Professional Documents
Culture Documents
03/03/2015
1. Identification
1.1. Product identifier
Product Identity
Alternate Names
1.2. Relevant identified uses of the substance or mixture and uses advised against
Intended use
Application Method
Emergency
Customer Service: Rouses Point Pharmaceuticals,
LLC
908.372.1209
Keith S. Rotenberg, PhD
Corporate Vice President & Chief Scientific Officer
Rouses Point Pharmaceuticals, LLC
Ph: 908.372.1209
Cell: 973.303.3507
2. Hazard(s) identification
2.1. Classification of the substance or mixture
Flam. Liq. 2;H225
Danger
H225 Highly flammable liquid and vapor.
[Prevention]:
P210 Keep away from heat / sparks / open flames / hot surfaces - No smoking.
P235 Keep cool.
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3. Composition/information on ingredients
This product contains the following substances that present a hazard within the meaning of the relevant State and
Federal Hazardous Substances regulations.
Ingredient/Chemical Designations
Ethanol
CAS Number:
Weight %
GHS Classification
Notes
75 - 100
[1][2]
1.0 - 10
Not Classified
[1]
0000064-17-5
hydroxypropyl cellulose
CAS Number: 0009004-64-2
In accordance with paragraph (i) of 1910.1200, the specific chemical identity and/or exact percentage (concentration) of composition has been
withheld as a trade secret.
[1] Substance classified with a health or environmental hazard.
[2] Substance with a workplace exposure limit.
[3] PBT-substance or vPvB-substance.
*The full texts of the phrases are shown in Section 16.
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Product is water soluble with low toxicity. Do not induce vomiting as aspiration of the
product might occur. Drink large amounts of water. In cases where the ingestion of a large
amount is suspected, gastric lavage may be performed by experienced medical
personnel.
4.2. Most important symptoms and effects, both acute and delayed
Overview
Tretinoin, also called retinoic acid or all-trans-retinoic acid may be irritating to the eye or
skin.
This product is considered safe for its intended use, however, as is the case with all topical
products, a small number of individuals may experience reactions such as redness, rash
and/or swelling. Use of this product should be discontinued any time a reaction occurs. A
physician, emergency room or Poison Control Center should be called any time the product
is ingested orally.
Symptoms of Exposure: Peeling and redness of the skin. Peeling of the skin may take
place if chronically exposed. May cause irritation of the nasal mucosa and respiratory tract.
Carcinogenicity: Not tested. Product does not contain any chemical included in the State of
California Environmental Protection Agency listing of chemicals known to the state to cause
cancer or reproductive toxicity. (Proposition 65 List). None of the ingredients in this product
are listed by International Agency for Research on Cancer (IARC), National Toxicology
Program (NTP) or Occupational Safety and Health Administration (OSHA) as carcinogens.
Exposure to solvent vapor concentrations from the component solvents in excess of the
stated occupational exposure limits may result in adverse health effects such as mucous
membrane and respiratory system irritation and adverse effects on the kidneys, liver and
central nervous system. Symptoms include headache, nausea, dizziness, fatigue, muscular
weakness, drowsiness and in extreme cases, loss of consciousness.
Repeated or prolonged contact with the preparation may cause removal of natural fat from
the skin resulting in dryness, irritation and possible non-allergic contact dermatitis. Solvents
may also be absorbed through the skin. Splashes of liquid in the eyes may cause irritation
and soreness with possible reversible damage. See section 2 for further details.
5. Fire-fighting measures
5.1. Extinguishing media
Use ABC all purpose extinguisher media or CO2.
5.2. Special hazards arising from the substance or mixture
Hazardous decomposition: High temperatures and fires may produce such toxic substances as carbon monoxide and
carbon dioxide.
Keep away from heat / sparks / open flames / hot surfaces - No smoking.
Keep cool.
Ground / bond container and receiving equipment.
Use explosion-proof electrical / ventilating / light / equipment.
Use only non-sparking tools.
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0009004-64-2
Ingredient
Source
Ethanol
hydroxypropyl cellulose
Value
OSHA
ACGIH
NIOSH
Supplier
No Established Limit
OSHA
No Established Limit
ACGIH
No Established Limit
NIOSH
No Established Limit
Supplier
No Established Limit
Carcinogen Data
CAS No.
0000064-17-5
0009004-64-2
Ingredient
Ethanol
hydroxypropyl cellulose
Source
Value
OSHA
Select Carcinogen: No
NTP
IARC
Group 1: Yes; Group 2a: No; Group 2b: No; Group 3: No; Group 4: No;
OSHA
Select Carcinogen: No
NTP
IARC
Group 1: No; Group 2a: No; Group 2b: No; Group 3: No; Group 4: No;
Wear overalls to keep skin contact to a minimum. Use neoprene or rubber gloves or
PVC..
Provide adequate ventilation. Where reasonably practicable this should be achieved by the
use of local exhaust ventilation and good general extraction. If these are not sufficient to
maintain concentrations of particulates and any vapor below occupational exposure limits
suitable respiratory protection must be worn.
Use good personal hygiene practices. Wash hands before eating, drinking, smoking or
using toilet. Promptly remove soiled clothing and wash thoroughly before reuse.
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Ethanol - (64-17-5)
Oral LD50,
mg/kg
7,060.00, Rat Category: NA
No data
available
Skin LD50,
mg/kg
Inhalation
Vapor LD50,
mg/L/4hr
Inhalation
Dust/Mist LD50,
mg/L/4hr
Inhalation
Gas LD50,
ppm
20,000.00,
Rabbit Category: NA
No data
available
No data
available
No data
available
No data
available
No data
available
No data
available
Note: When no route specific LD50 data is available for an acute toxin, the converted acute toxicity point estimate
was used in the calculation of the product's ATE (Acute Toxicity Estimate).
Classification
Category
Hazard Description
---
Not Applicable
---
Not Applicable
---
Not Applicable
Skin corrosion/irritation
---
Not Applicable
---
Not Applicable
Respiratory sensitization
---
Not Applicable
Skin sensitization
---
Not Applicable
---
Not Applicable
Carcinogenicity
---
Not Applicable
Reproductive toxicity
---
Not Applicable
STOT-single exposure
---
Not Applicable
STOT-repeated exposure
---
Not Applicable
Aspiration hazard
---
Not Applicable
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48 hr EC50 crustacea,
mg/l
ErC50 algae,
mg/l
42.00, Oncorhynchus
mykiss
Not Available
Not Available
Ingredient
Ethanol - (64-17-5)
hydroxypropyl cellulose - (9004-64-2)
Not Available
14.1. UN number
14.2. UN proper shipping
name
14.3. Transport hazard
class(es)
14.4. Packing group
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ICAO/IATA
UN1987
Alcohols, n.o.s.
03/03/2015
Fire:
Sudden Release of Pressure:
Reactive:
Immediate (Acute):
Delayed (Chronic):
Yes
No
No
No
No
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