Professional Documents
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Volume 20 - Issue 2
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Page 2 - The Lama Review
Objectives of the
Laboratory Animal Management
Association
To promote the dissemination of ideas, experiences, and knowledge
To encourage continued education
To act as spokesperson
To actively assist in the training of managers
This publication contains copyrighted material the use of which has not always been
specifically authorized by the copyright owner. Such material is made available to
advance understanding of ecological, political, economic, scientific, moral, ethical,
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of any such copyrighted material as provided for in section 107 of the US Copyright
Law. In accordance with Title 17 U.S.C Section 107, this material is distributed without
profit to those who have expressed a prior general interest in receiving similar information for research and educational purposes. If you wish to use copyrighted material
for purposes of your own that go beyond fair use, you must obtain permission from
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For more information concerning The LAMA Review, please contact the Editor in
Chief, Fred A Douglas at (765) 532-7177, FAX (765) 494-7569, or e-mail: fad712@
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T H E
L A M A
HIGHLIGHTS
IN THIS ISSUE
7
10
14
20
21
24
26
30
ASSOCIATE EDITOR
Carolyn Malinowski
Northwestern University
MANAGING EDITOR
Evelyn Macy
Lafayette, IN
EDITORIAL
ADVISORY BOARD
Steve Baker
Framingham, MA
Bob Beck
West Lafayette, IN
Gail Thompson
Wheatland, WY
Staff Contacts
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Executie Director
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Meeting Manager
(952) 253-6235 X115
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PRESIDENT
Kyrsten Koeback
Wilmington, MA
VICE PRESIDENT
Steve Baker
Framingham, MA
VICE PRESIDENT ELECT
Cammie Symonowicz
Wallingfort, CT
PAST-PRESIDENT
Regina M. Correa-Murphy
Providence, RI
SECRETARY/TREASURER
Howard Mosher
Wallingford, CT
EXECUTIVE DIRECTOR
Jim Manke
Eden Prairie, MN
BOARD OF DIRECTORS
ONE YEAR
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Denver,PA
DEPARTMENTS
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Membership &
Development Manager
(952) 253-6235 X139
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EXECUTIVE COMMITTEE
OFFICERS
Q&A
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Daily Drive
TWO YEAR
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Health
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Page 4 - The Lama Review
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Presidents Message
Hello everyone, and Happy Spring! We here at LAMA are just coming off a very successful
meeting in Portland, Oregon. Each years annual meeting seems to grow in not just numbers, but
in the depth of the program and the value that it brings to our members. We took some time at this
meeting to get feedback from our members at a Strategic Long Range Planning (SLRP) meeting
over lunch.
The Board of Directors and ASI, our management group, will be gathering that feedback and
incorporating it into our immediate plans for our long range vision of this group. Last year, we
did a very well received survey of our members. This recent planning meeting was a follow on to
that, and as a board we are collecting that data and will be using it for our SLRP. We as a board
feel very strongly that direct feedback from our members is the key to our long term success as a
group. We want to provide real time solutions to the challenges we all face as managers in our day
to day operations. LAMA as an organization strives to be a resource that we hope you look to first
either through our website, The LAMA Review, or our annual meetings.
The Portland meeting was a tremendous success. I would like to thank our program committee
for all of their hard work putting together such an outstanding program. Great job to Tracy Lewis,
Gordon Brackee, and Guerra Benberry. And to all of our speakers thank you so much for
sharing your expertise with us. We hope that you consider joining us again in the very near future.
A special thank you to Lynelle Dupupe for sharing her story of her experience at Tulane during
Hurricane Katrina. We know what a difficult time you and your staff went through, and we thank
you for sharing your story.
One last thank you and I promise Ill stop! As many of you know, I was unable to attend the
meeting in Portland due to health reasons. It was very difficult to sit back home while you all were
meeting, and I need to thank our OUTSTANDING Board of Directors for all of the support and hard
work not just in Portland, but the weeks leading up to it. Regina Correa-Murphy: This group would
be just lost without you. You are the glue that holds this group together, and you are such a mentor
to all of us. Thank you, thank you, thank you for all that you bring to our little family.
