Patheon Dosage Capabilities

All the Choices and Expertise
You Need to Succeed
Develop and Launch Products

Anywhere in the World
Solid Dose Forms Specialized and

Conventional
Americas
Cincinnati High Point Greenville Toronto
USA
USA
USA
Canada
Whitby
Canada
Europe
Manati
Mexico City Bourgoin
Puerto Rico Mexico
France
Monza
Italy
Ferentino Milton Park Swindon

Tilburg
Italy
UK
UK
Netherlands
Solid Dose Forms
With the experience of thousands of projects, Patheon provides access to a wide range of
conventional solid dose form as well as specialized combinations and controlled-release
technologies. All solid dose form choices are carried out with the expansive scientific resources
and expertise to build high-quality formulations for even the most complex drug products.
Trilayer Tablets
Microtablets
Beads in Capsules
Coated Beads
Tablets in Capsules
Specialized
Fast Dispersible Tablets
Softgels
Bolstered by the acquisition of Banner Pharmacaps, Patheon is your new highly capable
ally in the development and manufacture of softgel products. We give you access to a
host of patent-protected specialized technologies to meet the specific needs of your
molecules and markets. This includes advanced solutions for enhancing solubility and
bioavailability, as well as unique controlled-release and oral delivery technologies.
Laser-Drilled Controled-Release Tablets

Liquid-Filled Capsules
Biphasic Liquid-Filled Capsules
Bilayer Chewable Tablets
Beads in Liquid-Filled Capsules
Hydrophilic Gel Matrix
Polymer Matrix
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Wax Matrix
Pulsatile Release
Polymer Coating
Sublingual Tablets
Conventional
Sterile Products
Uncoated
Patheon offers extensive sterile product development and manufacturing capabilities in Europe
and North America, including world-class expertise in lyophilization and ready-to-use dose formats.
We have developed more than 100 large molecules for customers that include eight of the top
ten biotech companies. Because the challenges you face are ones weve likely overcome before,
you can be confident of your success. That plus our exceptional regulatory track record, Right First
Time and On-Time performance, and three consecutive years of European Outsourcing Awards.
Coated
Powder-Filled Capsules
Powders and Granules
Coated Beads
Multiparticulates
Softgel Capsules
Softgels
Twist-Off Softgels
EnteriCare Enteric Softgels
LiquiSoft Chewable Liquid-Filled Softgels
Versatrol Controlled-Release Softgels
Solvatrol Enhanced Solubility Softgels
Soflet Gelcaps
Chewels Chewable Gels
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Finished Dose Forms
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Sterile Products
Vials
Lyophilized Vials
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Prefilled Syringes
Cartridges
For more information on

our services or products,
contact your Patheon
Representative or email us at
doingbusiness@patheon.com
Published 9/14
PATH0340R1
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US Headquarters
European Headquarters
Japan Office
Patheon Inc.
4721 Emperor Blvd, Suite 200
Durham, NC 27703-8580
USA
P: +1 919 226 3200
F: +1 919 474 2269
www.patheon.com
Patheon UK Ltd.
Kingfisher Drive
Covingham, Swindon
Wiltshire SN3 5BZ
UK
P: +44 1793 524411
F: +44 1793 487053
www.patheon.com
Patheon K.K.
7F Wakamatsu Building, 3-3-6
Nihonbashi Hon-cho, Chuo-ku,
Tokyo 103-0023
Japan
P: +81 3 6202 7666
F: +81 3 6202 7676
www.patheon.com/home-japan.aspx
2 IRs or IR+CR/SR fixed-dose combination
Trilayer Tablets
3 IRs or IR+placebo+CR/SR fixed-dose combination

Sublingual Tablets
Beads in Hard-Shell Capsules
Laser-Drilled Controlled-Release
Tablets
Polymer Matrix
Wax Matrix
Pulsatile Release
Polymer Coating
IR or CR/SR single or bilayer fixed-dose combinations; ideal for

pediatrics and high-dose compounds
Powders, Granules, Coated
Beads Multiparticulates
Precise unit dosing for oral liquid and topical products

