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Abstract:
Introduction:. Acneiform eruption is a group of dermatoses characterised by
papules, pustules, nodules, cysts, or papulopustules resembling acne that clinically
lacks comedones. The report describes a case of acneiform eruption in a young
woman that showed significant improvements following several acne treatment
regiments.
Case Report
a 21 year-old young woman presented complaints of severe, pus-filled multiple
small bumps resembling acne that had quickly covered her face and neck. Careful
history taking revealed that the patient was a long-term consumer of diet pills.
Further examinations combined with anamnesis established the diagnosis of druginduced acneiform eruptions, specifically due to fad diet pills. A treatment
regiment consisting of oral doxycycline 100 mg 2x1, a topical gel containing
benzoyl peroxide 5% and clindamycin phosphate 1.2%, a topical lotion containing
70% alcohol, propylene glycol, zinc oxide, precipitated sulphur 6%, resorcinol
15%, and camphor to be used twice or three times daily, acne facial wash, and an
SPF 30 sunscreen lotion as well as cessation of diet pill consumption had
successfully improved her conditions. Subsequent therapy removed the antibiotic
and benzoyl peroxide still resulted in marked improvements, reaching a stable
state with some residual symptomatology.
Discussion
The diagnosis of was based on anamnesis, clinical manifestation and
histopathologic findings relevant to acneiform eruptions. The significant
alleviation of symptoms following the treatment as well as cessation of triggering
factor underlined the importance of proper diagnosis and management for patients
with persistent dermatologic conditions.
Keywords: acneiform eruption, drug-induced, diet pills
INTRODUCTION
Acneiform eruptions are a group of dermatoses that resemble acne
vulgaris. Lesions may consist of papules, nodules, pustules, papulopustules, or
cysts that lack comedones, contrasting this disorder from acne vulgaris. Being a
group of dermatoses, acneiform eruptions can appear due to infections, hormonal
or metabolic abnormalities, genetic disorders, and drug reactions. As the name
indicates, acneiform eruptions present with acnelike lesions. However, the lack of
comedones is a distinguishing factor. The lesions may localise outside of the area
in which acne vulgaris occurs. Acneiform eruptions can also be distinguished
from acne vulgaris by a history of sudden onset, monotonous lesion morphology,
and eruption development at an age outside the range typical of acne vulgaris. In
the case of drug-induced acneiform eruptions, the eruption resolves with
discontinuation of the medication 1.
A prominent dermatology textbook had listed steroid folliculitis, druginduced acne, occupational acne and chloracne, epidermal growth factor receptor
inhibitor-associated eruption, gram negative folliculitis, radiation acne, tropical
acne, acne aestivalis, pseudoacne of the nasal crease, and apert syndrome amongst
the possible entities 2, whereas other sources had included nevus comedonicus,
eruptive hair cysts, tuberous sclerosis
3, 4
5, 6
CASE REPORT
A 21 year-old young woman visited the dermatovenereology outpatient
clinic of Saiful Anwar General Hospital (RSSA) on the 25th of February 2016
complaining of severe, pus-filled multiple small bumps resembling acne that had
quickly covered her face since the day before the visit. It started to develop two
days ago after she took an over-the-counter cold medication that contained
phenylpropanolamine hydrochloride, chlorpheniramine maleate, and paracetamol.
When asked, she revealed that her acne-like condition had actually persisted for
three years. However, since the last month the disorder had significantly worsened
until acne-like lesions covered the whole facial surface area. The patient denied
consuming any drugs either orally or topically except a regiment of fad diet
pills, which she had been consuming for the past 7 months until then. Last year,
the patient visited a dermatovenereologist as a result of the same complaint. She
received oral clindamycin and topical desoxymethasone, which she consumed
without showing any significant improvements. Therefore, she decided to stop the
usage. She noticed that her lesions worsened during her menstrual period. Both of
her parents had also suffered from severe, untreated acne-like conditions.
General physical examination revealed that she was compos mentis, looked
generally well, blood pressure 120/90, pulse rate 68 times per minute, respiratory
rate 18 times per minute, and the body temperature was 37.0C. There were no
sign of anaemia, cyanotis, icterus, hyperemia and secret on conjunctiva and there
were no enlargement of lymphnodes. The heart and lungs were within normal
limits and there were no abnormalities on abdominal examination. Her extremities
were also within normal limit and there was no edema.
Dermatological examination showed multiple small pustules 0.1 cm in
diameter with erythematous base. Some joined to form multiple plaques. The
lesions were localised on the face and neck, evenly distributed. No comedones or
hyperkeratotic plugs were observed (Figures 1-4).
