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Exampro A-level Biology (2410)

Name:

BIOL 5.2

Class:

Author:
Date:
Time:

186

Marks:

159

Comments:

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Q1.

The diagram shows the change in the charge across the surface membrane of a nonmyelinated axon when an action potential is produced.

(a)

Describe how the change shown in the diagram occurs when an action potential is
produced.
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(2)

(b)

Explain what causes the conduction of impulses along a non-myelinated axon to be slower
than along a myelinated axon.
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(3)
(Total 5 marks)

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Q2.

When a finger accidentally touches a hot object, a reflex action occurs. The biceps muscle
contracts, causing the arm to be flexed and the finger is pulled away. The diagram shows the
arrangement of the bones in the arm, the muscles used for flexing and straightening the arm and
the nervous pathways associated with the contraction of these muscles.

(a)

Explain the importance of reflex actions.


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(3)

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(b)

(i)

Describe the sequence of events which allows information to pass from one neurone
to the next neurone across a cholinergic synapse.
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(6)

(ii)

Give two differences between a cholinergic synapse and a neuromuscular junction.


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(2)
(Total 11 marks)

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Q3.

Acetylcholine is a neurotransmitter which binds to postsynaptic membranes and stimulates


the production of nerve impulses. GABA is another neurotransmitter. It is produced by certain
neurones in the brain and spinal cord. GABA binds to postsynaptic membranes and inhibits the
production of nerve impulses. The diagram shows a synapse involving three neurones.

(a)

Describe the sequence of events leading to the release of acetylcholine and its binding to
the postsynaptic membrane.
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(4)

(b)

The binding of GABA to receptors on postsynaptic membranes causes negatively charged


chloride ions to enter postsynaptic neurones. Explain how this will inhibit transmission of
nerve impulses by postsynaptic neurones.
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(3)

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(c)

Epilepsy may result when there is increased neuronal activity in the brain.
(i)

One form of epilepsy is due to insufficient GABA. GABA is broken down on the
postsynaptic membrane by the enzyme GABA transaminase. Vigabatrin is a new
drug being used to treat this form of epilepsy. The drug has a similar molecular
structure to GABA. Suggest how Vigabatrin may be effective in treating this form of
epilepsy.
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(2)

(ii)

A different form of epilepsy has been linked to an abnormality in GABA receptors.


Suggest and explain how an abnormality in GABA receptors may result in epilepsy.
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(3)
(Total 12 marks)

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Q4.

The resting potential of a neurone is maintained by the unequal distribution of ions inside and
outside the plasma membrane. The diagram shows the plasma membrane of a neurone and the
three different proteins that are involved in maintaining the resting potential.

(a)

Protein C requires ATP to function. Describe the role of protein C.


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(2)

(b)

(i)

Proteins A and B differ from each other. Explain why different proteins are required
for the diffusion of different ions through the membrane.
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(2)

(ii)

The plasma membrane of the neurone is more permeable to potassium ions than to
sodium ions. Give the evidence from the diagram that supports this observation.
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(1)
(Total 5 marks)

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Q5.

(a)

Figure 1 shows part of a myofibril from skeletal muscle.

Figure 1
(i)

Describe two features, visible in the diagram, which show that the myofibril is
contracted.
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(2)

(ii)

Explain the role of calcium ions and ATP in bringing about contraction of a muscle
fibre.
Calcium ions ................................................................................
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ATP .....................................................................................................
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(3)

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(b)

Figure 2 shows the structure of a neuromuscular junction. The vesicles contain


acetylcholine.

Figure 2
(i)

An action potential is generated at the cell body of the motor neurone.


Explain how this action potential passes along the motor neurone to the
neuromuscular junction.
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(3)

(ii)

When the action potential arrives at the neuromuscular junction, it results in the
secretion of acetylcholine into the synaptic cleft. Explain how.
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(c)

Between the ages of 20 and 50, 10% of total muscle mass is lost. Between the ages of 50
and 80, a further 40% of the original total muscle mass is lost. Most of the muscle lost
consists of fast fibres.
(i)

Plot a graph on the grid below to show the percentage of muscle mass remaining
between the ages of 20 and 80. Assume that the rate of muscle loss in each age
range is constant.

(3)

(ii)

Explain why explosive exercises, such as sprinting and weightlifting, will be more
affected by this muscle loss than aerobic exercises, such as jogging.
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(1)
(Total 15 marks)

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Q6.

Secretion of neurotransmitters into a synaptic cleft may produce an action potential in a


postsynaptic neurone.
(i)

Explain how the release of acetylcholine at an excitatory synapse reduces the membrane
potential of the postsynaptic membrane.
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(2)

(ii)

Explain what causes transmission at a synapse to occur in only one direction.