Hermetic seal helps preserve API
Portable convenience improves patient compliance
Consistent dosing for reliable results in clinical trials
Lyophilized Vials
Enteric properties are integrated into the gelatin shell

Eliminates risk of reflux and gastric irritation
Protects acid-labile compounds
Compatible with SMEDDS, hydrophilic and viscous fills
Prefilled Syringes
Solvatrol Enhanced Solubility

Softgels
IR, disintegrates/disperses as suspension in water, divisible into 4

parts for titration, ideal for pediatrics
LiquiSoft Chewable
Liquid-Filled Softgels
IR, single layer tablets for sublingual administration.
IRs and/or CRs/SRs fixed-dose combination, uncoated or polymer

coated; extrusion, spheronization or drug layering
Soflet Gelcaps
IRs and/or CRs/SRs fixed-dose combination, hard shell, coated

beads in liquid vehicle
IR or CR/SR; hard shell; options to improve solubility, bioavailability

and absorption; ideal for Phase I and beyond
IR or CR/SR; hard shell; biohasic vehicle to improve solubility,
bioavailability and absorption; ideal for Phase I and beyond
Unique matrix system to fine-tune release

Controlled-release capabilities integrated into fill
Lipophilic and hydrophilic formulations
Suitable for compounds with low solubility
Cartridges
Enhances the solubility and bioavailability

Provides a stable solvent delivery system
Reduces plasma level variability
Controlled-release technology
Aseptic filling, terminal sterilization when required

Solutions, suspensions or emulsions
Extensive range of sizes and stopper/cap combinations
Clear or amber glass vials
World-class scientific and technical expertise
Wide selection of vial sizes, including ISO standard
Small- and large-scale manufacturing
Broad range of sizes and configurations with handles
Glass or polymeric
Fill range from 0.1 ml to 20 ml
Range of cartridge configurations

Glass or plastic
Sterile Doses
Vial Size* (ml)
Solid dose for oral liquid formulations

Soft, chewable shell with a pleasant burst of liquid Enhances
performance of poorly soluble compounds
Flavors and aromas mask unpleasant tastes and odors
Patented technology enrobes tablets
Traditional gelatin or non-animal gelatin
Safely encases highly potent compounds
Perfect for clinical trial blinding
Chewable for patient comfort and convenience
Rapid onset of action and relief of symptoms
Pursue pediatric and geriatric markets
Patented technology
Capsules
Liquid-Filled Vials
2
4
5
6
7
8
10
12
13
15
20
25
30
50
60
100
200
250
300
500
2
3
4
5
6
7
8
10
12
15
17
20
25
30
50
100
Softgels Shapes and Sizes
CR/SR; hard shell; osmotic, zero-order, controlled-release over a

defined time period
Conventional Solid Dose Forms

Tablets
Twist-Off Softgels
Versatrol Controlled-Release
Softgels
Oval
Chewable Tablets
Immediate-release soft gelatin capsules

Clinical development scale production
13.7B capsule commercial manufacturing capacity
Extensive range of sizes, colors and imprinting options
IR or CR/SR, over-encapsulation for blinded clinical supply
Oblong
Tablets in Capsules
Softgel Capsules
IR or CR/SR; low-dose tablets; via device, capsule or sachet
Required Container Size (cc) by Fill Count
Size
Fill Volume Range (CC)
60 Count
100 Count
250 Count
500 Count
0.089-0.111
60
60
75
150
0.182-0.228
60
75
120
200
0.209-0.261
60
100
150
250
0.312-0.389
75
100
150
300
0.318-0.397
75
100
150
400
7.5
0.386-0.482
75
100
225
400
0.469-0.586
100
120
300
600
10
0.567-0.709
100
120
300
600
0.181-0.227
75
75
200
350
0.243-0.304
100
120
250
400
0.285-0.356
100
120
300
750
0.338-0.422
100
120
400
750
Commercial
Stopper Size (mm)
13
13
20
20
20
20
20
20
13
20
20/13
20
20
20/32
28
20/28/32
28/32
32
28
28/32
13/20
13
13
13/20
20
20
20
20
20
20
20
20
20
20
20
20
Development
Greenville, USA
Monza, Italy
Ferentino, Italy
Ferentino, Italy
Greenville, USA
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Lyo Batch Sizes for the Most Readily Available Vial Sizes
0.452-0.564
120
200
500
950
14
0.863-1.079
200
300
750
1250
16
0.975-1.218
250
400
950
1500
IR or CR/SR, single-layer tablets, coated or uncoated, with or