I look forward to a very productive year for LAMA. This is your organization, and we welcome all of
your comments and feedback to provide you with the tools that you need to succeed.
All my best,
-KK
Kyrsten Koebach
2008-2009 LAMA President
Guide To Authors
The LAMA Review is a quarterly Publication of the
Laboratory Animal Management Association. It is dedicated
to providing the highest quality management
information to our membership, which is comprised of
professional managers, supervisors, and administrators of
laboratory animal care and use programs throughout the
world. All information published in this journal is for nonprofit educational purposes.
OBJECTIVES OF LAMA
Page 8 - The Lama Review
Contributing Writers
Bob Beck
Jacque Calnan
Casey Kilcullen-Steiner
Cammie Symonowicz
Steve Young
Bill Umiker (Dec)
Fran Langley
Ron Gordon
George Irving
Carolyn Malinowski
Katy Burns
Gail Heidbrink
Harriet Burgess
Jim Hendley
MANAGEMENT INFORMATION
By Bob Beck
Q:
A:
The study also shows that melanomas are smart, in that their
virulence is hidden within small sub-populations that are difficult to
identify and difficult to destroy as a result of expressing proteins
like ABCB5, adds Murphy. Now, the distinct possibility exists that
such cells actually can be outsmarted. Hopefully, this will lead
to new ways of treating metastatic disease, since our existing
treatments dont work well.
Frank and colleagues, including the papers first author, Tobias
Schatton, PharmD, of the Transplantation Research Center,
are pursuing further studies aimed at eventually bringing this
finding to the clinic. They are studying various alternative ways of
inhibiting ABCB5, such as human monoclonal antibodies (the one
used in this study was raised in a mouse) or small inhibitory RNA
molecules.
They are also closely studying the melanoma stem cell, now that
theyve isolated it, using gene-expression studies and proteomic
studies to understand what makes it tick. This could yield other
targets in the cell, says Frank. However, I favor ABCB5--its
not just a marker or beacon on the cell, but it relates to the cells
ability to develop drug resistance.
Frank adds that a cancer stem cell could try to outsmart
treatments that target ABCB5 by making less of the protein,
but since ABCB5 is so essential to the cells ability to survive
chemotherapy, this is unlikely to happen. ABCB5 might also be
a useful marker of a tumors virulence, indicating the need for
aggressive treatment, Murphy notes.
These ongoing studies are supported by the Specialized Program
in Research Excellence (SPORE) in Skin Cancer, a Dana Farber
Harvard Cancer Center-wide translational research grant based
at the BWH and funded through the National Cancer Institute/
National Institutes of Health.
It is gratifying to see this exciting work move closer to clinical
applications, thanks to the collaboration between Drs. Frank and
Murphy and the involvement of our patients with melanoma, says
study co-author Thomas Kupper, MD, SPORE Director and Chair
of Dermatology at the BWH. Effective treatments for advanced
melanoma are desperately needed.
This work was also supported by the Department of Defense.
Note:
1) Frank NY et al. ABCB5-mediated doxorubicin transport and chemoresistance
in human malignant melanoma. Cancer Res 2005 May 15; 65:4320-33.
Adapted from materials provided by Childrens Hospital Boston.
Panelist #1
1. Attempt to bridge the gap amongst the other
animal facilities throughout the campus by
establishing either:
a. Lunch and learns which brings all players to one
site to discuss hot topics weekly / monthly / quarterly.
b. Establish liaisons who will meet w/ the managers
/ staff from the other facilities and communicate back
to their respective arms (does not have to be a mgr,
could be lead technician (empowering this group /
individual)).
2. Acknowledge to the staff how over worked and
out of the loop they feel (include yourself in the
discussion). Identify areas w/in the facility that are
critical and brainstorm w/ the staff the best way to
accomplish these tasks during this crunch time (IE.,
Page 12 - The Lama Review
the long days and weeks will not last long- employee
turnover will inevitably rise, staff morale will plummet,
etc).
3. Establish a time line w/ senior managements
buy-in, the successful strategic plan implemented
by the upper administration, will only survive as
long as everyone involved remains informed and is
compensated (financially and / or spiritually). Stick
to the timeline which has been agreed upon- the staff
will need to see there is light @ the end of the tunnel.
