income of
many physicians." One CEO of an EHR company has argued if a physician performs tests
in the office, it might reduce his or her income.
27

Doubts have been raised about cost saving from EHRs by researchers at Harvard
University, the Wharton School of the University of Pennsylvania, Stanford University, and
others.
Time
The implementation of EMR can potentially decrease identification time of patients
upon hospital admission. A research from the Annals of Internal Medicine showed that
since the adoption of EMR a relative decrease in time by 65% has been recorded (from
130 to 46 hours).
Software quality and usability deficiencies
The Healthcare Information and Management Systems Society (HIMSS), a very
large U.S. healthcare IT industry trade group, observed that EHR adoption rates "have
been slower than expected in the United States, especially in comparison to other
industry sectors and other developed countries. A key reason, aside from initial costs and
lost productivity during EMR implementation, is lack of efficiency and usability of EMRs
currently available." The U.S. National Institute of Standards and Technology of the
Department of Commerce studied usability in 2011 and lists a number of specific issues
that have been reported by health care workers. The U.S. military's EHR, AHLTA, was
reported to have significant usability issues. It was observed that the efforts to improve
EHR usability should be placed in the context of physician-patient communication.
However, physicians are embracing mobile technologies such as smartphones and
tablets at a rapid pace. According to a 2012 survey by Physicians Practice, 62.6 percent of
respondents (1,369 physicians, practice managers, and other healthcare providers) say
28

they use mobile devices in the performance of their job. Mobile devices are increasingly
able to synch up with electronic health record systems thus allowing physicians to access
patient records from remote locations. Most devices are extensions of desk-top EHR
systems, using a variety of software to communicate and access files remotely. The
advantages of instant access to patient records at any time and any place are clear, but
bring a host of security concerns. As mobile systems become more prevalent, practices
will need comprehensive policies that govern security measures and patient privacy
regulations.
Eventually, EHR will be more secured because the cyber security professionals have
never stopped pursuing better ways to protect data with an enhanced software and
technology. At the same time, they need to beware that the system will be significantly
complicated and not user-friendly anymore as the data is growing and technology is more
advancing. While we have a better secured system, it could lead to an error-prone.
Therefore, efficient and effective trainings are needed along with a well-designed user
interface.
Unintended consequences
Per empirical research in social informatics, information and communications
technology (ICT) use can lead to both intended and unintended consequences.
A 2008 Sentinel Event Alert from the U.S. Joint Commission, the organization that
accredits American hospitals to provide healthcare services, states that "As health
information technology (HIT) and 'converging technologies'the interrelationship
between medical devices and HITare increasingly adopted by health care organizations,
users must be mindful of the safety risks and preventable adverse events that these
29

implementations can create or perpetuate. Technology-related adverse events can be


associated with all components of a comprehensive technology system and may involve
errors of either commission or omission. These unintended adverse events typically stem
from human-machine interfaces or organization/system design." The Joint Commission
cites as an example the United States Pharmacopeia MEDMARX database where of
176,409 medication error records for 2006, approximately 25 percent (43,372) involved
some aspect of computer technology as at least one cause of the error.
The National Health Service (NHS) in the UK reports specific examples of potential
and actual EHR-caused unintended consequences in their 2009 document on the
management of clinical risk relating to the deployment and use of health software.
In a Feb. 2010 U.S. Food and Drug Administration (FDA) memorandum, FDA notes
EHR unintended consequences include EHR-related medical errors due to (1) errors of
commission (EOC), (2) errors of omission or transmission (EOT), (3) errors in data analysis
(EDA), and (4) incompatibility between multi-vendor software applications or systems
(ISMA) and cites examples. In the memo FDA also notes the "absence of mandatory
reporting enforcement of H-IT safety issues limits the numbers of medical device reports
(MDRs) and impedes a more comprehensive understanding of the actual problems and
implications."
A 2010 Board Position Paper by the American Medical Informatics Association
(AMIA) contains recommendations on EHR-related patient safety, transparency, ethics
education for purchasers and users, adoption of best practices, and re-examination of
regulation of electronic health applications. Beyond concrete issues such as conflicts of

30

interest and privacy concerns, questions have been raised about the ways in which the
physician-patient relationship would be affected by an electronic intermediary.
During the implementation phase, cognitive workload for healthcare professionals
may be significantly increased as they become familiar with a new system.
Privacy and confidentiality
In the United States in 2011 there were 380 major data breaches involving 500 or
more patients' records listed on the website kept by the United States Department of
Health and Human Services (HHS) Office for Civil Rights. So far, from the first wall postings
in September 2009 through the latest on 8 December 2012, there have been 18,059,831
"individuals affected," and even that massive number is an undercount of the breach
problem. The civil rights office has not released the records of tens of thousands of
breaches it has received under a federal reporting mandate on breaches affecting fewer
than 500 patients per incident.

Goals and objectives

Improve care quality, safety, efficiency, and reduce health disparities


Quality and safety measurement
Clinical decision support (automated advice) for providers
Patient registries (e.g., "a directory of patients with diabetes")

Improve care coordination


31

Engage patients and families in their care

Improve population and public health


Electronic laboratory reporting for reportable conditions (hospitals)
Immunization reporting to immunization registries
Syndromic surveillance (health event awareness)

Ensure adequate privacy and security protections

Quality
Studies call into question whether, in real life, EMRs improve the quality of care.
2009 produced several articles raising doubts about EMR benefits. A major concern is the
reduction of physician-patient interaction due to formatting constraints. For example,
some doctors have reported that the use of check-boxes has led to fewer open-ended
questions.

Barriers to adoption
Costs
The steep price of EMR and provider uncertainty regarding the value they will
derive from adoption in the form of return on investment have a significant influence on
EMR adoption. In a project initiated by the Office of the National Coordinator for Health
Information (ONC), surveyors found that hospital administrators and physicians who had
adopted EMR noted that any gains in efficiency were offset by reduced productivity as

32

the technology was implemented, as well as the need to increase information technology
staff to maintain the system.
The U.S. Congressional Budget Office concluded that the cost savings may occur
only in large integrated institutions like Kaiser Permanente, and not in small physician
offices. They challenged the Rand Corporation's estimates of savings. "Office-based
physicians in particular may see no benefit if they purchase such a productand may
even suffer financial harm. Even though the use of health IT could generate cost savings
for the health system at large that might offset the EMR's cost, many physicians might
not be able to reduce their office expenses or increase their revenue sufficiently to pay
for it. For example, the use of health IT could reduce the number of duplicated diagnostic
tests. However, that improvement in efficiency would be unlikely to increase the income
of many physicians. "Given the ease at which information can be exchanged between
health IT systems, patients whose physicians use them may feel that their privacy is more
at risk than if paper records were used."
Doubts have been raised about cost saving from EMRs by researchers at Harvard
University, the Wharton School of the University of Pennsylvania, Stanford University, and
others.
Start-up costs
In a survey by DesRoches et al. (2008), 66% of physicians without EHRs cited capital
costs as a barrier to adoption, while 50% were uncertain about the investment. Around
56% of physicians without EHRs stated that financial incentives to purchase and/or use
EHRs would facilitate adoption. In 2002, initial costs were estimated to be $50,000
70,000 per physician in a 3-physician practice. Since then, costs have decreased with
33

increasing adoption. A 2011 survey estimated a cost of $32,000 per physician in a 5physician practice during the first 60 days of implementation.
One case study by Miller et al. (2005) of 14 small primary-care practices found that
the average practice paid for the initial and ongoing costs within 2.5 years. A 2003 costbenefit analysis found that using EMRs for 5 years created a net benefit of $86,000 per
provider.
Some physicians are skeptical of the positive claims and believe the data is skewed
by vendors and others with an interest in EHR implementation.
Brigham and Women's Hospital in Boston, Massachusetts, estimated it achieved
net savings of $5 million to $10 million per year following installation of a computerized
physician order entry system that reduced serious medication errors by 55 percent.
Another large hospital generated about $8.6 million in annual savings by replacing paper
medical charts with EHRs for outpatients and about $2.8 million annually by establishing
electronic access to laboratory results and reports.
Maintenance costs
Maintenance costs can be high. Miller et al. found the average estimated
maintenance cost was $8500 per FTE health-care provider per year.
Furthermore, software technology advances at a rapid pace. Most software
systems require frequent updates, often at a significant ongoing cost. Some types of
software and operating systems require full-scale re-implementation periodically, which
disrupts not only the budget but also workflow. Costs for upgrades and associated
regression testing can be particularly high where the applications are governed by FDA
34

regulations (e.g. Clinical Laboratory systems). Physicians desire modular upgrades and
ability to continually customize, without large-scale reimplementation.
Training costs
Training of employees to use an EHR system is costly, just as for training in the use
of any other hospital system. New employees, permanent or temporary, will also require
training as they are hired.
In the United States, a substantial majority of healthcare providers train at a VA
facility sometime during their career. With the widespread adoption of the Veterans
Health Information Systems and Technology Architecture (VistA) electronic health record
system at all VA facilities, few recently-trained medical professionals will be
inexperienced in electronic health record systems. Older practitioners who are less
experienced in the use of electronic health record systems will retire over time.
Software quality and usability deficiencies
The Healthcare Information and Management Systems Society (HIMSS), a very
large U.S. health care IT industry trade group, observed that EMR adoption rates "have
been slower than expected in the United States, especially in comparison to other
industry sectors and other developed countries. A key reason, aside from initial costs
and lost productivity during EMR implementation, is lack of efficiency and usability of
EMRs currently available. The U.S. National Institute of Standards and Technology of the
Department of Commerce studied usability in 2011 and lists a number of specific issues
that have been reported by health care workers. The U.S. military's EMR "AHLTA" was
reported to have significant usability issues.
35

Lack of semantic interoperability


In the United States, there are no standards for semantic interoperability of health
care data; there are only syntactic standards. This means that while data may be packaged
in a standard format (using the pipe notation of HL7, or the bracket notation of XML), it
lacks definition, or linkage to a common shared dictionary. The addition of layers of
complex information models (such as the HL7 v3 RIM) does not resolve this fundamental
issue.
Implementations
In the United States, the Department of Veterans Affairs (VA) has the largest enterprisewide health information system that includes an electronic medical record, known as
the Veterans Health Information Systems and Technology Architecture (VistA). A key
component in VistA is their VistA imaging System which provides a comprehensive
multimedia data from many specialties, including cardiology, radiology and orthopedics.
A graphical user interface known as the Computerized Patient Record System (CPRS)
allows health care providers to review and update a patient's electronic medical record
at any of the VA's over 1,000 healthcare facilities. CPRS includes the ability to place
orders, including medications, special procedures, X-rays, patient care nursing orders,
diets, and laboratory tests.