without break line or embossing, range of shapes and sizes
0.073-0.123
60
60
75
150
0.138-0.183
60
75
120
200
IR, two-piece gelatin or HPMC capsules in a range of sizes and

multiple color combinations
0.173-0.244
60
100
150
250
21
81,000
65,000
74,000 69,000
89,000 19,000
14,000 295,000 200,000 206,000
27,000
5,400
0.195-0.305
75
100
150
300
22
73,000
58,000
67,000 67,000
86,000 18,000
12,500 265,000 179,000 185,000
24,000
4,800
61,000
49,000
55,000 55,000
69,000 14,000
10,000 174,000 117,000 121,000
16,000
3,200
IR, bottles and sachets, packaged in bottles and sachets of varying

dimensions and fill weights
Round
Microtablets
Sterile Products
Liquid-Filled Vial
Bilayer Tablets
Softgels
Lyophilized Vial
Specialized Solid Dose Forms
Monza, Italy
Vial Size
Sterile
Area 1
External OD
Example Fill
(mm)
16
2, 4
2 Twin Lyo
Units
Sterile
Area 2
Ferentino, Italy
Sterile
Area 3
Sterile
Area 1
Sterile
Area 2
2 Twin Lyo 2 Twin Lyo

Lyo Unit 1 Lyo Unit 2
Units
Units
Sterile
Area 2
138,000 111,000 127,000 120,000 153,000 37,000
Greenville, USA
Development
Sterile Unit
Line 1
Line 2
Line 3
Cytotoxic
CTM
3 Lyo Units 3 Lyo Units 3 Lyo Units
24,000 490,000 318,000 329,000
43,000
8,600
0.279-0.367
75
100
150
400
24
10, 15
0.305-0.428
75
100
225
400
30
20, 25, 30
37,000
30,000
35,000 35,000
45,000
9,500
6,400 142,000
95,000
98,000
13,000
2,600
15
0.737-0.922
150
225
500
750
42
15
17,000
13,000
15,000 17,000
22,000
4,700
3,500
42,000
44,000
5,000
1,000
Other shapes and sizes available. Formulation can effect options.
* ISO standard and non-standard vials can be accommodated.
65,000
Trilayer Tablets

Sublingual Tablets
Tablets
Polymer Matrix
Wax Matrix
Pulsatile Release
Polymer Coating


Lyophilized Vials

Prefilled Syringes

Softgels

LiquiSoft Chewable

Soflet Gelcaps



Cartridges


Glass or polymeric

Glass or plastic
Sterile Doses
Vial Size* (ml)

Patented technology
Capsules
Liquid-Filled Vials
2
4
5
6
7
8
10
12
13
15
20
25
30
50
60
100
200
250
300
500
2
3
4
5
6
7
8
10
12
15
17
20
25
30
50
100