Panelist #2
These six facility managers have a great challenge.
Massive expansion across numerous departments
in a university is usually confusing, frustrating, and
exasperating. The key for these facility managers is
communication, collaboration, and their own plan.
The six managers should form a consortium. Hold
a meeting (it may take several hours) to air all of the
issues and challenges. Write these down. Develop
a plan to approach each of the items on the list. The
group must agree that they can best attack the list as
a unified group. Make a commitment to each other
at that first meeting. Start having a weekly meeting.
It would be best to pick a single location and initiate
a war room concept where they could leave lists
of tasks to do and the progress to completion on the
walls. The group will need plenty of white boards (or
flip charts) dry markers, etc.
Build a road map that depicts all of the things that
each facility must do to get where they want to be.
There will be overlap. Identify those overlaps and
form subgroups to work together to get those tasks
done. Identify what that task is, who is going to do
it and when it is to be completed. Identify phase
points or milestones along the way and put these
on a wall chart so they can be tracked. Microsoft
Project can be used to list all of the tasks, all of the
interconnections, all of the individuals working to
complete the task and all of the milestones. This is
real Program Manager Stuff! It identifies what needs
to be done and depicts it in an easy to follow format.
As time progresses additional items will need to be
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3
4
5
7
9
10
11
12
13
14
15
16
17
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20
21
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23
Across
1. Board of Directors and ATA Liaison
8. Managing Editor of the LAMA Review
13. Secretary/Treasurer
16. Board of Directors
18. Vice-President Elect
19. Chair of Awards Comittee
20. President
21. Chair of Financial Oversight Committee
22. Chair of Public Relations Committee
23. Board of Directors
Down
2. Co-Chair of Program, Education and Training Committee
3. Past-President and Chair of Strategic Planning Committee
4. Chair of Membership Committee
5. Chair of LAMA Foundation Board
6. AAALAC Liaison
7. Editor in Chief of the LAMA Review and Co-Chair of Publications Committee
9. Co-Chair of Program, Education and Training Committee
10. Associate Editor of the LAMA Review
11. Co-Chair of Program, Education and Training Committee
12. Chair of Policies and Procedures Committee
14. Board of Directors
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Page 16 - The Lama Review
Growing by Leaps
and Bounds!
MANAGERS FORUM
William Umiker M.D.
A common complaint expressed in workshops on time management is I cant get my boss out of my
office. Here are some suggestions from PERSONAL REPORT (September 18, 1984).
1.
2.
3.
4.
5.
6.
7.
Intercept them before they get into your office. When you see or hear them coming, grab a
clipboard or folder and head out. Dialogues in the corridor are shorter.
Get rid of the comfortable visitors chair.
Indicate youre busy by continuing to hold what you have in your hand, not changing
position, or standing next to your filing cabinet.
Change the subject to something he or she is uncomfortable with.
Arrange for an Associate to appear at your door and say that he wants to see you when
youre free.
Say youre busy!!!
When they keep conversations brief, thank them for noting that you are busy.
MANAGERS FORUM
William Umiker M.D.
When faced with an employee whose performance has taken
a dive, and you suspect some personal problem, a counseling
session is indicated. Inexperienced supervisors often ask how such
a meeting should start. Here are a series of questions that can
usually be used:
Are you aware that your performance has dropped recently?
What are the circumstances that may be contributing to this?
Is it possible that a personal problem may be contributing to
this change?
Where have you tried to get some relief/help/assistance?
Are you aware of our Employee Assistance Program (EAP)?
What can I do to help?
How can I arrange your work situation to give you some relief?
Reference: T.J. Griffith: Management Solutions 32:13 September 1987
Thoughts for LIFE The Mayonnaise Jar and Two Cups of Coffee
When things in your life seem almost too life.
much to handle, when 24 hours in a day
are not enough, remember the Mayonnaise The golf balls are the important things--- God,
Jar and the 2 Cups of Coffee.
your family, your children, your health, your
friends, and your favorite passions--- and
A professor
if everything else was lost and only they
stood before his
remained, your life would still be full.
philosophy class
and had some
The pebbles are the other things that matter-items in front of
your job, your house, and your car.
him. When the
class began, he
The sand is everything else--- the small stuff.
wordlessly picked
up a very large
If you put the sand into the jar first, he
and empty mayonnaise jar and proceeded to
continued, there is no room for the pebbles
fill it with golf balls.
or the golf balls.
