+

Compartmental Model for Chlamydia, a Sexually

Transmitted Disease

Figueroa-Monsanto, Hctor L.1

Pedrogo-Flores, Leonardo2
Cruz-Aponte, Mayte3
Department of Chemistry1, Department of Natural Sciences2, and
Department of Mathematics-Physics3
University of Puerto Rico at Cayey

Biological Disease: Chlamydia

Bacterium: Chlamydia trachomatis

Chlamydia is the most common sexually transmitted

disease (STD) in the world (Siam, 2012)

Transmission:
Direct contact with any infected area of the
Child Birth

Incubation period: 5 - 21 days

Treatment: Antibiotics

www.allposters.com

Disease Symptoms

Females
Blood flow between periods
Pain: periods, sex, abdomen, and urination
Vagina itch

Males
Pain: testicles and urination
Penis: swelling, pain, burn, itch, and transparent discharge
Urethritis: 55%
Recovered people could be susceptible again.

First Research Question

What

is the behavior of the model on a

bigger scale?

Bigger scale population dynamic of disease spreading.

How important is Chlamydia in our community?

Future Research Question

What

is the behavior of the disease in a

lower scale?

Lower scale on a cellular level within the host using

compartments for the progression of the incubation.

Can our model be more precise using equations that

better model the incubation period?

Purpose
By

this we intend to develop a much more

precise model that simulates the disease at
its best and contributes in a better scale to
the scientific community.

Better

define the behavior of the chlamydia

disease on a lower scale.

Schematic of disease dynamics:

Mathematical Model

S
SI/N

E
E

I
I

Schematic of disease dynamics:

Parameters
Parameter

1/
1/

Description

Range/Value

References

67%

Potterat (1999)

Incubation Period

5 - 21 days

http://www.antimicrobe.org/m04.asp

Days of Recovery if

7 days with

http://www.cdc.gov/std/treatment/2010

treated

treatment

/chlamydial-infections.htm

Probability of obtaining
the bacteria

# days after recovery

1/

that the person waits to

be sexually active again

7 days

http://www.cdc.gov/std/treatment/2010
/chlamydial-infections.htm

Results: Chlamydia Disease Trend

Mathematical Analysis

Equilibrium points:

+ =

= 0

= 0 =

+ =0

=0

Free Equilibrium , 0,0,0 "Trivial Solution

Unstable

Endemic

= 0 =

Disease

Stable

Equilibrium

, , ,

, 0

Results
Using

the endemic equilibrium point

and the fact that our population is constant:

Infected

Individuals at the endemic stage:

Range:
Between 16% 29%
of the population.

Endemic Equilibrium Point

Solving for I we established the general equation:

+ +

The specific case of our scenario:

1
= 1
.67(7)

1
7

1
1
+2
49
7

Varying our incubation period (5,15, 21) days:

1
.67(7)

5 = 1

15 = 1

21 = 1 .67(7)

1
.67(7)
1

1
7(5)

= 0.29

1
1
+2
49
7(5)
1
7(15)
1
1
+27(15)
49
1
7(21)
1
1
+2
49
7(21)

= 0.19
= 0.16

Endemic Equilibrium Point Graph

Graphical perturbation and

stability of the equilibrium point.

R0

Basic Reproductive Number

(Using the Next Genertation Operator)

0
= =
0
0

R0=

0
0 0

R0= = 7(.67)= 4.69

0
1

0
1

= 1

0
1

Basic Reproductive Number For

Known Diseases

Future Work
Develop

and agent-base model for a given

population.

Modify

schematic model by inserting new

equations that specify on the behavior of
the disease during its period of incubation.

Bibliography

Al-Mously N, Eley A. 2015. Transient exposure to Chlamydia

trachomatis can induce alteration of sperm function which cannot be
stopped by sperm washing. Middle East Fertility Society Journal 20,
48-53. doi:10.1016/j.mefs.2014.04.003.

Borges V, Gomes JP. 2015. Deep comparative genomics among

Chlamydia trachomatis lymphogranuloma venereum isolates
highlights genes potentially involved in pathoadaptation. Infection,
genetics and Evolution 32, 74-88. doi:10.1016/j.meegid.2015.02.026.

De Borborema-Alfaia APB, de Lima Freitas NS, Filho SA, BorboremaSantos CM. 2013. Chlamydia trachomatis infection in a simple of
northern Brazilian pregnant women: prevalence and prenatal
importance.
Braz
J
Infect
Dis
17(5):545-550.
doi:10.1016/j.bjid.2013.01.014.

Departamento de Salud. 2012. Datos de Puerto Rico.

http://www.estadisticas.gobierno.pr/iepr/LinkClick.aspx?fileticket
=RVOVIk8ka1A%3D&tabid=186.

Bibliography

Knittler MR, Berndt A, Bcker S, Dutow P, Hnel F, Heuer D,

Kgebein D, Klos A, Koch S, Liebler-Tenorio E, Ostermann C,
Reinhold P, Saluz HP, Schfl G, Sehnert P, Sachse K. 2014.
Chlamydia psittaci: New insights into genomic diversity, clinical
pathology, host-pathogen interaction and anti-bacterial
immunity. International Journal of Medical Microbiology 304,
877-893. doi:10.1016/j.ijmm.2014.06.010.

Occhionero M, Paniccia L, Pedersen D, Rossi G, Mazzucchini H,

Entrocassi A, Vaulet LG, Gualtieri V, Fermepin MR. 2015.
Prevalencia de la infeccin por Chlamydia trachomatis y factores
de riesgo de infecciones transmisibles sexualmente en
estudiantes universitarios. Rev Argent Microbiol 47(1): 9-16.
doi:10.1016/j.ram.2014.11.003.

Siam EM, Hefzy EM. 2012. The relationship between antisperm

antibodies prevalence and genital Chlamydia trachomatis infection
in women with unexplained infertility. Middle East fertility Society
Journal (2012) 17, 93-100. doi:10.1016/j.mefs.2011.09.003.

Acknowledgments

Mentors:
Dr. Mayte

Cruz-Aponte
Danilo Prez-Rivera