CHAPTER 1: Introduction to Laboratory Animal Medicine

1. The government agency that oversease the use of animals in an educational

or research istitution is the
USDA
United states department of agricultrure
2. The guide for the care and use of laboratory animals is published by the
NIH
National Institute of Health
3. the institutional group charged with evaluation of animal use and inspection
of facilities is
IACUC
Institutional animal care and use committee
4. the group that provides voluntary accrediation of biomedical research
facilities is
AAALAC
Association for assessment and accredidation for lab animal care
5. Research directed toward specific objectives such as development of new
drugs is referred to
Applied research
6. The use of procedures that cause the least amount of stress pain anxiety and
disturbance of normal life to the animal is an example of
Refinement
7. The use of fish or plants in basic research is an example of
Replacement

8. Vets who have reached the highest degree of proficiency in lab animal
medicine are board certified by
ACLAM
American college of lab animal medicine
9. Name the minimum membership of an IACUC

1 Vet with training and experience in lab animal medicine

1 person who has no affiliation
10.Name the 2 most active animal liberation groups in the United states
People for ethical treatment of animals PETA and the animal liberation front ALF

CHAPTER 2: The Research Environment

1. A biomedical facility designed for housing of germ-free animals is referred to
as a ________ facility.
barrier
2. Define microenvironment.
The temperature, humidity, lighting & ventilation in the area immediately
surrounding an animal.
3. Define thermo neutral zone.
The temperature range is which an animal does not need physical or chemical
mechanisms to control heat production or heat loss.
4. Animal rooms must have a minimum of ______ room air changes per hour.
10-15
5. Which type of room should be under negative air pressure?
Infectious ward
6. A diurnal lighting system is one that used _____ hours of light followed by
_____ hours of darkness.
12; 12
7. A type of plastic used for cages that is transparent & has high impact
strength & resistance to high heat & chemicals is ______.
polycarbonate
8. The study of animals with completely known flora & fauna is referred to as
________.
gnotobiology

9. Animals that are known to be free of certain pathogens are referred to as

__________.
specific pathogen free
10.Animal kept in animal rooms & experimental areas that undergo periodic
testing to identify the presence of any microorganisms in the animal colonies
are referred to as _________.
Sentinel animals
CHAPTER 3: The Rat
1. The scientific name of the most common species of laboratory rat is
______________.
rattus norgevis
2. In rats, secretions from the harderian gland are commonly referred to as
_________.
red tears
3. What physiologic feature makes the rat useful as a model for toxicology
studies?
The inability to vomit
4. Animals that are produced as a result of random matings are referred to as
______.
Outbred, or stocks
5. When 20 or more generations of brother-sister or parent-offspring mating
has occurred, the offspring are referred to as __________.
Inbred, or strains
6. An animal with a hole punch at the middle of the left ear and a notch at the
bottom of the right ear is designated with the number _____.
26
7. An appropriately sized needle to use for collection of blood from the lateral
tail vein of a rat is _______.
22g
8. Tyzzer's disease is caused by _______________.

Bacillus Piliformis
9. The most common respiratory disease of rats is ___________.
Murine respiratory mycoplasmosis
10. A parasite of rats that has significant zoonotic potential is _________.
Hymenolepis nana

CHPTER 4: The Mouse

1. The taxonomic name for the laboratory mouse is ________.
Mus musculus. Most widely used research animal.
2. The ready availability of well-characterized inbred strains of mice make
them good animal models for research in _____________.
tissue histocompatibility.
3. Timed mating of large groups of female mice is possible because of the
____ effect.
Whitten effect
4. Common methods to assess anesthetic depth in mice include ________ and
________.
Movement of the whiskers and ears in response to a puff of air. This indicates
minimal sedation.
Failure to withdraw a foot or tail in response to a pinch. This indicates surgical
anesthesia.
5. The recommended site for blood collection in the mouse is the _________.
retroorbital sinus
6. The causative agent of the disease syndrome known as transmissible
murine colonic hyperplasia is _______________.
gram-negative bacterium Citrobacter freundii (biotype 4280)
7. The primary causative agent of viral respiratory disease in mice is ________.
Sendai virus

8. Natural infection with the zoonotic virus that causes ______ is nearly 100%
in wild mouse populations.
lymphocytic choriomeningitis virus
9. Evidence of nonpruritic alopecia in mice housed in groups is most likely the
result of _______.
Barbering; in which the dominant male chews the facial hair and whiskers of his
cagemates.
10. Acceptable methods of euthanasia for mice include ______ and ________.
CO2 chamber and injectable barbiturate overdose.