He then asked the students if the jar was full.
They agreed that it was.
The professor then picked up a box of
pebbles and poured them into the jar.
He shook the jar lightly. The pebbles rolled
into the open areas between the golf balls.
He then asked the students again if the was
jar was full. They agreed it was.
The professor next picked up a box of sand
and poured it into the jar. Of course, the sand
filled up everything else.
He asked once more if the jar was full. The
students responded with a unanimous Yes.
The professor then produced two cups of
coffee from under the table and poured the
entire contents into the jar effectively filling
the empty space between the sand.
The students laughed. Now, said the
professor as the laughter subsided, I want
you to recognize that this jar represents your
> H I P P A _
10 Pitfalls to Avoid
When Asking for a Raise
requires
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Ms. Ann Murray receives the 2008 U. Kristina Stephens Award from LAMA Awards
committee member, Mr. Lane Watkins
The Portland Doubletree Hotel Lloyd Center was the site for the 2008 LAMA ATA Annual
Meeting and Educational Seminars. Nearly 200 attendees gathered April 2 4 to hear speakers
discuss topics related to this years theme of Planning Today for a Greener Tomorrow: Getting it
Right , Now.
The conference venue held a superb mix of seminars, workshops, forums, and a special topic
lecture. Topics covered over the three day time frame included disaster planning, facility design,
training, husbandry, diversity, and security planning. The first day was kicked off by a very
gripping presentation by Ms. Lynell Dupepe of Tulane University covering her facilitys response
during Hurricane Katrina. Ms. Regina Correa Murphy and Ms. Tracy Lewis rounded out the
morning session with additional thoughts and insights on disaster planning. Workshops and
Forums dealt with such areas as computational fluid dynamics, the Americans with Disabilities
Act and Training, husbandry of fish, manager-vendor relationships, and developing a full-service
animal facility. Among the several presentations that caught the mangers eye was one that
gave insights on hiring refugees and how to manage that process, a workforce study by the
Massachusetts Society for Medical Research, and how to meet the challenges of security in the
animal facility in light of new animal rights initiatives. The conference attendees were treated
to a night at the Portland Zoo complete with a green lecture by Mr. Michael Weatherman who
currently chairs the Oregon Zoos Green Team.
Leo Yanas, Chair of the LAMA Foundation, assists Liz Pelletier, maker of the quilt, in preparing
the item for the live portion of the Auction held by
the Foundation to raise funds for members of the
Association.
The Lama Review - Page 25
12 Memory
Tricks
By Tamim Ansary
ndisputably, we moderns
cant match the memory
feats of bygone times,
those days when people could do things like memorize
the Iliad in Greek without even knowing Greek. And
maybe its true, as some have speculated (me, for
instance), that weve lost this capacity because we now
tend to outsource our memory tasks to an exo-brain of
technological gadgets. We no longer have to remember
Moms birthday because our cell phone will remind us
about it when the time comes.
But it struck me recently what this doesnt mean. It
doesnt mean we depend on (organic) memory less than
people of the past. A good memory is still a power tool
in this world. Its just that our culture imposes different
demands on our memories.
Those ancestors of ours who could memorize the Iliad
and so forth lived in quieter times. They could sit under
a tree and devote themselves without distraction to a
single, sustained memorization project for days on end.
Who has that luxury now?
Expert testimony
So I decided to look into it myself and talk to the experts
-- people who teach memory skills professionally. At
the end of this column Im going to list 12 tips I distilled
from their recommendations, but first, to put those tips in
context, let me just review how memory works.
Biologically speaking, we actually have two kinds of
memory: short-term memory and long-term memory.
Think of them as the front room and the back room.