Figure 5. Microscopic examination of a lesion sample revealed mixed inflammatory inflitrates and
debris among oedematous cells, suggesting conspicuous superficial dermal inflammation. Neither
bacteria, mites, hyphae, nor keratotic plugs were observed
What remained from the past lesions were multiple erythematous plaque with
unclear definition. The size varied from 1-10 cm, with and without papules and
pustules on top Figures 6 - 9 .
improvement
neck
Figure 12. Further improvements on the second follow-up visit (Lateral View)
The patient came again for the final follow-up visit on the 4th of March 2016,
complimenting the progress of her improvements. Dermatological examination
was performed and revealing localised lesions on the face, which consisted of
erythematous plaque with several various sized papules and pustules (Figures 1012). The same therapy as the previous visit which consisted of topical clindamycin
phosphate 1.2% gel twice daily, lotion containing 70% alcohol, propylene glycol,
zinc oxide, precipitated sulphur 6%, resorcinol 15%, once at night times, and acne
facial wash was therefore given.
DISCUSSION
Acneiform eruptions are a group of dermatoses that resemble acne vulgaris.
Lesions may consist of papules, nodules, pustules, papulopustules, or cysts that
lack comedones, contrasting this disorder from acne vulgaris 2. The patient visited
the dermatovenereology outpatient clinic of Saiful Anwar General Hospital
(RSSA) on the 25th of February 2016 complaining of severe, pus-filled multiple
small bumps resembling acne covered her face. Dermatological examination
showed multiple small pustules 0.1 cm in diameter with erythematous base. Some
joined to form multiple plaques. The lesions were localised on the face and neck,
evenly distributed. No comedones or hyperkeratotic plugs were observed.
Therefore, the patient was diagnosed as having acneiform eruptions.
Being a group of dermatoses, acneiform eruptions can appear due to
infections, hormonal or metabolic abnormalities, genetic disorders, and drug
reactions. Steroid folliculitis appeared after systemic glucocorticoids or
corticotropin administration and observed as monomorphous small pustules and
red papules located predominantly on the trunk and extremities, with less
involvement of the face. Topical or inhaled corticosteroids may cause an
acneiform eruption of the area of skin under which the topical preparation is
applied or in around the nose or mouth in the case of inhaled steroids. The
eruption usually resolves after discontinuation of the steroid and, in addition, may
respond to the usual treatments of acne vulgaris such as topical retinoids and
antibiotics
2, 7
. This does not match the history taking from the patient which
claimed that she hand not been taking medications. The dermatological
examinations also did not match the aforementioned description of the lesions.
Therefore, the acneiform eruption in this patient is not due to steroid folliculitis.
Occupational acne and chloracne are induced by industrial compounds
encountered in the workplace, which may include coal tar derivatives, insoluble
cutting oils, and chlorinated hydrocarbons (chlornaphtalenes, chlordiphenyls, and
chlordiphenyloxides)
Exposure
to
halogenated
aromatic
hydrocarbon
1, 8
. This
does not match the history taking from the patient, as she had not been exposed to
the industrial chemicals. The dermatological examinations also did not match the
aforementioned description of the lesions as her condition lacked comedones and
cysts.
Gram-negative folliculitis sometimes occurs in individuals with preexisting acne vulgaris, which receives long-term oral antibiotics treatments,
especially the tetracyclines. It may appear as either papulopustules concentrated
around the nose or as deep-seated nodules. Enterobacter, Klebsiella, or
Escherichia may be revealed in papulo-pustular lesions, while Proteus is more
dominant in the nodules. Antibiotics against Gram-negative bacteria may be
employed as a treatment approach. Oral isotretinoin for 4 to 5 months have been
proven beneficial for recalcitrant cases. Sometimes, an oral cephalosporin in
combination with isotretinoin may be given for 2 weeks
2, 9
deep, large, inflammatory nodules with several draining areas not unlike acne
conglobata distributed chiefly on the trunk and buttocks. The treatment is by
removing the patient to a cooler environment and systemic antibiotics for
secondary coagulase-positive staphylococci infection that almost always ensues
2,
10, 11
. Again, despite the fact that the patient lived in a tropical country, her
dermatological examinations did not match the lesion description. Not only that
the lesions are distributed evenly on her face and neck, the manifestation also
lacked comedones.
Acne aestivalis occurs due to the effect of UV radiation, primarily
ulatraviolet A. It is mainly developed in women aged 20-30 years old. Pseudoacne
of the nasal crease develops as acneiform red papules within the nasal crease
along with milia. On the other hand, a condition called Apert syndrome is an
autosomal dominant disorder with acrocephalosyndactyly. Perioral dermatitis is an
inflammatory and chronic papulopustular and vesicular eruptions on the perioral
area, whilst Malassezia folliculitis is caused by overgrowth of Malassezia yeasts
11
. Unlike acne vulgaris, it is pruritic, does not contain comedones, and responds
13
dermatological examination suggested that the patient did not suffer from these
conditions. Moreover, hyphae were not found upon microscopic examination.
The eruptive vellus hair cysts manifest as flesh-colored papules found
usually on the face, chest, neck, thighs, groin, buttocks, and axillae and
representing
vellus
hair
follicle
anomaly,
which
may
be
hereditary.
14,
15
. The patient did not show vellus hair anomaly. Therefore, her condition must be
16
18
Despite the fact that no further tests were employed to eliminate these differential
causes, it is highly unlikely that the patient suffered from either condition. Both
conditions should also come with other sign and symptoms, which were negative
in the patient.
