Professional Documents
Culture Documents
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Dioscorides I century. AD
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Historical Historical
According to Berry (1984)
Traditional Traditional
Feverfew flowers: they are used as a
subtitute of Chamomile in case of L’Antonelli (1941) says that “all the plant is tonic, febrifuge,
dysmenorrhea, and disorder of female stimulant, antispasmodic, emmenagogue and antiflatulent” , he
cycle. Cataplams made with the infusion of says that it was very well known to the old physicians. The
flowers are used in case of contusion/bruise, flowers are used both fresh or dried, particularly in case of
dysmenorrhea.
and skin ulcers (Negri, 1979)
Dosage: herbal tea made with 4-16g/L, 3-4 glasses during the
morning, during the 4-5 days of the menstrual cycle.
The flowers are the part used in case of
aerophagia, headache, dysmenorrhea,
dispepsia... Antonelli G 1941. Le Piante che ridanno la salute. Edizione
Planta Medica, copia anastatica della III edizione "Riveduta ed
aumentata" del 1941.
Dosage: powder, 2-5 g/die; tincture,
30-60gtt, 3-5 times daily (Palma 1964).
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Traditional Modern-traditional
(Experience Based Phytotherapy- EBP)
2.
1. A. In prophylaxis of migraine
American Indian Mahuna used Used in case of: B. As symptomatic antinflammatory/painkiller
Headache,
Feverfew internally as
Dysmenorrhea,
antirheumatic. Rheumatic disorders
Moermann (1998)
3.
As a symptomatic the
Dosage is quite high
(around 2g/die of drug)
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• Variety
Costonulide
Parthenolide • Harvesting time
Santin
Centaureidin
Apigenin
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The activity of Parthenolide is 1/24 of the activity of an extract 3,6,4’ trimethylether (Centaureidin) ++ +++ +
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NF-kB
• Recently (Wu et al., 2007)
Parthenolide
Flavonoids
indentified different
iNOS dicaffeoylchinic acids
(inducible nitric oxide
synthase with elevated antioxidant
Inhibition of synovial action.
Fibroblast proliferation
(Parada-Turska et al., 2008)
Direct inhibition
Inhibition of agrecan Of COX-2 and
catabolism induced by TNF-α. Lypoxygenase
(in vitro chondrocyte
Osteoarthritis model)
(Zhonghua Yi Xue Za Zhi. 2008
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Sur R, Martin K, Liebel F, Lyte P, Shapiro S, Southall M. 2009. Anti-inflammatory activity of parthenolide-depleted
Feverfew (Tanacetum parthenium). Inflammopharmacology. Feb;17(1):42-9.
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“The mean daily dose of feverfew used by patients before entry to the • Up to 1800g/die (starting at the first sign of migraine)
Mitchell WA. 2003. Plant medicine in practice. Churchill Livingstone
study was 2.44 leaves (roughly 60mg). We therefore decided that
the dose of each capsule should be fixed at 25 mg and that each • “ …higher doses of up to 2g/day may be required for acute treatment of
patient should receive two capsules daily.” migraine or for inflammatory conditions”.
Hoffmann D 2003. Medical Herbalism - The science and practice of herbal medicine. Healing Art Press.
Rochester, Vermont.
Today recommended dosage: powder: 50-120 mg/die • About powder “…doses of 200mg bid are often recommended”.
Tincture 1:5 0,25-0,5ml tid (equivalent to max: 300mg)
Trickey R, 1998. Women hormones and the menstrual cycle. Allen Unwin
Roughly: 5-20 times lower than the traditional dosage • 1-3 ml/day of 1:5 tincture (equivalent to around 0,2-1 g/day of leaf).
Bone K 2003. A clinical guide to blending liquid herbs. Churchill Livingstone.
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CONCLUSION
• Phytochemistry shows that many active
constituents (es. different kind of
sesquiterpenlactones or flavonoids) make the
phytocomplex of flowers similar but not equal to THE END
that one of leaves and standard aerial parts.
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