The front room is what were actively dealing with at
any given moment. Call it consciousness. This room is
small: Only seven or eight items fit in there at a given
time, and nothing can stay in there for more than a
few seconds. The back room is a warehouse. For all
practical purposes, its infinitely large. Incredibly enough,
everything we ever learn or experience gets stored in
long-term memory, and once its there, its there for life.
The question is, once a piece of information goes into
that dusty back room where trillions of items are already
stored, how do you find it again when you need it? The
answer lies in that front room. What happens there is the
key, because nothing gets into the back room without
passing through the front.
Memory retrieval
All memories are recovered memories, and we recover
them through associations: We remember a past
event because something currently in our awareness
-- something were looking at, hearing, tasting, thinking
about, whatever -- reminds us of something, which
reminds us of something else, which reminds us of
something else and so on back. Thats why recent
events are easy to remember: The environment is still
loaded with cues and the chain of links is short.
Good memory, then, is all about processing information
properly as it goes into storage. Psychologist William
James summarized the fundamental principle in a single
phrase: The secret is forming diverse and multiple
associations with every fact we care to retain.
Here, then, are 12 concrete steps you can take to
remember particular facts and improve your general
capacity to retain what you learn. Note that only the last
step is one you can take when youre actually trying to
it, the less likely you are to forget it. (If you dont
understand football, youre not likely to remember the
scores.)
Health Tips...
Self-Esteem Tune Up
Pet Power
More than two-thirds of American households have
pets, the most popular being dogs and cats. They are
fun, interesting and warm companions. Science is
just tapping into the power pets posess in helping us
to heal emotionally, physically, and mentally.
Many studies show the animal-people bond can aid
patient recovery from serious illness and promote
a calming effect on Alzheimers patients, helping
soothe their fears and aggression. Others credit
Page 32 - The Lama Review
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We could put forth many more conjectures about them, but ultimately,
Millennials will define themselves. In the decades to come, they will
assume the mantle of leadership and will carve their generations
reputation into history.
To more thoughts from Jim Heskett about the Millennial generation, visit
http://hbswk.hbs.edu/item/5736.html#original.
CREATING CONFLICT AND BUILDING CONSENSUS
In decision-making, leaders walk a tightrope to balance healthy levels of
conflict and consensus. Too much conflict degenerates into antagonism
and infighting. Too much consensus and no one ventures forth criticism
of ill-informed choices. A leader has the responsibility to preside over an
organizations mixture of conflict and consensus. Both the quality of a
decision and its ease of implementation are at stake.
In his article, Why Leaders Dont Take Yes for an Answer, on www.
govleaders.org, Michael A. Roberto shares his thoughts on managing
the decision-making process.
CREATING CONFLICT
The first step for a leader to invite conflict into the decision-making
process involves actively seeking the participation of others. A surprising
number of leaders make decisions in a vacuum. Confidently relying on
their own wisdom and instincts, they bypass the expertise and feedback
of teammates. In doing so, their decisions fall prey to blind spots, biases,
or gaps in knowledge.
In the second step of creating conflict, leaders must set the tone of
communication so that dissenting opinions may be freely expressed
and assumptions may be openly questioned. Vigorous and candid
debate exposes weaknesses in a decision. Yet, many leaders surround
themselves with bobble-headed managers who are certain not to
contradict their directives. In such a climate, dissenters are chided for
not being team players. On the contrary, a wise leader prizes people
who fearlessly challenge the process and will include them in the inner
circle of their decision-making team.
As a final role of creating conflict, leaders make sure all parties respect
one another during the debate of ideas. When egos enter the picture,
conflict can become combustible. Leaders stay above the emotional
fray. They allow ideas to have interplay without allowing them to divide
the team. They maintain control of debate, and they do not tolerate
hectoring or bullying.
BUILDING CONSENSUS
As with creating conflict, consensus begins with inclusion. Key players
left in the dark during the decision-making process will have a difficult
time embracing the chosen course of action. Leaders do not relinquish
final authority in decision-making, but they do dignify their co-workers by
consulting them for advice.
Once a decision has been reached, a leader must switch the focus from
generating healthy conflict to building consensus around the decision.