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(2)

(iii)

GABA is a neurotransmitter which inhibits the production of action potentials.


The diagram and the graph show how the release of GABA from a presynaptic membrane
affects the membrane potential of a postsynaptic membrane.

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When the postsynaptic membrane is stimulated by acetylcholine, an action potential is


less likely if GABA is released at the same time. Explain why.
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(4)
(Total 8 marks)

Q7.

(a) The table shows the membrane potential of an axon at rest and during the different
phases of an action potential. Complete the table by writing in each box whether the
sodium ion (Na+) channels and potassium ion (K+) channels are open or closed.

Membrane
potential/mV

Resting

Starting to
depolarise

Repolarising

70

50

20

Na+ channels in
axon membrane
K+ channels in
axon membrane
(2)

(b)

Describe how the resting potential is established in an axon by the movement of ions
across the membrane.
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(2)

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(c)

Sodium and potassium ions can only cross the axon membrane through proteins.
Explain why.
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(2)
(Total 6 marks)

Q8.

(a) Figure 1 shows the changes in membrane potential at one point on an axon when an
action potential is generated.
Figure 1

The changes shown in Figure 1 are due to the movement of ions across the axon
membrane. Complete the table by giving the letter (A to D) that shows where each
process is occurring most rapidly.
Process

Letter

Active transport of sodium and potassium ions


Diffusion of sodium ions
Diffusion of potassium ions
(2)

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(b)

Figure 2 shows the relationship between axon diameter, myelination and the rate of
conduction of the nerve impulse in a cat (a mammal) and a lizard (a reptile).
Figure 2

(i)

Explain the effect of myelination on the rate of nerve impulse conduction.


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(2)

(ii)

For the same diameter of axon, the graph shows that the rate of conduction of the
nerve impulse in myelinated neurones in the cat is faster than that in the lizard.
Suggest an explanation for this.
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(2)

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Figure 3 shows how a stimulating electrode was used to change the potential difference across
an axon membrane. Two other electrodes, P and Q, were used to record any potential
difference produced after stimulation. The experiment was repeated six times, using a different
stimulus potential each time. In experiments 1 to 4, the stimulating voltage made the inside of the
axon less negative. In experiments 5 and 6, it made the inside of the axon more negative.
Figure 3

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(c)

Explain the results of experiments 1 to 4.


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(5)

(d)

Figure 4 shows two neurones, X and Y, which each have a synapse with neurone Z.
Figure 4

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Neurone X releases acetylcholine from its presynaptic vesicles. Neurone Y releases a


different neurotransmitter substance which allows chloride ions (Cl-) to enter neurone Z.
Use this information, and information from Figure 3, to explain how neurones X and Y
have an antagonistic effect on neurone Z.
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(4)
(Total 15 marks)

Q9.

The graph shows the electrical changes measured across the plasma membrane of an axon
during the passage of a single action potential.

(a)

Explain the shape of the curve


(i)

over the range labelled A;


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(ii)

over the range labelled B;


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(1)

(b)

Fewer action potentials occur along a myelinated axon than along an unmyelinated axon of
the same length. Explain why.
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(2)
(Total 5 marks)

Q10.

(a) Effectors bring about responses in the body. They are stimulated when neurones
secrete substances, called neurotransmitters, on to them.
(i)

Name the type of neurone that stimulates muscles.


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(1)

(ii)

Other than muscle tissue, name one type of tissue that acts as an effector.
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(1)

(b)

Substances, called hormones, can also stimulate effectors.


Humans produce a large number of different hormones but only a small number of
different neurotransmitters. Explain the significance of this difference.
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(3)
(Total 5 marks)

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Q11.

During an action potential, the permeability of the cell-surface membrane of an axon


changes. The graph shows changes in permeability of the membrane to sodium ions (Na+) and
to potassium ions (K+) during a single action potential.

(a)

Explain the shape of the curve for sodium ions between 0.5 ms and 0.7ms.
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(b)

During an action potential, the membrane potential rises to +40 mV and then falls. Use
information from the graph to explain the fall in membrane potential.
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(c)

After exercise, some ATP is used to re-establish the resting potential in axons. Explain
how the resting potential is re-established.
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(2)
(Total 8 marks)

Q12.

Essay
You should write your essay in continuous prose.
Your essay will be marked for its scientific accuracy.
It will also be marked for your selection of relevant material from different parts of the
specification and for the quality of your written communication.
The maximum number of marks that can be awarded is
Scientific
Breadth of knowledge
Relevance
Quality of written communication

16
3
3
3

Write an essay on the following topic:


A cycle is a biological pathway or process in which the end product of one cycle becomes the
starting point for the next cycle. Write an essay about cycles in biology.
(Total 25 marks)

Q13.

Different substances are involved in coordinating responses in animals.