defined time period

Tablets
Twist-Off Softgels
Softgels
Oval
Chewable Tablets

Oblong
Tablets in Capsules
Softgel Capsules
Size
60 Count
100 Count
250 Count
500 Count
0.089-0.111
60
60
75
150
0.182-0.228
60
75
120
200
0.209-0.261
60
100
150
250
0.312-0.389
75
100
150
300
0.318-0.397
75
100
150
400
7.5
0.386-0.482
75
100
225
400
0.469-0.586
100
120
300
600
10
0.567-0.709
100
120
300
600
0.181-0.227
75
75
200
350
0.243-0.304
100
120
250
400
0.285-0.356
100
120
300
750
0.338-0.422
100
120
400
750
Commercial
Stopper Size (mm)
13
13
20
20
20
20
20
20
13
20
20/13
20
20
20/32
28
20/28/32
28/32
32
28
28/32
13/20
13
13
13/20
20
20
20
20
20
20
20
20
20
20
20
20
Development
Greenville, USA
Monza, Italy
Ferentino, Italy
Ferentino, Italy
Greenville, USA
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0.452-0.564
120
200
500
950
14
0.863-1.079
200
300
750
1250
16
0.975-1.218
250
400
950
1500

0.073-0.123
60
60
75
150
0.138-0.183
60
75
120
200

0.173-0.244
60
100
150
250
21
81,000
65,000
74,000 69,000
89,000 19,000
14,000 295,000 200,000 206,000
27,000
5,400
0.195-0.305
75
100
150
300
22
73,000
58,000
67,000 67,000
86,000 18,000
12,500 265,000 179,000 185,000
24,000
4,800
61,000
49,000
55,000 55,000
69,000 14,000
10,000 174,000 117,000 121,000
16,000
3,200

Round
Microtablets
Sterile Products
Liquid-Filled Vial
Bilayer Tablets
Softgels
Lyophilized Vial
Monza, Italy
Vial Size
Sterile
Area 1
External OD
Example Fill
(mm)
16
2, 4
2 Twin Lyo
Units
Sterile
Area 2
Ferentino, Italy
Sterile
Area 3
Sterile
Area 1
Sterile
Area 2

Units
Units
Sterile
Area 2
138,000 111,000 127,000 120,000 153,000 37,000
Greenville, USA
Development
Sterile Unit
Line 1
Line 2
Line 3
Cytotoxic
CTM
24,000 490,000 318,000 329,000
43,000
8,600
0.279-0.367
75
100
150
400
24
10, 15
0.305-0.428
75
100
225
400
30
20, 25, 30
37,000
30,000
35,000 35,000
45,000
9,500
6,400 142,000
95,000
98,000
13,000
2,600
15
0.737-0.922
150
225
500
750
42
15
17,000
13,000
15,000 17,000
22,000
4,700
3,500
42,000
44,000
5,000
1,000
65,000
Trilayer Tablets

Sublingual Tablets
Tablets
Polymer Matrix
Wax Matrix
Pulsatile Release
Polymer Coating


Lyophilized Vials

Prefilled Syringes

Softgels

LiquiSoft Chewable

Soflet Gelcaps



Cartridges


Glass or polymeric

Glass or plastic
Sterile Doses
Vial Size* (ml)

Patented technology
Capsules
Liquid-Filled Vials
2
4
5
6
7
8
10
12
13
15
20
25
30
50
60
100
200
250
300
500
2
3
4
5
6
7
8
10
12
15
17
20
25
30
50
100

defined time period

Tablets
Twist-Off Softgels
Softgels
Oval
Chewable Tablets

Oblong
Tablets in Capsules
Softgel Capsules
Size
60 Count
100 Count
250 Count
500 Count
0.089-0.111
60
60
75
150
0.182-0.228
60
75
120
200
0.209-0.261
60
100
150
250
0.312-0.389
75
100
150
300
0.318-0.397
75
100
150
400
7.5
0.386-0.482
75
100
225
400
0.469-0.586
100
120
300
600
10
0.567-0.709
100
120
300
600
0.181-0.227
75
75
200
350
0.243-0.304
100
120
250
400
0.285-0.356
100
120
300
750
0.338-0.422
100
120
400
750
Commercial
Stopper Size (mm)
13
13
20
20
20
20
20
20
13
20
20/13
20
20
20/32
28
20/28/32
28/32
32
28
28/32
13/20
13
13
13/20
20
20
20
20
20
20
20
20
20
20
20
20
Development
Greenville, USA
Monza, Italy
Ferentino, Italy
Ferentino, Italy
Greenville, USA
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0.452-0.564
120
200
500
950
14
0.863-1.079
200
300
750
1250
16
0.975-1.218
250
400
950
1500

