DISSEMINATED INTRAVASCULAR COAGULOPATHY

Predisposing Factor Precipitating Factors

- Infections
- None- - Obstetric Complications
- Trauma or Surgery
- Vascular Disorder
- Shock

Stimulus

Tissue Destruction Endothelial Injury

Extrinsic Pathway Tissue Factor Endotoxin

Thrombin Generation Factor XII Activation

(Intrinsic Pathway)

Intravascular Fibrin Plasminogen Activation

Deposition
Platelet Consumption
Plasmin Generation

Decreased Amount of
Platelet

Thrombosis Fibrinolysis Clotting Factor

Degradation

Hemolytic Tissue Fibrin Degradation

Anemia Ischemia (Inhibit Thrombin and BLEEDING
Platelet Aggregation)

If Treated: If Not Treated:

- Anti-coagulants
- Blood Components
- Antifibrinolytics POOR PROGNOSIS

GOOD PROGNOSIS
Hypovolemic Shock

Coma

DEATH