In this step, team members must be convinced to emotionally accept
the grounds of a decisionregardless of personal feelings. Consensus
does not mean unanimity, widespread agreement on all facets of a
decision, or complete approval by a majority of organization members,
writes Roberto. Consensus does mean that peoplehave accepted the
final choice, even though they may not be completely satisfied with it.
The Lama Review - Page 35
EXPECTATIONS
What we see depends mainly on what we look for.
~ John Lubbock
To expect defeat is nine-tenths of defeat itself.
~ Henry Louis Mencken
Our circumstances answer to our expectations and the demand of
our natures.
~ Henry David Thoreau
TO PONDER
Good Leaders
by Duke Rohe
1.
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DREAMS
What happens to a dream deferred?
Does it dry up
Like a raisin in the sun?
Or fester like a sore-And then run?
Does it stink like rotten meat?
Or crust and sugar over-like a syrupy sweet?
Maybe it just sags
like a heavy load.
Or does it explode?
~ Langston Hughes
LAMA Committees
Awards Committee
John Park, Chair
T. Lane Watkins, Vice Chair
Cammie Symonowicz, Board of Director Liaison
18
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Across
1. Board of Directors and ATA Liaison
8. Managing Editor of the LAMA Review
13. Secretary/Treasurer
16. Board of Directors
18. Vice-President Elect
19. Chair of Awards Comittee
20. President
21. Chair of Financial Oversight Committee
22. Chair of Public Relations Committee
23. Board of Directors
Down
2. Co-Chair of Program, Education and Training Committee
3. Past-President and Chair of Strategic Planning Committee
4. Chair of Membership Committee
5. Chair of LAMA Foundation Board
6. AAALAC Liaison
7. Editor in Chief of the LAMA Review and Co-Chair of Publications Committee
9. Co-Chair of Program, Education and Training Committee
10. Associate Editor of the LAMA Review
11. Co-Chair of Program, Education and Training Committee
12. Chair of Policies and Procedures Committee
14. Board of Directors
Created with Discovery
School's
PuzzleMaker.
15.Channel
Co-Chair
of CMAR
Committee
17. President-Elect and Co-Chair of Publication Committee
The Lama Review - Page 39
Action Exercises
Here are two things you can do immediately to put these
ideas into practice.
First, ask the successful people around you for their best
book recommendations. Whatever advice they give you,
immediately go out and buy those books, take them home
and begin reading for one hour every morning before you
start work.
Second, when you read, underline and take notes when
you find important ideas that you can use. Implement them
immediately. Take action of some kind on good ideas. You
will be amazed at the change in your career.
Book Review
Our Iceberg is Melting
Written by: John Kotter
Book Review by: Carolyn Malinowski
FS
Research Advancement
WSU to offer bone marrow transplants
to sick pets Its a big give-back to
dogs for cancer help
By TOM PAULSON
P-I REPORTER
The bone marrow or stem cell transplant, a procedure that
every year saves tens of thousands of lives and won for the
Seattle physician who pioneered it the 1990 Nobel Prize
in Medicine, appears poised to come full circle and finally
become more widely available to those who first made it all
possible.
Dogs.
They helped us figure out how to help save ourselves,
and so this represents a big give-back to the canine
species, said Dr. Jeffrey Bryan, a veterinary oncologist at
Washington State University.
Bryan is spearheading a project to soon launch what would
be the worlds first large-scale clinical transplant program
for dogs. The program is expected to become available to
treat dogs with lymphoma sometime this summer.
Bone marrow transplants had been done experimentally in
dogs over the decades, Bryan said, and clinically for a few
dogs by some pioneering private-practice veterinarians. But
the procedure has never before been routinely offered as a
cancer therapy for the canine community, he said.
We are looking at this as an option for dealing with one of
the most common cancers in dogs, Bryan said. There are
tens of thousands of dogs diagnosed with lymphoma every
year. At WSU, we get five or six calls a week.
The WSU transplant program, which will be a partnership
with a private business based in North Carolina, is intended
to make the procedures available to pet owners for
about $15,000 to $20,000 per dog. Thats pricey, Bryan
acknowledged, but there appears to be enough demand
among pet owners to support the program.