Need for Electronic Health Records (EHR)


The following are the most significant reasons why our healthcare system would
benefit from the widespread transition from paper to electronic health records.
36

Paper records are severely limited


Much of what can be said about handwritten prescriptions can also be said about
handwritten office notes. Figure 4.2 illustrates the problems with a paper record. In spite
of the fact that this clinician used a template, the handwriting is illegible and the
document cannot be electronically shared or stored. It is not structured data that is
computable and hence shareable with other computers and systems.
Other shortcomings of paper: expensive to copy, transport and store; easy to
destroy; difficult to analyze and determine who has seen it; and the negative impact on
the environment. Electronic patient encounters represent a quantum leap forward in
legibility and the ability to rapidly retrieve information. Almost every industry is now
computerized and digitized for rapid data retrieval and trend analysis. Look at the stock
market or companies like Walmart or Federal Express. Why not the field of medicine?

37

Figure 4.2: Outpatient paper-based patient encounter form

With the relatively recent healthcare models of pay-for-performance, patient


centered medical home model and accountable care organizations there are new reasons
to embrace technology in order to aggregate and report results in order to receive
reimbursement. It is much easier to retrieve and track patient data using an EHR and
patient registries than to use labor intensive paper chart reviews. EHRs are much better
organized than paper charts, allowing for faster retrieval of lab or x-ray results. It is also
likely that an EHR will have an electronic problem summary list that outlines a patients
major illnesses, surgeries, allergies and medications. How many times does a physician
38

open a large paper chart, only to have loose lab results fall out? How many times does a
physician re-order a test because the results or the chart is missing? It is important to
note that paper charts are missing as much as 25% of the time, according to one study.
Even if the chart is available; specifics are missing in 13.6% of patient encounters,
according to another study. Table 4.1 shows the types of missing information and its
frequency. According to the Presidents Information Technology Advisory Committee,
20% of laboratory tests are re-ordered because previous studies are not accessible. This
statistic has great patient safety, productivity and financial implications.
Table 4.1: Types and frequencies of missing information
Information Missing During Patient Visits

% Visits

Lab results

45%

Letters/dictations

39%

Radiology results

28%

History and physical exams

27%

Pathology results

15%

EHRs allow easy navigation through the entire medical history of a patient. Instead
of pulling paper chart volume 1 of 3 to search for a lab result, it is simply a matter of a few
mouse clicks. Another important advantage is the fact that the record is available 24 hours
a day, seven days a week and doesnt require an employee to pull the chart, nor extra
space to store it. Adoption of electronic health records has saved money by decreasing
full time equivalents (FTEs) and converting records rooms into more productive space,
such as exam rooms. Importantly, electronic health records are accessible to multiple
39

healthcare workers at the same time, at multiple locations. While a billing clerk is looking
at the electronic chart, the primary care physician and a specialist can be analyzing clinical
information simultaneously. Moreover, patient information should be available to
physicians on call so they can review records on patients who are not in their panel.
Furthermore, it is believed that electronic health records improve the level of
coding. Do clinicians routinely submit a lower level of care for billing purposes because
they know that handwritten patient notes are short and incomplete? Templates may help
remind clinicians to add more history or details of the physical exam, thus justifying a
higher level of coding (templates are disease specific electronic forms that essentially
allow a user to point and click a history and physical exam). A study of the impact of an
EHR on the completeness of clinical histories in a labor and delivery unit demonstrated
improved documentation, compared to prior paper-based histories. Lastly, an EHR
provides clinical decision support such as alerts and reminders, which will be covered later
in this chapter.
Need for improved efficiency and productivity
The goal is to have patient information available to anyone who needs it, when they
need it and where they need it. With an EHR, lab results can be retrieved much more
rapidly, thus saving time and money. It should be pointed out however, that reducing
duplicated tests benefits the payers and patients and not clinicians so there is a
misalignment of incentives. Moreover, an early study using computerized order entry
showed that simply displaying past results reduced duplication and the cost of testing by
only 13%. If lab or x-ray results are frequently missing, the implication is that they need
to be repeated which adds to this countrys staggering healthcare bill. The same could be
40

said for duplicate prescriptions. It is estimated that 31% of the United States $2.3 trilliondollar healthcare bill is for administration.
EHRs are more efficient because they reduce redundant paperwork and have the
capability of interfacing with a billing program that submits claims electronically. Consider
what it takes to simply get the results of a lab test back to a patient using the old system.
This might involve a front office clerk, a nurse and a physician. The end result is frequently
placing the patient on hold or playing telephone tag. With an EHR, lab results can be
forwarded via secure messaging or available for viewing via a portal. Electronic health
records can help with productivity if templates are used judiciously. As noted, they allow
for point and click histories and physical exams that in some cases may save time.
Embedded clinical decision support is one of the newest features of a comprehensive
EHR. Clinical practice guidelines, linked educational content and patient handouts can be
part of the EHR. This may permit finding the answer to a medical question while the
patient is still in the exam room.
Several EHR companies also offer a centralized area for all physician approvals and
signatures of lab work, prescriptions, etc. This should improve work flow by avoiding the
need to pull multiple charts or enter multiple EHR modules. Although EHRs appear to
improve overall office productivity, they commonly increase the work of clinicians,
particularly with regard to data entry. Well discuss this further in the Loss of Productivity
section.
Quality of care and patient safety
As previously suggested, an EHR should improve patient safety through many
mechanisms: (1) Improved legibility of clinical notes, (2) Improved access anytime and
41

anywhere, (3) Reduced duplication, (4) Reminders that tests or preventive services are
overdue, (5) Clinical decision support that reminds clinicians about patient allergies,
correct dosage of drugs, etc., (6) Electronic problem summary lists provide diagnoses,
allergies and surgeries at a glance.
In spite of the before mentioned benefits, a study by Garrido of quality process
measures before and after implementation of a widespread EHR in the Kaiser Permanente
system, failed to show improvement. To date there has only been one study published
the authors are aware of that suggested use of an EHR decreased mortality. This particular
EHR had a disease management module designed specifically for renal dialysis patients
that could provide more specific medical guidelines and better data mining to potentially
improve medical care.
The study suggested that mortality was lower compared to a pre-implementation
period and compared to a national renal dialysis registry. It is likely that healthcare is only
starting to see the impact of EHRs on quality. Based on internal data Kaiser Permanente
determined that the drug Vioxx had an increased risk of cardiovascular events before that
information was published based on its own internal data. Similarly, within 90 minutes of
learning of the withdrawal of Vioxx from the market, the Cleveland Clinic queried its EHR
to see which patients were on the drug. Within seven hours they deactivated
prescriptions and notified clinicians via e-mail. Quality reports are far easier to generate
with an EHR compared to a paper chart that requires a chart review. Quality reports can
also be generated from a data warehouse or health information organization that
receives data from an EHR and other sources. Quality reports are the backbone for
healthcare reform which are discussed further in another chapter.

42

Public expectations
According to a 2006 Harris Interactive Poll for the Wall Street Journal Online, 55%
of adults thought an EHR would decrease medical errors; 60% thought an EHR would
reduce healthcare costs and 54% thought that the use of an EHR would influence their
decision about selecting a personal physician.
The Center for Health Information Technology would argue that EHR adoption
results in better customer satisfaction through fewer lost charts, faster refills and
improved delivery of patient educational material. Patient portals that are part of EHRs
are likely to be a source of patient satisfaction as they allow patients access to their
records with multiple other functionalities such as online appointing, medication
renewals, etc.
Governmental expectations
EHRs are considered by the federal government to be transformational and integral
to healthcare reform. As a result, EHR reimbursement is a major focal point of the HITECH
Act. It is the goal of the US Government to have an interoperable electronic health record
by 2014. In addition to federal government support, states and payers have initiatives to
encourage EHR adoption. Many organizations state that healthcare needs to move from
the cow path to the information highway. CMS is acutely aware of the potential benefits
of EHRs to help coordinate and improve disease management in older patients.
Financial savings
The Center for Information Technology Leadership (CITL) has suggested that
ambulatory EHRs would save $44 billion yearly and eliminate more than $10 in rejected
43

claims per patient per outpatient visit. This organization concluded that not only would
there be savings from eliminated chart rooms and record clerks; there would be a
reduction in the need for transcription. There would also be fewer callbacks from
pharmacists with electronic prescribing. It is likely that copying, faxing and mail expenses,
chart pulls and labor costs would be reduced with EHRs, thus saving full time equivalents
(FTEs). More rapid retrieval of lab and x-ray reports results in time/labor saving as does
the use of templates. It appears that part of the savings is from improved coding. More
efficient patient encounters mean more patients could be seen each day. Improved
savings to payers from medication management is possible with reminders to use the
drug of choice and generics. It should be noted that this optimistic financial projection
assumed widespread EHR adoption, health information exchange, interoperability and
change in workflow.
EHRs should reduce the cost of transcription if clinicians switch to speech
recognition and/or template use. Because of structured documentation with templates,
they may also improve the coding and billing of claims. It is not known if EHR adoption
will decrease malpractice, hence saving physician and hospital costs. A 2007 Survey by
the Medical Records Institute of 115 practices involving 27 specialties showed that 20%
of malpractice carriers offered a discount for having an EHR in place. Of those physicians
who had a malpractice case in which documentation was based on an EHR, 55% said the
EHR was helpful.
Technological advances
The timing seems to be right for electronic records partly because the technology
has evolved. The internet and World Wide Web make the application service provider
44

