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Bioethicists study ethical problems arising from biological or medical research. Professor Arthur
Caplan, director of the division of medical ethics at New York University School of Medicine
and one of four who authored the letter, said he is skeptical Brazil has the resources to protect the
public and is equally skeptical of "general assurances" from public health officials.
The letter called on the WHO to convene an independent group to advise it and the International
Olympic Committee.
"I believe in informed consent," Caplan said in an interview. "Let's have an independent set of
scientists look at this and let everyone hear the arguments."
Citing the "greater concern for global health", the letter also said, "The Brazilian strain of Zika
virus harms health in ways that science has not observed before."
Speaking at a lunch at the National Press Club in Washington on Thursday, Frieden said there
was no reason to delay the Olympics.
He was responding to a paper by a Canadian professor published earlier this month in the
Harvard Public Health Review which called for the Games to be canceled or moved because it
could speed the spread of Zika.
"The risk is not particularly high other than for pregnant women," Frieden said.
Zika infection in pregnant women has been shown to be a cause of the birth defect microcephaly
and other serious brain abnormalities in babies.
The connection between Zika and microcephaly first came to light last fall in Brazil, which has
confirmed more than 1,400 cases of microcephaly.
Frieden's view is shared by many infectious disease experts. A recent editorial in The Lancet
Infectious Diseases journal noted that the Zika outbreak has been concentrated in northeastern
Brazil, away from Rio. Moreover, it added, the infection-carrying mosquito is not particularly
active in August and athletes and spectators are likely to spend their time in places purged of
mosquito breeding sites.
"Available evidence indicates that for games participants, risk of exposure to Zika virus and
subsequent adverse health outcomes will be low," it said.