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MASTER OF TECHNOLOGY
in
April 2016
Abstract
Glaucoma is a neurodegenerative disorder of the optic nerve, which causes partial loss of
vision. Glaucoma is recognized to be the second most common cause of blindness. Large number of
people suffers from eye diseases in rural and semi urban areas all over the world. Early detection
and treatment of glaucoma is hence important for the prevention of disease. Current diagnosis of
retinal disease relies upon examining retinal fundus image using image processing. This paper
describes the application of various image processing techniques for automatic detection of
glaucoma. The key image processing techniques to detect eye diseases include image fusion, image
segmentation, feature extraction, image enhancement, morphology, pattern matching, image
classification, analysis and statistical measurements. . Many autonomous glaucoma detection
systems analyze fundus image by calculating Cup to Disc Ratio (CDR) and categorize the image as
glaucoma or healthy. The proposed methodology provides a novel algorithm to detect glaucoma
using a fusion of CDR and hybrid textural and intensity features. Image categorization (glaucoma,
non-glaucoma, suspect) is done based on the results from both CDR and classifier. This fusion of
CDR with hybrid features has improved the sensitivity of system to 1, specificity 0.88 and accuracy
92%.
1. INTRODUCTION
Glaucoma is an ocular disorder which might leads to permanent vision
loss if not detected at an early stage. Origin of glaucoma is the increase in
intraocular pressure (IOP) which if continues, destroys the optic nerve. Optic
nerve is responsible for the information transfer from eye to brain vice versa. A
destruction in optic nerve leads to blindness. Glaucoma is often called a silent
thief of sight, as it has no clear symptoms at an early stage and if the
progression of glaucoma is not stopped at an early stage the severe
destruction to the optic nerve will result in incurable blindness. The World
Health Organization has declared Glaucoma to be the second largest cause of
blindness all over the world and it encompasses 15% of the blindness cases in
world which makes 5.2 million of the world's population [1] and the number is
expected to increase up to 80 million by 2020 [2]. An early and accurate
detection of glaucoma is one of the major requirements to stop glaucoma
progression.
3. PROPOSED METHODOLOGY
The proposed methodology as shown in Fig. 3, takes an input image, after
preprocessing the image Value plane is extracted for disc detection. After
binary conversion, image is post processed to remove noise and extra
protrusions. Finally the boundary of disc is smoothened using ellipse fitting.
Cup extraction starts from Green plane processing to remove veins from image.
Region growing is done on the resultant image to extract cup. Post-processing
is applied on the image and boundary is smoothened using circular fitting. CDR
is calculated and
compared with
values. Color and
texture based
the input image
calculated and
classified by the
healthy or
Final result
is concluded by
results from CDR
the
clinical
features of
are
classifier as
glaucoma.
merging the
and classifier
Result
Analysis
Retinal image
sample No.
Sample 1
Sample 2
Sample 3
Detection
result
Cup to disk
Ratio
Detection
Results from
Proposed
Algorithm
0.538
Healthy
0.742
0.580
Glaucoma
Medical
Expert's
Diagnostic
Resluts
Compared
Result
Healthy
Positive
Glaucoma
Healthy
Healthy
Positive
Positive
Sample 4
0.651
Healthy
Glaucoma
Negative
Sample 5
0.718
Glaucoma
Glaucoma
Positive
Healthy
Glaucoma
Negative
Sample 6
0.496
Sample 7
Positive
Sample 8
Positive
V. CONCLUSION
Glaucoma is a chronic disease and whose progression can only be stopped if
detected at an early stage. CDR measurement is an important structural
change that is being used in autonomous glaucoma detection systems. Varying
intensities and other noise in fundus images might not enable the autonomous
systems to extract cup and disc accurately, thus affects the CDR and
misinterprets the results. This might results in a failure to detect glaucoma.
Intensity and texture based features can also be used as a biomarker to classify
glaucoma and non-glaucoma images. Feature based classification of fundus
images is also being used in autonomous glaucoma detection systems.
However, such systems sometimes also misclassify the images resulting in