(ASP) concept for an electronic health record possible. An ASP option means that the EHR
software and patient data reside on a remote web server that users can access via the
internet from the office, hospital or home. Computer speed, memory and bandwidth have
advanced such that digital imaging is also a reality, so images can be part of an EHR
system. Personal computers (PCs), laptops and tablets continue to add features and
improve speed and memory while purchase costs drop. Wireless and mobile technologies
permit access to the hospital information system, the electronic health record and the
internet using a variety of mobile technologies.
The chapter on health information exchange will point out that health information
organizations can link EHRs together via a web-based exchange, in order to share
information and services.
Need for aggregated data
In order to make evidence based decisions, clinicians need high quality data that
should derive from multiple sources: inpatient and outpatient care, acute and chronic
care settings, urban and rural care and populations at risk. This can only be accomplished
with electronic health records and discrete structured data. Moreover, healthcare data
needs to be combined or aggregated to achieve statistical significance. Although most
primary care is delivered by small practices, it is difficult to study because of relatively
small patient populations, making aggregation necessary. For large healthcare
organizations, there will be an avalanche of data generated from widespread EHR
adoption resulting in big data requiring new data analytic tools.

45

Need for integrated data


Paper health records are standalone, lacking the ability to integrate with other
paper forms or information. The ability to integrate health records with a variety of other
services and information and to share the information is critical to the future of
healthcare reform. Digital, unlike paper-based healthcare information can be integrated
with multiple internal and external applications:

Ability to integrate for sharing with health information organizations (another


chapter)

Ability to integrate with analytical software for data mining to examine optimal
treatments, etc.

Ability to integrate with genomic data as part of the electronic record. Many
organizations have begun this journey. There is more information in the chapter
on bioinformatics

Ability to integrate with local, state and federal governments for quality reporting
and public health issues

Ability to integrate with algorithms and artificial intelligence. Researchers from


the Mayo Clinic were able to extract Charlson Comorbidity determinations from
EHRs, instead of having to conduct manual chart reviews

EHR is a transformational tool


It is widely agreed that US Healthcare needs reform in multiple areas. To modernize
its infrastructure healthcare would need to have widespread adoption of EHRs. Large
organizations such as the Veterans Health Administration and Kaiser Permanente use

46

robust EHRs (VistA and Epic) that generate enough data to change the practice of
medicine.
In 2009 Kaiser Permanente reported two studies, one pertaining to the
management of bone disease (osteoporosis) and the other chronic kidney disease. They
were able to show that with their EHR they could focus on patients at risk and use all of
the tools available to improve disease management and population health. In another
study reported in 2009 Kaiser-Permanente reported that electronic visits that are part of
the electronic health record system were likely responsible for a 26.2% decrease in office
visits over a four-year period. They posited that this was good news for a system that
aligns incentives with quality, regardless whether the visit was virtual or face-to-face.
Other fee-for-service organizations might find this alarming if office visits decreased and
e-visits were not reimbursed. Kaiser also touts a total joint registry of over 100,000
patients with data generated from its universal EHR.
As a result of their comprehensive EHR (KP HealthConnect) and visionary
leadership they have seen improvement in standardization of care, care coordination and
population health. They also have been able to experience advanced EHR data analytics
with their Virtual Data Warehouse, use of artificial intelligence and use of computerized
simulation models (Archimedes). In addition, they have begun the process of collecting
genomic information for future linking to their electronic records.
Need for coordinated care
According to a Gallup poll it is very common for older patients to have more than
one physician: no physician (3%), one physician (16%), two physicians (26%), three
physicians (23%), four physicians (15%), five physicians (6%) and six or more physicians
47

(11%). Having more than one physician mandates good communication between the
primary care physician, the specialist and the patient. This becomes even more of an issue
when different healthcare systems are involved. OMalley et al. surveyed 12 medical
practices and found that in-office coordination was improved by EHRs but the technology
was not mature enough to improve coordination of care with external physicians.
Electronic health records are being integrated with health information
organizations (HIOs) so that inpatient and outpatient patient-related information can be
accessed and shared, thus improving communication between disparate healthcare
entities. Home monitoring (tele-homecare) can transmit patient data from home to an
offices EHR also assisting in the coordination of care. It will be pointed out in a later
section that coordination of care across multiple medical transitions is part of Meaningful
Use.

HEALTH INFORMATION MANAGEMENT


Health information management (HIM) is information management applied
to health and health care. It is the practice of acquiring, analyzing and protecting digital
and traditional medical information vital to providing quality patient care. With the
widespread computerization of health records, traditional (paper-based) records are
being

replaced

with electronic

health

records (EHRs).

The

tools

of health

informatics and health information technology are continually improving to bring


greater efficiency to information management in the health care sector.

48

Both hospital information systems and health human resources information


systems (HRHIS) are common implementations of HIM.
Health

information

management

professionals plan information

systems,

develop health policy, and identify current and future information needs. In addition,
they may apply the science of informatics to the collection, storage, analysis, use, and
transmission of information to meet legal, professional, ethical and administrative
records-keeping requirements of health care delivery. They work with clinical,
epidemiological, demographic, financial, reference, and coded healthcare data. Health
information administrators have been described to "play a critical role in the delivery of
healthcare in the United States through their focus on the collection, maintenance and
use of quality data to support the information-intensive and information-reliant
healthcare system".
The World Health Organization (WHO) stated that the proper collection,
management and use of information within healthcare systems will determine the
systems effectiveness in detecting health problems, defining priorities, identifying
innovative solutions and allocating resources to improve health outcomes.
Records

The patient health record is the primary legal record documenting the health care
services provided to a person in any aspect of the health care system. The term
includes routine clinical or office records, records of care in any health related
setting, preventive care, lifestyle evaluation, research protocols and various clinical
databases. This repository of information about a single patient is generated by

49

health care professionals as a direct result of interaction with a patient or with


individuals who have personal knowledge of the patient.

The primary patient record is the record that is used by health care professionals
while providing patient care services to review patient data or document their own
observations, actions, or instructions.

The secondary patient record is a record that is derived from the primary record and
contains selected data elements to aid non clinical persons in supporting, evaluating
and advancing patient care. Patient care support refers to administration, regulation,
and payment functions.

Methods to ensure Data Quality


The accuracy of data depends on the manual or computer information system
design for collecting, recording, storing, processing, accessing and displaying data as well
as the ability and follow- through of the people involved in each phase of these activities.
Everyone involved with documenting or using health information is responsible for its
quality. According to AHIMAs Data Quality Management Model, there are four key
processes for data:
1. Application: the purpose for which the data are collected.
2. Collection: the processes by which data elements are accumulated.
3. Warehousing: the processes and systems used to store and maintain data and
data journals.
4. Analysis: the process of translating data into information utilized for an
application.
50

Each aspect is analyzed with 10 different data characteristics:


1. Accuracy: Data are the correct values and are valid.
2. Accessibility: Data items should be easily obtainable and legal to collect.
3. Comprehensiveness: All required data items are included. Ensure that the entire
scope of the data is collected and document intentional limitations.
4. Consistency: The value of the data should be reliable and the same across
applications.
5. Currency: The data should be up to date. A datum value is up to date if it is
current for a specific point in time. It is outdated if it was current at some
preceding time yet incorrect at a later time.
6. Definition: Clear definitions should be provided so that current and future data
users will know what the data mean. Each data element should have clear
meaning and acceptable values.
7. Granularity: The attributes and values of data should be defined at the correct
level of detail.
8. Precision: Data values should be just large enough to support the application or
process.
9. Relevancy: The data are meaningful to the performance of the process or
application for which they are collected.
10.Timeliness: Timeliness is determined by how the data are being used and their
context.

51

HOME HEALTH CARE SOFTWARE


Home health care software sometimes referred to as home care software or home
health software falls under the broad category of health care information technology
(HIT).
HIT is the application of information processing involving both computer hardware
and software that deals with the storage, retrieval, sharing, and use of health care
information, data, and knowledge for communication and decision making Home health
software is designed specifically for companies employing home health providers, as well
as government entities who track payments to home health care providers.

Types of software
There are clinical and non-clinical applications of home health care software.
Including types such as agency software, hospice solutions, clinical management systems,
telehealth solutions, and electronic visit verification. Depending on the type of software
used, companies can track health care employee visits to patients, verify payroll, and
document patient care. Governments can also use home health care software to verify
visits from providers who bill them for services. Use of some software is mandated by
government agencies such as OASIS assessment information that must be transmitted
electronically by home health care providers.

