1THRASHER RESEARCH FUND CONCEPT PAPER

(Please see our website for current emphasis of what we fund and do not fund.
Instructions are written in italics and should be deleted prior to submission. The
completed form should be returned as a Word document in an e-mail attachment
to MartinezAF@ThrasherResearch.org)
Title: (limit to 100 characters, including spaces)
Principal Investigator: (include degrees)
Information for Principal Investigator
Academic Position/Title:
Phone:
Email:
Website: (if applicable)
Mailing Address:
Co-Principal Investigators: (include degrees)
Length of Study: (maximum 3 years)
Total Budget: (if a full proposal is invited, the proposal budget should be
consistent with the budget amount proposed here - all exceptions must be
cleared by the Fund)
Supervising Institution:
Project Site(s):

SCIENTIFIC SUMMARY

The Scientific Summary should be limited to one page using 11 point Calibri or Arial font
and .75 inch margins all around. References are not required or expected. If the applicant
feels that a reference is necessary, it should be included within the one page limit, either
embedded in the text or inserted at the bottom.
Background:
Give a brief general overview of the significance of the problem to childrens health.
Estimate the incidence/prevalence of the problem, being specific to the sub-population
that might benefit from the research. Include a brief evaluation of previous research,
existing knowledge or clinical practice, and include any additional background information
indicating the rationale for the proposed research. Specifically identify the research gap(s)
the project is intended to address. Include any preliminary data that may support the
hypotheses.
Hypothesis(es) and Aims:
State each hypothesis in a single sentence. Briefly describe the related aims.
Design:
Describe how the study will be carried out. Specifically State the design of the study (e.g.
randomized controlled trial, case-control, prospective cohort, cross sectional etc).
As applicable, include the following information (can be in paragraph form rather than a
numbered list):
1. Study subjects, including major inclusion/exclusion criteria
2. Sample size and resulting power(if there is not a calculated sample size,
state this and justify)
3. Other sample material to be used in the study
4. State the primary outcomes and how they will be measured
Potential Impact:
Discuss where the research is leading, in what ways and in how many years the findings
might potentially influence the prevention, diagnosis and/or treatment of the particular
medical problem in children.

STRUCTURED SUMMARY

The Structured Summary should be limited to one page using 11 point Calibri or Arial font
and .75 inch margins all around. Limit each response to a single sentence unless
otherwise noted. The purpose of the Structured Summary is to consolidate key elements
of the Scientific Summary in an easily referenced list. It is acceptable to copy and paste
relevant information directly from the Scientific Summary, although if the description is
technical, the language can be simplified in this summary for scientifically educated
readers who may not have expertise in the particular topical area.
Describe the medical problem as it relates to children

State the incidence/prevalence of problem in children

Background that will lead to the research gap (may use 2 sentences)

State the primary research gap this study will address

Hypotheses (one sentence per hypothesis)

Specific Aims (one sentence per aim, maximum 3 for the lay summary)

Study design

Describe study population or sample material

Sample size/power of primary endpoint

Assuming the project is successful, state the next step moving down the pathway to
clinical applicability