Pharmacology

Basic Medical Science

Time: 40 mins

Author Email: sidharta123@yahoo.com

Total Marks: 50 | Pass Marks: 30

PHARMACOLOGY
Please use a dark pencil/pen to complete the test. Read the instructions at the
begining carefully. This is an Sample Test Paper for practice.
Please Note: There is a Negative Marking of (-1) for each incorrect response.
1. Drugs that reduces the bioavailability and absorption of warfarin
A acetaminophen

C phenothiazine

B cholestyramine

D benzodiazepine

2. Which of the following is a B1 kinin receptor antagonist?

A [Leu8]des-Hyp3
-bradykinin

C d-Arg[Hyp3,Thi5,
D-Tic7,Oic8]bradykinin

B [Leu8]des-Arg9
-bradykinin

D DArg[Hyp3,DPhe7,
Leu8]bradykinin

3. Drugs that inhibit metabolism of Warfarin include all of the following except:
A amiodarone

C cimetidine

B disulfiram

D aspirin

4. Which of the following agent is a non-purine xanthine oxidase inhibitor?

A colchicine

C febuxostat

B allopurinol

D probenecid

5. What is not true about Caffeine?

A is a CNS stimulant

C plasma protein binding is <50%

B should be avoided in peptic ulcer

D metabolized by acetylation and

reduction in liver

6. Oral Cephalosporins include all of the following except

A cefixime

C cefaclor

B cefepime

D cefadroxil

7. Which of the following agents is not an immunosuppressant?

A IFN- 2

C mercaptopurine

B azathioprine

D infliximab

Basic Medical Sciences

-1-

Pharmacology
8. Uricosuric drugs are
A organic acids acting at cation
transport sites of renal tubules

C inorganic acids acting at anion

transport sites of renal tubules

B organic bases acting at cation

transport sites of renal tubules

D organic acids acting at anion

transport sites of renal tubules

9. Pick the correct statement regarding the mechanism of action of Leflunomide:

A increases TNA- dependent
NF-B activation

C its metabolite inhibits

dihydroorotate dehydrogenase

B its metabolite inhibits

dihydrofolate reductase

D decreases IL-10

10. Which of the following agents is not an immunostimulant?

A Deoxycholic acid

C Tacrolimus

B Chenodeoxycholic acid

D Macrokine

11. Match the following with their correct alternatives:

A.
B.
C.
D.
E.

pyrazolones
A. phenylbutazone
orange discoloration of urine
B. pyrazinamide
nicotinamide
C. oxaprozin
niacinamide
D. rifampin
propionic acid derivative NSAID E. energy metabolism

12. Which of the following is/are uricosuric agent?

A allopurinol

C losartan

B metamizol

D fenofibrate

13. Drugs that may cause hyperkalemia

A thiazide diuretic

C fluoride

B loop diuretics

D -agonists

14. Which of the following is a prodrug of mercaptopurine?

A allopurinol

C methothrexate

B cyclosporin

D azathioprine

Basic Medical Sciences

-2-

Pharmacology
15. Match the following on the left with their correct options on the right:
A.
B.
C.
D.
E.

Glycopeptide anitibiotic
Polyene antibiotic
3rd Generation Cephalosporin
2nd Generation Cephalosporin
Quinolone antibiotic

A.
B.
C.
D.
E.

Cefotaxime
Nalidixic acid
Vancomycin
Cefuroxime
Amphotericin-B

16. Ischaemic ventricular fibrillation is precipitated by

A hyponatremia

C hyperkalemia

B hypokalemia

D hypernatremia

17. Drugs that may cause hypokalemia:

A -blockers

C digitalis glycoside

B -agonists

D spironolactone

18. Factors that increase drug metabolism includes all of the following except
A administration of Phenobarbital

C heavy smoking

B charcoal-boiled foods

D young age (infants)

19. Which Leukotriene is a potent chemo attractant for eosinophils and T lymphocytes?
A Leukotriene C4

C Leukotriene D4

B Leukotriene B4

D all of the above

20. Drugs that are absorbed intact from the small intestine include all of the following
except
A pentazocine

C meperidine

B morphine

D clonazepam

21. An example of competitive enzyme inhibition in which finasteride competes with

testosterone for:
A cholinesterase

C aromatase enzyme

B 5a-reductase

D xanthine oxidase

22. ACE inhibitors are contraindicated in patients who have

A renovascular hypertension

C ischaemic heart disease

B bilateral renal artery stenosis

D congestive hear failure (CHF)

Basic Medical Sciences

-3-

Pharmacology
23. Match the following with their correct alternatives:
A.
B.
C.
D.
E.