52

Agency software
Agency software is used by home health care providers for office use and is a subset
of medical practice management software used by inpatient clinics and doctors offices.
Agency software is used for billing, paying vendors, staff scheduling, and maintaining
records associated with the business.
Agency software can be standalone or part of software packages, that include
electronic visit verification to track hours of employees and time spent on home visits and
patient care. Agency software can be purchased or leased through various vendors.
Electronic visit verification
Electronic visit verification (often referred to as EVV) is a method used to verify
home healthcare visits to ensure patients are not neglected and to cut down on
fraudulently documented home visits. EVV monitors locations of caregivers, and is
mandated by certain states, including Texas and Illinois. Other states do not mandate it,
but use it as part of its Medicaid fraud oversight, created by the passing of the Affordable
Care Act in 2010. It is also widely used by employers of home healthcare providers to
verify employee's locations and hours of work as well as document patient care.
Outcome and assessment information set (OASIS)
Home health care providers that participate in Medicaid are required to report
specific data about patient care known as Outcome and Assessment Information Set-C
(OASIS-C). Data includes health status, functional status, and support system information.
The data is used to establish a measurement of patient home health care options. Home
53

health care software allows health care providers to obtain and transmit such data while
on location with a patient.
Data collection is mandated by the Centers for Medicare and Medicaid Services, a
division of the United States Department of Health and Human Services. Software for
collecting and transmitting data is free through CMM and can also be purchased through
private vendors as an add-on to other home health care software.

DIAGNOSIS & SURGERY


Medical

diagnosis (abbreviated DS or Dx) is

the

process

of

determining

which disease or condition explains a person's symptoms andsigns. It is most often


referred to as diagnosis with the medical context being implicit. The information required
for diagnosis is typically collected from a history and physical examination of the person
seeking medical care. Often, one or more diagnostic procedures, such as diagnostic tests,
are also done during the process. Sometimes Posthumous diagnosis is considered a kind
of medical diagnosis.
Diagnosis is often challenging, because many signs and symptoms are nonspecific.
For example, redness of the skin (erythema), by itself, is a sign of many disorders and thus
doesn't tell the healthcare professional what is wrong. Thus differential diagnosis, in
which several possible explanations are compared and contrasted, must be performed.
54

This involves the correlation of various pieces of information followed by the recognition
and differentiation of patterns. Occasionally the process is made easy by a sign or
symptom (or a group of several) that is pathognomonic.
Diagnosis is a major component of the procedure of a doctor's visit. From the point
of view of statistics, the diagnostic procedure involves classification.

History and etymology


The first recorded examples of medical diagnosis are found in the writings
of Imhotep (2630-2611

BC)

in ancient

Egypt (the Edwin

Smith

Papyrus). A Babylonian medical textbook, the Diagnostic Handbook written by Esagil-kinapli (fl.1069-1046 BC), introduced the use of empiricism, logic and rationality in the
diagnosis of an illness or disease. Traditional Chinese Medicine, as described in the Yellow
Emperor's Inner Canon or Huangdi Neijing, specified four diagnostic methods: inspection,
auscultation-olfaction, interrogation, and palpation. Hippocrates was known to make
diagnoses by tasting his patients' urine and smelling their sweat.
The plural of diagnosis is diagnoses. The verb is to diagnose, and a person who
diagnoses is called a diagnostician. The word diagnosis /da.noss/ is derived
through Latinfrom the Greek word from , meaning "to discern,
distinguish".
Medical diagnosis or the actual process of making a diagnosis is a cognitive process.
A clinician uses several sources of data and puts the pieces of the puzzle together to make
a diagnostic impression. The initial diagnostic impression can be a broad term describing
a category of diseases instead of a specific disease or condition. After the initial diagnostic
55

impression, the clinician obtains follow up tests and procedures to get more data to
support or reject the original diagnosis and will attempt to narrow it down to a more
specific level. Diagnostic procedures are the specific tools that the clinicians use to narrow
the diagnostic possibilities.
Diagnostic procedures
A diagnosis, in the sense of diagnostic procedure, can be regarded as an attempt at
classification of an individual's condition into separate and distinct categories that allow
medical decisions about treatment and prognosis to be made. Subsequently, a diagnostic
opinion is often described in terms of a disease or other condition, but in the case of a
wrong diagnosis, the individual's actual disease or condition is not the same as the
individual's diagnosis.
A

diagnostic

professionals such

procedure
as

may

a physician,

be

performed

physical

by

various health

care

therapist, optometrist, healthcare

scientist, chiropractor, dentist, podiatrist, nurse practitioner, or physician assistant. This


article uses diagnostician as any of these person categories.
A diagnostic procedure (as well as the opinion reached thereby) does not
necessarily involve elucidation of the etiology of the diseases or conditions of interest,
that is, what caused the disease or condition. Such elucidation can be useful to optimize
treatment, further specify the prognosis or prevent recurrence of the disease or condition
in the future.

56

Diagnostic opinion
However, a diagnosis can take many forms. It might be a matter of naming the
disease, lesion, dysfunction or disability. It might be a management-naming or prognosisnaming exercise. It may indicate either degree of abnormality on a continuum or kind of
abnormality in a classification. Its influenced by non-medical factors such as power,
ethics and financial incentives for patient or doctor. It can be a brief summation or an
extensive formulation, even taking the form of a story or metaphor. It might be a means
of communication such as a computer code through which it triggers payment,
prescription, notification, information or advice. It might be pathogenic or salutogenic.
Its generally uncertain and provisional.
Indication for diagnostic procedure
The initial task is to detect a medical indication to perform a diagnostic procedure.
Indications include:

Detection of any deviation from what is known to be normal, such as can be described
in terms of, for example, anatomy (the structure of the human body), physiology (how
the body works), pathology (what can go wrong with the anatomy and
physiology), psychology (thought and behavior) and human homeostasis (regarding
mechanisms to keep body systems in balance). Knowledge of what is normal and
measuring of the patient's current condition against those norms can assist in
determining the patient's particular departure from homeostasis and the degree of
departure, which in turn can assist in quantifying the indication for further diagnostic
processing.

A complaint expressed by a patient.


57

The fact that a patient has sought a diagnostician can itself be an indication to perform
a diagnostic procedure. For example, in a doctor's visit, the physician may already start
performing a diagnostic procedure by watching the gait of the patient from the
waiting room to the doctor's office even before she or he has started to present any
complaints.
Even during an already ongoing diagnostic procedure, there can be an indication to

perform another, separate, diagnostic procedure for another, potentially concomitant,


disease or condition. This may occur as a result of an incidental finding of a sign unrelated
to the parameter of interest, such as can occur in comprehensive tests such as
radiological studies like magnetic resonance imaging or blood test panels that also
include blood tests that are not relevant for the ongoing diagnosis.
Additional types of diagnosis
Sub-types of diagnoses include:
Clinical diagnosis
A diagnosis made on the basis of medical signs and patient-reported symptoms,
rather than diagnostic tests

Laboratory diagnosis
A diagnosis based significantly on laboratory reports or test results, rather than
the physical examination of the patient. For instance, a proper diagnosis of infectious
58

diseases usually requires both an examination of signs and symptoms, as well as


laboratory characteristics of the pathogen involved.
Radiology diagnosis
A diagnosis based primarily on the results from medical imaging studies. Greenstick
fractures are common radiological diagnoses.
Principal diagnosis
The single medical diagnosis that is most relevant to the patient's chief
complaint or need for treatment. Many patients have additional diagnoses.
Admitting diagnosis
The diagnosis given as the reason why the patient was admitted to the hospital; it
may differ from the actual problem or from the discharge diagnoses, which are the
diagnoses recorded when the patient is discharged from the hospital.
Differential diagnosis
A process of identifying all of the possible diagnoses that could be connected to the
signs, symptoms, and lab findings, and then ruling out diagnoses until a final
determination can be made.

59

Diagnostic criteria
Designates

the combination of signs, symptoms, and test results

that

the clinician uses to attempt to determine the correct diagnosis. They are standards,
normally published by international committees, and they are designed to offer the
best sensitivity and specificity possible, respect the presence of a condition, with the
state-of-the-art technology.
Prenatal diagnosis
Diagnosis work done before birth
Diagnosis of exclusion
A medical condition whose presence cannot be established with complete
confidence from history, examination or testing. Diagnosis is therefore by elimination of
all other reasonable possibilities.
Dual diagnosis
The diagnosis of two related, but separate, medical conditions or co-morbidities;
the term almost always refers to a diagnosis of a serious mental illness and a substance
addiction.
Self-diagnosis
The diagnosis or identification of a medical conditions in oneself. Self-diagnosis is
very common and typically accurate for everyday conditions, such as headaches,
menstrual, and head lice.
60

Remote diagnosis
A type of telemedicine that diagnoses a patient without being physically in the
same room as the patient.
Nursing diagnosis
Rather than focusing on biological processes, a nursing diagnosis identifies people's
responses to situations in their lives, such as a readiness to change or a willingness to
accept assistance.
Computer-aided diagnosis
Providing symptoms allows the computer to identify the problem and diagnose the
user to the best of its ability. Health screening begins by identifying the part of the body
where the symptoms are located; the computer cross-references a database for the
corresponding disease and presents a diagnosis.
Wastebasket diagnosis
A vague, or even completely fake, medical or psychiatric label given to the patient
or to the medical records department for essentially non-medical reasons, such as to
reassure the patient by providing an official-sounding label, to make the provider look
effective, or to obtain approval for treatment. This term is also used as a derogatory label
for disputed, poorly described, overused, or questionably classified diagnoses, such
as pouchitis and senility, or to dismiss diagnoses that amount to over medicalization, such
as the labeling of normal responses to physical hunger as reactive hypoglycemia.