0.073-0.123
60
60
75
150
0.138-0.183
60
75
120
200

0.173-0.244
60
100
150
250
21
81,000
65,000
74,000 69,000
89,000 19,000
14,000 295,000 200,000 206,000
27,000
5,400
0.195-0.305
75
100
150
300
22
73,000
58,000
67,000 67,000
86,000 18,000
12,500 265,000 179,000 185,000
24,000
4,800
61,000
49,000
55,000 55,000
69,000 14,000
10,000 174,000 117,000 121,000
16,000
3,200

Round
Microtablets
Sterile Products
Liquid-Filled Vial
Bilayer Tablets
Softgels
Lyophilized Vial
Monza, Italy
Vial Size
Sterile
Area 1
External OD
Example Fill
(mm)
16
2, 4
2 Twin Lyo
Units
Sterile
Area 2
Ferentino, Italy
Sterile
Area 3
Sterile
Area 1
Sterile
Area 2

Units
Units
Sterile
Area 2
138,000 111,000 127,000 120,000 153,000 37,000
Greenville, USA
Development
Sterile Unit
Line 1
Line 2
Line 3
Cytotoxic
CTM
24,000 490,000 318,000 329,000
43,000
8,600
0.279-0.367
75
100
150
400
24
10, 15
0.305-0.428
75
100
225
400
30
20, 25, 30
37,000
30,000
35,000 35,000
45,000
9,500
6,400 142,000
95,000
98,000
13,000
2,600
15
0.737-0.922
150
225
500
750
42
15
17,000
13,000
15,000 17,000
22,000
4,700
3,500
42,000
44,000
5,000
1,000
65,000

You Need to Succeed


Conventional
Americas
USA
USA
USA
Canada
Whitby
Canada
Europe
Manati
Puerto Rico Mexico
France
Monza
Italy

Tilburg
Italy
UK
UK
Netherlands
Solid Dose Forms
Trilayer Tablets
Microtablets
Beads in Capsules
Coated Beads
Tablets in Capsules
Specialized
Softgels

Polymer Matrix
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Wax Matrix
Pulsatile Release
Polymer Coating
Sublingual Tablets
Conventional
Sterile Products
Uncoated
Coated
Coated Beads
Multiparticulates
Softgel Capsules
Softgels
Twist-Off Softgels
Soflet Gelcaps
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Finished Dose Forms
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Sterile Products
Vials
Lyophilized Vials
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Prefilled Syringes
Cartridges

Published 9/14
PATH0340R1
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Solid and Sterile
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US Headquarters
Japan Office
Patheon Inc.
Durham, NC 27703-8580
USA
P: +1 919 226 3200
F: +1 919 474 2269
www.patheon.com
Patheon UK Ltd.
Kingfisher Drive
Covingham, Swindon
Wiltshire SN3 5BZ
UK
P: +44 1793 524411
F: +44 1793 487053
www.patheon.com
Patheon K.K.
Tokyo 103-0023
Japan
P: +81 3 6202 7666
F: +81 3 6202 7676

You Need to Succeed


Conventional
Americas
USA
USA
USA
Canada
Whitby
Canada
Europe
Manati
Puerto Rico Mexico
France
Monza
Italy

Tilburg
Italy
UK
UK
Netherlands
Solid Dose Forms
Trilayer Tablets
Microtablets
Beads in Capsules
Coated Beads
Tablets in Capsules
Specialized
Softgels