(a)

Hormones are different from local chemical mediators such as histamine in the cells they
affect.
(i)

Describe how hormones are different in the cells they affect.


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(1)

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(ii)

Describe how hormones and local chemical mediators reach the cells they affect.
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(b)

Synapses are unidirectional. Explain how acetylcholine contributes to a synapse being


unidirectional.
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(c)

Cells in the stomach wall release gastric juice after a meal. The graph shows how the
volumes of gastric juice produced by nervous stimulation and by hormonal stimulation
change after a meal.

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(i)

Describe the evidence from the graph that curve A represents the volume of gastric
juice produced by nervous stimulation.
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(2)

(ii)

Complete the table to show the percentage of gastric juice produced by nervous
stimulation at the times shown.
Time after meal / hours
1

Percentage of gastric
juice produced by
nervous stimulation
(1)
(Total 8 marks)

Q14.

The black mamba is a poisonous snake. Its poison contains a toxin.


The table shows the base sequence of mRNA that codes for the first two amino acids of this
toxin.

Base sequence of anticodon on tRNA


Base sequence of mRNA

Base sequence of DNA


Complete the table to show
(a)

(i)

the base sequence of the anticodon on the first tRNA molecule that would bind to
this mRNA sequence
(1)

(ii)

the base sequence of the DNA from which this mRNA was transcribed.
(1)

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(b)

The length of the section of DNA that codes for the complete toxin is longer than the
mRNA used for translation. Explain why.
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(1)

(c)

A mutation in the base sequence of the DNA that codes for the toxin would change the
base sequence of the mRNA.
Explain how a change in the base sequence of the mRNA could lead to a change in the
tertiary structure of the toxin.
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(1)

(d)

The black mambas toxin kills prey by preventing their breathing. It does this by inhibiting
the enzyme acetylcholinesterase at neuromuscular junctions. Explain how this prevents
breathing.
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(Total 7 marks)

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Q15.

Serotonin is a neurotransmitter released in some synapses in the brain. It is transported


back out of the synaptic gap by a transport protein in the pre-synaptic membrane.
(a)

Serotonin diffuses across the synaptic gap and binds to a receptor on the post-synaptic
membrane.
Describe how this causes depolarisation of the post-synaptic membrane.
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(b)

It is important that a neurotransmitter such as serotonin is transported back out of


synapses. Explain why.
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(c)

Scientists investigated the effect of a drug called MDMA on movement of mice. They
measured the amount of movement of three groups of mice, K, L and M.

Group K, mice not given MDMA.

Group L, mice given MDMA.

Group M, mutant mice that did not produce a serotonin receptor on their
post-synaptic membranes and were given MDMA.

The graph shows their results.

The scientists concluded that MDMA affects movement by binding to serotonin receptors.
How do these results support this conclusion?
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(3)
(Total 7 marks)

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Q16.

The release of a substance called dopamine in some areas of the brain increases the
desire to eat.
Scientists measured increases in the release of dopamine in the brains of rats given different
concentrations of sucrose solution to drink.
Sucrose stimulates taste receptors on the tongue.
The graph shows their results. Each point is the result for one rat.

(a)

The scientists concluded that drinking a sucrose solution had a positive feedback effect on
the rats desire to eat.
How do these data support this conclusion?
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(b)

In this investigation, the higher the concentration of sucrose in a rats mouth, the higher the
frequency of nerve impulses from each taste receptor to the brain.
If rats are given very high concentrations of sucrose solution to drink, the refractory period
makes it impossible for information about the differences in concentration to reach the
brain. Explain why.
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(2)

(c)

In humans, when the stomach starts to become full of food, receptors in the wall of the
stomach are stimulated. This leads to negative feedback on the desire to eat. Suggest why
this negative feedback is important.
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(Total 8 marks)

Q17.

(a) A myelinated axon conducts impulses faster than a non-myelinated axon.


Explain this difference.
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(3)

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Doctors investigated the relationship between myelin in brain tissue and different types of
dementia. All types of dementia involve loss of mental ability.
The doctors measured the mean amount of myelin in samples of brain tissue from:

a control group of 12 people without dementia

20 people with vascular dementia (VaD)

19 people with Alzheimer's dementia (AD)

31 people with Lewy body dementia (LD).

The doctors results are shown in the figure. The vertical bars show standard errors.

Group of people
(b)

The doctors used a statistical test to compare the results for AD and LD.
They obtained a value for P of 0.047.
What does this result show about the difference between the means for AD and LD?
Use the words probability and chance in your answer.
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(2)

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(c)

A student who read this investigation concluded that there was a relationship between the
amount of myelin in a persons brain and whether or not they had dementia.
Do these data support this conclusion? Give reasons for your answer.
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(4)
(Total 9 marks)

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