61

Retrospective diagnosis
The labeling of an illness in a historical figure or specific historical event using
modern knowledge, methods and disease classifications.
Over diagnosis
Over diagnosis is the diagnosis of "disease" that will never cause symptoms or
death during a patient's lifetime. It is a problem because it turns people into patients
unnecessarily and because it can lead to economic waste (overutilization) and treatments
that may cause harm. Over diagnosis occurs when a disease is diagnosed correctly, but
the diagnosis is irrelevant. A correct diagnosis may be irrelevant because treatment for
the disease is not available, not needed, or not wanted.

COMPUTER-AIDED DIAGNOSIS
In radiology, computer-aided detection (CADe), also called computer-aided
diagnosis (CADx), are procedures in medicine that assist doctors in the interpretation of
medical images. Imaging techniques in X-ray, MRI, and Ultrasound diagnostics yield a
great deal of information, which the radiologist has to analyze and evaluate
comprehensively in a short time. CAD systems help scan digital images, e.g. from
computed tomography, for typical appearances and to highlight conspicuous sections,
such as possible diseases.
62

CAD

is

an interdisciplinary technology

combining

elements

of artificial

intelligence and computer vision with radiological image processing. A typical application
is the detection of a tumor. For instance, some hospitals use CAD to support preventive
medical check-ups in mammography (diagnosis of breast cancer), the detection of polyps
in the colon, andlung cancer.
Computer-aided detection (CADe) systems are usually confined to marking
conspicuous structures and sections. Computer-aided diagnosis (CADx) systems evaluate
the conspicuous structures. For example, in mammography CAD highlights micro
calcification clusters and hyperdense structures in the soft tissue. This allows the
radiologist to draw conclusions about the condition of the pathology. Another application
is CADq, which quantifies, e.g., the size of a tumor or the tumor's behavior in contrast
medium uptake.Computer-aided simple triage (CAST) is another type of CAD, which
performs a fully automatic initial interpretation and triage of studies into some
meaningful categories (e.g. negative and positive). CAST is particularly applicable in
emergency diagnostic imaging, where a prompt diagnosis of critical, life-threatening
condition is required.
Although CAD has been used in clinical environments for over 40 years, CAD cannot
and may not substitute the doctor, but rather plays a supporting role. The doctor
(generally a radiologist) is always responsible for the final interpretation of a medical
image.

63

Applications
CAD is used in the diagnosis of Pathological Brain Detection (PBD), breast
cancer, lung cancer, colon cancer, prostate cancer, bone metastases, coronary artery
disease, congenital heart defect, and Alzheimer's disease.
Pathological Brain Detection (PBD)
Chaplot et al. was the first to use Discrete Wavelet Transform (DWT) coefficients to
detect pathological brains. Maitra and Chatterjee employed the Slantlet transform, which
is an improved version of DWT. Their feature vector of each image is created by
64

considering the magnitudes of Slantlet transform outputs corresponding to six spatial


positions chosen according to a specific logic.
In 2010, Wang and Wu presented a forward neural network (FNN) based method
to classify a given MR brain image as normal or abnormal. The parameters of FNN were
optimized via adaptive chaotic particle swarm optimization (ACPSO). Results over 160
images showed that the classification accuracy was 98.75%.
In 2011, Wu and Wang proposed using DWT for feature extraction, PCA for feature
reduction, and FNN with scaled chaotic artificial bee colony (SCABC) as classifier.
In 2013, Saritha et al. were the first to apply wavelet entropy (WE) to detect
pathological brains. Saritha also suggested to use spider-web plots. Later, Zhang et al.
proved removing spider-web plots did not influence the performance. Genetic pattern
search method was applied to identify abnormal brain from normal controls. Its
classification accuracy was reported as 95.188%. Das et al. proposed to use Ripplet
transform. Zhang et al. proposed to use particle swarm optimization (PSO). Kalbkhani et
al. suggested to use GARCH model.
In 2014, El-Dahshan et al. suggested to use pulse coupled neural network. In 2015,
Zhou et al. suggested to apply naive Bayes classifier to detect pathological brains.
Breast cancer
CAD is used in screening mammography (X-ray examination of the female breast).
Screening mammography is used for the early detection of breast cancer. CAD is
especially established in US and the Netherlands and is used in addition to human
evaluation, usually by a radiologist. The first CAD system for mammography was
65

developed in a research project at the University of Chicago. Today it is commercially


offered by iCAD and Hologic.
There are currently some non-commercial projects being developed, such as Ashita
Project, a gradient-based screening software by Alan Hshieh, as well. However, while
achieving high sensitivities, CAD systems tend to have very low specificity and the benefits
of using CAD remain uncertain. Some studies suggest a positive impact on mammography
screening programs, but others show no improvement. A 2008 systematic review on
computer-aided detection in screening mammography concluded that CAD does not have
a significant effect on cancer detection rate, but does undesirably increase recall rate
(i.e. the rate of false positives). However, it noted considerable heterogeneity in the
impact on recall rate across studies.
Procedures to evaluate mammography based on magnetic resonance imaging exist too.
Lung cancer (bronchial carcinoma)
In the diagnosis of lung cancer, computed tomography with special threedimensional CAD systems are established and considered as gold standard. At this a
volumetric dataset with up to 3,000 single images is prepared and analyzed. Round lesions
(lung cancer, metastases and benign changes) from 1 mm are detectable. Today all wellknown vendors of medical systems offer corresponding solutions.
Early detection of lung cancer is valuable. The 5-year-survival-rate of lung cancer
has stagnated in the last 30 years and is now at approximately just 15%. Lung cancer takes
more victims than breast cancer, prostate cancer and colon cancer together. This is due
to the asymptomatic growth of this cancer. In the majority of cases it is too late for a
66

successful therapy if the patient develops first symptoms (e.g. chronic croakiness or
hemoptysis). But if the lung cancer is detected early (mostly by chance), there is a survival
rate at 47% according to the American Cancer Society. At the same time the standard xray-examination of the lung is the most frequently x-ray examination with a 50% share.
Indeed, the random detection of lung cancer in the early stage (stage 1) in the x-ray image
is difficult. It is a fact that round lesions vary from 510 mm are easily overlooked. The
routine application of CAD Chest Systems may help to detect small changes without initial
suspicion. Philips was the first vendor to present a CAD for early detection of round lung
lesions on x-ray images.
Colon cancer
CAD is available for detection of colorectal polyps in the colon. Polyps are small
growths that arise from the inner lining of the colon. CAD detects the polyps by identifying
their characteristic "bump-like" shape. To avoid excessive false positives, CAD ignores the
normal colon wall, including the haustral folds. In early clinical trials, CAD helped
radiologists find more polyps in the colon than they found prior to using CAD.
Coronary artery disease
CAD is available for the automatic detection of significant (causing more than
50% stenosis) coronary artery disease in coronary CT angiography (CCTA) studies. A low
false positives rate (60-70% specificity per patient) allows using it as a computer-aided
simple triage (CAST) tool distinguishing between positive and negative studies and
yielding a preliminary report. This, for example, can be used for chest pain patients' triage
in an emergency setting.

67

Congenital heart defect


Early detection of pathology can be the difference between life and death. CADe
can be done by auscultation with a digital stethoscope and specialized software, also
known as Computer-aided auscultation. Murmurs, irregular heart sounds, caused by
blood flowing through a defective heart, can be detected with high sensitivity and
specificity. Computer is sensitive to external noise and bodily sounds and requires an
almost silent environment to function accurately.
Alzheimer's disease
CADs can be used to identify subjects with Alzheimer's and mild cognitive
impairment from normal elder controls.
In 2014, Padma et al. used combined wavelet statistical texture features to
segment and classify AD benign and malignant tumor slices. Zhang et al. found kernel
support vector machine decision tree had 80% classification accuracy, with an average
computation time of 0.022s for each image classification.
Eigenbran is a novel brain feature that can help to detect AD. The results showed
polynomial kernel SVM achieved accuracy of 92.360.94, sensitivity of 83.483.27,
specificity of 94.901.09, and precision of 82.282.78. The polynomial KSVM performs
better than linear SVM and RBF kernel SVM.

68

Nuclear medicine
CADx is available for nuclear medicine images. Commercial CADx systems for the
diagnosis of bone metastases in whole-body bone scans and coronary artery disease in
myocardial perfusion images exist.

COMPUTER-ASSISTED SURGERY
Technology is revolutionizing the medical field with the creation of robotic devices
and complex imaging. Though these developments have made operations much less
invasive, robotic systems have their own disadvantages that prevent them from replacing
surgeons. Minimally invasive surgery is a broad concept encompassing many common
procedures that existed prior to the introduction of robots, such as laparoscopic
cholecystectomy or gall bladder excisions. It refers to general procedures that avoid long
cuts by entering the body through small (usually about 1cm) entry incisions, through
which surgeons use long-handled instruments to operate on tissue within the body. Such
operations are guided by viewing equipment (i.e. endoscope) and, therefore, do not
necessarily need the use of a robot. However, it is not incorrect to say that computerassisted and robotic surgeries are categories under minimally invasive surgery.
Both computer-assisted and robotic surgeries have similarities when it comes to
preoperative planning and registration. Because a surgeon can use computer simulation
69

to run a practice session of the robotic surgery beforehand, there is a close tie between
these two categories and this may explain why some people often confuse them as
interchangeable. However, their main distinctions lie in the intraoperative phase of the
procedure: robotic surgeries may use a large degree of computer assistance, but
computer-assisted surgeries do not use robots.
Computer-assisted surgery (CAS), also known as image-guided surgery, surgical
navigation, and 3-D computer surgery, is any computer-based procedure that uses
technologies such as 3D imaging and real-time sensing in the planning, execution and
follow-up of surgical procedures. CAS allows for better visualization and targeting of sites
as well as improved diagnostic capabilities, giving it a significant advantage over
conventional techniques. Robotic surgery, on the other hand, requires the use of a
surgical robot, which may or may not involve the direct role of a surgeon during the
procedure.
Robotics
A robot is defined as a computerized system with a motorized construction (usually
an arm) capable of interacting with the environment. In its most basic form, it contains
sensors, which provide feedback data on the robots current situation, and a system to
process this information so that the next action can be determined. One key advantage
of robotic surgery over computer-assisted is its accuracy and ability to repeat identical
motions.
A robot is a computer controlled mechanical system with anthropomorphic
(human-like) characteristics. In essence, most are extenders of the human arm with vast
manipulative capabilities that can utilized to extend and amplify, but not take over, the
70

many functions of the human hands. Robotics has become the most exciting and
promising arena where our ancient art couples onto the digital vehicle on the information
superhighway. Much touted as the likely successors of the industrial revolution, robots
had to wait in the aisles until computers came of age.
With vast computing powers at their command, designers have now turned their
attention on the potential benefits of robotic technology to surgical practice. Two systems
the Zeus and da Vinci have been licensed for use by the FDA in the United States of
America.