Polymer Matrix
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Wax Matrix
Pulsatile Release
Polymer Coating
Sublingual Tablets
Conventional
Sterile Products
Uncoated
Coated
Coated Beads
Multiparticulates
Softgel Capsules
Softgels
Twist-Off Softgels
Soflet Gelcaps
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Finished Dose Forms
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Sterile Products
Vials
Lyophilized Vials
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Prefilled Syringes
Cartridges

Published 9/14
PATH0340R1
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US Headquarters
Japan Office
Patheon Inc.
Durham, NC 27703-8580
USA
P: +1 919 226 3200
F: +1 919 474 2269
www.patheon.com
Patheon UK Ltd.
Kingfisher Drive
Covingham, Swindon
Wiltshire SN3 5BZ
UK
P: +44 1793 524411
F: +44 1793 487053
www.patheon.com
Patheon K.K.
Tokyo 103-0023
Japan
P: +81 3 6202 7666
F: +81 3 6202 7676

Patheon Dosage Capabilities

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Patheon Dosage Capabilities

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All the Choices and Expertise

You Need to Succeed

Develop and Launch Products

Solid Dose Forms Specialized and

Ferentino Milton Park Swindon

Solid Dose Forms

Fast Dispersible Tablets

Laser-Drilled Controled-Release Tablets

Finished Dose Forms

For more information on

Solid and Sterile

2 IRs or IR+CR/SR fixed-dose combination

3 IRs or IR+placebo+CR/SR fixed-dose combination

Fast Dispersible Tablets

IR or CR/SR single or bilayer fixed-dose combinations; ideal for

Precise unit dosing for oral liquid and topical products

EnteriCare Enteric Softgels

Enteric properties are integrated into the gelatin shell

Solvatrol Enhanced Solubility

IR, disintegrates/disperses as suspension in water, divisible into 4

IR, single layer tablets for sublingual administration.

IRs and/or CRs/SRs fixed-dose combination, uncoated or polymer

IRs and/or CRs/SRs fixed-dose combination, hard shell, coated

Chewels Chewable Gels

IR or CR/SR; hard shell; options to improve solubility, bioavailability

Unique matrix system to fine-tune release

Enhances the solubility and bioavailability

Aseptic filling, terminal sterilization when required

Range of cartridge configurations

Solid dose for oral liquid formulations

Softgels Shapes and Sizes

CR/SR; hard shell; osmotic, zero-order, controlled-release over a

Conventional Solid Dose Forms

Immediate-release soft gelatin capsules

IR or CR/SR, over-encapsulation for blinded clinical supply

IR or CR/SR; low-dose tablets; via device, capsule or sachet

Required Container Size (cc) by Fill Count

Fill Volume Range (CC)

Stopper Size (mm)

IR or CR/SR, single-layer tablets, coated or uncoated, with or

IR, two-piece gelatin or HPMC capsules in a range of sizes and

14,000 295,000 200,000 206,000

12,500 265,000 179,000 185,000

10,000 174,000 117,000 121,000

IR, bottles and sachets, packaged in bottles and sachets of varying

Specialized Solid Dose Forms

2 Twin Lyo 2 Twin Lyo

138,000 111,000 127,000 120,000 153,000 37,000

3 Lyo Units 3 Lyo Units 3 Lyo Units

24,000 490,000 318,000 329,000

Other shapes and sizes available. Formulation can effect options.

* ISO standard and non-standard vials can be accommodated.

2 IRs or IR+CR/SR fixed-dose combination

3 IRs or IR+placebo+CR/SR fixed-dose combination

Fast Dispersible Tablets

IR or CR/SR single or bilayer fixed-dose combinations; ideal for

Precise unit dosing for oral liquid and topical products

EnteriCare Enteric Softgels

Enteric properties are integrated into the gelatin shell

Solvatrol Enhanced Solubility

IR, disintegrates/disperses as suspension in water, divisible into 4

IR, single layer tablets for sublingual administration.

IRs and/or CRs/SRs fixed-dose combination, uncoated or polymer

IRs and/or CRs/SRs fixed-dose combination, hard shell, coated