We could never have done this in the first place without
dogs, said Dr. Rainer Storb, head of transplant biology
at the Fred Hutchinson Cancer Research Center and one
of the original members of the team of Seattle scientists
led by Nobel Laureate Dr. E. Donnall Thomas that worked
to perfect the procedure in humans during the 1960s and
Page 42 - The Lama Review
70s.
Its not just that the scientists happened to work with dogs
when the research started, Storb said. Dogs -- unlike mice
or monkeys or any other animals in research -- turned out
to be uniquely qualified to serve as animal models for the
experimental human bone marrow transplant, he said, in
part because of their broad genetic diversity.
It is the only species other than humans that has such
a large spectrum of genetic diversity, Storb said. Just
consider the difference between a dachshund and a Great
Dane, he said, and you get the picture. They also suffer
many of the same diseases as humans.
By 1965, when Storb moved from Europe to Seattle to
work with Thomas and his team, most researchers had
concluded that bone marrow transplantation would never
work. All of the earlier experimental attempts had failed
miserably in people, usually because of immune system
rejection. But the Seattle team stubbornly believed it could
be done and, working with veterinarians, recruited dog
owners to help advance the science.
The funniest one I remember was Richard, a very old
Chihuahua with no teeth, Storb said. He said the dog
was constantly fainting in the lab, and they eventually
determined he didnt actually have cancer but rather
severe anemia. They gave the owner anemia drugs to treat
Richard and sent him home.
Another time, a friend of Thomas brought in his energetic
German shorthaired pointer, which had lymphoma. The
dog escaped the lab, then located in West Seattle, and
the scientists spent hours searching the neighborhood
before finding him. Storb recalled many other dogs he
met while trying to perfect the transplant procedure. Many
died, anyway, of course, but mans best friends eventually
revealed to the scientists how to make it work.
The first clue dogs gave for making transplantation work
was identifying that a close tissue match between the
marrow donor and the patient was critical, Storb said.
This was not the case in mice, he said. We only
discovered this because of the dogs. And they also showed
us it wasnt the entire solution.
Research in dogs helped the Seattle scientists figure out
how to reduce the risk of immune system rejection and led
to the first successful human bone marrow transplants.
Storb continues to work with dogs and is now doing
Research Advancement
studies, all of them nonlethal, aimed at eliminating the need
for radiation and toxic chemotherapy altogether.
Dogs are still important to this science, Storb said.
So its only fair that we now make this as widely available
as a treatment option for them as well, said Dr. Edmund
Sullivan, a Bellingham veterinarian uniformly credited with
doing one of the first nonexperimental marrow transplants
for a dog in this region -- in 2004 on a golden retriever
named Comet who had T-cell lymphoma.
Comet was successfully treated for the lymphoma, and
enjoyed years more of life, but died last month at age 10
from a different cancer, said his owner, Darrell Hallett, a
Seattle attorney.
Sullivan has since done transplants for five other dogs,
some taken to Bellingham from as far away as Dallas and
New York City. The Bellingham vet, who charges between
$25,000 to $35,000 for the procedure, has been able to
pioneer the transplant here by working with Storb and using
WSUs radiation equipment.
But once WSU launches its own transplant program,
Sullivan has been told he will no longer be allowed to use
the universitys radiation equipment to do the procedures at
his Bellingham clinic.
Ed deserves a lot of credit for pushing this forward, Bryan
said. But in order for the transplants to be done at the
highest quality and become fully incorporated as a standard
of care within veterinary medicine, the WSU oncologist
said, the entire procedure needs to be comprehensively
managed within an institutionalized program.
Sullivan agrees with the need for an institutionalized
program, but said he sees no reason why he cant also
continue to do the transplants, given his successful track
record. The Bellingham vet said he suspects there are
turf or business concerns playing into this and plans to
continue to press WSU to allow him access to the radiation
equipment.
I mean, I helped get this whole thing going, starting with
Comet, Sullivan said.
However this professional dispute plays out, it appears that
bone marrow transplantation will soon become an option
for the species that allowed scientists to develop one of
the most powerful and innovative anti-cancer therapies out
there.
Good dogs.