There are six main valuable areas in which robotics are of interest to surgery:
Augmentation of the surgeons arm
Akin to providing the third arm for the surgeon, voice-controlled robotics can
hold and manipulate endoscopes for the surgeon. A lot of work was done in this regard
by companies in collaboration with aerospace industry.
Enhanced dexterity
The robotic hand is more precise, dampening tremors, an unnecessary side effect
of ageing among surgeons. They also show superior consistency in procedures where
repeated precision is needed as in spinal canal surgery and modeling bone planes for
orthopedic prosthetics insertion. Newer, exact-fitting orthopedic prostheses could now
be tailor-made from 3-d CAT images of the intact contra-lateral side. The robotic arm does

71

not yet have as great a range of motion as the human arm but further refinement will
soon correct this minor problem.
The last few years have witnessed great innovations in the miniaturization of
computers. Advanced microchip and battery technologies have stimulated research into
the applications of small robots capable of working in remote terrain. Nanotechnology,
as this new field is called, has many possibilities for surgery. It is envisaged that Nanorobots will in the foreseeable future, be programmed to invade specific areas of the body
and target diseased tissues, delivering cytotoxic agents to tumor beds and unclogging
cerebral vessels of blood clots after a cerebrovascular accident.
The possibilities are many and the future is not as far as it may seem. Sometime
ago, researchers at a British laboratory demonstrated an ingenious Nano-robotic
gastrointestinal endoscope which, swallowed as a capsule, sends back pulses of clear
pictures as it migrates down the digestive tract for many hours. It has since been
successfully used in diagnostic imaging of the small bowel and miniaturized machines will
be increasingly available for clinical use within this new decade.
Improved ergonomics
For once, the surgeon does not have to stand all through the duration of the surgery
anymore. Rather, he can sit comfortably at a control and, through virtual reality,
manipulate the robotic controls remotely to handle instruments and navigate successfully
through delicate operations such as coronary bypass, cholecystectomy and endoscopic
hernia repairs. This has vast applicability in telemedicine (vide infra)

72

Image guided positioning


Stereotaxis has enhanced success and safety of many surgical procedures. Through
simulation in training of surgeons as well as in surgical planning, image-guided fine-needle
aspiration biopsy and cytology of mammo-graphically detected small breast lumps are
more precise and simpler. Endo-vascular ablation of berry aneurysm is demonstrably
possible with robotic tracking and guidance. Elimination of hazards The surgical team may
now be safely removed from hazardous irradiation and caustic chemicals while treating
his patients. Robotic arms may safely place therapeutic radioactive rods in body tissues
and cavities without exposing the surgeon to any harmful effects
Telemedicine
With an ever increasing speed of the Internet, it is now feasible to bridge distance
barriers and perform various tasks remotely controlled robotic tools. This development
has commanded much attention from military, navy submarine, nuclear facilities and
space exploration programs. Tele-collaboration has been employed in surgery, with
robotics enabling surgeons not physically present in the operating room to interactively
take part in surgeries. It is hoped that shortage of specialist manpower experienced in
third world countries will be addressed through this aspect of telemedicine.
Telemedicine is a fast-expanding application of computers in Medicare. It involves
the instantaneous, two-way transmission of digitally encrypted medical data over
telephone lines to vast distances across the globe. Thus doctors can hold teleconferences,
exchanging text, picture, voice and video data. Cosmonauts aboard the permanently
orbiting Spacelab have a full surgical capability backed by a ground team of specialists via
telemedicine. It must be pointed out that these benefits are synergistic and not mutually
73

exclusive. Surgical utilization of these attributes often employ as many of these


capabilities as possible.
Computer-assisted surgery (CAS) represents a surgical concept and set of
methods, that use computer technology for surgical planning, and for guiding or
performing

surgical

interventions.

CAS

is

also

known

as computer-aided

surgery, computer-assisted intervention, image-guided surgery and surgical navigation,


but these are terms that are more or less synonymous with CAS. CAS has been a leading
factor in the development of robotic surgery.

Applications
Computer-assisted surgery is the beginning of a revolution in surgery. It already
makes a great difference in high-precision surgical domains, but it is also used in standard
surgical procedures.
Computer-assisted neurosurgery
Tele-manipulators have been used for the first time in neurosurgery, in the 1980s.
This allowed a greater development in brain microsurgery (compensating surgeons
physiological tremor by 10-fold), increased accuracy and precision of the intervention. It
also opened a new gate to minimally invasive brain surgery, furthermore reducing the risk
of post-surgical morbidity by avoiding accidental damage to adjacent centers.

74

Computer-assisted oral and maxillofacial surgery


Bone segment navigation is the modern surgical approach in orthognathic
surgery (correction of the anomalies of the jaws and skull), in temporo-mandibular joint
(TMJ) surgery, or in the reconstruction of the mid-face and orbit.
It is also used in implantology where the available bone can be seen and the
position, angulation and depth of the implants can be simulated before the surgery.
During the operation surgeon is guided visually and by sound alerts. IGI (Image Guided
Implantology) is one of the navigation systems which uses this technology.
Guided Implantology
New therapeutic concepts as guided surgery is being developed and applied in the
placement of dental implants. The prosthetic rehabilitation is also planned and performed
parallel to the surgical procedures. The planning steps are at the foreground and carried
out in a cooperation of the surgeon, the dentist and the dental technician. Edentulous
patients, either one or both jaws, benefit as the time of treatment is reduced.
Regarding the edentulous patients, conventional denture support is often
compromised due to moderate bone atrophy, even if the dentures are constructed based
on correct anatomic morphology.
Using cone beam computed tomography, the patient and the existing prosthesis
are being scanned. Furthermore, the prosthesis alone is also scanned. Glass pearls of
defined diameter are placed in the prosthesis and used as reference points for the
upcoming planning. The resulting data is processed and the position of the implants
determined. The surgeon, using special developed software, plans the implants based on
75

prosthetic concepts considering the anatomic morphology. After the planning of the
surgical part is completed, a CAD/CAM surgical guide for dental placement is constructed.
The mucosal-supported surgical splint ensures the exact placement of the implants in the
patient. Parallel to this step, the new implant supported prosthesis is constructed.
The dental technician, using the data resulting from the previous scans,
manufactures a model representing the situation after the implant placement. The
prosthetic compounds, abutments, are already prefabricated. The length and the
inclination can be chosen. The abutments are connected to the model at a position in
consideration of the prosthetic situation. The exact position of the abutments is
registered. The dental technician can now manufacture the prosthesis.
The fit of the surgical splint is clinically proved. After that, the splint is attached
using a three-point support pin system. Prior to the attachment, irrigation with a chemical
disinfectant is advised. The pins are driven through defined sheaths from the vestibular
to the oral side of the jaw. Ligaments anatomy should be considered, and if necessary
decompensation can be achieved with minimal surgical interventions. The proper fit of
the template is crucial and should be maintained throughout the whole treatment.
Regardless of the mucosal resilience, a correct and stable attachment is achieved through
the bone fixation. The access to the jaw can now only be achieved through the sleeves
embedded in the surgical template. Using specific burs through the sleeves the mucosa is
removed. Every bur used, carries a sleeve compatible to the sleeves in the template,
which ensures that the final position is achieved but no further progress in the alveolar
ridge can take place. Further procedure is very similar to the traditional implant
placement. The pilot hole is drilled and then expanded. With the aid of the splint, the
implants are finally placed. After that, the splint can be removed.
76

