Professional Documents
Culture Documents
DISCUSSIONS
PHARMACODYNAMICS
1) Define ;
Potency
Mechanisms by which drugs act
Tachyphylaxis
2) Define ;
Antagonist
Receptor regulation
Receptor selectivity
3) Define;
Dose response curve
Therapeutic efficacy
Therapeutic index
Tolerance
PHARMACOKINETICS
1)Bio availability
2)1st order Kinetics
3)Zero order kinetics
4)Loading dose
5)Steady state concentration
6)Plasma life
7)Apparent volume of distribution.
8)Clearance
(b)State the precautions and advices that you would take and
give at the administration of Bisphosphanates.
(c) What other drugs are available for the treatment of
osteoporosis?
(d)Describe the pharmacological basis of using calcitriol in a
patient with chronic renal failure.
1) (a) Describe the mode of action, clinical uses and A/E of Tetracyclines.
(b) What is the advantage of using Doxycycline instead of using
Tetracycline in a patient with renal impairment?
2)(a) Describe the mechanism of action of Macrolides.
(b)Describe the different types of Macrolides.
(c) Describe the significant drug interactions of Macrolides.
3)(a) List the conditions for which Erythromycin is used as a drug of choice.
(b)Describe the mechanism of action of chloramphenicol.
(c)Describe the mechanism of action of sulfonamide.
4)(a) What is the sulfonamide and Trimethoprim combination.
(b) Write the clinical uses of this combination.
ANTIMICROBIALS(ANTI-MYCOBACTERIALS)
1)(a) A 25 year old unmarried woman is found to have Pulmonary T. State the
drug regime for this patient and describe the pharmacological basis for using
the drugs that you have mentioned.
(b) Discuss the problems that may arise during the treatment.
2)Describe the drug regime for;
(a) Pausi Bacillary leprosy.
(b)Multi bacillary leprosy.
ANTIMICROBIALS ( ANTI-MALARIALS)
1) Describe the drug treatment for uncomplicated plasmodium vivax
infection.
2) Describe the mechanism of action of the drugs mentioned in 1).
3) Outline the treatment of severe malaria.
4) What are the indications to use quartem or ACT and what
precaution
would you take when prescribing quartem?
ANTIMICROBIALS (ANTI-HELMINTHICS)
1) Write the names of the drugs its mechanism of action for the following
conditions;
(a) Mixed worm infections.
3) Name the drugs that can be used for a diabetic patient with renal
impairment.
ADRENAL STEROIDS
1) A 15 year old girl, with non-minimal change nephrotic
syndrome was prescribed high dose steroids for more than
2 weeks.
(a) Describe the mechanism of action of
corticosteroids.
(b)What advice would you give her on her use of
steroids?
(c) What precautions would you take when prescribing
steroids?
2) (a) List some other uses of steroids.
(b) Name the corticosteroid preparations that are used
clinically and their methods of administration.
3)A patient on high dose of steroids is admitted to your ward on
appendectomy. State your management?
ANTICONVULSANTS
1) (a) A 15 year old girl was diagnosed with grand-mal epilepsy. Name a
drug that could be prescribed for this patient & explain your reasons
for selecting this drug.
(b) Describe the pharmacokinetic properties of Phenytoin.
(c)Describe the A/E of Carbamazepine.
2) A young female epileptic patient who wishes to become pregnant
seeks medical advice. Discuss how you would advise this patient.