Hepatolenticular degeneration
Cysteinyl LT1 receptor antagonist
Diabetes insipidus
-lactams
Aminoglycosides

A.
B.
C.
D.
E.

Carbapenems
Desmopressin
Penicillamine
Gentamicin
Montelukast

24. Colchicine inhibits the formation of which of the following cytokine?

A Leukotriene D4

C IL-1

B IL-1a

D Leukotriene C4

25. Drug that does not undergo enterohepatic circulation

A Oxaprozin

C Ezetimibe

B Gemfibrozil

D Flurbiprofen

26. An immunomodulatory derivative (IMiD) of thalidomide:

A cyclophosphamide

C Leflunomide

B Lenalidomide

D Tolazamide

27. ACE inhibitor with least bioavailability:

A perindopril

C lisinopril

B fosinopril

D enalapril

28. Drug which should not be used for analgesia in patients with gout
A indomethacin

C oxaprozin

B aspirin

D glucocorticoid

29. Which of the following agents suppress insulin release?

A phenobarbitone

C metformin

B thiazides

D diazoxide

30. Mechanism of action of metformin:

A depresses anaerobic glycolysis

C suppress hepatic
gluconeogenesis

B slows hepatic degradation of

insulin

Basic Medical Sciences

D stimulates insulin release

-4-

Pharmacology
31. Mechanism of action and indications not common to both diazoxide and
sulfonylureas
A both cause membrane
depolarization

C both affects insulin release

D both can be used to treat
hypoglycemia and hypertension

B both acts on K+ channels

32. Statements not true about desmopressin:
A has a circulating T life of 1.5-2.5
hrs

C should not be used in diabetes

mellitus (DM)

B has little effect on blood pressure

D used in coagulopathy in
Hemophilia B

33. Side effect of guanethidine:

A sedation

C postural hypotension

B severe mental depression

D extrapyramidal effects resembling

Parkinsons' Disease

34. Drugs that should not be suddenly withdrawn after prolonged treatment include all
of the following except:
A -adrenergic blockers

C procyclidine

B clozapine

D fluoxetine

35. Match the following medications with their adverse reactions:

A.
B.
C.

cyclophosphamide
nafcillin
ondansetron

A. neutropenia
B. torsades de pointes
C. acute myeloid leukemia

D.
E.

ampicillin
cisplatin

D. nephrotoxicity
E. pseudomembranous colitis

36. Which of the following drugs is an immunomodulator?

A azathioprine

C methotrexate

B cyclophosphamide

D Glatiramer

37. Match the following classes of interferons & interleukins with their correct sources:
A.
B.
C.
D.
E.

IFN-
IFN-
IFN-
interleukin-2
interleukin -3

Basic Medical Sciences

A.
B.
C.
D.
E.
-5-

mast cells
lectin or antigen stimulated T cells
white cells
fibroblasts
lymphocytes

Pharmacology
38. What is not true regarding the actions of clonidine?
A has no effect on cardiac output

C has no effect on capacitance

vessels

B decreases heart rate

D reduces peripheral vascular

resistance

39. Which of the following is an adrenergic neuron blocking agent?

A clonidine

C propanolol

B guanethidine

D prazosin

40. Gray baby syndrome is a side effect of treatment with

A polymixin B

C amphotericin B

B chloramphenicol

D gentamicin

41. Drugs eliminated by zero order kinetics:

A phenobarbital

C ethosuximide

B nicorandil

D cisplatin

42. Drug with the longest T life:

A Dutasteride

C Fluoxetin

B Bedaquiline

D Amiodarone

43. Match the following drugs with their correct T lives:

A.
B.
C.
D.
E.

Doxycycline
Salbutamol
Digoxin
Morphine
chlorpropamide

A.
B.
C.
D.
E.

1.6 hrs
32 hrs
40 hrs
2-3 hrs
20 hrs

44. Drugs that follow Michaelis Menten kinetics

A alprenolol

C chlorthiazide

B amitriptyline

D clomethiazole

45. Drugs that block myocardial Na+ ion channels

A Amiodarone

C Amiloride

B Quinidine

D Nifedipine

Basic Medical Sciences

-6-

Pharmacology
46. Mechanism of action of amiloride
A antagonize the effect of
aldosterone in collecting tubules

C blocks Na+/Cl- transporter (NCC)

in DCT

B enhances Na+ and Ca2+

reabsorption in the PCT

D inhibits renal epithelial Na+

channels

47. Drug that inhibits T-type Ca2+ channels in thalamic neurons

A Ethosuximide

C zolpidem

B Lithium

D carbamazepine

48. Which of the following agent is a pyrozolopyrimidine hypnotic?

A zolpidem

C eszopiclone

B zaleplon

D ziprasidone

49. Which of the following is not an exclusive secondary active metabolite of

chlordiazepoxide following its biotransformation?
A desmethylchlordiazepoxide

C -hydroxy metabolites

B desmomethyldiazepam

D demoxepam

50. Drugs that inhibit peripheral conversion of T4 to T3

A carbimazole

C propylthiouracil

B methimazole

D amiodarone

Basic Medical Sciences

-7-