With the aid of a registration template, the abutments can be attached and
connected to the implants at the defined position. No less than a pair of abutments should
be connected simultaneously to avoid any discrepancy. An important advantage of this
technique is the parallel positioning of the abutments. A radiological control is necessary
to verify the correct placement and connection of implant and abutment.
In a further step, abutments are covered by gold cone caps, which represent the
secondary crowns. Where necessary, the transition of the gold cone caps to the mucosa
can be isolated with rubber dam rings.
The new prosthesis corresponds to a conventional total prosthesis but the basis
contains cavities so that the secondary crowns can be incorporated. The prosthesis is
controlled at the terminal position and corrected if needed. The cavities are filled with a
self-curing cement and the prosthesis is placed in the terminal position. After the selfcuring process, the gold caps are definitely cemented in the prosthesis cavities and the
prosthesis can now be detached. Excess cement may be removed and some corrections
like polishing or under filling around the secondary crowns may be necessary. The new
prosthesis is fitted using a construction of telescope double cone crowns. At the end
position, the prosthesis buttons down on the abutments to ensure an adequate hold.
At the same sitting, the patient receives the implants and the prosthesis. An interim
prosthesis is not necessary. The extend of the surgery is kept to minimum. Due to the
application of the splint, a reflection of soft tissues in not needed. The patient experiences
less bleeding, swelling and discomfort. Complications such as injuring of neighboring
structures are also avoided. Using 3D imaging during the planning phase, the
communication between the surgeon, dentist and dental technician is highly supported
77

and any problems can easily be detected and eliminated. Each specialist accompanies the
whole treatment and interaction can be made. As the end result is already planned and
all surgical intervention is carried according to the initial plan, the possibility of any
deviation is kept to a minimum. Given the effectiveness of the initial planning the whole
treatment duration is shorter than any other treatment procedures.
Computer-assisted ENT surgery
Image-guided surgery and CAS in ENT commonly consists of navigating
preoperative image data such as CT or cone beam CT to assist with locating or avoiding
anatomically important regions such as the optical nerve or the opening to the frontal
sinuses. For use in middle-ear surgery there has been some application of robotic surgery
due to the requirement for high-precision actions.
Computer-assisted orthopedic surgery (CAOS)
The application of robotic surgery is widespread in orthopedics, especially in
routine interventions, like total hip replacement. It is also useful in pre-planning and
guiding the correct anatomical position of displaced bone fragments in fractures, allowing
a good fixation by osteosynthesis. Early CAOS systems include the HipNav, OrthoPilot,
and Praxim.
Computer-assisted visceral surgery
With the advent of computer-assisted surgery, great progresses have been made
in general surgery towards minimal invasive approaches. Laparoscopy in abdominal and
gynecologic surgery is one of the beneficiaries, allowing surgical robots to perform routine
operations, like colecystectomies, or even hysterectomies. In cardiac surgery, shared
78

control systems can perform mitral valve replacement or ventricular pacing by small
thoracotomies. In urology, surgical robots contributed in laparoscopic approaches for
pyeloplasty or nephrectomy or prostatic interventions.
Computer-assisted radiosurgery
Radiosurgery is also incorporating advanced robotic systems. CyberKnife is such a
system that has a lightweight linear accelerator mounted on the robotic arm. It is guided
towards tumor processes, using the skeletal structures as a reference system
(Stereotactic Radiosurgery System). During the procedure, real time X-ray is used to
accurately position the device before delivering radiation beam. The robot can
compensate for respiratory motion of the tumor in real-time.

Advantages
CAS starts with the premise of a much better visualization of the operative field,
thus allowing a more accurate preoperative diagnostic and a well-defined surgical
planning, by using surgical planning in a preoperative virtual environment. This way, the
surgeon can easily assess most of the surgical difficulties and risks and have a clear idea
about how to optimize the surgical approach and decrease surgical morbidity. Science of
designing user interaction with equipment and work places to fit the user. During the
operation, the computer guidance improves the geometrical accuracy of the surgical
gestures and also reduce the redundancy of the surgeons acts. This significantly
improves ergonomy in the operating theatre, decreases the risk of surgical errors and
reduces the operating time.

79

Disadvantages
There are several disadvantages of computer-assisted surgery. A major
disadvantage of this system is their cost. With a price tag of a million dollars, their cost is
nearly prohibitive. Some people believe that improvements in technology, such as
haptics, increased processor speeds, and more complex and capable software will
increase the cost of these systems. Another disadvantage is the size of these systems.
These systems have relatively large footprints and relatively cumbersome robotic arms.
This is an important disadvantage in today's already crowded-operating rooms. It may be
difficult for both the surgical team and the robot to fit into the operating room. Another
factor that is stunting the development of robotic surgery is that of latency which is the
time delay between the instructions issued by the surgeon and the movement of the
robot which responds to the instructions. With the current level of technology, the
surgeon must be in close proximity.

80

81

MEDICAL RESEARCH
Biomedical research (or experimental medicine) is in general simply known
as medical research. It is the basic research, applied research, or translational
research conducted to aid and support the development body of knowledge in the field
of medicine.
An important kind of medical research is clinical research, which is distinguished by
the involvement of patients. Other kinds of medical research include pre-clinical research,
for example on animals, and basic medical research, for example in genetics.
Both clinical and pre-clinical research phases exist in the pharmaceutical industry's
drug pipelines, where the clinical phase is denoted by the term clinical trial. However,
only part of the whole of clinical or pre-clinical research is oriented towards a specific
pharmaceutical purpose. The need for understanding, diagnostics, medical devices and
non-pharmaceutical therapies means that medical research is much bigger than just
trying to make new drugs.
The most basic medical research is a rapidly evolving area that owes much to basic
biology and is given names such as Human Biosciences by universities.
A new paradigm to biomedical research is being termed translational research,
which focuses on iterative feedback loops between the basic and clinical research
domains to accelerate knowledge translation from the bedside to the bench, and back
again.

Medical

research

may

involve

doing

research

into public

health, biochemistry, clinical research, microbiology, physiology, oncology, surgery and

82

research

into

many

other non-communicable

diseases such

as diabetes and

cardiovascular diseases.
The increased longevity of humans over the past century can be significantly
attributed to advances resulting from medical research. Among the major benefits of
medical

research

have

been vaccines for measles and polio, insulin treatment

for diabetes, classes of antibiotics for treating a host of maladies, medication for
high blood pressure, improved treatments for AIDS, statins and other treatments
for atherosclerosis, new surgical techniques such as microsurgery, and increasingly
successful treatments for cancer. New, beneficial tests and treatments are expected as a
result of the Human Genome Project. Many challenges remain, however, including the
appearance of antibiotic resistance and the obesity epidemic.
Most of the research in the field is pursued by biomedical scientists, however
significant contributions are made by other biologists, as well as chemists and physicists.
Medical research, done on humans, has to strictly follow the medical ethics as sanctioned
in the Declaration of Helsinki and elsewhere. In all cases, the research ethics has to be
respected.
Patient Management

Health care clinicians and administrators alike are showing enthusiasm for one of
the medical field's newest technological trends: patient information management
systems. These electronic systems serve as a database for storing patient files.
Information can be easily added, changed, deleted, printed or audited by clicking
a few buttons on the computer. Doctors do not have to store or carry around

83

health records any longer, because all they need is access to a computer or laptop
to pull up patient information.

Scheduling

When a patients call a health care facility to make an appointment, the


representative who answers the phone can schedule them through the use of a
computer appointment scheduling system. These electronic systems allow front
office staff to add, delete or change appointments with the click of a mouse. If
there is more than one doctor in a clinic, schedules can be sorted by doctor, as
well as be color-coded to indicate when a doctor has availability.

Medical Claims

Computers are what health care companies are using to submit, review, process
and pay medical claims, according to a 2006 article by the Healthcare Financial
Management Association. Health technology trends indicate that more and more
companies are relying on computers to submit their claims, rather than
submitting them via hard copy, because computers expedite the process.
Information management engineers have created systems and technology tools
that make the claims process of the medical field more efficient and easy to use.

Imaging

Computers are being broadly utilized in the radiology realm of health care,
according to CMT Medical Technologies. Technology advancements have led to
84

more sophisticated ways of taking X-rays and performing imaging services.


Imaging technology could not be done without computers. Computers allow
radiologists and technicians to study and print the final images.

Communication

Because so much information is stored on computer networks, health care


employees rely on the electronic transmittal of patient information by way of
computers. In hospital settings, one department can use a computer to transmit a
patient's X-ray results or lab work to another department. A 2010 update by the
Healthcare Information and Management Systems Society explains that health
care professionals rely on computers and information systems to enhance the
provision of medical services through the sharing of information.

85

CHAPTER FOUR
FINDINGS/DISCUSSION

At the introduction, some questions were asked and will be asked again in other to
clarify the effect of computer to medicine.
How has computers improved quality of care and documented that quality?
How can computers improve medical education?
What are the disadvantages of computer use in medicine?
Does the use of computer in medicine has more merits to demerits? If yes,
Of what use has it been? How?
These questions are critical as it would be able to know the real effect of computer
in the medical field. During the course of this explanation, we have categorically
expatiated the use of computer and we have seen it has more advantages to the
disadvantages
Although the inventors of the computer could not have conceptualized the grand
scale of its vast influence in human life, practitioners in diverse realms such as arts,
humanities, weather- forecasting, deep-sea fishing and industry now increasingly turn to
its awesome power. The field of surgery has not been left out and has gone beyond the
realms of simple record keeping and word processing. Contrary to expectations,
86

computers are still years behind human capabilities at thinking, an advanced form of
informed reasoning such as doctors use in making diagnoses and formulating treatment.

87

CHAPTER FOUR
CONCLUSION
In this book we have summarized the most important directions and areas of
computer sciences application in medical services and technologies. We have also
presented our contribution in such important and fascinating from scientific point
of view field. Our work is mainly concentrated on two- three- and four dimensional
image data: image processing and recognition (classification tasks), semantic
interpretation, as well as visualization and user interfaces.
The one of remarkable research trends in this area is adaptation of existing
state of the art methods and developing new algorithms in the way to make them
suitable to mobile or low power consumption devices by using hardware
optimization, web technologies and novel easy to learn and reliable interfaces. Also
our up to date researches are concentrated in this area mainly on gesture
recognition applied in medical system navigation.
The field of use of computer methods in medicine is very wide and surely will
grow in near future with development of new diagnostic methods that mainly
generate digitalized information that has to be processed by software or hardware
algorithms. Also people quickly get use to new technologies like web and mobile
applications, and in our opinion it is a matter of time while mobile applications will
be used to for every day contact with chronically ill people that do not have to be
under continuous observation in hospital. However, it should be remembered that
no computer program can replace the face-to-face contact of doctor with his or
her patient.