Rosacea appears similarly to acne vulgaris with papulopustules on the
face, but in addition, patients may also have facial flushing and telangiectasias.
Four subtypes of rosacea exist: (1) erythematotelangiectatic, (2) papulopustular,
(3) phymatous, and (4) ocular. Rosaea is more common in the white population
and in women in the third and fourth decades of life. Men, however, more
commonly develop sebaceous hyperplasia of the nose, known as rhinophyma.
Although the definitive etiology is unknown, weather extremes, hot or spicy
foods, alcohol, and Demodex folliculorum mites can trigger and exacerbate this
condition. Acne rosacea has also been associated with the ingestion of a high-dose
vitamin B6 supplement. Treatment primarily includes skin barrier sunscreens and
topical antibiotics such as metronidazole, retinoids, and oral tetracyclines 2. Signs
of rosacea were absent in this patient. There was no telangiectasia, Demodex
finding, amongst other things. Therefore, this cause could be easily excluded.
Perioral dermatitis is mainly observed in the young, white, female
population as papulopustules with erythematous base. The condition has an
unclear aetiology. The eruption is predominantly perioral in location,
characteristically sparing the vermilion border of the lip, but it may also include
the perinasal and periorbital areas. Periocular dermatitis is a variant of this
condition and affects the skin around the eyes. The eruption is thought to be a
variant of rosacea, as biopsies show changes similar to those of rosacea. Therapy
typically includes cessation of topical steroids or other offending agents and
topical anti-inflammatory treatments such as topical metronidazole, topical
pimecrolimus cream, azelaic acid, as well as oral anti-inflammatory dose
antibiotics such as doxycycline
1, 2
the patient as her lesions were spread widely over her face and neck. Therefore,
another cause should be considered.
Epidermal growth factor receptor inhibitors (EGFR inhibitors) are used
mainly to treat non-small cell lung cancer, colorectal cancer, and breast cancer.
They include gefitinib, cetuximab, erlotinib, and trastuzumab. The lesions due to
EGFR inhibitors appear as perifollicular papulopustular eruption distributed on
the face and upper torso. This occurs in up to 86% patients. Interestingly, the
presence and severity of the lesion correlate with a positive treatment response.
Therefore, without eruption, dosing may not be enough or the tumour is
unresponsive to the therapy
2, 19, 20
currently taking any EGFR inhibitors. Therefore, this cause could be easily
excluded.
Drug-induced acne is a condition not dissimilar to steroid folliculitis and
may be caused by halogenated compounds containing bromides or iodides
commonly found in cold and asthma medication. Kelp that presents in many fad
diet pills, and other vitamin-mineral combinations are also amongst the most
common cause in young women
2, 21, 22
and other halogens can also induce an acneiform eruption similar to that of steroid
acne; however, the iodide-induced eruption may be more extreme. Antibiotics
may induce an acute generalized pustular eruption. Penicillins and macrolides are
the greatest offenders. Patients usually are febrile with leukocytosis, and the
eruption does not usually involve comedones. Other implicated antibiotics include
co-trimoxazole, doxycycline, ofloxacin, and chloramphenicol. Other types of
medications can also produce an acnelike eruption, including corticotropin,
nystatin, isoniazid, itraconazole, hydroxychloroquine, naproxen, mercury,
amineptine 23, the antipsychotics olanzapine and lithium, chemotherapy drugs, and
epidermal growth factor receptor inhibitors (EGFR inhibitors) 1, 8, 24. History taking
matched the description for drug-induced acneiform eruptions. The patient had
been using fad diet pills for a prolonged period, and cessation of consumption did
help improve her lesions. Dermatological examinations also revealed relevant
findings, with pustular eruption localised on face and neck without the presence of
comedones. Therefore, it could be deducted that the patient's condition was due to
the kelp-containing fad diet pills consumption.
The goals of pharmacotherapy in acneiform eruptions are to reduce
inflammation, eliminate infection if present, reduce morbidity, and prevent
complications
1, 8, 21
antifungals can be used. The use of topical agents has few adverse effects besides
an allergic reaction to the active agent or inactive component. The mechanism of
action usually involves the inhibition of pathways (eg, enzyme, substrate,
transport) that are necessary for sterol and/or cell membrane synthesis, or the
permeability of the cell membrane (polyenes) of the fungal cell is altered. For this
purpose, ciclopirox, econazole, or ketoconazole are especially useful
12
. As the
patient did not suffer from fungal infection, antifungal treatments were not
included within the treatment regiments.
Because the aetiology and the pathogenesis of acneiform eruptions have
not been fully elucidated, no established treatment schemes exist. A number of
options have been tried with various results; however, no controlled treatment
trials have been performed for this condition. Oral indomethacin consistently
appears to be most beneficial, at least in the classic form of the eosinophilic
pustular folliculitis. First generation antihistamines such as cyproheptadine and
hydroxyzine may alleviate itching in some HIV-associated cases of eosinophilic
pustular folliculitis. For nocturnal pruritus, sedating forms may be more effective
16
16, 25
SUMMARY
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