P-I reporter Tom Paulson can be reached at 206-448-8318
or tompaulson@seattlepi.com.
1998-2008 Seattle Post-Intelligencer
FS
Research Advancement
Angeles County Superior Court Judge Jerald Rosenberg
approved a temporary restraining order sought by the
Regents of the University of California, to prohibit five
named defendants from ALF and other extremist groups
from harassing UCLA personnel, and specifically from
coming within 50 feet of them during a demonstration. The
restraining order also requires that personal information
about UCLA personnel be removed from websites
maintained by extremists.
The order came within weeks of an incendiary device set
at the home of Edythe London, protesting her medical
research at UCLA. In October, ALF activists had flooded
Londons home by breaking a first floor window and
inserting a garden hose. They left her the following note:
It would have been just as easy to burn your house down,
Edythe. As you slosh around your flooded house, consider
yourself fortunate this time.
Karin Immergut, the U.S. Attorney for the District of
Oregon, and I met this past August. After nine years of
investigation, she and her lead prosecutors had obtained
guilty pleas from the largest eco-terrorism group in the
country, known as Operation Backfire. These conspirators
had led a string of arsons across the West whose targets
included the University of Washingtons Center for Urban
Horticulture.
The Northwest research community wanted to understand
what Immergut and her Assistant U.S. Attorneys, the FBI,
the ATF and local law enforcement had learned about
the mindset and the tactics employed by the domestic
terrorists in our midst. I came to ask her to convene a
private advisory session with us at the Portland Federal
Courthouse.
Scientists, security, facilities and communications
managers from research facilities in Washington and
Oregon were joined by local law enforcement from nearly
every local county. We learned that these animal rights
activists are highly educated. Almost all are college
graduates; many have doctorates. Their goal was to stop
research that they judged unjust.
The FBI explained that when members of Operation
Backfire were finally apprehended, many were frustrated
because they had come to realize that arsons alone were
not succeeding in getting their message across, and plans
were under way to increase their level of violence.
As Michael Conn, assistant director of the Oregon National
Primate Research Center, stated in his prepared remarks
at our session, The public needs a warning. The animal
rights war on animal research is dangerous to our health.
Who pays when researchers give up productive careers?
We all do.
On Feb. 6, the Society for Neuroscience released a new
FS
Vets/animal rights
Vets groups duke it out on whos more
humane
Newsday.com
Denise Flaim-Animal House
January 31, 2008
FS
FS
developing tumors.
FS
FS
POSITION AVAILABLE
SCHOOL OF VETERINARY MEDICINE
VETERINARY LABORATORY ANIMAL CARE UNIT
SUPERVISOR OF HUSBANDRY
The Purdue University School of Veterinary Medicine Veterinary Laboratory Animal Care Facility is
recruiting a Supervisor of Animal Husbandry. The position is responsible for the overall supervision of
an animal care staff of 7 full-time animal care technicians and 7 part-time animal caretakers. The duties
include developing work schedules, weekly work plans, daily work assignments, husbandry resource
procurement, and supervising the Units OSHA compliance for a diverse population that includes both small
and large animals. In addition, the position is responsible for assisting in the development of Animal Care
and Use Protocols (ACUPS), Unit Standard Operating Procedures (SOPS), and supervising the training
associated with the above. The position works closely with research and teaching faculty, maintenance
personnel, and members of the Laboratory Animal Program to ensure the health and welfare of the animals
housed in the facility.
REQUIREMENTS: Bachelors degree in Animal Science and 3 years experience working with laboratory
animals in a USDA regulated animal facility. Consideration will be given to an equivalent combination of
related education and required work experience. One year of supervisory experience is also required.
LATG certification is desirable. Qualified applicants lacking LATG certification will be expected to obtain
certification within 3 years of employment.
For additional information please call or contact Fred Douglas, BS, RLATG at (765) 494-7591 or fad@
purdue.edu.
Interested applicants should apply for the open position at: http://www.purdue.edu/jobs, by referencing
position 0800593. Questions regarding the application process can be directed to Joy Loflin in Human
Resources at loflin@purdue.edu or 765-496-7266.
Purdue University is an equal access/equal opportunity/affirmative action employer
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