88

REFERENCES
[1] J. C. Calvo, J. Ortega, and M. Anguita. Comparison of parallel multi-objective
approaches to protein structure prediction. The Journal of Supercomputing,
58(2):253260, December 2011.
[2] C.-Y. Chang, S.-J. Chen, and M.-F. Tsai. Application of support-vector-machinebased method for feature selection and classification of thyroid nodules in ultrasound
images. Pattern Recognition, 43(10):34943506, October 2010.
[3] C.-Y. Chang, P.-C. Chung, Y.-C. Hong, and C.-H. Tseng. A neural network for thyroid
segmentation and volume estimation in CT images. IEEE Computational Intelligence
Magazine, 6(4):4355, November 2011.
[4] C.-Y. Chang, Y.-F. Lei, C.-H. Tseng, and S.-R. Shih. Thyroid segmentation and volume
estimation in ultrasound images. IEEE Transactions on Biomedical Engineering,
57(6):13481357, June 2010.
[5] C.-Y. Chang and D.-F. Zhuang. A fuzzy-based learning vector quantization neural
network for recurrent nasal papilloma detection. IEEE Transactions on Circuits and
Systems Part I: Regular Papers, 54(12):26192627, December 2007.
[6] A. H. Foruzan, R. A. Zoroofi, M. Hori, and Y. Sato. Liver segmentation by intensity
analysis and anatomical information in multi-slice CT images. International Journal of
Computer Assisted Radiology and Surgery, 4(3):287297, May 2009.
[7] L. Franco. Weaning: can the computer help? Intensive Care Medicine, 34(10):1746
1748, July 2008.
89

[8] R. Frankel, A. Altschuler, S. George, J. Kinsman, H. Jimison, N. R. Robertson, and J.


Hsu. Effects of examroom computing on clinician-patient communication: a
longitudinal qualitative study. Journal of General Internal Medicine, 20(8):677682,
August 2005.
[9] L. A. Guner, N. I. Karabacak, O. U. Akdemir, P. S. Karagoz, S. A. Kocaman, A. Cengel,
and M. Unlu. An open-source framework of neural networks for diagnosis of coronary
artery disease from myocardial perfusion SPECT. Journal of Nuclear Cardiology,
17(3):405413, June 2010.
[10] T. Hachaj and M. R. Ogiela. Augmented reality approaches in intelligent health
technologies and brain lesion detection. In Proc. of the 1st IFIP International
Workshop on Security and Cognitive Informatics for Homeland Defense (SeCIHD11),
Vienna, Austria, LNCS, volume 6908, pages 135148. Springer-Verlag, August 2011.
[11] T. Hachaj and M. R. Ogiela. CAD system for automatic analysis of CT perfusion
maps. Opto-electronics Review, 19(1):95103, March 2011.
[12] T. Hachaj and M. R. Ogiela. A system for detecting and describing pathological
changes using dynamic perfusion computer tomography brain maps. Computers in
Biology and Medicine, 41(6):402410, June 2011.
[13] T. Hachaj and M. R. Ogiela. The automatic two - step vessel lumen segmentation
algorithm for carotid bifurcation analysis during perfusion examination. Intelligent
Decision Technologies Smart Innovation, Systems and Technologies, 16:485493,
2012.

90

[14] T. Hachaj and M. R. Ogiela. Evaluation of carotid artery segmentation with


centerline detection and active contours without edges algorithm. In Proc. of 2nd IFIP
International Workshop on Security and Cognitive Informatics for Homeland Defense
(SeCIHD12), Prague, Czech Republic, LNCS, volume 7465, pages 468478. SpringerVerlag, August 2012.
[15] T. Hachaj and M. R. Ogiela. Framework for cognitive analysis of dynamic perfusion
computed tomography with visualization of large volumetric data. Journal of
Electronic Imaging, 21(4):043017, November 2012.
[16] T. Hachaj and M. R. Ogiela. Recognition of human body poses and gesture
sequences with gesture description language. Journal of medical informatics and
technology, 20:129135, 2012.
[17] T. Hachaj and M. R. Ogiela. Semantic description and recognition of human body
poses and movement sequences with gesture description language. Computer
Applications for Bio-technology, Multimedia, and Ubiquitous City Communications in
Computer and Information Science, 353:18, December 2012.
[18] T. Hachaj and M. R. Ogiela. Visualization of perfusion abnormalities with GPUbased volume rendering. Computers & Graphics, 36(3):163169, May 2012.
[19] S.-L. Hsieh, S.-H. Hsieh, P.-H. Cheng, C.-H. Chen, K.-P. Hsu, I.-S. Lee, Z. Wang, and
F. Lai. Design ensemble machine learning model for breast cancer diagnosis. Journal of
Medical Systems, 36(5):28412847, October 2012.

91

[20] H. Huang. From PACS toWeb-based ePR system with image distribution for
enterprise-level filmless healthcare delivery. Radiological Physics and Technology,
4(2):91108, 2011.
[21] S. John, A. C. C. Poh, T. C. C. Lim, E. H. Y. Chan, and L. R. Chong. The iPad Tablet
Computer for Mobile On-Call Radiology Diagnosis? Auditing Discrepancy in CT and MRI
Reporting. Journal of Digital Imaging, (October):628634, 2012.
[22] A. Kho, L. E. Henderson, D. D. Dressler, and S. Kripalani. Use of handheld
computers in medical education. a systematic review. Journal of General Internal
Medicine, 21(5):531537, May 2006.
[23] C. Kirmizibayrak, Y. Yim, M. Wakid, and J. K. Hahn. Interactive visualization and
analysis of multimodal datasets for surgical applications. The Journal of Digital
Imaging, 25(6):792801, December 2012.
[24] A. Kleiboer, K. Gowing, C. H. Hansen, C. Hibberd, L. Hodges, J. Walker, P.
Thekkumpurath, M. OConnor, G. Murray, and M. Sharpe. Monitoring symptoms at
home: what methods would cancer patients be comfortable using? Quality of Life
Research, 19(7):965968, 2010.
[25] G. Lam, N. T. Ayas, D. E. Griesdale, and A. D. Peets. Medical simulation in
respiratory and critical care medicine. LUNG, 188(6):445457, 2010.
[26] S.-F. Lin, K.-T. Xiao, Y.-T. Huang, C.-C. Chiu, and V.-W. Soo. Analysis of adverse
drug reactions using drugand drug target interactions and graph-based methods.
Artificial Intelligence in Medicine, 48(23):161166, February 2010.
92

[27] D.-Y. Liu, H.-L. Chen, B. Yang, X.-E. Lv, L.-N. Li, and J. Liu. Design of an enhanced
fuzzy k-nearest neighbor classifier based computer aided diagnostic system for thyroid
disease. Journal of Medical Systems, 36(5):32433254, September 2012.
[28] F. Matthews, P. Messmer, V. Raikov, G. A. Wanner, A. L. Jacob, P. Regazzoni, and
A. Egli. Patient-specific three-dimensional composite bone models for teaching and
operation planning. The Journal of Digital Imaging, 22(5):473482, October 2009.
[29] T. Mehmet. Physicians views and assessments on picture archiving and
communication systems (pacs) in two turkish public hospitals. Journal of Medical
Systems, 36(6):35553562, December 2012.
[30] P. G. Mezey. Computer Aided Drug Design: Some Fundamental Aspects. Journal of
Molecular Modeling, 6(2):150157, February 2000.
[31] Z. B. Miled, J. Liu, O. Bukhres, H. Li, J. Martin, C. Balagopalakrishna, and R. Oppelt.
Use and maintenance of histograms for large scientific database access planning: A
case study of a pharmaceutical data repository. Journal of Intelligent Information
Systems, 23(2):145178, September 2004.
[32] D. P. Miller, J. R. Kimberly, L. D. Case, and J. L. Wofford. Using a computer to teach
patients about fecal occult blood screening. a randomized trial. Journal of General
Internal Medicine, 20(11):984988, November 2005.
[33] T. Murase, K. Oka, H. Moritomo, A. Goto, K. Sugamoto, and H. Yoshikawa.
Correction of severe wrist deformity following physeal arrest of the distal radius with
the aid of a three-dimensional computer simulation. Archives of Orthopaedic and
Trauma Surgery, 129(11):14671471, November 2009.
93

[34] P. Phan, N. Mezghani, C.- E. Aubin, J. A. de Guise, and H. Labelle. Computer


algorithms and applications used to assist the evaluation and treatment of adolescent
idiopathic scoliosis: a review of published articles 2000-2009. European Spine Journal,
20(7):10581068, July 2011.
[35] O. S. Pianykh. Digital Imaging and Communications in Medicine (DICOM).
Springer, 2011.
[36] G. Sambuceti, M. Brignone, C. Marini, M. Massollo, F. Fiz, S. Morbelli, A.
Buschiazzo, C. Campi, R. Piva, A. M. Massone, M. Piana, and F. Frassoni. Estimating the
whole bone-marrow asset in humans by a computational approach to integrated
PET/CT imaging. European Journal of Nuclear Medicine and Molecular Imaging,
39(8):13261338, December 2012.
[37] R. G. C. Soares, R. L. Oliveira, A. P. H. Junqueira, de Moraes Thiago Franco, and da
Silva Jorge Vicente Lopes. Touchless gesture user interface for interactive image
visualization in urological surgery. World Journal of Urology, 30(5):687691, October
2012.
[38] A. Stuurman-Bieze, P. B. van den Berg, T. D. F. Tromp., and L. T. de Jong-van den
Berg. Computer assisted medication review for asthmatic patients as a basis for
intervention. constructing and validating an algorithmic computer instrument in
pharmacy practice. Pharmacy World and Science, 26(5):289296, October 2004.
[39] Wikipedia, the free encyclopedia.

94

95

You might also like